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Aliases for GPX8 Gene

Aliases for GPX8 Gene

  • Glutathione Peroxidase 8 (Putative) 2 3 5
  • GSHPx-8 3 4
  • GPx-8 3 4
  • Probable Glutathione Peroxidase 8 3
  • EC 4
  • EPLA847 3
  • UNQ847 3

External Ids for GPX8 Gene

Previous GeneCards Identifiers for GPX8 Gene

  • GC05P054493
  • GC05P051429
  • GC05P054455

Summaries for GPX8 Gene

GeneCards Summary for GPX8 Gene

GPX8 (Glutathione Peroxidase 8 (Putative)) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX7.

Gene Wiki entry for GPX8 Gene

Additional gene information for GPX8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX8 Gene

Genomics for GPX8 Gene

GeneHancer (GH) Regulatory Elements for GPX8 Gene

Promoters and enhancers for GPX8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J055159 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.7 673 2.4 FOXA2 INSM2 MZF1 SIN3A BRCA1 ZNF2 RAD21 YY1 RFX5 ZNF335 GPX8 CCNO LOC105378973 ENSG00000249016 LOC100130990 SNX18 CDC20B MIR449A
GH05J055463 Enhancer 0.9 FANTOM5 20.7 +304.0 303985 0.3 ZNF493 ZFP64 MZF1 ZNF155 ZNF121 ZNF23 ZNF138 KLF7 ZNF202 ZNF680 DHX29 MTREX SLC38A9 GPX8 RNF138P1 ENSG00000264281 LOC100419851 FLJ31104 ENSG00000279883 GC05M055421
GH05J054984 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.1 -174.3 -174320 2.1 BMI1 ZNF2 ZNF335 ZNF366 SCRT2 FOS REST ZEB2 PRDM6 CBX8 ESM1 ENSG00000249016 GZMA GZMK ENSG00000240535 GPX8
GH05J054900 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12 -257.9 -257939 2.7 PKNOX1 MAX STAT5A EBF1 BATF IRF4 RELA NFATC1 EED ETV6 GPX8 LOC100130990 ENSG00000249016 GZMK MIR449A MIR449B CDC20B MIR449C ENSG00000240535 SNX18
GH05J054873 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.6 -285.3 -285330 1.7 PKNOX1 NFIB RXRA CEBPB GATAD2B CEBPG DPF2 EP300 ZKSCAN1 SP1 SNX18 GPX8 LOC100130574 LOC727930
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPX8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPX8 gene promoter:
  • SRF (504 AA)
  • SRF
  • AML1a
  • HNF-1A
  • HNF-1
  • TBP
  • MZF-1
  • ISGF-3
  • Evi-1
  • HSF1short

Genomic Locations for GPX8 Gene

Genomic Locations for GPX8 Gene
7,184 bases
Plus strand
7,184 bases
Plus strand

Genomic View for GPX8 Gene

Genes around GPX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX8 Gene

Proteins for GPX8 Gene

  • Protein details for GPX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable glutathione peroxidase 8
    Protein Accession:

    Protein attributes for GPX8 Gene

    209 amino acids
    Molecular mass:
    23881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GPX8 Gene

neXtProt entry for GPX8 Gene

Post-translational modifications for GPX8 Gene

  • Ubiquitination at Lys128
  • Modification sites at PhosphoSitePlus

Other Protein References for GPX8 Gene

No data available for DME Specific Peptides for GPX8 Gene

Domains & Families for GPX8 Gene

Gene Families for GPX8 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GPX8 Gene

Suggested Antigen Peptide Sequences for GPX8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutathione peroxidase family.
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX8: view

Function for GPX8 Gene

Molecular function for GPX8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.

Enzyme Numbers (IUBMB) for GPX8 Gene

Gene Ontology (GO) - Molecular Function for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity EXP 21215271
GO:0004602 glutathione peroxidase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX8: view
genes like me logo Genes that share phenotypes with GPX8: view

Animal Models for GPX8 Gene

MGI Knock Outs for GPX8:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX8

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX8 Gene

Localization for GPX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX8 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX8 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPX8: view

Pathways & Interactions for GPX8 Gene

genes like me logo Genes that share pathways with GPX8: view

Pathways by source for GPX8 Gene

Gene Ontology (GO) - Biological Process for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0034599 cellular response to oxidative stress TAS --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX8: view

No data available for SIGNOR curated interactions for GPX8 Gene

Drugs & Compounds for GPX8 Gene

(4) Drugs for GPX8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with GPX8: view

Transcripts for GPX8 Gene

mRNA/cDNA for GPX8 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPX8 Gene

Glutathione peroxidase 8 (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX8 Gene

No ASD Table

Relevant External Links for GPX8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPX8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPX8 Gene

This gene is overexpressed in Bone (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPX8 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPX8 Gene:


SOURCE GeneReport for Unigene cluster for GPX8 Gene:


Evidence on tissue expression from TISSUES for GPX8 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GPX8: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX8 Gene

Orthologs for GPX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPX8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPX8 34 33
  • 99.2 (n)
(Bos Taurus)
Mammalia GPX8 34 33
  • 91.55 (n)
(Canis familiaris)
Mammalia GPX8 34 33
  • 91.39 (n)
-- 34
  • 86 (a)
(Rattus norvegicus)
Mammalia Gpx8 33
  • 83.73 (n)
(Mus musculus)
Mammalia Gpx8 16 34 33
  • 82.62 (n)
(Monodelphis domestica)
Mammalia mdo-mir-449c 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia GPX8 34
  • 75 (a)
(Gallus gallus)
Aves GPX8 34 33
  • 75.28 (n)
(Anolis carolinensis)
Reptilia GPX8 34
  • 69 (a)
(Danio rerio)
Actinopterygii gpx8 34 33
  • 64.75 (n)
(Caenorhabditis elegans)
Secernentea gpx-5 34
  • 22 (a)
gpx-3 34
  • 22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03905g 33
  • 44.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPX2 34
  • 39 (a)
HYR1 34
  • 36 (a)
GPX1 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for GPX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPX8 Gene

Gene Tree for GPX8 (if available)
Gene Tree for GPX8 (if available)
Evolutionary constrained regions (ECRs) for GPX8: view image

Paralogs for GPX8 Gene

Paralogs for GPX8 Gene

(2) SIMAP similar genes for GPX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPX8: view

Variants for GPX8 Gene

Sequence variations from dbSNP and Humsavar for GPX8 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000064221 -- 55,161,974(+) G/A intron_variant
rs1000204806 -- 55,163,201(+) T/C intron_variant
rs1000459556 -- 55,163,629(+) C/T intron_variant
rs1000543736 -- 55,161,750(+) A/G intron_variant
rs1000654791 -- 55,161,307(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPX8 Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Variation tolerance for GPX8 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX8 Gene

Disorders for GPX8 Gene

Additional Disease Information for GPX8

No disorders were found for GPX8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPX8 Gene

Publications for GPX8 Gene

  1. GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum. (PMID: 24566470) Ramming T … Appenzeller-Herzog C (Free radical biology & medicine 2014) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Regulation of Calcium Fluxes by GPX8, a Type-II Transmembrane Peroxidase Enriched at the Mitochondria-Associated Endoplasmic Reticulum Membrane. (PMID: 28129698) Yoboue ED … Sitia R (Antioxidants & redox signaling 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GPX8 Gene

Sources for GPX8 Gene

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