Aliases for GRAP Gene
External Ids for GRAP Gene
Previous GeneCards Identifiers for GRAP Gene
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
GeneCards Summary for GRAP Gene
GRAP (GRB2 Related Adaptor Protein) is a Protein Coding gene. Diseases associated with GRAP include Deafness, Autosomal Recessive 114 and Mucocele Of Salivary Gland. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is GRB2.
UniProtKB/Swiss-Prot Summary for GRAP Gene
Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.