Aliases for GRB14 Gene
External Ids for GRB14 Gene
Previous GeneCards Identifiers for GRB14 Gene
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for GRB14 Gene
GRB14 (Growth Factor Receptor Bound Protein 14) is a Protein Coding gene. Diseases associated with GRB14 include Diabetes Mellitus, Noninsulin-Dependent and Kabuki Syndrome 1. Among its related pathways are Cell surface interactions at the vascular wall and Insulin Pathway. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB10.
UniProtKB/Swiss-Prot Summary for GRB14 Gene
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.