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The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway.... See more...
Aliases for GRB2 Gene
Aliases for GRB2 Gene
External Ids for GRB2 Gene
- HGNC: 4566
- NCBI Entrez Gene: 2885
- Ensembl: ENSG00000177885
- OMIM®: 108355
- UniProtKB/Swiss-Prot: P62993
Previous GeneCards Identifiers for GRB2 Gene
- GC17M073313
- GC17M076374
- GC17M073779
- GC17M073911
- GC17M070825
- GC17M068724
Summaries for GRB2 Gene
-
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRB2 Gene
GRB2 (Growth Factor Receptor Bound Protein 2) is a Protein Coding gene. Diseases associated with GRB2 include Hepatitis C and Hepatitis E. Among its related pathways are TCR signaling in naive CD4+ T cells and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is GRAP.
UniProtKB/Swiss-Prot Summary for GRB2 Gene
-
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
-
[Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Additional gene information for GRB2 Gene
- HGNC (4566)
- NCBI Entrez Gene (2885)
- Ensembl (ENSG00000177885)
- OMIM® (108355)
- UniProtKB/Swiss-Prot (P62993)
- Open Targets Platform(ENSG00000177885)
- Monarch Initiative
- Search for GRB2 at DataMed
- Search for GRB2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRB2 Gene
Genomics for GRB2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GRB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRB2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRB2
- Top Transcription factor binding sites by QIAGEN in the GRB2 gene promoter:
-
- p53
- Sp1
Genomic Locations for GRB2 Gene
Latest Assembly
- chr17:75,318,076-75,405,709
- (GRCh38/hg38)
- Size:
- 87,634 bases
- Orientation:
- Minus strand
Previous Assembly
- chr17:73,314,157-73,401,759
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 87,603 bases
- Orientation:
- Minus strand
- chr17:73,314,157-73,401,790
- (GRCh37/hg19 by Ensembl)
- Size:
- 87,634 bases
- Orientation:
- Minus strand
Genomic View for GRB2 Gene
Genes around GRB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
GRB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRB2 Gene
Proteins for GRB2 Gene
-
Protein details for GRB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62993-GRB2_HUMAN
- Recommended name:
- Growth factor receptor-bound protein 2
- Protein Accession:
- P62993
- P29354
- Q14450
- Q63057
- Q63059
Protein attributes for GRB2 Gene
- Size:
- 217 amino acids
- Molecular mass:
- 25206 Da
- Quaternary structure:
-
- Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated) (PubMed:10026169, PubMed:19836242). Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (By similarity). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains (PubMed:8388384, PubMed:8491186, PubMed:9553137, PubMed:11433379). It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Interacts with SOS1 (PubMed:8493579, PubMed:7664271). Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1 (PubMed:7664271). Interacts with phosphorylated MET (PubMed:11063574, PubMed:11827484). Interacts with phosphorylated TOM1L1 (By similarity). Interacts with the phosphorylated C-terminus of SH2B2 (PubMed:9233773). Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation (By similarity) (PubMed:9489702, PubMed:12359715, PubMed:12486104, PubMed:12514734). Interacts with NISCH, PTPNS1 and REPS2 (PubMed:9062191, PubMed:9422736, PubMed:11912194). Interacts with syntrophin SNTA1 (By similarity). Interacts (via SH3 domains) with REPS1 (By similarity). Interacts (via SH3 domains) with PIK3C2B (PubMed:11533253). Interacts with CBL and CBLB (PubMed:10022120, PubMed:10086340). Interacts with AJUBA and CLNK (By similarity). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2 (PubMed:8723348, PubMed:9108392, PubMed:9484780, PubMed:10942756, PubMed:12171928). Interacts with PTPN11 (By similarity). Interacts with PRNP (By similarity). Interacts with RALGPS1 (PubMed:10747847). Interacts with HCST (PubMed:16582911). Interacts with KDR (By similarity). Interacts with FLT1 (tyrosine-phosphorylated) (By similarity). Interacts with GAPT and PTPRE (PubMed:10980613, PubMed:18559951). Interacts (via SH2 domain) with KIF26A (PubMed:19914172). Interacts (via SH3 2) with GAB2 (PubMed:19523899). Interacts with ADAM15 (PubMed:18296648). Interacts with THEMIS2 (By similarity). Interacts (via SH2 domain) with AXL (phosphorylated) (PubMed:9178760, PubMed:19815557). Interacts (via SH2 domain) with KIT (phosphorylated) (PubMed:15526160, PubMed:16129412). Interacts with PTPRJ and BCR (PubMed:12475979, PubMed:15302586). Interacts with PTPN23 (PubMed:21179510). Interacts with FLT4 (tyrosine phosphorylated) (PubMed:15102829). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:8798570, PubMed:12925710). Part of a complex including TNK2, GRB2, LTK and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2 (PubMed:9178760, PubMed:19815557). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:8262059). Interacts with ERBB4 (PubMed:10867024). Interacts with NTRK1 (phosphorylated upon ligand-binding) (PubMed:15488758). Interacts with PTK2/FAK1 (tyrosine phosphorylated) (PubMed:9148935). Interacts with PTK2B/PYK2 (tyrosine phosphorylated) (PubMed:20521079). Interacts (via SH3 domains) with GAREM1 isoform 1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation (PubMed:19509291). Interacts with DAB2 (By similarity). Interacts with TESPA1 (PubMed:22561606). Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1 (By similarity). Interacts with CD28 (PubMed:24098653). Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA (By similarity). Interacts with ASAP3 (phosphorylated form) (PubMed:22027826). Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts (via SH3 domain 2) with PRR14 (via proline-rich region) (PubMed:27041574). Interacts with FCRL6 (tyrosine phosphorylated form) (PubMed:20933011). Interacts with RHEX (via tyrosine-phosphorylated form) (PubMed:25092874). Interacts with DENND2B (PubMed:29030480). Interacts with SPRY2 (PubMed:17974561).
- [Isoform 1]: Interacts (via SH2-domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-69'.
- (Microbial infection) Interacts (via SH3 domain) with hepatitis E virus/HEV ORF3 protein.
- (Microbial infection) Interacts with hepatitis C virus/HCV protein NS5A via its SH3 domains.
- (Microbial infection) Interacts with herpes simplex virus 1 protein UL46.
Three dimensional structures from OCA and Proteopedia for GRB2 Gene
Alternative splice isoforms for GRB2 Gene
- UniProtKB/Swiss-Prot:
Protein Expression for GRB2 Gene
Post-translational modifications for GRB2 Gene
Other Protein References for GRB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences GRB2 Antibody (LS-B3923) and GRB2 Antibody (LS-B4508)
- RayBiotech Rabbit anti-GRB2 antibody
- NSJ Bioreagents GRB2 Antibody
- GeneTex Anti-GRB2 antibody
-
Custom Antibody ServicesOriGene Antibodies for GRB2
- Novus Biologicals Antibodies for GRB2
-
Abcam antibodies for GRB2
- Invitrogen Antibodies for GRB2 (AFLGC-GRB2)
- antibodies-online: Show 237 available GRB2 Antibodies ranked by validation data
- Compare Top GRB2 Antibodies
-
Recommended
- 64 WB Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 61 WB Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 159 WB Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IP Antibody (anti-human)
-
Custom Antibody ServicesProSci Antibodies for GRB2
- growth factor receptor-bound protein 2 [19-796]
- growth factor receptor-bound protein 2 [45-066]
- Growth factor receptor-bound protein 2 [62-216]
- Growth factor receptor-bound protein 2 [62-217]
- growth factor receptor-bound protein 2 [71-240]
- growth factor receptor-bound protein 2 [71-309]
- growth factor receptor-bound protein 2 [XW-7229]
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRB2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for GRB2
- Origene Custom Protein Services for GRB2
- ProSpec Recombinant Proteins for GRB2
-
ProSci Proteins for GRB2
-
Abcam proteins for GRB2
Assay products for research
No data available for DME Specific Peptides for GRB2 Gene
Domains & Families for GRB2 Gene
Gene Families for GRB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GRB2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRB2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA (B0LPF3_HUMAN)
- SH2/SH3 adapter GRB2 (GRB2_HUMAN)
- GRB2 protein (Q6ICN0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62993UniProtKB/Swiss-Prot:
GRB2_HUMAN :- The SH3 domains mediate interaction with RALGPS1 and SHB.
- Belongs to the GRB2/sem-5/DRK family.
- Domain:
-
- The SH3 domains mediate interaction with RALGPS1 and SHB.
- Family:
-
- Belongs to the GRB2/sem-5/DRK family.
Function for GRB2 Gene
Molecular function for GRB2 Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
- GENATLAS Biochemistry:
- growth factor receptor bound protein 2,major CBL associated protein,homolog to Caenorhabditis elegans Sem5 gene and Drosophila Drk,STAR playing a key role in insulin signal transduction through connecting with IRS1 and IGFR5,and in mitogenic RAS signalic through interaction with SHC1
Phenotypes From GWAS Catalog for GRB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005154 | epidermal growth factor receptor binding | IPI | 12577067 |
| GO:0005168 | neurotrophin TRKA receptor binding | IPI | 15488758 |
| GO:0005515 | protein binding | IEA,IPI | 7504175 |
Phenotypes for GRB2 Gene
- MGI mutant phenotypes for GRB2:
-
inferred from 7 alleles
- normal phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- mortality/aging
- renal/urinary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- embryo phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for GRB2:
-
- Decreased hepcidin::fluc mRNA expression
- Decreased viability
- no effect
- Reduced mammosphere formation
- shRNA abundance <= 25%
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Increased shRNA abundance
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell spreading
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GRB2 - Starting at $85 >
- * GRB2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GRB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB2
miRNA for GRB2 Gene
- miRTarBase miRNAs that target GRB2
-
- hsa-miR-433-3p (MIRT001201)
- hsa-miR-378a-3p (MIRT007278)
- hsa-miR-124-3p (MIRT022221)
- hsa-miR-34a-5p (MIRT025255)
- hsa-miR-7-5p (MIRT025709)
- hsa-miR-93-5p (MIRT027965)
- hsa-miR-16-5p (MIRT031431)
- hsa-miR-92b-3p (MIRT040690)
- hsa-miR-100-5p (MIRT048495)
- hsa-miR-376c-3p (MIRT053350)
- hsa-miR-27a-3p (MIRT437946)
- hsa-miR-200a-3p (MIRT438100)
- hsa-miR-541-5p (MIRT440533)
- hsa-miR-6834-5p (MIRT476076)
- hsa-miR-3915 (MIRT476077)
- hsa-miR-5196-5p (MIRT476078)
- hsa-miR-6787-5p (MIRT476079)
- hsa-miR-4747-5p (MIRT476080)
- hsa-miR-663a (MIRT476081)
- hsa-miR-1908-5p (MIRT476082)
- hsa-miR-1255b-5p (MIRT476083)
- hsa-miR-1255a (MIRT476084)
- hsa-miR-6077 (MIRT476085)
- hsa-miR-4749-5p (MIRT476086)
- hsa-miR-4706 (MIRT476087)
- hsa-miR-6133 (MIRT476088)
- hsa-miR-6130 (MIRT476089)
- hsa-miR-6129 (MIRT476090)
- hsa-miR-6127 (MIRT476091)
- hsa-miR-4510 (MIRT476092)
- hsa-miR-6875-5p (MIRT476093)
- hsa-miR-4419a (MIRT476094)
- hsa-miR-3126-5p (MIRT476095)
- hsa-miR-3928-3p (MIRT476096)
- hsa-miR-9500 (MIRT476097)
- hsa-miR-6165 (MIRT476098)
- hsa-miR-5586-3p (MIRT476100)
- hsa-miR-3934-5p (MIRT502280)
- hsa-miR-7853-5p (MIRT502281)
- hsa-miR-105-5p (MIRT502282)
- hsa-miR-522-3p (MIRT502283)
- hsa-miR-224-3p (MIRT502284)
- hsa-miR-2054 (MIRT548005)
- hsa-miR-6739-5p (MIRT548006)
- hsa-miR-6733-5p (MIRT548007)
- hsa-miR-3153 (MIRT548008)
- hsa-miR-6081 (MIRT548009)
- hsa-miR-6783-5p (MIRT548010)
- hsa-miR-4779 (MIRT548011)
- hsa-miR-4519 (MIRT548012)
- hsa-miR-6838-5p (MIRT548013)
- hsa-miR-497-5p (MIRT548014)
- hsa-miR-424-5p (MIRT548015)
- hsa-miR-195-5p (MIRT548016)
- hsa-miR-15b-5p (MIRT548017)
- hsa-miR-15a-5p (MIRT548018)
- hsa-miR-6891-5p (MIRT548019)
- hsa-miR-3173-3p (MIRT548020)
- hsa-miR-583 (MIRT548021)
- hsa-miR-4282 (MIRT548022)
- hsa-miR-548x-3p (MIRT562257)
- hsa-miR-548j-3p (MIRT562258)
- hsa-miR-548aq-3p (MIRT562259)
- hsa-miR-548am-3p (MIRT562260)
- hsa-miR-548aj-3p (MIRT562261)
- hsa-miR-548ah-3p (MIRT562262)
- hsa-miR-548ae-3p (MIRT562263)
- hsa-miR-548z (MIRT562264)
- hsa-miR-548h-3p (MIRT562265)
- hsa-miR-548d-3p (MIRT562266)
- hsa-miR-548bb-3p (MIRT562267)
- hsa-miR-548ac (MIRT562268)
- mmu-miR-466i-3p (MIRT583190)
- mmu-miR-329-3p (MIRT583191)
- mmu-miR-362-3p (MIRT583192)
- mmu-miR-669f-3p (MIRT583193)
- mmu-miR-466f-3p (MIRT583194)
- mmu-miR-467f (MIRT583195)
- mmu-miR-3971 (MIRT603946)
- rno-miR-19b-3p (MIRT731376)
- hsa-miR-329-3p (MIRT731549)
- hsa-miR-411-5p (MIRT732351)
- hsa-miR-96-3p (MIRT733604)
- hsa-miR-1281 (MIRT736985)
- hsa-miR-18a-3p (MIRT738295)
- hsa-miR-1913 (MIRT738488)
- hsa-miR-221-5p (MIRT739074)
- hsa-miR-22-3p (MIRT739093)
- hsa-miR-3120-3p (MIRT739955)
- hsa-miR-3155a (MIRT740432)
- hsa-miR-3155b (MIRT740443)
- hsa-miR-3194-3p (MIRT741049)
- hsa-miR-324-3p (MIRT741230)
- hsa-miR-4438 (MIRT744502)
- hsa-miR-4632-3p (MIRT746255)
- hsa-miR-484 (MIRT749047)
- hsa-miR-5197-3p (MIRT750085)
- hsa-miR-545-3p (MIRT750452)
- hsa-miR-558 (MIRT751045)
- hsa-miR-660-3p (MIRT753537)
- hsa-miR-6791-3p (MIRT756034)
- hsa-miR-6829-3p (MIRT757088)
- hsa-miR-760 (MIRT759451)
- hsa-miR-8073 (MIRT760122)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB2
- Browse OriGene Inhibitory RNA Products For GRB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB2
Clone products for research
- Applied Biological Materials (abm): Clones for GRB2 - Starting at $45 >
- * GRB2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202420
- MR202420
- MR202420L3
- MR202420L4
- RC200469
- RC200469L1
- RC200469L2
- RC200469L3
- RC200469L4
- RC213101
- RC213101L1
- RC213101L2
- RC213101L3
- RC213101L4
- RG200469
- RG213101
- RR206650
- RR206650L3
- RR206650L4
- MR202420L3V
- MR202420L4V
- RC200469L1V
- RC200469L2V
- RC200469L3V
- RC200469L4V
- RC213101L1V
- RC213101L2V
- RC213101L3V
- RC213101L4V
- RR206650L3V
- RR206650L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRB2
- Addgene plasmids for GRB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB2
Cell Lines for research
-
Horizon Cell Lines for GRB2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRB2 Gene
Localization for GRB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRB2 Gene
- Nucleus. Cytoplasm. Endosome. Golgi apparatus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
- Nucleoli (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 21179510 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 21179510 |
| GO:0005768 | endosome | IEA,IDA | 21179510 |
Pathways & Interactions for GRB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Transcription Receptor-mediated HIF regulation
.51
Translation Regulation of EIF2 activity
.47
Translation Regulation of EIF4F activity
.44
Development CNTF receptor signaling
.43
|
Cell adhesion PLAU signaling
.35
Development Growth hormone signaling via PI3K/AKT and MAPK cascades
.34
|
| 4 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
Immune response IL-9 signaling pathway
.42
Development Thrombopoietin-regulated cell processes
.38
|
|
| 5 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
|
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
TREM1 Pathway
.43
IL-4 Pathway
.34
|
Pathways by source for GRB2 Gene
6 Sino Biological pathways for GRB2 Gene
74 BioSystems pathways for GRB2 Gene
150 Reactome pathways for GRB2 Gene
2 PharmGKB pathways for GRB2 Gene
48 KEGG pathways for GRB2 Gene
82 GeneGo (Thomson Reuters) pathways for GRB2 Gene
- Apoptosis and survival BAD phosphorylation
- Apoptosis and survival NGF signaling pathway
- Cell adhesion Ephrins signaling
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cell adhesion PLAU signaling
13 R&D Systems pathways for GRB2 Gene
83 Qiagen pathways for GRB2 Gene
- 14-3-3 Induced Intracellular Signaling
- Activation of cAMP-Dependent PKA
- Angiopoietin-TIE2 Signaling
- BAD Phosphorylation
- BDNF Pathway
1 Cell Signaling Technology pathway for GRB2 Gene
1 GeneTex pathway for GRB2 Gene
Interacting Proteins for GRB2 Gene
Selected Interacting proteins:
P62993-GRB2_HUMAN
ENSP00000376345
for GRB2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GRB2
SIGNOR curated interactions for GRB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 1322798 |
| GO:0007265 | Ras protein signal transduction | TAS | 8253073 |
| GO:0007411 | axon guidance | TAS | -- |
| GO:0007568 | aging | IEA | -- |
Drugs & Compounds for GRB2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pegademase | Approved | Pharma | Target, binder | 0 | ||
| 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid | Experimental | Pharma | Target | 0 | ||
| Guanosine diphosphate | Experimental | Pharma | 0 | |||
| Guanosine monophosphate | Experimental | Pharma | 0 | |||
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
Transcripts for GRB2 Gene
mRNA/cDNA for GRB2 Gene
- 2 REFSEQ mRNAs :
- 23 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000316615 3181 nts (view in UCSC)
- ENST00000316804 3273 nts (view in UCSC)
- ENST00000392562 3729 nts (view in UCSC)
- ENST00000392563 2851 nts (view in UCSC)
- ENST00000392564 3182 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GRB2 - Starting at $85 >
- * GRB2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GRB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB2
- Browse OriGene Inhibitory RNA Products For GRB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB2
Clone products for research
- Applied Biological Materials (abm): Clones for GRB2 - Starting at $45 >
- * GRB2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202420
- MR202420
- MR202420L3
- MR202420L4
- RC200469
- RC200469L1
- RC200469L2
- RC200469L3
- RC200469L4
- RC213101
- RC213101L1
- RC213101L2
- RC213101L3
- RC213101L4
- RG200469
- RG213101
- RR206650
- RR206650L3
- RR206650L4
- MR202420L3V
- MR202420L4V
- RC200469L1V
- RC200469L2V
- RC200469L3V
- RC200469L4V
- RC213101L1V
- RC213101L2V
- RC213101L3V
- RC213101L4V
- RR206650L3V
- RR206650L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRB2
- Addgene plasmids for GRB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB2
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||
| SP7: | - | - | - |
Relevant External Links for GRB2 Gene
- GeneLoc Exon Structure for
- GRB2
Expression for GRB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hypoblast (Extraembryonic Tissues)
- Hypoblast Cells Hypoblast
- Brain (Nervous System)
- Bone (Muscoskeletal System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for GRB2 Gene
This gene is overexpressed in Whole Blood (x5.9).
This gene is overexpressed in Peripheral blood mononuclear cells (12.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRB2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRB2
SOURCE GeneReport for Unigene cluster for GRB2 Gene:
Hs.444356Evidence on tissue expression from TISSUES for GRB2 Gene
- Nervous system(5)
- Lung(4.9)
- Skin(4.7)
- Blood(4.6)
- Liver(3.2)
- Kidney(3.1)
- Intestine(3.1)
- Lymph node(3.1)
- Muscle(3.1)
- Heart(3.1)
- Bone marrow(3.1)
- Spleen(3)
- Pancreas(3)
- Eye(2.8)
- Adrenal gland(2.8)
- Thyroid gland(2.6)
- Stomach(2.6)
- Gall bladder(2.1)
Primer products for research
-
OriGene qPCR primer pairs for GRB2
-
OriGene qPCR primer pairs and template standards for GRB2
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRB2 Gene
Orthologs for GRB2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GRB2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GRB2 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GRB2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GRB2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Grb2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Grb2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GRB2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GRB2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GRB2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grb2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | grb2a 31 |
|
OneToMany | |
| grb2b 30 31 |
|
OneToMany | |||
| wufb18e12 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011768 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | drk 30 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | sem-5 30 31 32 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PIN3 33 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8309 31 |
|
OneToMany |
- Species where no ortholog for GRB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GRB2 Gene
- ENSEMBL:
- Gene Tree for GRB2 (if available)
- TreeFam:
- Gene Tree for GRB2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GRB2: view image
Paralogs for GRB2 Gene
(26) SIMAP similar genes for GRB2 Gene using alignment to 6 proteins:
- GRB2_HUMAN
- B0LPF3_HUMAN
- J3KT38_HUMAN
- J3QLF6_HUMAN
- J3QRL5_HUMAN
- Q6ICN0_HUMAN
Variants for GRB2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRB2 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2229610 | Benign: not provided | 75,325,960(-) |
G/A NM_002086.5(GRB2):c.237C>T (p.His79=) |
SYNONYMOUS_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2716238 | CNV | deletion | 23290073 |
| esv3369141 | CNV | insertion | 20981092 |
| nsv1066312 | CNV | gain | 25217958 |
| nsv111943 | CNV | deletion | 16902084 |
| nsv1134676 | CNV | deletion | 24896259 |
| nsv1140206 | CNV | deletion | 24896259 |
| nsv479218 | CNV | novel sequence insertion | 20440878 |
| nsv510727 | CNV | deletion | 20534489 |
| nsv576027 | CNV | gain | 21841781 |
| nsv833541 | CNV | loss | 17160897 |
| nsv960529 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.04;
0.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRB2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GRB2
