Aliases for GRAPL Gene

Aliases for GRAPL Gene

  • GRB2 Related Adaptor Protein Like 2 3 5
  • GRB2-Related Adapter Protein-Like 3 4
  • GRB2-Related Adapter Protein LOC400581 3
  • GRAPL 5

External Ids for GRAPL Gene

Previous GeneCards Identifiers for GRAPL Gene

  • GC17P018972
  • GC17P019030
  • GC17P019127

Summaries for GRAPL Gene

GeneCards Summary for GRAPL Gene

GRAPL (GRB2 Related Adaptor Protein Like) is a Protein Coding gene. Diseases associated with GRAPL include Cantu Syndrome and Postaxial Acrofacial Dysostosis. Among its related pathways are RET signaling and Signaling by GPCR. An important paralog of this gene is GRAP.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRAPL Gene

Genomics for GRAPL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GRAPL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J019128 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 250.4 +5.1 5112 2.2 GRAPL ENSG00000262319 SNORD3C lnc-SLC5A10-3 EPN2
GH17J019120 Enhancer 0.3 Ensembl dbSUPER 250.7 -1.7 -1688 3 GRAPL ENSG00000228157 ENSG00000262202 SNORD3D lnc-SLC5A10-3 SNORD3C GRAP
GH17J019502 Enhancer 0.6 FANTOM5 Ensembl ENCODE 4.4 +379.3 379348 1 HSALNG0115135 GRAPL SLC47A1 RPL17P43 lnc-SLC47A1-5 ALDH3A2
GH17J019109 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -11.4 -11388 4 SP1 IKZF1 NCOR1 POLR2A NFIC NONO BCL11A SMAD5 ZNF639 ZNF341 ENSG00000262202 HSALNG0115095 SNORD3D EPN2 MAPK7 SMCR8 FOXO3B AKAP10 TOP3A ENSG00000228157
GH17J019061 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 0.2 -60.2 -60188 4.8 ZNF207 NCOR1 ZNF600 ZNF580 KLF9 POLR2A CEBPA ZNF10 NFIC ZIC2 SNORD3B-1 SNORD3B-2 lnc-GRAP-1 lnc-SLC5A10-3 FOXO3B DRG2 MAPK7 ENSG00000262202 FLII GRAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRAPL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRAPL

Genomic Locations for GRAPL Gene

Latest Assembly
35,999 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
31,599 bases
Plus strand

(GRCh37/hg19 by Ensembl)
31,708 bases
Plus strand

Genomic View for GRAPL Gene

Genes around GRAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAPL Gene

Proteins for GRAPL Gene

  • Protein details for GRAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRB2-related adapter protein-like
    Protein Accession:
    Secondary Accessions:
    • B2RXI8

    Protein attributes for GRAPL Gene

    118 amino acids
    Molecular mass:
    13442 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GRAPL Gene


neXtProt entry for GRAPL Gene

Post-translational modifications for GRAPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GRAPL Gene

Domains & Families for GRAPL Gene

Gene Families for GRAPL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRAPL Gene

Suggested Antigen Peptide Sequences for GRAPL Gene

GenScript: Design optimal peptide antigens:
  • GRB2-related adapter protein-like (GRAPL_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GRB2/sem-5/DRK family.
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAPL: view

Function for GRAPL Gene

Phenotypes From GWAS Catalog for GRAPL Gene

Gene Ontology (GO) - Molecular Function for GRAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 32296183
genes like me logo Genes that share ontologies with GRAPL: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRAPL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GRAPL Gene

Localization for GRAPL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRAPL gene
Compartment Confidence
cytosol 3
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GRAPL Gene

Pathways & Interactions for GRAPL Gene

PathCards logo

SuperPathways for GRAPL Gene

SuperPathway Contained pathways
1 Signaling by GPCR
2 RET signaling
genes like me logo Genes that share pathways with GRAPL: view

Pathways by source for GRAPL Gene

2 Reactome pathways for GRAPL Gene

Gene Ontology (GO) - Biological Process for GRAPL Gene


No data available for SIGNOR curated interactions for GRAPL Gene

Drugs & Compounds for GRAPL Gene

No Compound Related Data Available

Transcripts for GRAPL Gene

mRNA/cDNA for GRAPL Gene

4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRAPL

Alternative Splicing Database (ASD) splice patterns (SP) for GRAPL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for GRAPL Gene

GeneLoc Exon Structure for

Expression for GRAPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GRAPL Gene

Protein differential expression in normal tissues from HIPED for GRAPL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GRAPL Gene

Protein tissue co-expression partners for GRAPL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRAPL

SOURCE GeneReport for Unigene cluster for GRAPL Gene:

genes like me logo Genes that share expression patterns with GRAPL: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRAPL Gene

Orthologs for GRAPL Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAPL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRAP 30
  • 47 (a)
(Monodelphis domestica)
Mammalia -- 30
  • 45 (a)
(Canis familiaris)
Mammalia GRAPL 30
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 32 (a)
(Gallus gallus)
Aves GRAP 30
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 30
  • 38 (a)
(Danio rerio)
Actinopterygii grapb 30
  • 33 (a)
grapa 30
  • 32 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta drk 30
  • 31 (a)
(Caenorhabditis elegans)
Secernentea sem-5 30
  • 27 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8309 30
  • 27 (a)
Species where no ortholog for GRAPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for GRAPL Gene

Gene Tree for GRAPL (if available)
Gene Tree for GRAPL (if available)
Alliance of Genome Resources:
Additional Orthologs for GRAPL

Paralogs for GRAPL Gene

Paralogs for GRAPL Gene

(31) SIMAP similar genes for GRAPL Gene using alignment to 5 proteins:

  • I3L2E9_HUMAN
genes like me logo Genes that share paralogs with GRAPL: view

Variants for GRAPL Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GRAPL Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GRAPL Gene

Variant ID Type Subtype PubMed ID
dgv1705e59 CNV duplication 20981092
dgv1706e59 CNV duplication 20981092
dgv3116n100 CNV gain 25217958
dgv5492n54 CNV loss 21841781
dgv5493n54 CNV loss 21841781
dgv5494n54 CNV loss 21841781
dgv5495n54 CNV loss 21841781
dgv5496n54 CNV loss 21841781
dgv895e212 CNV loss 25503493
esv25927 CNV gain+loss 19812545
esv2758678 CNV gain+loss 17122850
esv2763157 CNV loss 21179565
esv3330222 CNV duplication 20981092
esv3352703 CNV duplication 20981092
esv3352743 CNV duplication 20981092
esv33572 CNV gain 17666407
esv3367269 CNV duplication 20981092
esv3375507 CNV duplication 20981092
esv3385860 CNV duplication 20981092
esv3892975 CNV loss 25118596
esv3892976 CNV loss 25118596
esv3892977 CNV loss 25118596
esv3892978 CNV loss 25118596
esv3892979 CNV loss 25118596
nsv1061317 CNV gain 25217958
nsv2001 CNV deletion 18451855
nsv428336 CNV gain+loss 18775914
nsv574555 CNV loss 21841781
nsv574569 CNV loss 21841781
nsv7291 OTHER inversion 18451855
nsv833391 CNV loss 17160897
nsv833393 CNV gain+loss 17160897
nsv9504 CNV gain+loss 18304495
nsv953843 CNV deletion 24416366
nsv960073 CNV duplication 23825009
nsv960434 CNV duplication 23825009
nsv960435 CNV duplication 23825009
nsv978386 CNV duplication 23825009
nsv978479 CNV duplication 23825009

Additional Variant Information for GRAPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for GRAPL Gene

Disorders for GRAPL Gene

MalaCards: The human disease database

(2) MalaCards diseases for GRAPL Gene - From: COP

Disorder Aliases PubMed IDs
cantu syndrome
  • hypertrichotic osteochondrodysplasia
postaxial acrofacial dysostosis
  • poads
- elite association - COSMIC cancer census association via MalaCards
Search GRAPL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GRAPL

genes like me logo Genes that share disorders with GRAPL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GRAPL Gene

Publications for GRAPL Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4
  3. Identification of differential protein expression associated with development of unstable human carotid plaques. (PMID: 16507914) Slevin M … Gaffney J (The American journal of pathology 2006) 22
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for GRAPL Gene

Sources for GRAPL Gene