Aliases for GPX8 Gene

Aliases for GPX8 Gene

  • Glutathione Peroxidase 8 (Putative) 2 3 5
  • Probable Glutathione Peroxidase 8 3 4
  • EC 4 52
  • GSHPx-8 3 4
  • GPx-8 3 4
  • EC 1.11.1 52
  • EPLA847 3
  • UNQ847 3

External Ids for GPX8 Gene

Previous GeneCards Identifiers for GPX8 Gene

  • GC05P054493
  • GC05P051429
  • GC05P054455

Summaries for GPX8 Gene

GeneCards Summary for GPX8 Gene

GPX8 (Glutathione Peroxidase 8 (Putative)) is a Protein Coding gene. Diseases associated with GPX8 include Photokeratitis and Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency. Among its related pathways are Detoxification of Reactive Oxygen Species and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX7.

Gene Wiki entry for GPX8 Gene

Additional gene information for GPX8 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPX8 Gene

Genomics for GPX8 Gene

GeneHancer (GH) Regulatory Elements for GPX8 Gene

Promoters and enhancers for GPX8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J055159 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.8 831 2.8 ZNF217 CTCF PHF8 TEAD4 REST POLR2A TRIM28 RAD21 EZH2 ATF2 HSALNG0041862 GPX8 CCNO ENSG00000251307 ENSG00000249016 ENSG00000226810 SNX18 CDC20B MIR449A
GH05J055158 Enhancer 0.3 Ensembl 500.7 -1.6 -1555 1.2 SCRT1 HSALNG0041862 GPX8 ENSG00000240535 CDC20B CCNO FJ601678-026
GH05J054308 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -849.9 -849855 4.6 ZNF217 EP300 CTCF SIN3A POLR2G SP1 PHF8 ZNF639 ZNF10 POLR2A ARL15 LINC01033 MTREX DHX29 GPX8 ENSG00000279638
GH05J055463 Enhancer 0.8 FANTOM5 20.7 +303.9 303947 0.3 RBAK ZNF639 ZNF354C ZNF623 KLF7 ZNF341 MYNN WT1 ZBTB11 ZNF426 MTREX DHX29 RNF138P1 SLC38A9 GPX8 FLJ31104 ENSG00000264281 LOC100419851 piR-57460-544 ENSG00000279883
GH05J054982 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 10.1 -176.1 -176129 5.7 JUND FOS ZIC2 TRIM28 OSR2 MYC ZBTB17 CTCF ZNF76 JUN ESM1 ENSG00000249016 GZMA GZMK ENSG00000240535 GPX8 CCNO piR-57135-004
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPX8 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPX8

Top Transcription factor binding sites by QIAGEN in the GPX8 gene promoter:
  • AML1a
  • Evi-1
  • HNF-1
  • HNF-1A
  • HSF1short
  • ISGF-3
  • MZF-1
  • SRF
  • SRF (504 AA)
  • TBP

Genomic Locations for GPX8 Gene

Genomic Locations for GPX8 Gene
7,146 bases
Plus strand
7,184 bases
Plus strand

Genomic View for GPX8 Gene

Genes around GPX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX8 Gene

Proteins for GPX8 Gene

  • Protein details for GPX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable glutathione peroxidase 8
    Protein Accession:

    Protein attributes for GPX8 Gene

    209 amino acids
    Molecular mass:
    23881 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GPX8 Gene

neXtProt entry for GPX8 Gene

Selected DME Specific Peptides for GPX8 Gene


Post-translational modifications for GPX8 Gene

  • Ubiquitination at Lys128
  • Modification sites at PhosphoSitePlus

Other Protein References for GPX8 Gene

Domains & Families for GPX8 Gene

Gene Families for GPX8 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GPX8 Gene

  • Glutathione peroxidase

Suggested Antigen Peptide Sequences for GPX8 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione peroxidase (E7ETY7_HUMAN)
  • Probable glutathione peroxidase 8 (GPX8_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutathione peroxidase family.
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX8: view

Function for GPX8 Gene

Molecular function for GPX8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=;.

Enzyme Numbers (IUBMB) for GPX8 Gene

Phenotypes From GWAS Catalog for GPX8 Gene

Gene Ontology (GO) - Molecular Function for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IBA 21873635
GO:0004602 glutathione peroxidase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX8: view
genes like me logo Genes that share phenotypes with GPX8: view

Animal Models for GPX8 Gene

MGI Knock Outs for GPX8:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX8

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX8 Gene

Localization for GPX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX8 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX8 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
plasma membrane 1
nucleus 1
lysosome 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPX8: view

Pathways & Interactions for GPX8 Gene

genes like me logo Genes that share pathways with GPX8: view

Pathways by source for GPX8 Gene

Gene Ontology (GO) - Biological Process for GPX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0034599 cellular response to oxidative stress TAS --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX8: view

No data available for SIGNOR curated interactions for GPX8 Gene

Drugs & Compounds for GPX8 Gene

(4) Drugs for GPX8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Hydrogen peroxide Approved, Vet_approved Pharma 103
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with GPX8: view

Transcripts for GPX8 Gene

mRNA/cDNA for GPX8 Gene

15 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX8 Gene

No ASD Table

Relevant External Links for GPX8 Gene

GeneLoc Exon Structure for

Expression for GPX8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPX8 Gene

This gene is overexpressed in Bone (49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPX8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPX8

SOURCE GeneReport for Unigene cluster for GPX8 Gene:


Evidence on tissue expression from TISSUES for GPX8 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GPX8: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX8 Gene

Orthologs for GPX8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPX8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPX8 31 30
  • 99.2 (n)
(Bos Taurus)
Mammalia GPX8 31 30
  • 91.55 (n)
(Canis familiaris)
Mammalia GPX8 31 30
  • 91.39 (n)
-- 31
  • 86 (a)
(Rattus norvegicus)
Mammalia Gpx8 30
  • 83.73 (n)
(Mus musculus)
Mammalia Gpx8 17 31 30
  • 82.62 (n)
(Monodelphis domestica)
Mammalia mdo-mir-449c 31
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia GPX8 31
  • 75 (a)
(Gallus gallus)
Aves GPX8 31 30
  • 75.28 (n)
(Anolis carolinensis)
Reptilia GPX8 31
  • 69 (a)
(Danio rerio)
Actinopterygii gpx8 31 30
  • 64.75 (n)
(Caenorhabditis elegans)
Secernentea gpx-5 31
  • 22 (a)
gpx-3 31
  • 22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03905g 30
  • 44.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPX2 31
  • 39 (a)
HYR1 31
  • 36 (a)
GPX1 31
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
Species where no ortholog for GPX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPX8 Gene

Gene Tree for GPX8 (if available)
Gene Tree for GPX8 (if available)
Evolutionary constrained regions (ECRs) for GPX8: view image

Paralogs for GPX8 Gene

Paralogs for GPX8 Gene

(2) SIMAP similar genes for GPX8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPX8: view

Variants for GPX8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPX8 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs381852 - p.Lys182Arg

Additional dbSNP identifiers (rs#s) for GPX8 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPX8 Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Variation tolerance for GPX8 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX8 Gene

Disorders for GPX8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPX8 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search GPX8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPX8

genes like me logo Genes that share disorders with GPX8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX8 Gene

Publications for GPX8 Gene

  1. GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum. (PMID: 24566470) Ramming T … Appenzeller-Herzog C (Free radical biology & medicine 2014) 2 3 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  4. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 54
  5. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. (PMID: 29656893) Gupta R … Choudhary C (Cell 2018) 3 54

Products for GPX8 Gene

Sources for GPX8 Gene