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This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras... See more...
Aliases for GRAP Gene
Aliases for GRAP Gene
External Ids for GRAP Gene
- HGNC: 4562
- Entrez Gene: 10750
- Ensembl: ENSG00000154016
- OMIM: 604330
- UniProtKB: Q13588
Previous GeneCards Identifiers for GRAP Gene
- GC17M019170
- GC17M020585
- GC17M018867
- GC17M019124
- GC17M018864
- GC17M018923
- GC17M018491
- GC17M019021
- GC17M019022
- GC17M019077
- GC17M019098
- GC17M019111
- GC17M019481
- GC17M019025
Summaries for GRAP Gene
-
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
GeneCards Summary for GRAP Gene
GRAP (GRB2 Related Adaptor Protein) is a Protein Coding gene. Diseases associated with GRAP include Deafness, Autosomal Recessive 114 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB2.
UniProtKB/Swiss-Prot Summary for GRAP Gene
-
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing (PubMed:30610177).
Additional gene information for GRAP Gene
- HGNC(4562)
- Entrez Gene(10750)
- Ensembl(ENSG00000154016)
- OMIM(604330)
- UniProtKB(Q13588)
- Open Targets Platform(ENSG00000154016)
- Search for GRAP at DataMed
- Search for GRAP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GRAP Gene
Genomics for GRAP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GRAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GRAP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GRAP
- Top Transcription factor binding sites by QIAGEN in the GRAP gene promoter:
-
- aMEF-2
- AREB6
- GATA-1
- HTF
- ITF-2
- MEF-2A
- Sox9
- SRY
- Tal-1beta
Genomic Locations for GRAP Gene
Genomic Locations for GRAP Gene
- chr17:19,020,656-19,047,637
- (GRCh38/hg38)
- Size:
- 26,982 bases
- Orientation:
- Minus strand
- chr17:18,923,986-18,950,950
- (GRCh37/hg19)
- Size:
- 26,965 bases
- Orientation:
- Minus strand
Genomic View for GRAP Gene
Genes around GRAP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p11.2 by HGNC
- 17p11.2 by Entrez Gene
- 17p11.2 by Ensembl
GRAP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GRAP Gene
Proteins for GRAP Gene
-
Protein details for GRAP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13588-GRAP_HUMAN
- Recommended name:
- GRB2-related adapter protein
- Protein Accession:
- Q13588
Protein attributes for GRAP Gene
- Size:
- 217 amino acids
- Molecular mass:
- 25337 Da
- Quaternary structure:
-
- Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.
Protein Expression for GRAP Gene
Post-translational modifications for GRAP Gene
Other Protein References for GRAP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Grap Antibody
- Novus Biologicals Antibodies for GRAP
-
Abcam antibodies for GRAP
- Invitrogen Antibodies for GRAP (AFLGC-GRAP)
-
Biorbyt antibodies for GRAP
- Sino Biological Antibodies for GRAP
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GRAP
- Origene Custom Protein Services for GRAP
- antibodies-online: Show 5 available GRAP Proteins ranked by validation data
- Compare Top GRAP Proteins
-
Quality Products:
-
Signalway Proteins for GRAP
-
Abcam proteins for GRAP
Assay Products
- antibodies-online: Show 5 available GRAP Elisa Kits ranked by validation data
- Compare Top GRAP Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for GRAP Gene
Domains & Families for GRAP Gene
Gene Families for GRAP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GRAP Gene
- InterPro:
- Blocks:
-
- SH2 domain signature
- SH3 domain signature
- ProtoNet:
Suggested Antigen Peptide Sequences for GRAP Gene
- GenScript: Design optimal peptide antigens:
-
- GRB2-related adapter protein (GRAP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13588- Family:
-
- Belongs to the GRB2/sem-5/DRK family.
Function for GRAP Gene
Molecular function for GRAP Gene
- UniProtKB/Swiss-Prot Function:
- Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing (PubMed:30610177).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | -- |
| GO:0005515 | protein binding | IEA,IPI | 25036101 |
Phenotypes for GRAP Gene
- MGI mutant phenotypes for GRAP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GRAP:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Elongated cells
- Negative genetic interaction between PTEN-/- and PTEN+/+
Animal Models for GRAP Gene
- MGI Knock Outs for GRAP:
-
- Grap Grap<tm1Gsf>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GRAP - Select products 50% OFF >
- * GRAP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GRAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRAP
miRNA for GRAP Gene
- miRTarBase miRNAs that target GRAP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRAP
- Browse OriGene Inhibitory RNA Products For GRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRAP
Clone Products
- Applied Biological Materials (abm): Clones for GRAP - Select products 50% OFF >
- * GRAP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GRAP
- Addgene plasmids for GRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRAP
Cell Line Products
-
Horizon Cell Lines for GRAP
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for GRAP Gene
Localization for GRAP Gene
Subcellular locations from UniProtKB/Swiss-Prot for GRAP Gene
- Membrane. Peripheral membrane protein. Cell junction, synapse. Note=Localizes at the presynaptic terminal. {ECO:0000250 UniProtKB:Q08012}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Centrosome (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 8647802 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
| GO:0045202 | synapse | IEA | -- |
Pathways & Interactions for GRAP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | RET signaling | ||
Pathways by source for GRAP Gene
2 Reactome pathways for GRAP Gene
Interacting Proteins for GRAP Gene
Selected Interacting proteins:
Q13588-GRAP_HUMAN
ENSP00000284154
for GRAP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GRAP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007265 | Ras protein signal transduction | TAS | 8647802 |
| GO:0007267 | cell-cell signaling | TAS | 8647802 |
| GO:0007605 | sensory perception of sound | IDA | 30610177 |
| GO:0009967 | positive regulation of signal transduction | IEA | -- |
Transcripts for GRAP Gene
mRNA/cDNA for GRAP Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000284154 2651 nts (view in UCSC)
- ENST00000395635 834 nts (view in UCSC)
- ENST00000571380 610 nts (view in UCSC)
- ENST00000573099 846 nts (view in UCSC)
- ENST00000583020 776 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GRAP - Select products 50% OFF >
- * GRAP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GRAP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRAP
-
Santa Cruz Biotechnology (SCBT) CRISPR for GRAP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRAP
- Browse OriGene Inhibitory RNA Products For GRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRAP
Clone Products
- Applied Biological Materials (abm): Clones for GRAP - Select products 50% OFF >
- * GRAP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GRAP
- Addgene plasmids for GRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRAP
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - | - | - |
Relevant External Links for GRAP Gene
- GeneLoc Exon Structure for
- GRAP
Expression for GRAP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for GRAP Gene
This gene is overexpressed in Spleen (x7.7) and Whole Blood (x5.0).
This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Tlymphocyte (20.6), and Monocytes (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRAP Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GRAP
SOURCE GeneReport for Unigene cluster for GRAP Gene:
Hs.567416Evidence on tissue expression from TISSUES for GRAP Gene
- Blood(4.4)
- Nervous system(4.2)
- Spleen(2.1)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for GRAP
-
OriGene qPCR primer pairs and template standards for GRAP
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRAP Gene
Orthologs for GRAP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | GRAP 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | GRAP 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Grap 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Grap 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | GRAP 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100127598 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | grapa 30 31 |
|
ManyToMany | |
| grapb 31 |
|
ManyToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | drk 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | sem-5 31 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8309 31 |
|
OneToMany |
- Species where no ortholog for GRAP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GRAP Gene
- ENSEMBL:
- Gene Tree for GRAP (if available)
- TreeFam:
- Gene Tree for GRAP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GRAP: view image
Paralogs for GRAP Gene
(22) SIMAP similar genes for GRAP Gene using alignment to 4 proteins:
- GRAP_HUMAN
- A8MW78_HUMAN
- I3L2P9_HUMAN
- J3QRP9_HUMAN
Pseudogenes.org Pseudogenes for GRAP Gene
Variants for GRAP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GRAP Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 769911 | Likely Benign: not provided | 19,041,812(-) | G/A | SYNONYMOUS_VARIANT | |
| rs370564476 | Likely Pathogenic: DEAFNESS, AUTOSOMAL RECESSIVE 114. Deafness, autosomal recessive, 114 (DFNB114) [MIM:618456] | 19,024,372(-) | T/Ap.Gln104Leu | MISSENSE_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1700e59 | CNV | duplication | 20981092 |
| dgv3116n100 | CNV | gain | 25217958 |
| dgv895e212 | CNV | loss | 25503493 |
| esv25927 | CNV | gain+loss | 19812545 |
| esv2758678 | CNV | gain+loss | 17122850 |
| esv33572 | CNV | gain | 17666407 |
| esv3387737 | CNV | duplication | 20981092 |
| esv3398141 | CNV | duplication | 20981092 |
| esv3444578 | CNV | duplication | 20981092 |
| esv3892975 | CNV | loss | 25118596 |
| esv3892976 | CNV | loss | 25118596 |
| nsv428336 | CNV | gain+loss | 18775914 |
| nsv574554 | CNV | loss | 21841781 |
| nsv7291 | OTHER | inversion | 18451855 |
| nsv833391 | CNV | loss | 17160897 |
| nsv9504 | CNV | gain+loss | 18304495 |
| nsv953842 | CNV | deletion | 24416366 |
| nsv960071 | CNV | duplication | 23825009 |
| nsv962282 | CNV | duplication | 23825009 |
| nsv962450 | CNV | duplication | 23825009 |
| nsv978383 | CNV | duplication | 23825009 |
Gene Damage Index Score:
0.44;
9.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GRAP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GRAP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAP Gene
Disorders for GRAP Gene
(4) MalaCards diseases for GRAP Gene - From: UniProtKB/Swiss-Prot, OMIM, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 114 |
|
|
| autosomal recessive non-syndromic sensorineural deafness type dfnb |
|
|
| mucocele of salivary gland |
|
|
| sensorineural hearing loss |
|
|
Search GRAP in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GRAP_HUMAN- Deafness, autosomal recessive, 114 (DFNB114) [MIM:618456]: A form of non-syndromic deafness characterized by congenital profound sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:30610177}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for GRAP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for GRAP Gene
Publications for GRAP Gene
- Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. (PMID: 8647802) Feng GS … Ni J (The Journal of biological chemistry 1996) 2 3 4 23
- The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. (PMID: 8995379) Trüb T … Shoelson SE (The Journal of biological chemistry 1997) 2 3 23
- Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. (PMID: 30610177) Li C … Tekin M (Proceedings of the National Academy of Sciences of the United States of America 2019) 3 4
- Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. (PMID: 19836472) Cummins TD … Powell DW (Biochimica et biophysica acta 2010) 3 23
- CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (PMID: 18295596) Schneider H … Rudd CE (Biochemical and biophysical research communications 2008) 3 23
ExternalLinks
Products for GRAP Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for GRAP
- Origene Custom Protein Services for GRAP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GRAP
- Browse OriGene Inhibitory RNA Products For GRAP
- OriGene qPCR primer pairs for GRAP
- OriGene qPCR primer pairs and template standards for GRAP
- OriGene CRISPR knockouts for GRAP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GRAP
- Sino Biological Human cDNA Clone for GRAP
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for GRAP
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GRAP
- Novus Biologicals proteins and lysates for GRAP
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GRAP
- Abcam proteins for GRAP
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for GRAP (AFLGC-GRAP)
- VectorBuilder Custom and pre-made DNA vectors for GRAP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GRAP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GRAP (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GRAP CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GRAP
- Addgene plasmids for GRAP
- antibodies-online: Show 13 available GRAP Antibodies ranked by validation data
- Compare Top GRAP Antibodies
- antibodies-online: Show 5 available GRAP Elisa Kits ranked by validation data
- Compare Top GRAP Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available GRAP Proteins ranked by validation data
- Compare Top GRAP Proteins
- Quality Products:
- Horizon Cell Lines for GRAP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GRAP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GRAP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GRAP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GRAP
- Biorbyt antibodies for GRAP
- Signalway Proteins for GRAP
Sources for GRAP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
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