Aliases for GRB7 Gene
Aliases for GRB7 Gene
External Ids for GRB7 Gene
- HGNC: 4567
- Entrez Gene: 2886
- Ensembl: ENSG00000141738
- OMIM: 601522
- UniProtKB: Q14451
Previous GeneCards Identifiers for GRB7 Gene
- GC17M037569
- GC17P039891
- GC17P037804
- GC17P038269
- GC17P035147
- GC17P037894
- GC17P033688
Summaries for GRB7 Gene
-
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
GeneCards Summary for GRB7 Gene
GRB7 (Growth Factor Receptor Bound Protein 7) is a Protein Coding gene. Diseases associated with GRB7 include Silver-Russell Syndrome and Breast Cancer. Among its related pathways are RET signaling and Signaling events mediated by focal adhesion kinase. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is GRB10.
UniProtKB/Swiss-Prot for GRB7 Gene
-
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRB7 Gene
Genomics for GRB7 Gene
GeneHancer (GH) Regulatory Elements for GRB7 Gene
Promoters and enhancers for GRB7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRB7 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GRB7 gene promoter:
-
- E2F-2
- E2F
- E2F-1
- ZIC2
- E2F-3a
- E2F-4
Regulatory Element Products
Genomic Locations for GRB7 Gene
Genomic Locations for GRB7 Gene
- chr17:39,737,909-39,747,291
- (GRCh38/hg38)
- Size:
- 9,383 bases
- Orientation:
- Plus strand
- chr17:37,894,162-37,903,544
- (GRCh37/hg19)
- Size:
- 9,383 bases
- Orientation:
- Plus strand
Genomic View for GRB7 Gene
Genes around GRB7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by Entrez Gene
- 17q12 by HGNC
- 17q12 by Ensembl
GRB7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRB7 Gene
Proteins for GRB7 Gene
-
Protein details for GRB7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14451-GRB7_HUMAN
- Recommended name:
- Growth factor receptor-bound protein 7
- Protein Accession:
- Q14451
- B2RAV1
- B3KNL0
- B3KWP9
- B7WP75
- J3KQM4
- Q53YD3
- Q92568
- Q96DF9
- Q9Y220
Protein attributes for GRB7 Gene
- Size:
- 532 amino acids
- Molecular mass:
- 59681 Da
- Quaternary structure:
-
- Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).
Three dimensional structures from OCA and Proteopedia for GRB7 Gene
Protein Expression for GRB7 Gene
Post-translational modifications for GRB7 Gene
- Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for GRB7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GRB7 (GRB7)
- Novus Biologicals Antibodies for GRB7
-
Abcam antibodies for GRB7
- Invitrogen Antibodies for GRB7
- GeneTex GRB7 Antibody for GRB7
-
Boster Bio Antibodies for GRB7
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRB7
Protein Products
-
OriGene Purified Proteins for GRB7
- Search Origene for MassSpec and Protein Over-expression Lysates for GRB7
- Origene Custom Protein Services for GRB7
- Search GeneTex for Proteins for GRB7
-
Abcam proteins for GRB7
Assay Products
No data available for DME Specific Peptides for GRB7 Gene
Domains & Families for GRB7 Gene
Gene Families for GRB7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for GRB7 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRB7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14451UniProtKB/Swiss-Prot:
GRB7_HUMAN :- The PH domain mediates interaction with membranes containing phosphoinositides.
- Belongs to the GRB7/10/14 family.
- Domain:
-
- The PH domain mediates interaction with membranes containing phosphoinositides.
- Family:
-
- Belongs to the GRB7/10/14 family.
Function for GRB7 Gene
Molecular function for GRB7 Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
- GENATLAS Biochemistry:
- growth factor receptor bound protein 7,homolog to a newly identified C elegans gene,coamplified with ERBB2 in primary gastric cancer,with two isoforms GRB7 and GRB7V,overexpressed in invasive esophageal carcinomas
Phenotypes From GWAS Catalog for GRB7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005070 | SH3/SH2 adaptor activity | IEA,TAS | -- |
| GO:0005515 | protein binding | IPI | 8940081 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0019901 | protein kinase binding | IDA | 12021278 |
Phenotypes for GRB7 Gene
- MGI mutant phenotypes for GRB7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRB7:
-
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability in esophageal squamous lineage
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella enterica Typhimurium ruffling
- Decreased Salmonella enterica Typhimurium effector injection
- Decreased viability
- Increased cell migration
- Decreased cell migration
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Mildly decreased CFP-tsO45G cell surface transport
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Increased cell number in S
- Decreased IL-8 secretion
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for GRB7 Gene
- MGI Knock Outs for GRB7:
-
- Grb7 Grb7<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GRB7
-
CRISPR Products
-
OriGene CRISPR knockouts for GRB7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB7
- genomics-online: gRNA clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
- Applied Biological Materials CRISPR for GRB7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB7
- GenScript: Design CRISPR guide RNA sequences for GRB7
miRNA for GRB7 Gene
- miRTarBase miRNAs that target GRB7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB7
- Browse OriGene Inhibitory RNA Products For GRB7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB7
- genomics-online: shRNA clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
Clone Products
-
OriGene ORF clones in human for GRB7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for GRB7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRB7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GRB7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB7
- Applied Biological Materials Clones for GRB7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GRB7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRB7 Gene
Localization for GRB7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRB7 Gene
- Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. {ECO:0000250 UniProtKB:Q03160}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| cytoskeleton | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005925 | focal adhesion | IEA,IDA | 10893408 |
| GO:0010494 | cytoplasmic stress granule | ISS | -- |
Pathways & Interactions for GRB7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response IL-23 signaling pathway | ||
| 2 | RET signaling |
.92
|
|
| 3 | Developmental Biology |
.51
|
|
| 4 | Cell surface interactions at the vascular wall |
.01
|
|
| 5 | Signaling by ERBB2 | ||
Pathways by source for GRB7 Gene
7 BioSystems pathways for GRB7 Gene
12 Reactome pathways for GRB7 Gene
4 GeneGo (Thomson Reuters) pathways for GRB7 Gene
1 R&D Systems pathway for GRB7 Gene
4 Qiagen pathways for GRB7 Gene
Interacting Proteins for GRB7 Gene
Selected Interacting proteins:
Q14451-GRB7_HUMAN
ENSP00000403459
for GRB7 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GRB7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 9710451 |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0009967 | positive regulation of signal transduction | IEA | -- |
| GO:0017148 | negative regulation of translation | ISS | -- |
Transcripts for GRB7 Gene
mRNA/cDNA for GRB7 Gene
- (6) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (125) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000577695 612 bps (uc060etr.1)
- ENST00000309156 2243 bps (uc002hsr.4)
- ENST00000485182 879 bps (uc060ets.1)
- ENST00000583813 560 bps (uc060ett.1)
- ENST00000584853 570 bps (uc060etu.1)
Unigene Clusters for GRB7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GRB7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB7
- genomics-online: gRNA clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
- Applied Biological Materials CRISPR for GRB7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB7
- GenScript: Design CRISPR guide RNA sequences for GRB7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB7
- Browse OriGene Inhibitory RNA Products For GRB7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB7
- genomics-online: shRNA clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
Clone Products
-
OriGene ORF clones in human for GRB7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for GRB7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GRB7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GRB7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB7
- Applied Biological Materials Clones for GRB7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
| ExUns: | 16 | ^ | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: |
Expression for GRB7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Gut Tube (Gastrointestinal Tract)
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Epithelial Cells
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
- Lower Urinary Tract (Urinary System)
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for GRB7 Gene
This gene is overexpressed in Esophagus - Mucosa (x7.0), Skin - Not Sun Exposed (Suprapubic) (x4.9), Skin - Sun Exposed (Lower leg) (x4.7), Kidney - Cortex (x4.6), and Pancreas (x4.1).
This gene is overexpressed in Lung (68.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRB7 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GRB7 Gene:
GRB7SOURCE GeneReport for Unigene cluster for GRB7 Gene:
Hs.86859Evidence on tissue expression from TISSUES for GRB7 Gene
- Lung(4.2)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for GRB7
-
OriGene qPCR primer pairs for GRB7
- genomics-online: primer clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRB7 Gene
Orthologs for GRB7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRB7 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GRB7 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GRB7 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Grb7 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Grb7 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GRB7 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GRB7 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GRB7 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GRB7 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | grb7 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | GRB7 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | pico 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | mig-10 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10684 34 |
|
OneToMany |
- Species where no ortholog for GRB7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for GRB7 Gene
- ENSEMBL:
- Gene Tree for GRB7 (if available)
- TreeFam:
- Gene Tree for GRB7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GRB7: view image
Paralogs for GRB7 Gene
Variants for GRB7 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000106146 | -- | 39,742,842(+) | A/G | 5_prime_UTR_variant, intron_variant | |
| rs1000180125 | -- | 39,737,641(+) | C/T | upstream_transcript_variant | |
| rs1000232299 | -- | 39,737,940(+) | T/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000569285 | -- | 39,746,321(+) | C/T | intron_variant | |
| rs1001010065 | -- | 39,740,993(+) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1056234 | CNV | gain | 25217958 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv2048 | CNV | insertion | 18451855 |
| nsv953895 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.59;
56.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRB7 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRB7 Gene
Disorders for GRB7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| silver-russell syndrome |
|
|
| breast cancer |
|
|
| esophageal cancer |
|
Search GRB7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GRB7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GRB7 Gene
Publications for GRB7 Gene
- Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis. (PMID: 19473962) Chu PY … Shen TL (The Journal of biological chemistry 2009) 3 4 22 58
- Grb7-SH2 domain dimerisation is affected by a single point mutation. (PMID: 15841400) Porter CJ … Wilce JA (European biophysics journal : EBJ 2005) 3 4 22 58
- Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2. (PMID: 12975581) Ivancic M … Lyons BA (Journal of biomolecular NMR 2003) 3 4 22 58
- Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. (PMID: 12021278) Shen TL … Guan JL (The Journal of biological chemistry 2002) 3 4 22 58
- Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. (PMID: 10803466) Kasus-Jacobi A … Burnol AF (Oncogene 2000) 3 4 22 58
Products for GRB7 Gene
- R&D Systems Antibodies for GRB7 (GRB7)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
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- OriGene Purified Proteins for GRB7
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- GenScript: Next-day shipping of latest version cDNA ORF clones for GRB7 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GRB7
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- GenScript Custom overexpressing Cell Line Services for GRB7
- GenScript: Design CRISPR guide RNA sequences for GRB7
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Gene Mutant Library, Variants up to 10^11
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- VectorBuilder custom plasmid, inducible vectors for GRB7
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for GRB7
- antibodies-online: Search results for 103 available GRB7 Antibodies ranked by validation data
- Compare Top GRB7 Antibodies
- antibodies-online: Search results for 20 available GRB7 Elisa Kits ranked by validation data
- Compare Top GRB7 Elisa Kits
- antibodies-online: Search results for 11 available GRB7 Proteins ranked by validation data
- Compare Top GRB7 Proteins
- GeneTex GRB7 Antibody for GRB7
- Search GeneTex for Proteins for GRB7
- Santa Cruz Biotechnology (SCBT) Antibodies for GRB7
- Search Santa Cruz Biotechnology (SCBT) for GRB7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GRB7
- Horizon Cell Lines for GRB7
- genomics-online: cdna clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
- orf clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
- genomics-online: gRNA clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
- genomics-online: primer clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
- genomics-online: shRNA clones - Search results for 97 available GRB7 gene related products
- Overview of 97 available GRB7 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB7
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- GeneCopoeia miRNA 3'UTR Target clone products for GRB7
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- Boster Bio Antibodies for GRB7
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Sources for GRB7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt