Aliases for GRAMD1A Gene
External Ids for GRAMD1A Gene
Previous HGNC Symbols for GRAMD1A Gene
Previous GeneCards Identifiers for GRAMD1A Gene
GeneCards Summary for GRAMD1A Gene
GRAMD1A (GRAM Domain Containing 1A) is a Protein Coding gene. An important paralog of this gene is GRAMD1B.
UniProtKB/Swiss-Prot Summary for GRAMD1A Gene
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192).