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GPX8 (Glutathione Peroxidase 8 (Putative)) is a Protein Coding gene. Diseases associated with GPX8 include Photokeratitis and Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency. Among its related pathways are Detoxification of Reactive Oxygen Species and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004601 | peroxidase activity | IEA,IBA | 21873635 |
GO:0004602 | glutathione peroxidase activity | IEA | -- |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Detoxification of Reactive Oxygen Species | ||
2 | Amyotrophic lateral sclerosis (ALS) | ||
3 | Linoleic acid metabolism | ||
4 | Glutathione metabolism | ||
5 | Parkinson disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006979 | response to oxidative stress | IEA | -- |
GO:0034599 | cellular response to oxidative stress | TAS | -- |
GO:0055114 | oxidation-reduction process | IEA | -- |
GO:0098869 | cellular oxidant detoxification | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPX8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPX8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GPX8 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Gpx8 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Gpx8 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-449c 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GPX8 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GPX8 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GPX8 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | gpx8 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | gpx-5 31 |
|
ManyToMany | |
gpx-3 31 |
|
ManyToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D03905g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GPX2 31 |
|
ManyToMany | |
HYR1 31 |
|
ManyToMany | |||
GPX1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
photokeratitis |
|
|
anemia, nonspherocytic hemolytic, due to g6pd deficiency |
|
|