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The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
GRB7 (Growth Factor Receptor Bound Protein 7) is a Protein Coding gene. Diseases associated with GRB7 include Breast Cancer and Gastric Cancer. Among its related pathways are Integrin Pathway and MAPK Signaling: Mitogen Stimulation Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is GRB10.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 8940081 |
GO:0008289 | lipid binding | IEA | -- |
GO:0019901 | protein kinase binding | IDA | 12021278 |
GO:0035091 | phosphatidylinositol binding | IDA | 12021278 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0005925 | focal adhesion | IEA,IDA | 10893408 |
GO:0010494 | cytoplasmic stress granule | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response IL-23 signaling pathway |
Development Angiopoietin - Tie2 signaling
.38
Angiopoietin-TIE2 Signaling
.36
|
|
2 | RET signaling |
.92
|
|
3 | Developmental Biology |
.51
|
|
4 | Cell surface interactions at the vascular wall |
.01
|
|
5 | Development ERBB-family signaling |
Development ERBB-family signaling
.51
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 9710451 |
GO:0007411 | axon guidance | TAS | -- |
GO:0008286 | NOT insulin receptor signaling pathway | IBA | 21873635 |
GO:0017148 | negative regulation of translation | ISS | -- |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - |
ExUns: | 16 | ^ | 17a | · | 17b | · | 17c |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GRB7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GRB7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GRB7 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Grb7 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Grb7 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GRB7 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GRB7 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GRB7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GRB7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grb7 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | GRB7 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | pico 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | mig-10 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10684 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs138488202 | Benign: not provided | 39,745,316(+) |
C/T NM_005310.5(GRB7):c.1085C>T (p.Pro362Leu) |
MISSENSE | |
rs139030455 | Benign: not provided | 39,743,199(+) |
C/T NM_005310.5(GRB7):c.483C>T (p.His161=) |
SYNONYMOUS | |
rs145723329 | Benign: not provided | 39,745,774(+) |
C/A NM_005310.5(GRB7):c.1256C>A (p.Thr419Lys) |
MISSENSE | |
rs66788250 | Benign: not provided | 39,745,724(+) |
A/G NM_005310.5(GRB7):c.1210-4A>G |
INTRON | |
rs777523440 | Uncertain Significance: Severe Myopia | 39,744,134(+) |
G/A NM_005310.4(GRB7):c.728G>A (p.Arg243Gln) |
MISSENSE |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1056234 | CNV | gain | 25217958 |
nsv1146669 | OTHER | inversion | 26484159 |
nsv2048 | CNV | insertion | 18451855 |
nsv953895 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|
gastric cancer |
|
|