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GRAP Gene(Protein Coding)

GRB2-Related Adaptor Protein

GCID:
GC17M019022
GIFtS:
48
Genes Participants
UDN Logo

Aliases for GRAP Gene

Aliases for GRAP Gene

  • GRB2-Related Adaptor Protein 2 3 5

External Ids for GRAP Gene

Previous GeneCards Identifiers for GRAP Gene

  • GC17M019170
  • GC17M020585
  • GC17M018867
  • GC17M019124
  • GC17M018864
  • GC17M018923
  • GC17M018491
  • GC17M019021

Summaries for GRAP Gene

Entrez Gene Summary for GRAP Gene

  • This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]

GeneCards Summary for GRAP Gene

GRAP (GRB2-Related Adaptor Protein) is a Protein Coding gene. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB2.

UniProtKB/Swiss-Prot for GRAP Gene

  • Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Gene Wiki entry for GRAP Gene

Additional gene information for GRAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRAP Gene

Genomics for GRAP Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for GRAP Gene

Promoters and enhancers for GRAP Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I019046 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 550.8 +0.9 934 0.6 GRAP ENSG00000279825
GH17I019048 Enhancer 0.2 dbSUPER 550.8 -1.3 -1254 1.5 GRAP ENSG00000262319 LOC105371572
GH17I019645 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 5 -601.5 -601524 7.8 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ALDH3A2 ENSG00000264932 ENSG00000275982 PIR59862 ZNF286B MAPK7 RNF112 ENSG00000231625 ENSG00000262202 SLC47A1
GH17I019042 Enhancer 0.4 Ensembl dbSUPER 0.8 +4.3 4336 1 GRAP ENSG00000279825
GH17I019031 Enhancer 0.6 Ensembl dbSUPER 0.4 +14.9 14911 2.1 CTCF PKNOX1 ZNF654 ENSG00000279825 ENSG00000230197 GRAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRAP gene promoter:

Genomic Locations for GRAP Gene

Genomic Locations for GRAP Gene
chr17:19,020,673-19,047,637
(GRCh38/hg38)
Size:
26,965 bases
Orientation:
Minus strand
chr17:18,923,986-18,950,950
(GRCh37/hg19)

Genomic View for GRAP Gene

Genes around GRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRAP Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GRAP Gene

Proteins for GRAP Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13588-GRAP_HUMAN
    Recommended name:
    GRB2-related adapter protein
    Protein Accession:
    Q13588

    Protein attributes for GRAP Gene

    Size:
    217 amino acids
    Molecular mass:
    25337 Da
    Quaternary structure:
    • Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.

neXtProt entry for GRAP Gene

Protein Expression for GRAP Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GRAP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GRAP Gene

Domains & Families for GRAP Gene

Gene Families for GRAP Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GRAP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GRAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13588

UniProtKB/Swiss-Prot:

GRAP_HUMAN :
  • Belongs to the GRB2/sem-5/DRK family.
Family:
  • Belongs to the GRB2/sem-5/DRK family.
genes like me logo Genes that share domains with GRAP: view

Function for GRAP Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GRAP Gene

UniProtKB/Swiss-Prot Function:
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Phenotypes From GWAS Catalog for GRAP Gene

Gene Ontology (GO) - Molecular Function for GRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005070 SH3/SH2 adaptor activity TAS 8647802
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GRAP: view
genes like me logo Genes that share phenotypes with GRAP: view

Animal Models for GRAP Gene

MGI Knock Outs for GRAP:

Animal Model Products

Clone Products

  • Addgene plasmids for GRAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GRAP Gene

Localization for GRAP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRAP gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8647802
GO:0005829 cytosol TAS --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with GRAP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GRAP Gene

Pathways & Interactions for GRAP Gene

SuperPathways for GRAP Gene

PathCards logo More details on SuperPathways for GRAP
SuperPathway Contained pathways
1 Signaling by GPCR
Signal Transduction
.52
2 RET signaling
Signaling by SCF-KIT
.85
genes like me logo Genes that share pathways with GRAP: view

Pathways by source for GRAP Gene

2 Reactome pathways for GRAP Gene

SIGNOR curated interactions for GRAP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007265 Ras protein signal transduction TAS 8647802
GO:0007267 cell-cell signaling TAS 8647802
GO:0009967 positive regulation of signal transduction IEA --
GO:0016477 cell migration IBA --
genes like me logo Genes that share ontologies with GRAP: view

Drugs & Compounds for GRAP Gene

Products:

  1. Drug

(4) Drugs for GRAP Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with GRAP: view

Transcripts for GRAP Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GRAP Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(88) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRAP Gene

GRB2-related adaptor protein:
Representative Sequences:

Clone Products

  • Addgene plasmids for GRAP

Alternative Splicing Database (ASD) splice patterns (SP) for GRAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1:
SP2: -
SP3: - -
SP4: - - -

Relevant External Links for GRAP Gene

GeneLoc Exon Structure for
GRAP
ECgene alternative splicing isoforms for
GRAP

Expression for GRAP Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRAP Gene

mRNA expression in normal human tissues for GRAP Gene
mRNA expression by BioGPS for GRAP GenemRNA expression by GTEx for GRAP Gene

mRNA differential expression in normal tissues according to GTEx for GRAP Gene

This gene is overexpressed in Spleen (x7.7) and Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for GRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Tlymphocyte (20.6), and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GRAP Gene



Protein tissue co-expression partners for GRAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRAP Gene:

GRAP

SOURCE GeneReport for Unigene cluster for GRAP Gene:

Hs.567416

Evidence on tissue expression from TISSUES for GRAP Gene

  • Blood(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with GRAP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRAP Gene

Orthologs for GRAP Gene

This gene was present in the common ancestor of animals.

Orthologs for GRAP Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia GRAP 33
  • 90.78 (n)
cow
(Bos Taurus)
 Mammalia GRAP 33
  • 89.25 (n)
mouse
(Mus musculus)
 Mammalia Grap 34 16 33
  • 87.4 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Grap 33
  • 86.18 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 86 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 71 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves GRAP 33 34
  • 77.31 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 67 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100127598 33
  • 70.09 (n)
zebrafish
(Danio rerio)
 Actinopterygii grapa 33 34
  • 63.38 (n)
grapb 34
  • 59 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta drk 35 34
  • 54 (a)
worm
(Caenorhabditis elegans)
 Secernentea sem-5 35 34
  • 51 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8309 34
  • 48 (a)
 OneToMany
Species where no ortholog for GRAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GRAP Gene

ENSEMBL:
Gene Tree for GRAP (if available)
TreeFam:
Gene Tree for GRAP (if available)

Paralogs for GRAP Gene

Paralogs for GRAP Gene

(22) SIMAP similar genes for GRAP Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for GRAP Gene

genes like me logo Genes that share paralogs with GRAP: view

Variants for GRAP Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for GRAP Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000132617 -- 19,032,348(-) C/T intron_variant
rs1000235019 -- 19,020,856(-) G/C 3_prime_UTR_variant
rs1000247685 -- 19,031,600(-) A/G intron_variant
rs1001192834 -- 19,021,044(-) C/T 3_prime_UTR_variant
rs1001581627 -- 19,027,891(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GRAP Gene

Variant ID Type Subtype PubMed ID
dgv1700e59 CNV duplication 20981092
dgv3116n100 CNV gain 25217958
dgv895e212 CNV loss 25503493
esv25927 CNV gain+loss 19812545
esv2758678 CNV gain+loss 17122850
esv33572 CNV gain 17666407
esv3387737 CNV duplication 20981092
esv3398141 CNV duplication 20981092
esv3444578 CNV duplication 20981092
esv3892975 CNV loss 25118596
esv3892976 CNV loss 25118596
nsv428336 CNV gain+loss 18775914
nsv574554 CNV loss 21841781
nsv7291 OTHER inversion 18451855
nsv833391 CNV loss 17160897
nsv9504 CNV gain+loss 18304495
nsv953842 CNV deletion 24416366
nsv960071 CNV duplication 23825009
nsv962282 CNV duplication 23825009
nsv962450 CNV duplication 23825009
nsv978383 CNV duplication 23825009

Variation tolerance for GRAP Gene

Gene Damage Index Score: 0.44; 9.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRAP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRAP Gene

Disorders for GRAP Gene

Additional Disease Information for GRAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GRAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRAP Gene

Publications for GRAP Gene

  1. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. (PMID: 8647802) Feng GS … Ni J (The Journal of biological chemistry 1996) 2 3 4 22 58
  2. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. (PMID: 8995379) Trüb T … Shoelson SE (The Journal of biological chemistry 1997) 2 3 22 58
  3. Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling. (PMID: 19836472) Cummins TD … Powell DW (Biochimica et biophysica acta 2010) 3 22 58
  4. CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription. (PMID: 18295596) Schneider H … Rudd CE (Biochemical and biophysical research communications 2008) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GRAP Gene

  • Addgene plasmids for GRAP

Sources for GRAP Gene

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