Aliases for GRAMD2A Gene
External Ids for GRAMD2A Gene
Previous HGNC Symbols for GRAMD2A Gene
GeneCards Summary for GRAMD2A Gene
GRAMD2A (GRAM Domain Containing 2A) is a Protein Coding gene. An important paralog of this gene is GRAMD2B.
UniProtKB/Swiss-Prot Summary for GRAMD2A Gene
Participates in the organization of endoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE).