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The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GRB2 (Growth Factor Receptor Bound Protein 2) is a Protein Coding gene. Diseases associated with GRB2 include Hepatitis and Hepatitis E. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is GRAP.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005070 | SH3/SH2 adaptor activity | TAS | 8253073 |
GO:0005154 | epidermal growth factor receptor binding | IPI | 12577067 |
GO:0005168 | neurotrophin TRKA receptor binding | IPI | 15488758 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA,IEA | 21179510 |
GO:0005654 | nucleoplasm | IEA,IDA | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IDA,IEA | 21179510 |
GO:0005768 | endosome | IEA,IDA | 21179510 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Downstream signaling of activated FGFR2 | ||
3 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
4 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
5 | IL-2 Pathway |
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
Thrombopoietin Pathway
.51
|
ErbB2-ErbB3 Heterodimers
.49
IL-2 Pathway
.48
TREM1 Pathway
.43
IL-4 Pathway
.34
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 1322798 |
GO:0007265 | Ras protein signal transduction | TAS | 8253073 |
GO:0007267 | cell-cell signaling | TAS | 8253073 |
GO:0007411 | axon guidance | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Pegademase | Approved | Pharma | Target, binder | 0 | ||
4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid | Experimental | Pharma | Target | 0 | ||
Guanosine diphosphate | Experimental | Pharma | 0 | |||
Guanosine monophosphate | Experimental | Pharma | 0 | |||
Guanosine triphosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||
SP7: | - | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GRB2 33 32 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | GRB2 33 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | GRB2 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | GRB2 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Grb2 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Grb2 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | GRB2 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GRB2 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | GRB2 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | grb2 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | grb2a 33 |
|
OneToMany | |
grb2b 33 |