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Aliases for GPX7 Gene

Aliases for GPX7 Gene

  • Glutathione Peroxidase 7 2 3 3 5
  • GSHPx-7 3 4
  • CL683 3 4
  • GPx-7 3 4
  • GPX6 3 4
  • Non-Selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase 3
  • Glutathione Peroxidase 6 3
  • EC 1.11.1.9 4
  • NPGPx 3

External Ids for GPX7 Gene

Previous GeneCards Identifiers for GPX7 Gene

  • GC00U990130
  • GC01U900343
  • GC01P052438
  • GC01P052780
  • GC01P052840
  • GC01P053068
  • GC01P051188

Summaries for GPX7 Gene

GeneCards Summary for GPX7 Gene

GPX7 (Glutathione Peroxidase 7) is a Protein Coding gene. Diseases associated with GPX7 include Barrett Esophagus and Gastroesophageal Reflux. Among its related pathways are Glutathione metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX8.

UniProtKB/Swiss-Prot for GPX7 Gene

  • It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Gene Wiki entry for GPX7 Gene

Additional gene information for GPX7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX7 Gene

Genomics for GPX7 Gene

GeneHancer (GH) Regulatory Elements for GPX7 Gene

Promoters and enhancers for GPX7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J052601 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 720.3 +0.9 929 4.3 SOX13 PKNOX1 BACH1 ZNF644 ZNF316 POLR2A SCRT2 ATF7 PRDM10 NR2F6 GPX7 CC2D1B SHISAL2A TUT4 GC01P052619
GH01J052600 Enhancer 0.7 ENCODE 650.7 -1.4 -1447 0.2 SOX13 FOXA2 CEBPG ZNF644 ZKSCAN1 NR2F6 SOX5 HLF CEBPB ZNF623 GPX7 EEF1GP7
GH01J052631 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.9 +33.0 32981 8.1 HDGF PKNOX1 YBX1 IRF4 ZNF766 ZNF207 ATF7 RUNX3 RXRA CAVIN1 TUT4 SHISAL2A GPX7 MAGOH ENSG00000230953 CC2D1B ENSG00000266993 ORC1 ECHDC2 RPS13P2
GH01J052550 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 19.8 -49.5 -49472 5.6 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B CBX5 ZNF207 TUT4 ENSG00000272371 ENSG00000228838 PRPF38A MAGOH ENSG00000266993 CC2D1B RPS13P2 ENSG00000230953 GPX7
GH01J051874 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -724.9 -724904 5.3 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC NRDC ENSG00000266993 TUT4 PRPF38A KTI12 GAPDHP51 SLC25A6P3 TXNDC12-AS1 CC2D1B TXNDC12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPX7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPX7 gene promoter:
  • c-Ets-1
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • Chx10
  • USF-1
  • USF1
  • Pax-4a

Genomic Locations for GPX7 Gene

Genomic Locations for GPX7 Gene
chr1:52,602,371-52,609,051
(GRCh38/hg38)
Size:
6,681 bases
Orientation:
Plus strand
chr1:53,068,043-53,074,723
(GRCh37/hg19)
Size:
6,681 bases
Orientation:
Plus strand

Genomic View for GPX7 Gene

Genes around GPX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX7 Gene

Proteins for GPX7 Gene

  • Protein details for GPX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SL4-GPX7_HUMAN
    Recommended name:
    Glutathione peroxidase 7
    Protein Accession:
    Q96SL4
    Secondary Accessions:
    • O95337
    • Q5T501

    Protein attributes for GPX7 Gene

    Size:
    187 amino acids
    Molecular mass:
    20996 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72961.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPX7 Gene

neXtProt entry for GPX7 Gene

Post-translational modifications for GPX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPX7 Gene

Domains & Families for GPX7 Gene

Gene Families for GPX7 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted secreted proteins

Protein Domains for GPX7 Gene

Suggested Antigen Peptide Sequences for GPX7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96SL4

UniProtKB/Swiss-Prot:

GPX7_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX7: view

Function for GPX7 Gene

Molecular function for GPX7 Gene

UniProtKB/Swiss-Prot Function:
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.

Enzyme Numbers (IUBMB) for GPX7 Gene

Gene Ontology (GO) - Molecular Function for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004096 catalase activity IDA 22157330
GO:0004601 peroxidase activity EXP 21215271
GO:0004602 glutathione peroxidase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX7: view
genes like me logo Genes that share phenotypes with GPX7: view

Animal Models for GPX7 Gene

MGI Knock Outs for GPX7:
  • Gpx7 Gpx7<tm1Whle>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX7

Clone Products

  • Addgene plasmids for GPX7

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX7 Gene

Localization for GPX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX7 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 3
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA 21215271
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with GPX7: view

Pathways & Interactions for GPX7 Gene

genes like me logo Genes that share pathways with GPX7: view

Pathways by source for GPX7 Gene

1 GeneGo (Thomson Reuters) pathway for GPX7 Gene

Gene Ontology (GO) - Biological Process for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0034599 cellular response to oxidative stress TAS --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX7: view

No data available for SIGNOR curated interactions for GPX7 Gene

Drugs & Compounds for GPX7 Gene

(5) Drugs for GPX7 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target, cofactor 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Selenium Approved, Investigational, Vet_approved Pharma 193
Water Approved Pharma 0

(5) Additional Compounds for GPX7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
  • (15S)-Hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • (5Z,8Z,11Z,13E,15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
71774-08-8
5-HETE
  • (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid
  • (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (6E,8Z,11Z,14Z)-5-Hydroperoxyicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-icosatetraenoic acid
  • 6,8,11,14-Eicosatetraenoic acid 5-hydroperoxide
  • Arachidonic acid 5-hydroperoxide
74581-83-2
genes like me logo Genes that share compounds with GPX7: view

Transcripts for GPX7 Gene

mRNA/cDNA for GPX7 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(87) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPX7 Gene

Glutathione peroxidase 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPX7

Alternative Splicing Database (ASD) splice patterns (SP) for GPX7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -
SP3:

Relevant External Links for GPX7 Gene

GeneLoc Exon Structure for
GPX7
ECgene alternative splicing isoforms for
GPX7

Expression for GPX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPX7 Gene

This gene is overexpressed in Fetal testis (14.8), Fetal gut (7.3), Fetal heart (6.5), and Fetal Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPX7 Gene



NURSA nuclear receptor signaling pathways regulating expression of GPX7 Gene:

GPX7

SOURCE GeneReport for Unigene cluster for GPX7 Gene:

Hs.43728

mRNA Expression by UniProt/SwissProt for GPX7 Gene:

Q96SL4-GPX7_HUMAN
Tissue specificity: Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.

Evidence on tissue expression from TISSUES for GPX7 Gene

  • Blood(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPX7: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX7 Gene

Orthologs for GPX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPX7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX7 34 33
  • 99.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPX7 34 33
  • 91.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx7 33
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Gpx7 16 34 33
  • 88.49 (n)
dog
(Canis familiaris)
Mammalia GPX7 34 33
  • 85.39 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPX7 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPX7 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPX7 34 33
  • 70.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPX7 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx7 33
  • 70.44 (n)
zebrafish
(Danio rerio)
Actinopterygii gpx7 34 33
  • 69.06 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gpx-4 34
  • 25 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL039C 33
  • 54.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYR1 34 33
  • 49.46 (n)
ManyToMany
GPX2 36 34
  • 36 (a)
GPX1 34
  • 33 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06732g 33
  • 47.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09534 33
  • 53.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpx1 33
  • 45.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
Species where no ortholog for GPX7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPX7 Gene

ENSEMBL:
Gene Tree for GPX7 (if available)
TreeFam:
Gene Tree for GPX7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPX7: view image

Paralogs for GPX7 Gene

Paralogs for GPX7 Gene

(4) SIMAP similar genes for GPX7 Gene using alignment to 1 proteins:

  • GPX7_HUMAN
genes like me logo Genes that share paralogs with GPX7: view

Variants for GPX7 Gene

Sequence variations from dbSNP and Humsavar for GPX7 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000019423 -- 52,603,197(+) C/G intron_variant
rs1000477403 -- 52,609,050(+) C/T 3_prime_UTR_variant
rs1000517957 -- 52,609,296(+) T/C downstream_transcript_variant
rs1000621703 -- 52,601,897(+) A/G upstream_transcript_variant
rs1000993913 -- 52,601,465(+) T/C upstream_transcript_variant

Variation tolerance for GPX7 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPX7 Gene

Disorders for GPX7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GPX7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
barrett esophagus
  • cle
gastroesophageal reflux
  • ger
childhood kidney cell carcinoma
  • pediatric renal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search GPX7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GPX7_HUMAN
  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269 PubMed:22157330}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.

Additional Disease Information for GPX7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPX7: view

No data available for Genatlas for GPX7 Gene

Publications for GPX7 Gene

  1. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. (PMID: 22157330) Peng D … El-Rifai W (Gut 2012) 3 4 58
  2. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for GPX7 Gene

Sources for GPX7 Gene

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