Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPX6 Gene

Aliases for GPX6 Gene

  • Glutathione Peroxidase 6 2 3 5
  • Glutathione Peroxidase 6 (Olfactory) 2 3
  • EC 1.11.1.9 4 56
  • GSHPx-6 3 4
  • GPx-6 3 4
  • Glutathione Peroxidase Pseudogene 3 2
  • DJ1186N24.1 3
  • DJ1186N24 3
  • EC 1.11.1 56
  • GPX5p 3
  • GPXP3 3

External Ids for GPX6 Gene

Previous HGNC Symbols for GPX6 Gene

  • GPXP3

Previous GeneCards Identifiers for GPX6 Gene

  • GC00U990129
  • GC06M028541
  • GC06P028601
  • GC06M028579
  • GC06M028471
  • GC06M028277

Summaries for GPX6 Gene

Entrez Gene Summary for GPX6 Gene

  • The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]

GeneCards Summary for GPX6 Gene

GPX6 (Glutathione Peroxidase 6) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX3.

Gene Wiki entry for GPX6 Gene

Additional gene information for GPX6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPX6 Gene

Genomics for GPX6 Gene

GeneHancer (GH) Regulatory Elements for GPX6 Gene

Promoters and enhancers for GPX6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I028586 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 -59.0 -58950 1.9 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 ZBED9 TRQ-TTG2-1 ZSCAN23 ZKSCAN3 ZNF311 ZNF603P ZSCAN12 ENSG00000261839 ZSCAN31 ZKSCAN8
GH06I028588 Promoter/Enhancer 1.5 Ensembl ENCODE 10.4 -61.4 -61383 1.5 PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 GC06P028589 PIR54179 ZNF603P ZKSCAN8 ZSCAN12 ZKSCAN3 ZSCAN23 ZSCAN9 GPX6 ZKSCAN4
GH06I028398 Promoter/Enhancer 1.6 Ensembl ENCODE 9.1 +128.9 128872 2.5 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZSCAN12 LOC105374998 ZKSCAN3 ZNF603P ZKSCAN8 ZKSCAN4 ZSCAN23 ZSCAN31 ZSCAN9 TRIM27
GH06I028474 Enhancer 1.2 Ensembl ENCODE 10.5 +53.3 53283 1.3 PKNOX1 FOXA2 ARNT ARID4B ZNF2 SLC30A9 POLR2B ZNF213 E2F8 FOS GC06M028475 TRT-TGT1-1 ZSCAN12 ZSCAN23 ZKSCAN8 ZKSCAN4 ZKSCAN3 PGBD1 ZSCAN26 ZSCAN9
GH06I028606 Enhancer 1.2 Ensembl ENCODE 10.2 -78.7 -78702 1.2 PKNOX1 ARID4B SIN3A ZNF2 ZNF213 E2F8 ZNF143 ZNF548 FOS KLF13 GC06P028608 PIR59298 TRA-AGC3-1 ZSCAN12 ZKSCAN8 ZKSCAN3 ZSCAN9 ZSCAN23 ZKSCAN4 ZNF165
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPX6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPX6 gene promoter:

Genomic Locations for GPX6 Gene

Genomic Locations for GPX6 Gene
chr6:28,503,296-28,528,215
(GRCh38/hg38)
Size:
24,920 bases
Orientation:
Minus strand
chr6:28,471,073-28,495,992
(GRCh37/hg19)

Genomic View for GPX6 Gene

Genes around GPX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX6 Gene

Proteins for GPX6 Gene

  • Protein details for GPX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59796-GPX6_HUMAN
    Recommended name:
    Glutathione peroxidase 6
    Protein Accession:
    P59796
    Secondary Accessions:
    • Q4PJ17

    Protein attributes for GPX6 Gene

    Size:
    221 amino acids
    Molecular mass:
    24971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPX6 Gene

Selected DME Specific Peptides for GPX6 Gene

P59796:
  • WNFEKFL
  • ELNALQE
  • WNFEKFLVG
  • NQFGKQEPG
  • FEKFLVGPDGVP
  • NSEILLGLKYV
  • LAFPCNQF
  • QYPELNALQ
  • KGDVNGE
  • FPCNQFG

Post-translational modifications for GPX6 Gene

No Post-translational modifications

Other Protein References for GPX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX6 Gene

Gene Families for GPX6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for GPX6 Gene

Suggested Antigen Peptide Sequences for GPX6 Gene

Graphical View of Domain Structure for InterPro Entry

P59796

UniProtKB/Swiss-Prot:

GPX6_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX6: view

Function for GPX6 Gene

Molecular function for GPX6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.

Enzyme Numbers (IUBMB) for GPX6 Gene

Phenotypes From GWAS Catalog for GPX6 Gene

Gene Ontology (GO) - Molecular Function for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004602 glutathione peroxidase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX6: view
genes like me logo Genes that share phenotypes with GPX6: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPX6 Gene

Localization for GPX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX6 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GPX6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPX6 Gene

Pathways & Interactions for GPX6 Gene

genes like me logo Genes that share pathways with GPX6: view

Pathways by source for GPX6 Gene

Gene Ontology (GO) - Biological Process for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX6: view

No data available for SIGNOR curated interactions for GPX6 Gene

Drugs & Compounds for GPX6 Gene

(5) Drugs for GPX6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target, cofactor 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Selenium Approved, Investigational, Vet_approved Pharma 193
Water Approved Pharma 0

(5) Additional Compounds for GPX6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosic acid
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
  • 15-Hydroperoxyicosatetraenoate
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
71774-08-8
5-HETE
  • 5(S)-HETE
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate
  • 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoate
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-HPETE
74581-83-2
genes like me logo Genes that share compounds with GPX6: view

Transcripts for GPX6 Gene

mRNA/cDNA for GPX6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPX6 Gene

Glutathione peroxidase 6 (olfactory):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPX6 Gene

No ASD Table

Relevant External Links for GPX6 Gene

GeneLoc Exon Structure for
GPX6
ECgene alternative splicing isoforms for
GPX6

Expression for GPX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX6 Gene

This gene is overexpressed in Testis (x43.1).

NURSA nuclear receptor signaling pathways regulating expression of GPX6 Gene:

GPX6

SOURCE GeneReport for Unigene cluster for GPX6 Gene:

Hs.448570

mRNA Expression by UniProt/SwissProt for GPX6 Gene:

P59796-GPX6_HUMAN
Tissue specificity: Expressed in olfactory epithelium and embryos.
genes like me logo Genes that share expression patterns with GPX6: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX6 Gene

Orthologs for GPX6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX6 33 34
  • 98.94 (n)
dog
(Canis familiaris)
Mammalia GPX6 33 34
  • 88.61 (n)
cow
(Bos Taurus)
Mammalia GPX6 33 34
  • 87.33 (n)
mouse
(Mus musculus)
Mammalia Gpx6 33 16 34
  • 81 (n)
rat
(Rattus norvegicus)
Mammalia Gpx6 33
  • 79.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves GPX3 34
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii gpx3 34
  • 54 (a)
OneToMany
Species where no ortholog for GPX6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPX6 Gene

ENSEMBL:
Gene Tree for GPX6 (if available)
TreeFam:
Gene Tree for GPX6 (if available)

Paralogs for GPX6 Gene

Paralogs for GPX6 Gene

(4) SIMAP similar genes for GPX6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPX6: view

Variants for GPX6 Gene

Sequence variations from dbSNP and Humsavar for GPX6 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000073950 -- 28,512,026(-) G/C intron_variant
rs1000085202 -- 28,514,457(-) C/G intron_variant
rs1000297654 -- 28,514,200(-) A/G intron_variant
rs1000594187 -- 28,506,052(-) T/C intron_variant
rs1000870997 -- 28,517,681(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPX6 Gene

Variant ID Type Subtype PubMed ID
dgv3296n106 CNV deletion 24896259
esv3576110 CNV gain 25503493
nsv1074388 CNV deletion 25765185
nsv601210 CNV gain 21841781
nsv601211 CNV loss 21841781
nsv830621 CNV gain 17160897

Variation tolerance for GPX6 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX6 Gene

Disorders for GPX6 Gene

Additional Disease Information for GPX6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPX6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPX6 Gene

Publications for GPX6 Gene

  1. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov GV … Gladyshev VN (Science (New York, N.Y.) 2003) 3 4 58
  4. Composition and evolution of the vertebrate and mammalian selenoproteomes. (PMID: 22479358) Mariotti M … Gladyshev VN (PloS one 2012) 3 58
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58

Products for GPX6 Gene

Sources for GPX6 Gene

Content
Loading form....