Aliases for GRAMD1B Gene
GRAM Domain Containing 1B
Long Intergenic Non-Protein Coding RNA 1059 2
GRAM Domain-Containing Protein 1B 3
Protein Aster-B 3
External Ids for GRAMD1B Gene
Previous HGNC Symbols for GRAMD1B Gene
Previous GeneCards Identifiers for GRAMD1B Gene
GRAMD1B (GRAM Domain Containing 1B) is a Protein Coding gene.
Among its related pathways are Ectoderm Differentiation.
An important paralog of this gene is GRAMD1A.
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).
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Entrez Gene Summary ,
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Rfam classification and
for GRAMD1B Gene