Aliases for GPX6 Gene
Aliases for GPX6 Gene
External Ids for GPX6 Gene
- HGNC: 4558
- Entrez Gene: 257202
- Ensembl: ENSG00000198704
- OMIM: 607913
- UniProtKB: P59796
Previous HGNC Symbols for GPX6 Gene
- GPXP3
Previous GeneCards Identifiers for GPX6 Gene
- GC00U990129
- GC06M028541
- GC06P028601
- GC06M028579
- GC06M028471
- GC06M028277
Summaries for GPX6 Gene
-
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]
GeneCards Summary for GPX6 Gene
GPX6 (Glutathione Peroxidase 6) is a Protein Coding gene. Among its related pathways are Folate Metabolism and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX3.
Additional gene information for GPX6 Gene
- Monarch Initiative
- Search for GPX6 at DataMed
- Search for GPX6 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX6 Gene
Genomics for GPX6 Gene
GeneHancer (GH) Regulatory Elements for GPX6 Gene
Promoters and enhancers for GPX6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPX6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GPX6 gene promoter:
-
- SRY
- AML1a
- MIF-1
- Elk-1
- C/EBPalpha
- PPAR-gamma1
- PPAR-gamma2
- FOXO1a
- FOXO1
- SRF (504 AA)
Regulatory Element Products
Genomic Locations for GPX6 Gene
Genomic Locations for GPX6 Gene
- chr6:28,503,296-28,528,215
- (GRCh38/hg38)
- Size:
- 24,920 bases
- Orientation:
- Minus strand
- chr6:28,471,073-28,495,992
- (GRCh37/hg19)
- Size:
- 24,920 bases
- Orientation:
- Minus strand
Genomic View for GPX6 Gene
Genes around GPX6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC
- 6p22.1 by Ensembl
GPX6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPX6 Gene
Proteins for GPX6 Gene
-
Protein details for GPX6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P59796-GPX6_HUMAN
- Recommended name:
- Glutathione peroxidase 6
- Protein Accession:
- P59796
- Q4PJ17
Protein attributes for GPX6 Gene
- Size:
- 221 amino acids
- Molecular mass:
- 24971 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for GPX6 Gene
Other Protein References for GPX6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GPX6
- Search GeneTex for Antibodies for GPX6
-
Custom Antibody ServicesProSci Antibodies for GPX6
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GPX6
- Origene Custom Protein Services for GPX6
- Search GeneTex for Proteins for GPX6
Assay Products
No data available for DME Specific Peptides for GPX6 Gene
Domains & Families for GPX6 Gene
Gene Families for GPX6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted secreted proteins
Protein Domains for GPX6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPX6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P59796- Family:
-
- Belongs to the glutathione peroxidase family.
Function for GPX6 Gene
Molecular function for GPX6 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Enzyme Numbers (IUBMB) for GPX6 Gene
Phenotypes From GWAS Catalog for GPX6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004602 | glutathione peroxidase activity | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
Phenotypes for GPX6 Gene
- GenomeRNAi human phenotypes for GPX6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for GPX6
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPX6
- GenScript: Design CRISPR guide RNA sequences for GPX6
miRNA for GPX6 Gene
- miRTarBase miRNAs that target GPX6
-
- hsa-mir-6715b-3p (MIRT610704)
- hsa-mir-8485 (MIRT610705)
- hsa-mir-3941 (MIRT610706)
- hsa-mir-5690 (MIRT610707)
- hsa-mir-603 (MIRT610708)
- hsa-mir-362-3p (MIRT610709)
- hsa-mir-329-3p (MIRT610710)
- hsa-mir-627-3p (MIRT615663)
- hsa-mir-676-5p (MIRT615664)
- hsa-mir-7151-5p (MIRT635415)
- hsa-mir-4639-5p (MIRT646288)
- hsa-mir-4643 (MIRT646289)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GPX6
- Browse OriGene Inhibitory RNA Products For GPX6
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Clone Products
- Sino Biological Human cDNA Clone for GPX6
- VectorBuilder custom plasmid, inducible vectors for GPX6
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPX6
- genomics-online: cdna clones - Search results for 77 available Glutathione Peroxidase 6 gene related products
- Overview of 77 available Glutathione Peroxidase 6 gene related products
- orf clones - Search results for 77 available Glutathione Peroxidase 6 gene related products
- Overview of 77 available Glutathione Peroxidase 6 gene related products
- Applied Biological Materials Clones for GPX6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GPX6
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPX6 Gene
Localization for GPX6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPX6 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPX6 Gene
Pathways & Interactions for GPX6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glutathione metabolism | ||
| 2 | Detoxification of Reactive Oxygen Species | ||
| 3 | Folate Metabolism | ||
| 4 | Linoleic acid metabolism | ||
| 5 | Aldosterone synthesis and secretion | ||
Pathways by source for GPX6 Gene
4 BioSystems pathways for GPX6 Gene
2 Reactome pathways for GPX6 Gene
3 KEGG pathways for GPX6 Gene
1 GeneGo (Thomson Reuters) pathway for GPX6 Gene
Interacting Proteins for GPX6 Gene
GPS-Prot Interaction Network for GPX6
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006979 | response to oxidative stress | IEA | -- |
| GO:0055114 | oxidation-reduction process | IEA | -- |
| GO:0098869 | cellular oxidant detoxification | IEA | -- |
No data available for SIGNOR curated interactions for GPX6 Gene
Drugs & Compounds for GPX6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutathione | Approved, Investigational | Nutra | Target, cofactor | 0 | ||
| Hydrogen peroxide | Approved, Vet_approved | Pharma | 73 | |||
| Oxidized glutathione | Approved, Experimental, Investigational | Pharma | 0 | |||
| Selenium | Approved, Investigational, Vet_approved | Pharma | 193 | |||
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 15(S)-HETE |
|
54845-95-3 |
|
|||
| 15(S)-HPETE |
|
70981-96-3 |
|
|||
| 5(S)-Hydroperoxyeicosatetraenoic acid |
|
71774-08-8 |
|
|||
| 5-HETE |
|
70608-72-9 |
|
|||
| 5-Hpete |
|
74581-83-2 |
|
Drug Products
Transcripts for GPX6 Gene
mRNA/cDNA for GPX6 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000361902 1712 bps (uc021yrx.1)
- ENST00000474923 716 bps (uc063mlr.1)
- ENST00000483058 557 bps (uc063mls.1)
- ENST00000612264 1709 bps (uc063mlq.1)
Unigene Clusters for GPX6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GPX6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPX6
- Applied Biological Materials CRISPR for GPX6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPX6
- GenScript: Design CRISPR guide RNA sequences for GPX6
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for GPX6
- Browse OriGene Inhibitory RNA Products For GPX6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPX6
Clone Products
- Sino Biological Human cDNA Clone for GPX6
- VectorBuilder custom plasmid, inducible vectors for GPX6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPX6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPX6
- genomics-online: cdna clones - Search results for 77 available Glutathione Peroxidase 6 gene related products
- Overview of 77 available Glutathione Peroxidase 6 gene related products
- orf clones - Search results for 77 available Glutathione Peroxidase 6 gene related products
- Overview of 77 available Glutathione Peroxidase 6 gene related products
- Applied Biological Materials Clones for GPX6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GPX6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Kidney (Urinary System)
- Loop of Henle Cells Loop of Henle
- Loop of Henle
- Metanephros
- Lung (Respiratory System)
-
Epithelial Cells
- Loop of Henle Cells Loop of Henle
- Lower Urinary Tract (Urinary System)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for GPX6 Gene
This gene is overexpressed in Testis (x43.1).
NURSA nuclear receptor signaling pathways regulating expression of GPX6 Gene:
GPX6SOURCE GeneReport for Unigene cluster for GPX6 Gene:
Hs.448570mRNA Expression by UniProt/SwissProt for GPX6 Gene:
P59796-GPX6_HUMAN
Tissue specificity:
Expressed in olfactory epithelium and embryos.
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX6 Gene
Orthologs for GPX6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPX6 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GPX6 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GPX6 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gpx6 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gpx6 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | GPX3 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | gpx3 34 |
|
OneToMany |
- Species where no ortholog for GPX6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GPX6 Gene
Variants for GPX6 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000073950 | -- | 28,512,026(-) | G/C | intron_variant | |
| rs1000085202 | -- | 28,514,457(-) | C/G | intron_variant | |
| rs1000297654 | -- | 28,514,200(-) | A/G | intron_variant | |
| rs1000594187 | -- | 28,506,052(-) | T/C | intron_variant | |
| rs1000870997 | -- | 28,517,681(-) | G/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3296n106 | CNV | deletion | 24896259 |
| esv3576110 | CNV | gain | 25503493 |
| nsv1074388 | CNV | deletion | 25765185 |
| nsv601210 | CNV | gain | 21841781 |
| nsv601211 | CNV | loss | 21841781 |
| nsv830621 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.94;
67.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPX6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPX6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX6 Gene
Disorders for GPX6 Gene
Additional Disease Information for GPX6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GPX6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPX6 Gene
Publications for GPX6 Gene
- Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov GV … Gladyshev VN (Science (New York, N.Y.) 2003) 3 4 58
- Composition and evolution of the vertebrate and mammalian selenoproteomes. (PMID: 22479358) Mariotti M … Gladyshev VN (PloS one 2012) 3 58
- Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58
Products for GPX6 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 14 available Glutathione Peroxidase 6 Antibodies ranked by validation data
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- Search GeneTex for Antibodies for GPX6
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- Custom Antibody ServicesProSci Antibodies for GPX6
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- Horizon Cell Lines for GPX6
- genomics-online: cdna clones - Search results for 77 available Glutathione Peroxidase 6 gene related products
- Overview of 77 available Glutathione Peroxidase 6 gene related products
- orf clones - Search results for 77 available Glutathione Peroxidase 6 gene related products
- Overview of 77 available Glutathione Peroxidase 6 gene related products
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- Overview of 77 available Glutathione Peroxidase 6 gene related products
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- Overview of 77 available Glutathione Peroxidase 6 gene related products
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- Overview of 77 available Glutathione Peroxidase 6 gene related products
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Sources for GPX6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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