Aliases for GPX7 Gene

Aliases for GPX7 Gene

  • Glutathione Peroxidase 7 2 3 4 5
  • EC 4 52
  • GSHPx-7 3 4
  • CL683 3 4
  • GPx-7 3 4
  • GPX6 3 4
  • Non-Selenocysteine Containing Phospholipid Hydroperoxide Glutathione Peroxidase 3
  • Glutathione Peroxidase 6 3
  • EC 1.11.1 52
  • NPGPx 3

External Ids for GPX7 Gene

Previous GeneCards Identifiers for GPX7 Gene

  • GC00U990130
  • GC01U900343
  • GC01P052438
  • GC01P052780
  • GC01P052840
  • GC01P053068
  • GC01P051188

Summaries for GPX7 Gene

GeneCards Summary for GPX7 Gene

GPX7 (Glutathione Peroxidase 7) is a Protein Coding gene. Diseases associated with GPX7 include Barrett Esophagus and Gastroesophageal Reflux. Among its related pathways are Detoxification of Reactive Oxygen Species and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and peroxidase activity. An important paralog of this gene is GPX8.

UniProtKB/Swiss-Prot Summary for GPX7 Gene

  • It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Gene Wiki entry for GPX7 Gene

Additional gene information for GPX7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPX7 Gene

Genomics for GPX7 Gene

GeneHancer (GH) Regulatory Elements for GPX7 Gene

Promoters and enhancers for GPX7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J052601 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 570.3 +0.9 929 4.3 NCOR1 ZNF623 GABPA POLR2A ZNF316 MAFF MAFK PHF8 MEF2B MIER3 GPX7 RF00017-212 CC2D1B SHISAL2A TUT4
GH01J052600 Enhancer 0.7 ENCODE 500.7 -1.4 -1447 0.2 NCOR1 ZNF623 CEBPB MIER3 BCL6 EHMT2 HNF4A ZKSCAN1 NR2F6 NFIL3 GPX7 piR-31926-002
GH01J052631 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 34.9 +33.0 32981 8.1 ZBTB40 SIN3A USF1 SP1 EP300 RELA MEF2C TOE1 RCOR1 CTBP1 SHISAL2A TUT4 GPX7 CC2D1B ENSG00000266993 ORC1 RPS13P2 PRPF38A HSALNG0003638
GH01J052550 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 19.8 -49.5 -49472 5.6 HNRNPK CTCF SIN3A NRF1 POLR2G SP1 NCOR1 PHF8 ZNF639 ZNF10 TUT4 ENSG00000272371 MAGOH CC2D1B ENSG00000266993 PRPF38A GPX7 ENSG00000272100 RPS13P2 ENSG00000230953
GH01J052587 Enhancer 0.8 Ensembl CraniofacialAtlas 27.7 -13.2 -13206 3.5 EP300 SPI1 EHMT2 BMI1 ZNF189 FOXM1 EGR1 NR2F6 POLR2A ZMYM3 piR-31926-002 GPX7 CC2D1B TUT4 SHISAL2A piR-44451-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPX7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPX7

Top Transcription factor binding sites by QIAGEN in the GPX7 gene promoter:
  • c-Ets-1
  • Chx10
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Pax-4a
  • USF-1
  • USF1

Genomic Locations for GPX7 Gene

Genomic Locations for GPX7 Gene
6,681 bases
Plus strand
6,681 bases
Plus strand

Genomic View for GPX7 Gene

Genes around GPX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX7 Gene

Proteins for GPX7 Gene

  • Protein details for GPX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutathione peroxidase 7
    Protein Accession:
    Secondary Accessions:
    • O95337
    • Q5T501

    Protein attributes for GPX7 Gene

    187 amino acids
    Molecular mass:
    20996 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC72961.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPX7 Gene

neXtProt entry for GPX7 Gene

Selected DME Specific Peptides for GPX7 Gene


Post-translational modifications for GPX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX7 Gene

Gene Families for GPX7 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted secreted proteins

Protein Domains for GPX7 Gene

  • Glutathione peroxidase

Suggested Antigen Peptide Sequences for GPX7 Gene

GenScript: Design optimal peptide antigens:
  • CL683 (GPX7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glutathione peroxidase family.
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX7: view

Function for GPX7 Gene

Molecular function for GPX7 Gene

UniProtKB/Swiss-Prot Function:
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=;.

Enzyme Numbers (IUBMB) for GPX7 Gene

Phenotypes From GWAS Catalog for GPX7 Gene

Gene Ontology (GO) - Molecular Function for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004096 catalase activity IDA 22157330
GO:0004601 peroxidase activity IBA,EXP 21873635
GO:0004602 glutathione peroxidase activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX7: view
genes like me logo Genes that share phenotypes with GPX7: view

Animal Models for GPX7 Gene

MGI Knock Outs for GPX7:
  • Gpx7 Gpx7<tm1Whle>
  • Gpx7 Gpx7<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX7

Clone Products

  • Addgene plasmids for GPX7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX7 Gene

Localization for GPX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
nucleus 3
plasma membrane 2
mitochondrion 2
peroxisome 2
cytosol 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA 21215271
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with GPX7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPX7 Gene

Pathways & Interactions for GPX7 Gene

genes like me logo Genes that share pathways with GPX7: view

Pathways by source for GPX7 Gene

1 GeneGo (Thomson Reuters) pathway for GPX7 Gene
  • Glutathione metabolism

Gene Ontology (GO) - Biological Process for GPX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0034599 cellular response to oxidative stress TAS --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX7: view

No data available for SIGNOR curated interactions for GPX7 Gene

Drugs & Compounds for GPX7 Gene

(5) Drugs for GPX7 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target, cofactor 0
Hydrogen peroxide Approved, Vet_approved Pharma 103
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Selenium Approved, Investigational, Vet_approved Pharma 226
Water Approved Pharma 0

(5) Additional Compounds for GPX7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
  • (15S)-Hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • (5Z,8Z,11Z,13E,15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
5(S)-Hydroperoxyeicosatetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid
  • (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-5-Hydroperoxyicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-icosatetraenoic acid
  • 6,8,11,14-Eicosatetraenoic acid 5-hydroperoxide
  • Arachidonic acid 5-hydroperoxide
genes like me logo Genes that share compounds with GPX7: view

Transcripts for GPX7 Gene

mRNA/cDNA for GPX7 Gene

7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GPX7

Alternative Splicing Database (ASD) splice patterns (SP) for GPX7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -

Relevant External Links for GPX7 Gene

GeneLoc Exon Structure for

Expression for GPX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GPX7 Gene

This gene is overexpressed in Fetal testis (14.8), Fetal gut (7.3), Fetal heart (6.5), and Fetal Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPX7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPX7

SOURCE GeneReport for Unigene cluster for GPX7 Gene:


mRNA Expression by UniProt/SwissProt for GPX7 Gene:

Tissue specificity: Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.

Evidence on tissue expression from TISSUES for GPX7 Gene

  • Blood(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPX7: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX7 Gene

Orthologs for GPX7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GPX7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPX7 31 30
  • 99.11 (n)
(Bos Taurus)
Mammalia GPX7 31 30
  • 91.82 (n)
(Rattus norvegicus)
Mammalia Gpx7 30
  • 88.89 (n)
(Mus musculus)
Mammalia Gpx7 17 31 30
  • 88.49 (n)
(Canis familiaris)
Mammalia GPX7 31 30
  • 85.39 (n)
(Ornithorhynchus anatinus)
Mammalia GPX7 31
  • 78 (a)
(Monodelphis domestica)
Mammalia GPX7 31
  • 73 (a)
(Gallus gallus)
Aves GPX7 31 30
  • 70.83 (n)
(Anolis carolinensis)
Reptilia GPX7 31
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx7 30
  • 70.44 (n)
(Danio rerio)
Actinopterygii gpx7 31 30
  • 69.06 (n)
(Caenorhabditis elegans)
Secernentea gpx-4 31
  • 25 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL039C 30
  • 54.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYR1 31 30
  • 49.46 (n)
GPX2 33 31
  • 36 (a)
GPX1 31
  • 33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06732g 30
  • 47.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09534 30
  • 53.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpx1 30
  • 45.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
Species where no ortholog for GPX7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPX7 Gene

Gene Tree for GPX7 (if available)
Gene Tree for GPX7 (if available)
Evolutionary constrained regions (ECRs) for GPX7: view image

Paralogs for GPX7 Gene

Paralogs for GPX7 Gene

(4) SIMAP similar genes for GPX7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPX7: view

Variants for GPX7 Gene

Additional dbSNP identifiers (rs#s) for GPX7 Gene

Variation tolerance for GPX7 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for GPX7 Gene

Disorders for GPX7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GPX7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
barrett esophagus
  • barrett metaplasia
gastroesophageal reflux
  • ger
esophagus adenocarcinoma
  • oesophageal adenocarcinoma
hemifacial microsomia
  • goldenhar syndrome with ipsilateral radial defect
- elite association - COSMIC cancer census association via MalaCards
Search GPX7 in MalaCards View complete list of genes associated with diseases


  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269 PubMed:22157330}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.

Additional Disease Information for GPX7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPX7: view

No data available for Genatlas for GPX7 Gene

Publications for GPX7 Gene

  1. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. (PMID: 22157330) Peng D … El-Rifai W (Gut 2012) 3 4 54
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  3. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41 54
  4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 41 54
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54

Products for GPX7 Gene

Sources for GPX7 Gene