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The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migra... See more...
Aliases for GRB7 Gene
Aliases for GRB7 Gene
External Ids for GRB7 Gene
- HGNC: 4567
- NCBI Entrez Gene: 2886
- Ensembl: ENSG00000141738
- OMIM®: 601522
- UniProtKB/Swiss-Prot: Q14451
Previous GeneCards Identifiers for GRB7 Gene
- GC17M037569
- GC17P039891
- GC17P037804
- GC17P038269
- GC17P035147
- GC17P037894
- GC17P033688
Summaries for GRB7 Gene
-
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
GeneCards Summary for GRB7 Gene
GRB7 (Growth Factor Receptor Bound Protein 7) is a Protein Coding gene. Diseases associated with GRB7 include Breast Cancer and Gastric Cancer. Among its related pathways are Integrin Pathway and MAPK Signaling: Mitogen Stimulation Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is GRB10.
UniProtKB/Swiss-Prot Summary for GRB7 Gene
-
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
Additional gene information for GRB7 Gene
- HGNC (4567)
- NCBI Entrez Gene (2886)
- Ensembl (ENSG00000141738)
- OMIM® (601522)
- UniProtKB/Swiss-Prot (Q14451)
- Open Targets Platform(ENSG00000141738)
- Search for GRB7 at DataMed
- Search for GRB7 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRB7 Gene
Genomics for GRB7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GRB7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRB7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRB7
- Top Transcription factor binding sites by QIAGEN in the GRB7 gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- ZIC2
Genomic Locations for GRB7 Gene
Latest Assembly
- chr17:39,737,927-39,747,291
- (GRCh38/hg38)
- Size:
- 9,365 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:37,894,191-37,903,538
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,348 bases
- Orientation:
- Plus strand
- chr17:37,894,180-37,903,544
- (GRCh37/hg19 by Ensembl)
- Size:
- 9,365 bases
- Orientation:
- Plus strand
Genomic View for GRB7 Gene
Genes around GRB7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12 by HGNC
- 17q12 by Entrez Gene
- 17q12 by Ensembl
GRB7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRB7 Gene
Proteins for GRB7 Gene
-
Protein details for GRB7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14451-GRB7_HUMAN
- Recommended name:
- Growth factor receptor-bound protein 7
- Protein Accession:
- Q14451
- B2RAV1
- B3KNL0
- B3KWP9
- B7WP75
- J3KQM4
- Q53YD3
- Q92568
- Q96DF9
- Q9Y220
Protein attributes for GRB7 Gene
- Size:
- 532 amino acids
- Molecular mass:
- 59681 Da
- Quaternary structure:
-
- Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1, PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with SHC1. Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1 (By similarity). Interacts (via SH2 domain) with RET and PTK2/FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, PTK2/FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).
Three dimensional structures from OCA and Proteopedia for GRB7 Gene
Protein Expression for GRB7 Gene
Post-translational modifications for GRB7 Gene
- Phosphorylated on serine and threonine residues in response to heregulin. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues in response to NTN1 signaling. Phosphorylation promotes stress granule disassembly during recovery after cellular stress (By similarity). Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases. Tyrosine phosphorylation is essential for activation of down-stream protein kinases.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for GRB7 Gene
Antibodies for research
- G Biosciences Immunotag™ GRB7 Antibody
- LifeSpan BioSciences GRB7 Antibody
- NSJ Bioreagents GRB7 Antibody
- Novus Biologicals Antibodies for GRB7
-
Abcam antibodies for GRB7
- Invitrogen Antibodies for GRB7 (AFLGC-GRB7)
- antibodies-online: Show 37 available GRB7 Antibodies ranked by validation data
- Compare Top GRB7 Antibodies
-
Recommended
- 24 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 13 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 87 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
-
Biorbyt antibodies for GRB7
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRB7
Protein products for research
-
OriGene Purified Proteins for GRB7
- Search Origene for MassSpec and Protein Over-expression Lysates for GRB7
- Origene Custom Protein Services for GRB7
-
Abcam proteins for GRB7
Assay products for research
- antibodies-online: Show 28 available GRB7 Elisa Kits ranked by validation data
- Compare Top GRB7 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for GRB7 Gene
Domains & Families for GRB7 Gene
Gene Families for GRB7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for GRB7 Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- Pleckstrin-like
- RA domain
- ProtoNet:
Suggested Antigen Peptide Sequences for GRB7 Gene
- GenScript: Design optimal peptide antigens:
-
- GRB7 adapter protein (GRB7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14451UniProtKB/Swiss-Prot:
GRB7_HUMAN :- The PH domain mediates interaction with membranes containing phosphoinositides.
- Belongs to the GRB7/10/14 family.
- Domain:
-
- The PH domain mediates interaction with membranes containing phosphoinositides.
- Family:
-
- Belongs to the GRB7/10/14 family.
Function for GRB7 Gene
Molecular function for GRB7 Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
- GENATLAS Biochemistry:
- growth factor receptor bound protein 7,homolog to a newly identified C elegans gene,coamplified with ERBB2 in primary gastric cancer,with two isoforms GRB7 and GRB7V,overexpressed in invasive esophageal carcinomas
Phenotypes From GWAS Catalog for GRB7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 8940081 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0019901 | protein kinase binding | IDA | 12021278 |
| GO:0035091 | phosphatidylinositol binding | IDA | 12021278 |
Phenotypes for GRB7 Gene
- MGI mutant phenotypes for GRB7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRB7:
-
- Increased vaccinia virus (VACV) infection
- Increased viability
- no effect
- Decreased viability in esophageal squamous lineage
- Decreased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Strongly decreased CFP-tsO45G cell surface transport
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased IL-8 secretion
- Decreased Salmonella enterica Typhimurium invasion
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased Salmonella enterica Typhimurium ruffling
- Increased cell number in G1, average or increased nuclei size in G1
- Decreased viability
- Decreased cell migration
- Downregulation of NF-kappaB pathway after IL-1beta stimulation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance, increased peripheral FA formation, increased cell spreading
- Increased Salmonella enterica Typhimurium effector injection
Animal Models for GRB7 Gene
- MGI Knock Outs for GRB7:
-
- Grb7 Grb7<tm1b(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GRB7 - Starting at $85 >
- * GRB7 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GRB7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB7
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB7
miRNA for GRB7 Gene
- miRTarBase miRNAs that target GRB7
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB7
- Browse OriGene Inhibitory RNA Products For GRB7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB7
Clone products for research
- Applied Biological Materials (abm): Clones for GRB7 - Starting at $45 >
- * GRB7 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG208570
- MR208570
- MR208570L3
- MR208570L4
- RC200330
- RC200330L1
- RC200330L2
- RC200330L3
- RC200330L4
- RC215362
- RC215362L1
- RC215362L2
- RC215362L3
- RC215362L4
- RC234367
- RC234421
- RG200330
- RG215362
- RG234367
- RG234421
- RR203064
- RR203064L3
- RR203064L4
- MR208570L3V
- MR208570L4V
- RC200330L1V
- RC200330L2V
- RC200330L3V
- RC200330L4V
- RC215362L1V
- RC215362L2V
- RC215362L3V
- RC215362L4V
- RR203064L3V
- RR203064L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRB7
- Addgene plasmids for GRB7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB7
Cell Lines for research
-
Horizon Cell Lines for GRB7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRB7 Gene
Localization for GRB7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRB7 Gene
- Cytoplasm. Cell junction, focal adhesion. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasmic granule. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. {ECO:0000250 UniProtKB:Q03160}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005925 | focal adhesion | IEA,IDA | 10893408 |
| GO:0010494 | cytoplasmic stress granule | ISS | -- |
Pathways & Interactions for GRB7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response IL-23 signaling pathway |
Development Angiopoietin - Tie2 signaling
.38
Angiopoietin-TIE2 Signaling
.36
|
|
| 2 | RET signaling |
.92
|
|
| 3 | Developmental Biology |
.51
|
|
| 4 | Cell surface interactions at the vascular wall |
.01
|
|
| 5 | Development ERBB-family signaling |
Development ERBB-family signaling
.51
|
|
Pathways by source for GRB7 Gene
7 BioSystems pathways for GRB7 Gene
12 Reactome pathways for GRB7 Gene
4 GeneGo (Thomson Reuters) pathways for GRB7 Gene
- Cell adhesion Ephrins signaling
- Development Angiopoietin - Tie2 signaling
- Development ERBB-family signaling
- Neurophysiological process Receptor-mediated axon growth repulsion
1 R&D Systems pathway for GRB7 Gene
4 Qiagen pathways for GRB7 Gene
- Angiopoietin-TIE2 Signaling
- Breast Cancer Regulation by Stathmin1
- Caspase Cascade
- Integrin Pathway
Interacting Proteins for GRB7 Gene
Selected Interacting proteins:
Q14451-GRB7_HUMAN
ENSP00000403459
for GRB7 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GRB7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 9710451 |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0008286 | NOT insulin receptor signaling pathway | IBA | 21873635 |
| GO:0017148 | negative regulation of translation | ISS | -- |
Transcripts for GRB7 Gene
mRNA/cDNA for GRB7 Gene
- 5 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000309156 2233 nts (view in UCSC)
- ENST00000394204 1667 nts (view in UCSC)
- ENST00000394209 1955 nts (view in UCSC)
- ENST00000394211 2093 nts (view in UCSC)
- ENST00000445327 2197 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GRB7 - Starting at $85 >
- * GRB7 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GRB7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB7
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB7
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB7
- Browse OriGene Inhibitory RNA Products For GRB7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB7
Clone products for research
- Applied Biological Materials (abm): Clones for GRB7 - Starting at $45 >
- * GRB7 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG208570
- MR208570
- MR208570L3
- MR208570L4
- RC200330
- RC200330L1
- RC200330L2
- RC200330L3
- RC200330L4
- RC215362
- RC215362L1
- RC215362L2
- RC215362L3
- RC215362L4
- RC234367
- RC234421
- RG200330
- RG215362
- RG234367
- RG234421
- RR203064
- RR203064L3
- RR203064L4
- MR208570L3V
- MR208570L4V
- RC200330L1V
- RC200330L2V
- RC200330L3V
- RC200330L4V
- RC215362L1V
- RC215362L2V
- RC215362L3V
- RC215362L4V
- RR203064L3V
- RR203064L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRB7
- Addgene plasmids for GRB7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB7
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
| ExUns: | 16 | ^ | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: |
Relevant External Links for GRB7 Gene
- GeneLoc Exon Structure for
- GRB7
Expression for GRB7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Gut Tube (Gastrointestinal Tract)
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Epithelial Cells
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
- Lower Urinary Tract (Urinary System)
- Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for GRB7 Gene
This gene is overexpressed in Esophagus - Mucosa (x7.0), Skin - Not Sun Exposed (Suprapubic) (x4.9), Skin - Sun Exposed (Lower leg) (x4.7), Kidney - Cortex (x4.6), and Pancreas (x4.1).
This gene is overexpressed in Lung (68.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRB7 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRB7
SOURCE GeneReport for Unigene cluster for GRB7 Gene:
Hs.86859Evidence on tissue expression from TISSUES for GRB7 Gene
- Nervous system(4.4)
- Lung(4.4)
- Skin(2.3)
- Kidney(2.3)
- Intestine(2.2)
- Stomach(2)
Primer products for research
-
OriGene qPCR primer pairs for GRB7
-
OriGene qPCR primer pairs and template standards for GRB7
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRB7 Gene
Orthologs for GRB7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GRB7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GRB7 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GRB7 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Grb7 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Grb7 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | GRB7 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GRB7 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GRB7 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GRB7 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grb7 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | GRB7 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | pico 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | mig-10 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10684 31 |
|
OneToMany |
- Species where no ortholog for GRB7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GRB7 Gene
- ENSEMBL:
- Gene Tree for GRB7 (if available)
- TreeFam:
- Gene Tree for GRB7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GRB7: view image
Paralogs for GRB7 Gene
Variants for GRB7 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRB7 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs138488202 | Benign: not provided | 39,745,316(+) |
C/T NM_005310.5(GRB7):c.1085C>T (p.Pro362Leu) |
MISSENSE | |
| rs139030455 | Benign: not provided | 39,743,199(+) |
C/T NM_005310.5(GRB7):c.483C>T (p.His161=) |
SYNONYMOUS | |
| rs145723329 | Benign: not provided | 39,745,774(+) |
C/A NM_005310.5(GRB7):c.1256C>A (p.Thr419Lys) |
MISSENSE | |
| rs66788250 | Benign: not provided | 39,745,724(+) |
A/G NM_005310.5(GRB7):c.1210-4A>G |
INTRON | |
| rs777523440 | Uncertain Significance: Severe Myopia | 39,744,134(+) |
G/A NM_005310.4(GRB7):c.728G>A (p.Arg243Gln) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1056234 | CNV | gain | 25217958 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv2048 | CNV | insertion | 18451855 |
| nsv953895 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.59;
56.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRB7 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRB7 Gene
Disorders for GRB7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| gastric cancer |
|
|
Search GRB7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GRB7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Family of Databases
- (TGDB)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GRB7 Gene
Publications for GRB7 Gene
- Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis. (PMID: 19473962) Chu PY … Shen TL (The Journal of biological chemistry 2009) 3 4 23
- Grb7-SH2 domain dimerisation is affected by a single point mutation. (PMID: 15841400) Porter CJ … Wilce JA (European biophysics journal : EBJ 2005) 3 4 23
- Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2. (PMID: 12975581) Ivancic M … Lyons BA (Journal of biomolecular NMR 2003) 3 4 23
- Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. (PMID: 12021278) Shen TL … Guan JL (The Journal of biological chemistry 2002) 3 4 23
- Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. (PMID: 10803466) Kasus-Jacobi A … Burnol AF (Oncogene 2000) 3 4 23
ExternalLinks
Products for GRB7 Gene
- Custom Antibody ServicesOriGene Antibodies for GRB7
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- MG208570
- MR208570
- MR208570L3
- MR208570L4
- RC200330
- RC200330L1
- RC200330L2
- RC200330L3
- RC200330L4
- RC215362
- RC215362L1
- RC215362L2
- RC215362L3
- RC215362L4
- RC234367
- RC234421
- RG200330
- RG215362
- RG234367
- RG234421
- RR203064
- RR203064L3
- RR203064L4
- MR208570L3V
- MR208570L4V
- RC200330L1V
- RC200330L2V
- RC200330L3V
- RC200330L4V
- RC215362L1V
- RC215362L2V
- RC215362L3V
- RC215362L4V
- RR203064L3V
- RR203064L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Invitrogen Antibodies for GRB7 (AFLGC-GRB7)
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- Addgene plasmids for GRB7
- antibodies-online: Show 37 available GRB7 Antibodies ranked by validation data
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- Recommended
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- 1 IHC Antibody (anti-rat)
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- 87 WB Antibodies (anti-human)
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- 5 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- antibodies-online: Show 28 available GRB7 Elisa Kits ranked by validation data
- Compare Top GRB7 Elisa Kits
- Quality Products:
- antibodies-online: Show 13 available GRB7 Proteins ranked by validation data
- Compare Top GRB7 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for GRB7
- Search Santa Cruz Biotechnology (SCBT) for GRB7 siRNA/shRNA
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- Horizon Cell Lines for GRB7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB7
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB7
- Biorbyt antibodies for GRB7
Sources for GRB7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
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- (115) NCBI Bookshelf
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB