Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GRAP2 Gene

Aliases for GRAP2 Gene

  • GRB2 Related Adaptor Protein 2 2 3
  • Hematopoietic Cell-Associated Adapter Protein GrpL 3 4
  • Growth Factor Receptor-Binding Protein 3 4
  • SH3-SH2-SH3 Adapter Mona 3 4
  • Grf40 Adapter Protein 3 4
  • Adapter Protein GRID 3 4
  • GRB-2-Like Protein 3 4
  • Grf-40 3 4
  • GRB2L 3 4
  • GRBLG 3 4
  • GADS 3 4
  • GRID 3 4
  • P38 3 4
  • Growth Factor Receptor-Bound Protein 2-Related Adaptor Protein 2 3
  • Hematopoietic Cell-Associated Adaptor Protein GRPL 3
  • GRB2-Related Protein With Insert Domain 3
  • GRB2-Related Adapter Protein 2 3
  • GRB2-Related Adaptor Protein 2 5
  • SH3-SH2-SH3 Adaptor Molecule 3
  • Protein GADS 4
  • GRAP-2 3
  • Grf40 3
  • GRPL 3
  • GrbX 3
  • Mona 3
  • GRBX 4

External Ids for GRAP2 Gene

Previous GeneCards Identifiers for GRAP2 Gene

  • GC22P036911
  • GC22P038540
  • GC22P038621
  • GC22P040297
  • GC22P023272

Summaries for GRAP2 Gene

Entrez Gene Summary for GRAP2 Gene

  • This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GeneCards Summary for GRAP2 Gene

GRAP2 (GRB2 Related Adaptor Protein 2) is a Protein Coding gene. Among its related pathways are T cell receptor signaling pathway and JNK signaling in the CD4+ TCR pathway. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB2.

UniProtKB/Swiss-Prot for GRAP2 Gene

  • Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.

Gene Wiki entry for GRAP2 Gene

Additional gene information for GRAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAP2 Gene

Genomics for GRAP2 Gene

GeneHancer (GH) Regulatory Elements for GRAP2 Gene

Promoters and enhancers for GRAP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J039946 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 663.2 +56.1 56121 7.7 HDGF ATF1 PKNOX1 SMAD1 ARNT NCOA2 TCF12 ZNF121 POLR2B ZNF766 GRAP2 ENTHD1 FAM83F TNRC6B ENSG00000225528
GH22J039898 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 650.4 +8.1 8113 6.6 HDGF PKNOX1 SMAD1 YBX1 IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 GRAP2 CACNA1I RPS19BP1 ENTHD1 ENSG00000225528
GH22J039893 Promoter 0.5 EPDnew 650.7 0.0 -28 0.1 ENTHD1 GRAP2 GC22M043055
GH22J039958 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13 +66.8 66838 4.5 HDGF ATF1 ARNT IRF4 NCOA2 TCF12 ZNF766 ZFP91 ATF7 FOS ENSG00000225528 FAM83F GRAP2 ENTHD1 CACNA1I MIEF1 TNRC6B GC22P039976
GH22J039956 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +63.5 63476 0.6 HDGF HDAC1 BATF ZNF143 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM GRAP2 ENTHD1 FAM83F TNRC6B MIEF1 ENSG00000225528
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GRAP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRAP2 gene promoter:
  • IRF-2
  • STAT5A
  • Brachyury
  • TBP
  • SRY
  • CUTL1
  • AML1a
  • NF-AT4
  • NF-AT3

Genomic Locations for GRAP2 Gene

Genomic Locations for GRAP2 Gene
79,914 bases
Plus strand
72,640 bases
Plus strand

Genomic View for GRAP2 Gene

Genes around GRAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRAP2 Gene

Proteins for GRAP2 Gene

  • Protein details for GRAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRB2-related adapter protein 2
    Protein Accession:
    Secondary Accessions:
    • B7Z8I3
    • O43726
    • Q9NRB7

    Protein attributes for GRAP2 Gene

    330 amino acids
    Molecular mass:
    37909 Da
    Quaternary structure:
    • Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.

    Three dimensional structures from OCA and Proteopedia for GRAP2 Gene

    Alternative splice isoforms for GRAP2 Gene


neXtProt entry for GRAP2 Gene

Post-translational modifications for GRAP2 Gene

  • Ubiquitination at Lys141
  • Modification sites at PhosphoSitePlus

Other Protein References for GRAP2 Gene

No data available for DME Specific Peptides for GRAP2 Gene

Domains & Families for GRAP2 Gene

Gene Families for GRAP2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GRAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GRB2/sem-5/DRK family.
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAP2: view

Function for GRAP2 Gene

Molecular function for GRAP2 Gene

UniProtKB/Swiss-Prot Function:
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
GENATLAS Biochemistry:
Grb2-related adaptor protein 2,expressed in thymus and spleen interacting with cKIT,EPOR,coupling tyrosine kinase to the RAS pathway

Gene Ontology (GO) - Molecular Function for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005070 SH3/SH2 adaptor activity TAS 9878555
GO:0005102 signaling receptor binding IBA --
GO:0005515 protein binding IPI 10913131
genes like me logo Genes that share ontologies with GRAP2: view
genes like me logo Genes that share phenotypes with GRAP2: view

Animal Models for GRAP2 Gene

MGI Knock Outs for GRAP2:

Animal Model Products

Clone Products

  • Addgene plasmids for GRAP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRAP2 Gene

Localization for GRAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRAP2 Gene

Nucleus. Cytoplasm. Endosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRAP2 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 5
plasma membrane 4
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21179510
GO:0005737 cytoplasm IDA,TAS 21179510
GO:0005768 endosome IDA,IEA 21179510
GO:0005829 cytosol TAS --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with GRAP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GRAP2 Gene

Pathways & Interactions for GRAP2 Gene

genes like me logo Genes that share pathways with GRAP2: view

Gene Ontology (GO) - Biological Process for GRAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007265 Ras protein signal transduction TAS 9878555
GO:0007267 cell-cell signaling TAS 9878555
GO:0009967 positive regulation of signal transduction IEA --
GO:0016477 cell migration IBA --
genes like me logo Genes that share ontologies with GRAP2: view

No data available for SIGNOR curated interactions for GRAP2 Gene

Drugs & Compounds for GRAP2 Gene

(2) Drugs for GRAP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for GRAP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GRAP2: view

Transcripts for GRAP2 Gene

Unigene Clusters for GRAP2 Gene

GRB2-related adaptor protein 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for GRAP2

Alternative Splicing Database (ASD) splice patterns (SP) for GRAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP2: -

Relevant External Links for GRAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRAP2 Gene

mRNA differential expression in normal tissues according to GTEx for GRAP2 Gene

This gene is overexpressed in Whole Blood (x20.5) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for GRAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.5), Tlymphocyte (19.4), and CD8 Tcells (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRAP2 Gene

Protein tissue co-expression partners for GRAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRAP2 Gene:


SOURCE GeneReport for Unigene cluster for GRAP2 Gene:


Evidence on tissue expression from TISSUES for GRAP2 Gene

  • Blood(4.5)
  • Lung(4.2)
  • Spleen(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with GRAP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRAP2 Gene

Orthologs for GRAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GRAP2 34 33
  • 99.39 (n)
(Canis familiaris)
Mammalia GRAP2 34 33
  • 90.05 (n)
(Bos Taurus)
Mammalia GRAP2 34 33
  • 86.81 (n)
(Rattus norvegicus)
Mammalia Grap2 33
  • 83.28 (n)
(Mus musculus)
Mammalia Grap2 16 34 33
  • 83.02 (n)
(Ornithorhynchus anatinus)
Mammalia GRAP2 34
  • 75 (a)
(Monodelphis domestica)
Mammalia GRAP2 34
  • 62 (a)
(Gallus gallus)
Aves GRAP2 34 33
  • 68.82 (n)
(Anolis carolinensis)
Reptilia GRAP2 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grap2 33
  • 55.52 (n)
(Danio rerio)
Actinopterygii grap2b 34 33
  • 60.59 (n)
grap2a 34
  • 52 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta drk 34
  • 48 (a)
(Caenorhabditis elegans)
Secernentea sem-5 34
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8309 34
  • 44 (a)
Species where no ortholog for GRAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAP2 Gene

Gene Tree for GRAP2 (if available)
Gene Tree for GRAP2 (if available)
Evolutionary constrained regions (ECRs) for GRAP2: view image

Paralogs for GRAP2 Gene

Paralogs for GRAP2 Gene

(38) SIMAP similar genes for GRAP2 Gene using alignment to 8 proteins:

  • B1AH86_HUMAN
  • B7Z8E3_HUMAN
  • B7Z8I3_HUMAN
  • F5H1V3_HUMAN
  • F5H548_HUMAN
  • Q6FI14_HUMAN
genes like me logo Genes that share paralogs with GRAP2: view

Variants for GRAP2 Gene

Sequence variations from dbSNP and Humsavar for GRAP2 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000001181 -- 39,939,046(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000121576 -- 39,910,083(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000177726 -- 39,950,346(+) T/C intron_variant
rs1000228368 -- 39,902,929(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000235966 -- 39,947,663(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRAP2 Gene

Variant ID Type Subtype PubMed ID
esv3647768 CNV loss 21293372
nsv1131660 CNV deletion 24896259
nsv510808 CNV deletion 20534489
nsv834201 CNV gain 17160897
nsv979678 CNV duplication 23825009

Variation tolerance for GRAP2 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAP2 Gene

Disorders for GRAP2 Gene

Additional Disease Information for GRAP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GRAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAP2 Gene

Publications for GRAP2 Gene

  1. Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. (PMID: 9878555) Qiu M … Liu M (Biochemical and biophysical research communications 1998) 2 3 4 22 58
  2. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. (PMID: 10811803) Zhang W … Samelson LE (The Journal of biological chemistry 2000) 3 4 22 58
  3. Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. (PMID: 10224278) Asada H … Sugamura K (The Journal of experimental medicine 1999) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. (PMID: 21179510) Tanase CA (PloS one 2010) 3 4 58

Products for GRAP2 Gene

Sources for GRAP2 Gene

Loading form....