Free for academic non-profit institutions. Other users need a Commercial license
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase si... See more...
Aliases for GRB14 Gene
Aliases for GRB14 Gene
External Ids for GRB14 Gene
- HGNC: 4565
- Entrez Gene: 2888
- Ensembl: ENSG00000115290
- OMIM: 601524
- UniProtKB: Q14449
Previous GeneCards Identifiers for GRB14 Gene
- GC02M163404
- GC02M163891
- GC02M165313
- GC02M165551
- GC02M165174
- GC02M165057
- GC02M157231
- GC02M165350
Summaries for GRB14 Gene
-
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for GRB14 Gene
GRB14 (Growth Factor Receptor Bound Protein 14) is a Protein Coding gene. Diseases associated with GRB14 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Immune response IL-23 signaling pathway and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB10.
UniProtKB/Swiss-Prot Summary for GRB14 Gene
-
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Additional gene information for GRB14 Gene
- HGNC(4565)
- Entrez Gene(2888)
- Ensembl(ENSG00000115290)
- OMIM(601524)
- UniProtKB(Q14449)
- Open Targets Platform(ENSG00000115290)
- Search for GRB14 at DataMed
- Search for GRB14 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRB14 Gene
Genomics for GRB14 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GRB14 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J164620 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +1.8 | 1758 | 2.4 | HNRNPL REST ZIC2 RBFOX2 PATZ1 SP1 POLR2A ZNF600 GTF2F1 ZNF561 | HSALNG0020110 GRB14 SLC38A11 EIF3EP3 FIGN | |
| GH02J164622 | Promoter | 0.8 | EPDnew | 600.7 | +0.5 | 500 | 0.1 | REST SP1 FOXA2 YY1 ZBTB33 JUND RAD21 HNF4A RXRA HNF4G | HSALNG0020110 GRB14 FIGN | |
| GH02J164567 | Enhancer | 0.8 | Ensembl ENCODE | 16 | +55.0 | 54951 | 1.6 | REST SP1 CEBPA FOXA2 YY1 NR2F2 FOXA1 HNF4A RXRA MAFK | lnc-COBLL1-4 GRB14 lnc-COBLL1-5 FIGN | |
| GH02J164661 | Enhancer | 0.9 | Ensembl ENCODE | 10.5 | -38.6 | -38561 | 0.2 | CEBPG TARDBP SP1 CEBPA ATF7 CEBPB CTBP1 FOXA2 ATF3 YY1 | piR-32651-006 SNORA70F ENSG00000224331 GRB14 lnc-SCN2A-8 lnc-COBLL1-1 COBLL1 | |
| GH02J164560 | Enhancer | 0.5 | Ensembl | 15.5 | +61.6 | 61559 | 1.6 | GATAD2A CTCF TRIM22 RAD21 ZNF157 ZBTB25 ZSCAN9 ZGPAT | GRB14 lnc-COBLL1-4 lnc-COBLL1-5 FIGN |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRB14 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRB14
- Top Transcription factor binding sites by QIAGEN in the GRB14 gene promoter:
-
- AML1a
- AREB6
- C/EBPalpha
- Egr-2
- FOXI1
- FOXL1
- HFH-3
- Lmo2
Genomic Locations for GRB14 Gene
Genomic Locations for GRB14 Gene
- chr2:164,492,417-164,622,959
- (GRCh38/hg38)
- Size:
- 130,543 bases
- Orientation:
- Minus strand
- chr2:165,349,322-165,478,360
- (GRCh37/hg19)
- Size:
- 129,039 bases
- Orientation:
- Minus strand
Genomic View for GRB14 Gene
Genes around GRB14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q24.3 by HGNC
- 2q24.3 by Entrez Gene
- 2q24.3 by Ensembl
GRB14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRB14 Gene
Proteins for GRB14 Gene
-
Protein details for GRB14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14449-GRB14_HUMAN
- Recommended name:
- Growth factor receptor-bound protein 14
- Protein Accession:
- Q14449
- B7Z7F9
- Q7Z6I1
Protein attributes for GRB14 Gene
- Size:
- 540 amino acids
- Molecular mass:
- 60988 Da
- Quaternary structure:
-
- Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor (INSR), through the SH2 domain (By similarity). Interacts with GRB14 (via BPS domain); this interaction protects the tyrosines in the activation loop on INSR from dephosphorylation. Binds to the ankyrin repeat region of TNKS2 via its N-terminus. Interacts with activated NRAS. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated).
Protein Expression for GRB14 Gene
Post-translational modifications for GRB14 Gene
- Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for GRB14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GRB14 Antibody
- GeneTex Anti-GRB14 antibody [N1C2]
-
Custom Antibody ServicesOriGene Antibodies for GRB14
- Novus Biologicals Antibodies for GRB14
- Invitrogen Antibodies for GRB14 (AFLGC-GRB14)
- Sino Biological Antibodies for GRB14
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GRB14
- Origene Custom Protein Services for GRB14
-
Signalway Proteins for GRB14
-
Abcam proteins for GRB14
Assay Products
No data available for DME Specific Peptides for GRB14 Gene
Domains & Families for GRB14 Gene
Gene Families for GRB14 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GRB14 Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- Pleckstrin-like
- RA domain
- ProtoNet:
Suggested Antigen Peptide Sequences for GRB14 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51137, highly similar to Growth factor receptor-bound protein 14 (B7Z7F9_HUMAN)
- GRB14 adapter protein (GRB14_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q14449UniProtKB/Swiss-Prot:
GRB14_HUMAN :- The PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3.
- Belongs to the GRB7/10/14 family.
- Domain:
-
- The PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3.
- Family:
-
- Belongs to the GRB7/10/14 family.
Function for GRB14 Gene
Molecular function for GRB14 Gene
- UniProtKB/Swiss-Prot Function:
- Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
- GENATLAS Biochemistry:
- growth factor receptor bound protein 14,homolog to C elegans mig 10 gene,widely expressed,involved in signal transduction
Phenotypes From GWAS Catalog for GRB14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | IEA | -- |
| GO:0030971 | receptor tyrosine kinase binding | IPI | 16246733 |
Phenotypes for GRB14 Gene
- MGI mutant phenotypes for GRB14:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRB14:
Animal Models for GRB14 Gene
- MGI Knock Outs for GRB14:
-
- Grb14 Grb14<tm1Daly>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GRB14 - Select products 50% OFF >
- * GRB14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GRB14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB14
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB14
miRNA for GRB14 Gene
- miRTarBase miRNAs that target GRB14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB14
- Browse OriGene Inhibitory RNA Products For GRB14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB14
Clone Products
- Applied Biological Materials (abm): Clones for GRB14 - Select products 50% OFF >
- * GRB14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GRB14
- Addgene plasmids for GRB14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB14
Cell Line Products
-
Horizon Cell Lines for GRB14
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRB14 Gene
Localization for GRB14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRB14 Gene
- Cytoplasm. Endosome membrane. Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane. {ECO:0000269 PubMed:15210700, ECO:0000269 PubMed:19648926}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 3 |
| endosome | 3 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IDA | 11278563 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IDA | 11278563 |
| GO:0010008 | endosome membrane | IEA | -- |
Pathways & Interactions for GRB14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Immune response IL-23 signaling pathway |
Development Angiopoietin - Tie2 signaling
.38
Angiopoietin-TIE2 Signaling
.36
|
|
| 2 | Cell surface interactions at the vascular wall |
.01
|
|
| 3 | GPCR Pathway |
Breast Cancer Regulation by Stathmin1
.58
|
|
| 4 | nNOS Signaling in Skeletal Muscle |
Caspase Cascade
.36
|
|
| 5 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for GRB14 Gene
4 BioSystems pathways for GRB14 Gene
3 Reactome pathways for GRB14 Gene
1 GeneGo (Thomson Reuters) pathway for GRB14 Gene
- Development Angiopoietin - Tie2 signaling
3 Qiagen pathways for GRB14 Gene
- Angiopoietin-TIE2 Signaling
- Breast Cancer Regulation by Stathmin1
- Caspase Cascade
Interacting Proteins for GRB14 Gene
Selected Interacting proteins:
Q14449-GRB14_HUMAN
ENSP00000263915
for GRB14 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GRB14
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA,TAS | 8647858 |
| GO:0008286 | insulin receptor signaling pathway | IBA | 21873635 |
| GO:0009967 | positive regulation of signal transduction | IEA | -- |
| GO:0046627 | negative regulation of insulin receptor signaling pathway | IMP | 16246733 |
| GO:0050900 | leukocyte migration | TAS | -- |
No data available for SIGNOR curated interactions for GRB14 Gene
Transcripts for GRB14 Gene
mRNA/cDNA for GRB14 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000263915 2415 nts (view in UCSC)
- ENST00000424693 587 nts (view in UCSC)
- ENST00000446413 1435 nts (view in UCSC)
- ENST00000469573 984 nts (view in UCSC)
- ENST00000488342 1983 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GRB14 - Select products 50% OFF >
- * GRB14 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GRB14
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB14
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRB14
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB14
- Browse OriGene Inhibitory RNA Products For GRB14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB14
Clone Products
- Applied Biological Materials (abm): Clones for GRB14 - Select products 50% OFF >
- * GRB14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GRB14
- Addgene plasmids for GRB14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB14
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - |
Relevant External Links for GRB14 Gene
- GeneLoc Exon Structure for
- GRB14
Expression for GRB14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Endothelium (Cardiovascular System)
- Neural Tube (Nervous System)
- Bone (Muscoskeletal System)
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for GRB14 Gene
This gene is overexpressed in Liver (x12.2), Kidney - Cortex (x4.9), and Adrenal Gland (x4.6).
This gene is overexpressed in Testis (45.3) and Liver (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRB14 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRB14
SOURCE GeneReport for Unigene cluster for GRB14 Gene:
Hs.411881mRNA Expression by UniProt/SwissProt for GRB14 Gene:
Q14449-GRB14_HUMAN
Tissue specificity:
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
Evidence on tissue expression from TISSUES for GRB14 Gene
- Liver(4.5)
- Skin(4.4)
- Kidney(2.3)
- Pancreas(2.3)
- Muscle(2.3)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for GRB14
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GRB14 Gene
Orthologs for GRB14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GRB14 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GRB14 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GRB14 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GRB14 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Grb14 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Grb14 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | GRB14 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GRB14 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GRB14 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | grb14 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100334415 30 |
|
||
| CABZ01083696.1 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | pico 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | mig-10 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10684 31 |
|
OneToMany |
- Species where no ortholog for GRB14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GRB14 Gene
- ENSEMBL:
- Gene Tree for GRB14 (if available)
- TreeFam:
- Gene Tree for GRB14 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GRB14: view image
Paralogs for GRB14 Gene
Variants for GRB14 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRB14 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 779408 | Benign: not provided | 164,502,282(-) | G/A | SYNONYMOUS_VARIANT | |
| rs747345020 | Uncertain Significance: not specified | 164,494,433(-) | G/A | MISSENSE_VARIANT | |
| rs144301087 | - | p.His507Tyr | |||
| rs61748245 | - | p.Phe90Ile |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3593219 | CNV | loss | 21293372 |
| nsv473323 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.08;
95.08% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRB14 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRB14 Gene
Disorders for GRB14 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, noninsulin-dependent |
|
Search GRB14 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GRB14
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GRB14 Gene
Publications for GRB14 Gene
- Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. (PMID: 19648926) Depetris RS … Hubbard SR (Nature structural & molecular biology 2009) 3 4 23
- Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14. (PMID: 16246733) Depetris RS … Hubbard SR (Molecular cell 2005) 3 4 23
- The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. (PMID: 15210700) King CC … Newton AC (The Journal of biological chemistry 2004) 3 4 23
- Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner JS … Chambers JC (Nature genetics 2011) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
ExternalLinks
Products for GRB14 Gene
- Custom Antibody ServicesOriGene Antibodies for GRB14
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for GRB14
- Origene Custom Protein Services for GRB14
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRB14
- Browse OriGene Inhibitory RNA Products For GRB14
- OriGene qPCR primer pairs for GRB14
- OriGene CRISPR knockouts for GRB14
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GRB14
- Sino Biological Human cDNA Clone for GRB14
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for GRB14
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GRB14
- Novus Biologicals proteins and lysates for GRB14
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for GRB14
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for GRB14 (AFLGC-GRB14)
- VectorBuilder Custom and pre-made DNA vectors for GRB14 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GRB14 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GRB14 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GRB14 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GRB14
- Addgene plasmids for GRB14
- antibodies-online: Show 13 available GRB14 Antibodies ranked by validation data
- Compare Top GRB14 Antibodies
- antibodies-online: Show 31 available GRB14 Elisa Kits ranked by validation data
- Compare Top GRB14 Elisa Kits
- antibodies-online: Show 11 available GRB14 Proteins ranked by validation data
- Compare Top GRB14 Proteins
- Horizon Cell Lines for GRB14
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRB14
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRB14
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GRB14
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRB14
- Signalway Proteins for GRB14
Sources for GRB14 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB