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The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway.... See more...
Aliases for GRB2 Gene
Aliases for GRB2 Gene
External Ids for GRB2 Gene
- HGNC: 4566
- Entrez Gene: 2885
- Ensembl: ENSG00000177885
- OMIM: 108355
- UniProtKB: P62993
Previous GeneCards Identifiers for GRB2 Gene
- GC17M073313
- GC17M076374
- GC17M073779
- GC17M073911
- GC17M070825
- GC17M068724
Summaries for GRB2 Gene
-
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GRB2 Gene
GRB2 (Growth Factor Receptor Bound Protein 2) is a Protein Coding gene. Diseases associated with GRB2 include Hepatitis and Hepatitis E. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is GRAP.
UniProtKB/Swiss-Prot Summary for GRB2 Gene
-
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
-
Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Additional gene information for GRB2 Gene
- Monarch Initiative
- Search for GRB2 at DataMed
- Search for GRB2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRB2 Gene
Genomics for GRB2 Gene
GeneHancer (GH) Regulatory Elements for GRB2 Gene
Promoters and enhancers for GRB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRB2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GRB2 gene promoter:
-
- p53
- Sp1
Genomic Locations for GRB2 Gene
Genomic Locations for GRB2 Gene
- chr17:75,318,076-75,405,709
- (GRCh38/hg38)
- Size:
- 87,634 bases
- Orientation:
- Minus strand
- chr17:73,314,157-73,401,790
- (GRCh37/hg19)
- Size:
- 87,634 bases
- Orientation:
- Minus strand
Genomic View for GRB2 Gene
Genes around GRB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
GRB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRB2 Gene
Proteins for GRB2 Gene
-
Protein details for GRB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62993-GRB2_HUMAN
- Recommended name:
- Growth factor receptor-bound protein 2
- Protein Accession:
- P62993
- P29354
- Q14450
- Q63057
- Q63059
Protein attributes for GRB2 Gene
- Size:
- 217 amino acids
- Molecular mass:
- 25206 Da
- Quaternary structure:
-
- Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated) (PubMed:10026169, PubMed:19836242). Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (By similarity). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains (PubMed:8388384, PubMed:8491186, PubMed:9553137, PubMed:11433379). It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Interacts with SOS1 (PubMed:8493579, PubMed:7664271). Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1 (PubMed:7664271). Interacts with phosphorylated MET (PubMed:11063574, PubMed:11827484). Interacts with phosphorylated TOM1L1 (By similarity). Interacts with the phosphorylated C-terminus of SH2B2 (PubMed:9233773). Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation (By similarity) (PubMed:9489702, PubMed:12359715, PubMed:12486104, PubMed:12514734). Interacts with NISCH, PTPNS1 and REPS2 (PubMed:9062191, PubMed:9422736, PubMed:11912194). Interacts with syntrophin SNTA1 (By similarity). Interacts (via SH3 domains) with REPS1 (By similarity). Interacts (via SH3 domains) with PIK3C2B (PubMed:11533253). Interacts with CBL and CBLB (PubMed:10022120, PubMed:10086340). Interacts with AJUBA and CLNK (By similarity). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2 (PubMed:8723348, PubMed:9108392, PubMed:9484780, PubMed:10942756, PubMed:12171928). Interacts with PTPN11 (By similarity). Interacts with PRNP (By similarity). Interacts with RALGPS1 (PubMed:10747847). Interacts with HCST (PubMed:16582911). Interacts with KDR (By similarity). Interacts with FLT1 (tyrosine-phosphorylated) (By similarity). Interacts with GAPT and PTPRE (PubMed:10980613, PubMed:18559951). Interacts (via SH2 domain) with KIF26A (PubMed:19914172). Interacts (via SH3 2) with GAB2 (PubMed:19523899). Interacts with ADAM15 (PubMed:18296648). Interacts with THEMIS2 (By similarity). Interacts (via SH2 domain) with AXL (phosphorylated) (PubMed:9178760, PubMed:19815557). Interacts (via SH2 domain) with KIT (phosphorylated) (PubMed:15526160, PubMed:16129412). Interacts with PTPRJ and BCR (PubMed:12475979, PubMed:15302586). Interacts with PTPN23 (PubMed:21179510). Interacts with FLT4 (tyrosine phosphorylated) (PubMed:15102829). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:8798570, PubMed:12925710). Part of a complex including TNK2, GRB2, LTK and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2 (PubMed:9178760, PubMed:19815557). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:8262059). Interacts with ERBB4 (PubMed:10867024). Interacts with NTRK1 (phosphorylated upon ligand-binding) (PubMed:15488758). Interacts with PTK2/FAK1 (tyrosine phosphorylated) (PubMed:9148935). Interacts with PTK2B/PYK2 (tyrosine phosphorylated) (PubMed:20521079). Isoform 1 interacts with SCIMP (PubMed:21930792). Interacts (via SH3 domains) with GAREM1 isoform 1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation (PubMed:19509291). Interacts with DAB2 (By similarity). Interacts with TESPA1 (PubMed:22561606). Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1 (By similarity). Interacts with CD28 (PubMed:24098653). Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA (By similarity). Interacts with ASAP3 (phosphorylated form) (PubMed:22027826). Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts (via SH3 domain 2) with PRR14 (via proline-rich region) (PubMed:27041574). Interacts with FCRL6 (tyrosine phosphorylated form) (PubMed:20933011). Interacts with RHEX (via tyrosine-phosphorylated form) (PubMed:25092874). Interacts with ST5 (PubMed:29030480).
- (Microbial infection) Interacts (via SH3 domain) with hepatitis E virus/HEV ORF3 protein.
- (Microbial infection) Interacts with hepatitis C virus/HCV protein NS5A via its SH3 domains.
- (Microbial infection) Interacts with herpes simplex virus 1 protein UL46.
Three dimensional structures from OCA and Proteopedia for GRB2 Gene
Alternative splice isoforms for GRB2 Gene
- UniProtKB/Swiss-Prot:
Protein Expression for GRB2 Gene
Post-translational modifications for GRB2 Gene
Other Protein References for GRB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- RayBiotech Rabbit anti-GRB2 antibody
- NSJ Bioreagents GRB2 Antibody
- Atlas Antibodies Anti-GRB2 Antibody (HPA030749) and Anti-GRB2 Antibody (HPA030750)
-
Creative Biolabs
- Recombinant Anti-Human GRB2 Antibody Fab Fragment
- Recombinant Anti-Human GRB2 Antibody
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1702)
- Hi-Affi™ Recombinant Rabbit Anti-GAB2 Monoclonal Antibody (DS1379AB)
- Recombinant Mouse Anti-Human GRB2 Antibody (clone S22)
- Mouse Anti-GRB2 Recombinant Antibody (5G121)
- Mouse Anti-GRB2 Recombinant Antibody (2GB04)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-219)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1703)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1712)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1707)
- Mouse Anti-GRB2 Recombinant Antibody (4C6-H6)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1706)
- Mouse Anti-GRB2 (AA 1-217) Recombinant Antibody (CBFYH-0470)
- Mouse Anti-GRB2 Recombinant Antibody (13k59)
- Mouse Anti-GRB2 Recombinant Antibody (15B163)
- Mouse Anti-GRB2 Recombinant Antibody (2GB04C1.4)
- Mouse Anti-GRB2 Recombinant Antibody (C1-4)
- Mouse Anti-GRB2 Recombinant Antibody (481021)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-217)
- Mouse Anti-GRB2 Recombinant Antibody (3H2183)
- Mouse Anti-GRB2 Recombinant Antibody (669604)
- Mouse Anti-GRB2 Recombinant Antibody (R11)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1701)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1699)
- Rabbit Anti-GRB2 Recombinant Antibody (Y237)
- Mouse Anti-GRB2 Recombinant Antibody (2B2.23)
- Rabbit Anti-GRB2 Recombinant Antibody (6BA29)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1704)
- Chicken Anti-GRB2 Polyclonal IgY
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1709)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1708)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-1705)
- Mouse Anti-GRB2 Recombinant Antibody (CBLG1-218)
- Hi-Affi™ Recombinant Rabbit Anti-GRB2 Monoclonal Antibody (DS1502AB)
- GeneTex Anti-GRB2 antibody
-
Custom Antibody ServicesOriGene Antibodies for GRB2
- Novus Biologicals Antibodies for GRB2
-
Abcam antibodies for GRB2
- Invitrogen Antibodies for GRB2 (AFLGC-GRB2)
- antibodies-online: Show 237 available GRB2 Antibodies ranked by validation data
- Compare Top GRB2 Antibodies
-
Recommended
- 64 WB Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 61 WB Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 159 WB Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IP Antibody (anti-human)
-
Santa Cruz Biotechnology (SCBT) Antibodies for GRB2
Protein Products
- Atlas Antibodies PrEST Antigen GRB2 (APrEST89286) and PrEST Antigen GRB2 (APrEST89287)
-
Creative Biomart
- Recombinant Human GRB2
- Recombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
- Recombinant Human GRB2, His-tagged
- Recombinant Human GRB2 293 Cell Lysate
- Recombinant Human GRB2 protein, His-tagged
- Recombinant Human GRB2 Protein, GST/His-tagged
- Recombinant Human GRB2 protein, T7/His-tagged
- Creative Diagnostics Human GRB2 peptide
- Search Origene for MassSpec and Protein Over-expression Lysates for GRB2
- Origene Custom Protein Services for GRB2
- ProSpec Recombinant Proteins for GRB2
-
ProSci Proteins for GRB2
-
Abcam proteins for GRB2
Assay Products
- Aviva Systems Biology Grb2 ELISA Kit (Human) (OKDD00296) and GRB2 ELISA Kit (Human) (OKCD08168)
No data available for DME Specific Peptides for GRB2 Gene
Domains & Families for GRB2 Gene
Gene Families for GRB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GRB2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GRB2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA (B0LPF3_HUMAN)
- SH2/SH3 adapter GRB2 (GRB2_HUMAN)
- GRB2 protein (Q6ICN0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62993UniProtKB/Swiss-Prot:
GRB2_HUMAN :- The SH3 domains mediate interaction with RALGPS1 and SHB.
- Belongs to the GRB2/sem-5/DRK family.
- Domain:
-
- The SH3 domains mediate interaction with RALGPS1 and SHB.
- Family:
-
- Belongs to the GRB2/sem-5/DRK family.
Function for GRB2 Gene
Molecular function for GRB2 Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
- UniProtKB/Swiss-Prot Function:
- Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
- GENATLAS Biochemistry:
- growth factor receptor bound protein 2,major CBL associated protein,homolog to Caenorhabditis elegans Sem5 gene and Drosophila Drk,STAR playing a key role in insulin signal transduction through connecting with IRS1 and IGFR5,and in mitogenic RAS signalic through interaction with SHC1
Phenotypes From GWAS Catalog for GRB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | 8253073 |
| GO:0005154 | epidermal growth factor receptor binding | IPI | 12577067 |
| GO:0005168 | neurotrophin TRKA receptor binding | IPI | 15488758 |
Phenotypes for GRB2 Gene
- MGI mutant phenotypes for GRB2:
-
inferred from 7 alleles
- cardiovascular system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for GRB2:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased shRNA abundance (Z-score < -2)
- Increased cell death HMECs cells
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Reduced mammosphere formation
- Decreased shRNA abundance
- Decreased viability
- Increased cell migration
- Decreased cell migration
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for GRB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB2
- genomics-online: gRNA clones - Search for available GRB2 gRNA products
- Overview of 133 available GRB2 gene related products
- Applied Biological Materials (abm): CRISPR Clones for GRB2 - Select products 50% OFF >
- * GRB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * GRB2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB2
miRNA for GRB2 Gene
- miRTarBase miRNAs that target GRB2
-
- hsa-mir-433-3p (MIRT001201)
- hsa-mir-378a-3p (MIRT007278)
- hsa-mir-124-3p (MIRT022221)
- hsa-mir-34a-5p (MIRT025255)
- hsa-mir-7-5p (MIRT025709)
- hsa-mir-93-5p (MIRT027965)
- hsa-mir-16-5p (MIRT031431)
- hsa-mir-92b-3p (MIRT040690)
- hsa-mir-100-5p (MIRT048495)
- hsa-mir-376c-3p (MIRT053350)
- hsa-mir-27a-3p (MIRT437946)
- hsa-mir-200a-3p (MIRT438100)
- hsa-mir-541-5p (MIRT440533)
- hsa-mir-6834-5p (MIRT476076)
- hsa-mir-3915 (MIRT476077)
- hsa-mir-5196-5p (MIRT476078)
- hsa-mir-6787-5p (MIRT476079)
- hsa-mir-4747-5p (MIRT476080)
- hsa-mir-663a (MIRT476081)
- hsa-mir-1908-5p (MIRT476082)
- hsa-mir-1255b-5p (MIRT476083)
- hsa-mir-1255a (MIRT476084)
- hsa-mir-6077 (MIRT476085)
- hsa-mir-4749-5p (MIRT476086)
- hsa-mir-4706 (MIRT476087)
- hsa-mir-6133 (MIRT476088)
- hsa-mir-6130 (MIRT476089)
- hsa-mir-6129 (MIRT476090)
- hsa-mir-6127 (MIRT476091)
- hsa-mir-4510 (MIRT476092)
- hsa-mir-6875-5p (MIRT476093)
- hsa-mir-4419a (MIRT476094)
- hsa-mir-3126-5p (MIRT476095)
- hsa-mir-3928-3p (MIRT476096)
- hsa-mir-9500 (MIRT476097)
- hsa-mir-6165 (MIRT476098)
- hsa-mir-5586-3p (MIRT476100)
- hsa-mir-3934-5p (MIRT502280)
- hsa-mir-7853-5p (MIRT502281)
- hsa-mir-105-5p (MIRT502282)
- hsa-mir-522-3p (MIRT502283)
- hsa-mir-224-3p (MIRT502284)
- hsa-mir-2054 (MIRT548005)
- hsa-mir-6739-5p (MIRT548006)
- hsa-mir-6733-5p (MIRT548007)
- hsa-mir-3153 (MIRT548008)
- hsa-mir-6081 (MIRT548009)
- hsa-mir-6783-5p (MIRT548010)
- hsa-mir-4779 (MIRT548011)
- hsa-mir-4519 (MIRT548012)
- hsa-mir-6838-5p (MIRT548013)
- hsa-mir-497-5p (MIRT548014)
- hsa-mir-424-5p (MIRT548015)
- hsa-mir-195-5p (MIRT548016)
- hsa-mir-15b-5p (MIRT548017)
- hsa-mir-15a-5p (MIRT548018)
- hsa-mir-6891-5p (MIRT548019)
- hsa-mir-3173-3p (MIRT548020)
- hsa-mir-583 (MIRT548021)
- hsa-mir-4282 (MIRT548022)
- hsa-mir-548x-3p (MIRT562257)
- hsa-mir-548j-3p (MIRT562258)
- hsa-mir-548aq-3p (MIRT562259)
- hsa-mir-548am-3p (MIRT562260)
- hsa-mir-548aj-3p (MIRT562261)
- hsa-mir-548ah-3p (MIRT562262)
- hsa-mir-548ae-3p (MIRT562263)
- hsa-mir-548z (MIRT562264)
- hsa-mir-548h-3p (MIRT562265)
- hsa-mir-548d-3p (MIRT562266)
- hsa-mir-548bb-3p (MIRT562267)
- hsa-mir-548ac (MIRT562268)
- hsa-mir-329-3p (MIRT731549)
- hsa-mir-411-5p (MIRT732351)
- hsa-mir-96-3p (MIRT733604)
- hsa-mir-1281 (MIRT736985)
- hsa-mir-18a-3p (MIRT738295)
- hsa-mir-1913 (MIRT738488)
- hsa-mir-221-5p (MIRT739074)
- hsa-mir-22-3p (MIRT739093)
- hsa-mir-3120-3p (MIRT739955)
- hsa-mir-3155a (MIRT740432)
- hsa-mir-3155b (MIRT740443)
- hsa-mir-3194-3p (MIRT741049)
- hsa-mir-324-3p (MIRT741230)
- hsa-mir-4438 (MIRT744502)
- hsa-mir-4632-3p (MIRT746255)
- hsa-mir-484 (MIRT749047)
- hsa-mir-5197-3p (MIRT750085)
- hsa-mir-545-3p (MIRT750452)
- hsa-mir-558 (MIRT751045)
- hsa-mir-660-3p (MIRT753537)
- hsa-mir-6791-3p (MIRT756034)
- hsa-mir-6829-3p (MIRT757088)
- hsa-mir-760 (MIRT759451)
- hsa-mir-8073 (MIRT760122)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GRB2
- Browse OriGene Inhibitory RNA Products For GRB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB2
- genomics-online: shRNA clones - Search for available GRB2 shRNA products
- Overview of 133 available GRB2 gene related products
Clone Products
-
- MG202420
- MR202420
- MR202420L3
- MR202420L3V
- MR202420L4
- MR202420L4V
- RC200469
- RC200469L1
- RC200469L1V
- RC200469L2
- RC200469L2V
- RC200469L3
- RC200469L3V
- RC200469L4
- RC200469L4V
- RC213101
- RC213101L1
- RC213101L1V
- RC213101L2
- RC213101L2V
- RC213101L3
- RC213101L3V
- RC213101L4
- RC213101L4V
- RG200469
- RG213101
- RR206650
- RR206650L3
- RR206650L3V
- RR206650L4
- RR206650L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRB2
- Addgene plasmids for GRB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB2
- genomics-online: cdna clones - Search for available GRB2 CDNA products
- Overview of 133 available GRB2 gene related products
- orf clones - Search for available GRB2 ORF products
- Overview of 133 available GRB2 gene related products
- Applied Biological Materials (abm): Clones for GRB2 - Select products 50% OFF >
- * GRB2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GRB2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for GRB2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRB2 Gene
Localization for GRB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRB2 Gene
- Nucleus. Cytoplasm. Endosome. Golgi apparatus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| endosome | 5 |
| cytosol | 5 |
| golgi apparatus | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 1 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 21179510 |
| GO:0005654 | nucleoplasm | IEA,IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 21179510 |
| GO:0005768 | endosome | IEA,IDA | 21179510 |
Pathways & Interactions for GRB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
| 4 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
| 5 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
|
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
TREM1 Pathway
.43
IL-4 Pathway
.34
|
Pathways by source for GRB2 Gene
3 Sino Biological pathways for GRB2 Gene
73 BioSystems pathways for GRB2 Gene
150 Reactome pathways for GRB2 Gene
2 PharmGKB pathways for GRB2 Gene
47 KEGG pathways for GRB2 Gene
82 GeneGo (Thomson Reuters) pathways for GRB2 Gene
13 R&D Systems pathways for GRB2 Gene
83 Qiagen pathways for GRB2 Gene
- 14-3-3 Induced Intracellular Signaling
- Activation of cAMP-Dependent PKA
- Angiopoietin-TIE2 Signaling
- BAD Phosphorylation
- BDNF Pathway
1 Cell Signaling Technology pathway for GRB2 Gene
1 GeneTex pathway for GRB2 Gene
Interacting Proteins for GRB2 Gene
Selected Interacting proteins:
P62993-GRB2_HUMAN
ENSP00000376345
for GRB2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GRB2
SIGNOR curated interactions for GRB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 1322798 |
| GO:0007265 | Ras protein signal transduction | TAS | 8253073 |
| GO:0007267 | cell-cell signaling | TAS | 8253073 |
| GO:0007411 | axon guidance | TAS | -- |
Drugs & Compounds for GRB2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pegademase | Approved | Pharma | Target, binder | 0 | ||
| 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid | Experimental | Pharma | Target | 0 | ||
| Guanosine diphosphate | Experimental | Pharma | 0 | |||
| Guanosine monophosphate | Experimental | Pharma | 0 | |||
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Atlas Antibodies PrEST Antigen GRB2 (APrEST89286) and PrEST Antigen GRB2 (APrEST89287)
-
Creative Biomart
- Recombinant Human GRB2
- Recombinant Human Growth Factor Receptor-Bound Protein 2, GST-tagged
- Recombinant Human GRB2, His-tagged
- Recombinant Human GRB2 293 Cell Lysate
- Recombinant Human GRB2 protein, His-tagged
- Recombinant Human GRB2 Protein, GST/His-tagged
- Recombinant Human GRB2 protein, T7/His-tagged
- Creative Diagnostics Human GRB2 peptide
Transcripts for GRB2 Gene
mRNA/cDNA for GRB2 Gene
- (2) REFSEQ mRNAs :
- (23) Additional mRNA sequences :
- (631) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000581959 359 bps (ENST00000581959.1)
- ENST00000392563 2851 bps (ENST00000392563.5)
- ENST00000392564 3182 bps (ENST00000392564.5)
- ENST00000392562 3729 bps (ENST00000392562.5)
- ENST00000316804 3273 bps (ENST00000316804.9)
CRISPR Products
-
OriGene CRISPR knockouts for GRB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB2
- genomics-online: gRNA clones - Search for available GRB2 gRNA products
- Overview of 133 available GRB2 gene related products
- Applied Biological Materials (abm): CRISPR Clones for GRB2 - Select products 50% OFF >
- * GRB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * GRB2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GRB2
- Browse OriGene Inhibitory RNA Products For GRB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB2
- genomics-online: shRNA clones - Search for available GRB2 shRNA products
- Overview of 133 available GRB2 gene related products
Clone Products
-
- MG202420
- MR202420
- MR202420L3
- MR202420L3V
- MR202420L4
- MR202420L4V
- RC200469
- RC200469L1
- RC200469L1V
- RC200469L2
- RC200469L2V
- RC200469L3
- RC200469L3V
- RC200469L4
- RC200469L4V
- RC213101
- RC213101L1
- RC213101L1V
- RC213101L2
- RC213101L2V
- RC213101L3
- RC213101L3V
- RC213101L4
- RC213101L4V
- RG200469
- RG213101
- RR206650
- RR206650L3
- RR206650L3V
- RR206650L4
- RR206650L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GRB2
- Addgene plasmids for GRB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB2
- genomics-online: cdna clones - Search for available GRB2 CDNA products
- Overview of 133 available GRB2 gene related products
- orf clones - Search for available GRB2 ORF products
- Overview of 133 available GRB2 gene related products
- Applied Biological Materials (abm): Clones for GRB2 - Select products 50% OFF >
- * GRB2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * GRB2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||
| SP7: | - | - | - |
Expression for GRB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hypoblast (Extraembryonic Tissues)
- Hypoblast Cells Hypoblast
- Brain (Nervous System)
- Bone (Muscoskeletal System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for GRB2 Gene
This gene is overexpressed in Whole Blood (x5.9).
This gene is overexpressed in Peripheral blood mononuclear cells (12.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRB2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GRB2 Gene:
GRB2SOURCE GeneReport for Unigene cluster for GRB2 Gene:
Hs.444356Evidence on tissue expression from TISSUES for GRB2 Gene
- Nervous system(5)
- Lung(4.8)
- Blood(4.6)
- Skin(4.6)
- Kidney(2.8)
- Liver(2.8)
- Muscle(2.8)
- Bone marrow(2.7)
- Heart(2.6)
- Adrenal gland(2.5)
- Intestine(2.4)
- Lymph node(2.4)
- Pancreas(2.3)
- Spleen(2.3)
- Eye(2.2)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for GRB2
-
OriGene qPCR primer pairs and template standards for GRB2
- genomics-online: primer clones - Search for available GRB2 Primer products
- Overview of 133 available GRB2 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRB2 Gene
Orthologs for GRB2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GRB2 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GRB2 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GRB2 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GRB2 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Grb2 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Grb2 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GRB2 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GRB2 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GRB2 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | grb2 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | grb2a 33 |
|
OneToMany | |
| grb2b 33 |