The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migra... See more...

Aliases for GRB7 Gene

Aliases for GRB7 Gene

  • Growth Factor Receptor Bound Protein 7 2 3 5
  • Growth Factor Receptor-Bound Protein 7 2 3 4
  • Epidermal Growth Factor Receptor GRB-7 3 4
  • GRB7 Adapter Protein 3 4
  • B47 3 4
  • GRB7 5

External Ids for GRB7 Gene

Previous GeneCards Identifiers for GRB7 Gene

  • GC17M037569
  • GC17P039891
  • GC17P037804
  • GC17P038269
  • GC17P035147
  • GC17P037894
  • GC17P033688

Summaries for GRB7 Gene

Entrez Gene Summary for GRB7 Gene

  • The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for GRB7 Gene

GRB7 (Growth Factor Receptor Bound Protein 7) is a Protein Coding gene. Diseases associated with GRB7 include Breast Cancer and Gastric Cancer. Among its related pathways are Integrin Pathway and MAPK Signaling: Mitogen Stimulation Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is GRB10.

UniProtKB/Swiss-Prot Summary for GRB7 Gene

  • Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).

Gene Wiki entry for GRB7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRB7 Gene

Genomics for GRB7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GRB7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRB7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRB7

Top Transcription factor binding sites by QIAGEN in the GRB7 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • ZIC2

Genomic Locations for GRB7 Gene

Latest Assembly
chr17:39,737,927-39,747,291
(GRCh38/hg38)
Size:
9,365 bases
Orientation:
Plus strand

Previous Assembly
chr17:37,894,191-37,903,538
(GRCh37/hg19 by Entrez Gene)
Size:
9,348 bases
Orientation:
Plus strand

chr17:37,894,180-37,903,544
(GRCh37/hg19 by Ensembl)
Size:
9,365 bases
Orientation:
Plus strand

Genomic View for GRB7 Gene

Genes around GRB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRB7 Gene

Proteins for GRB7 Gene

  • Protein details for GRB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14451-GRB7_HUMAN
    Recommended name:
    Growth factor receptor-bound protein 7
    Protein Accession:
    Q14451
    Secondary Accessions:
    • B2RAV1
    • B3KNL0
    • B3KWP9
    • B7WP75
    • J3KQM4
    • Q53YD3
    • Q92568
    • Q96DF9
    • Q9Y220

    Protein attributes for GRB7 Gene

    Size:
    532 amino acids
    Molecular mass:
    59681 Da
    Quaternary structure:
    • Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).

    Three dimensional structures from OCA and Proteopedia for GRB7 Gene

    Alternative splice isoforms for GRB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRB7 Gene

Post-translational modifications for GRB7 Gene

  • Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRB7 Gene

Domains & Families for GRB7 Gene

Gene Families for GRB7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for GRB7 Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Pleckstrin-like
  • RA domain
ProtoNet:

Suggested Antigen Peptide Sequences for GRB7 Gene

GenScript: Design optimal peptide antigens:
  • GRB7 adapter protein (GRB7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14451

UniProtKB/Swiss-Prot:

GRB7_HUMAN :
  • The PH domain mediates interaction with membranes containing phosphoinositides.
  • Belongs to the GRB7/10/14 family.
Domain:
  • The PH domain mediates interaction with membranes containing phosphoinositides.
Family:
  • Belongs to the GRB7/10/14 family.
genes like me logo Genes that share domains with GRB7: view

Function for GRB7 Gene

Molecular function for GRB7 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
GENATLAS Biochemistry:
growth factor receptor bound protein 7,homolog to a newly identified C elegans gene,coamplified with ERBB2 in primary gastric cancer,with two isoforms GRB7 and GRB7V,overexpressed in invasive esophageal carcinomas

Phenotypes From GWAS Catalog for GRB7 Gene

Gene Ontology (GO) - Molecular Function for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 8940081
GO:0008289 lipid binding IEA --
GO:0019901 protein kinase binding IDA 12021278
GO:0035091 phosphatidylinositol binding IDA 12021278
genes like me logo Genes that share ontologies with GRB7: view
genes like me logo Genes that share phenotypes with GRB7: view

Animal Models for GRB7 Gene

MGI Knock Outs for GRB7:
  • Grb7 Grb7<tm1b(EUCOMM)Wtsi>

miRNA for GRB7 Gene

miRTarBase miRNAs that target GRB7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRB7 Gene

Localization for GRB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRB7 Gene

Cytoplasm. Cell junction, focal adhesion. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasmic granule. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. {ECO:0000250 UniProtKB:Q03160}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRB7 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IEA,IDA 10893408
GO:0010494 cytoplasmic stress granule ISS --
genes like me logo Genes that share ontologies with GRB7: view

Pathways & Interactions for GRB7 Gene

genes like me logo Genes that share pathways with GRB7: view

Pathways by source for GRB7 Gene

4 GeneGo (Thomson Reuters) pathways for GRB7 Gene
  • Cell adhesion Ephrins signaling
  • Development Angiopoietin - Tie2 signaling
  • Development ERBB-family signaling
  • Neurophysiological process Receptor-mediated axon growth repulsion
1 R&D Systems pathway for GRB7 Gene
4 Qiagen pathways for GRB7 Gene
  • Angiopoietin-TIE2 Signaling
  • Breast Cancer Regulation by Stathmin1
  • Caspase Cascade
  • Integrin Pathway

SIGNOR curated interactions for GRB7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for GRB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS 9710451
GO:0007411 axon guidance TAS --
GO:0008286 NOT insulin receptor signaling pathway IBA 21873635
GO:0017148 negative regulation of translation ISS --
genes like me logo Genes that share ontologies with GRB7: view

Drugs & Compounds for GRB7 Gene

(2) Drugs for GRB7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for GRB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GRB7: view

Transcripts for GRB7 Gene

mRNA/cDNA for GRB7 Gene

5 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB7

Alternative Splicing Database (ASD) splice patterns (SP) for GRB7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - -
SP6: - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - -
SP9: - -

ExUns: 16 ^ 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for GRB7 Gene

GeneLoc Exon Structure for
GRB7

Expression for GRB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GRB7 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.0), Skin - Not Sun Exposed (Suprapubic) (x4.9), Skin - Sun Exposed (Lower leg) (x4.7), Kidney - Cortex (x4.6), and Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for GRB7 Gene

This gene is overexpressed in Lung (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRB7 Gene



Protein tissue co-expression partners for GRB7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRB7

SOURCE GeneReport for Unigene cluster for GRB7 Gene:

Hs.86859

Evidence on tissue expression from TISSUES for GRB7 Gene

  • Nervous system(4.4)
  • Lung(4.4)
  • Skin(2.3)
  • Kidney(2.3)
  • Intestine(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GRB7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRB7 Gene

Orthologs for GRB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRB7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GRB7 30 31
  • 99.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GRB7 30 31
  • 88.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GRB7 30 31
  • 86.97 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Grb7 30 17 31
  • 86.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Grb7 30
  • 85.94 (n)
Oppossum
(Monodelphis domestica)
Mammalia GRB7 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GRB7 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GRB7 30 31
  • 74.32 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GRB7 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia grb7 30
  • 67.76 (n)
Zebrafish
(Danio rerio)
Actinopterygii GRB7 31
  • 49 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta pico 31
  • 11 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea mig-10 31
  • 11 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10684 31
  • 35 (a)
OneToMany
Species where no ortholog for GRB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GRB7 Gene

ENSEMBL:
Gene Tree for GRB7 (if available)
TreeFam:
Gene Tree for GRB7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GRB7: view image

Paralogs for GRB7 Gene

Paralogs for GRB7 Gene

(2) SIMAP similar genes for GRB7 Gene using alignment to 3 proteins:

  • GRB7_HUMAN
  • J3QKK7_HUMAN
  • J3QL76_HUMAN
genes like me logo Genes that share paralogs with GRB7: view

Variants for GRB7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRB7 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs138488202 Benign: not provided 39,745,316(+) C/T
NM_005310.5(GRB7):c.1085C>T (p.Pro362Leu)
MISSENSE
rs139030455 Benign: not provided 39,743,199(+) C/T
NM_005310.5(GRB7):c.483C>T (p.His161=)
SYNONYMOUS
rs145723329 Benign: not provided 39,745,774(+) C/A
NM_005310.5(GRB7):c.1256C>A (p.Thr419Lys)
MISSENSE
rs66788250 Benign: not provided 39,745,724(+) A/G
NM_005310.5(GRB7):c.1210-4A>G
INTRON
rs777523440 Uncertain Significance: Severe Myopia 39,744,134(+) G/A
NM_005310.4(GRB7):c.728G>A (p.Arg243Gln)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GRB7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GRB7 Gene

Variant ID Type Subtype PubMed ID
nsv1056234 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv2048 CNV insertion 18451855
nsv953895 CNV deletion 24416366

Variation tolerance for GRB7 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRB7 Gene

Human Gene Mutation Database (HGMD)
GRB7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRB7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRB7 Gene

Disorders for GRB7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRB7 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search GRB7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRB7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Family of Databases
(TGDB)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GRB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRB7 Gene

Publications for GRB7 Gene

  1. Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis. (PMID: 19473962) Chu PY … Shen TL (The Journal of biological chemistry 2009) 3 4 23
  2. Grb7-SH2 domain dimerisation is affected by a single point mutation. (PMID: 15841400) Porter CJ … Wilce JA (European biophysics journal : EBJ 2005) 3 4 23
  3. Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2. (PMID: 12975581) Ivancic M … Lyons BA (Journal of biomolecular NMR 2003) 3 4 23
  4. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. (PMID: 12021278) Shen TL … Guan JL (The Journal of biological chemistry 2002) 3 4 23
  5. Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. (PMID: 10803466) Kasus-Jacobi A … Burnol AF (Oncogene 2000) 3 4 23

Products for GRB7 Gene

Sources for GRB7 Gene