The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this g... See more...

Aliases for GPX6 Gene

Aliases for GPX6 Gene

  • Glutathione Peroxidase 6 2 3 4 5
  • Glutathione Peroxidase 6 (Olfactory) 2 3
  • EC 1.11.1.9 4 51
  • GSHPx-6 3 4
  • GPx-6 3 4
  • Glutathione Peroxidase Pseudogene 3 2
  • DJ1186N24.1 3
  • DJ1186N24 3
  • EC 1.11.1 51
  • GPX5p 3
  • GPXP3 3
  • GPX6 5

External Ids for GPX6 Gene

Previous HGNC Symbols for GPX6 Gene

  • GPXP3

Previous GeneCards Identifiers for GPX6 Gene

  • GC00U990129
  • GC06M028541
  • GC06P028601
  • GC06M028579
  • GC06M028471
  • GC06M028277

Summaries for GPX6 Gene

Entrez Gene Summary for GPX6 Gene

  • The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]

GeneCards Summary for GPX6 Gene

GPX6 (Glutathione Peroxidase 6) is a Protein Coding gene. Diseases associated with GPX6 include Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency and Photokeratitis. Among its related pathways are Folate Metabolism and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX3.

Gene Wiki entry for GPX6 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPX6 Gene

Genomics for GPX6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPX6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPX6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPX6

Top Transcription factor binding sites by QIAGEN in the GPX6 gene promoter:
  • AML1a
  • C/EBPalpha
  • Elk-1
  • FOXO1
  • FOXO1a
  • MIF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF (504 AA)
  • SRY

Genomic Locations for GPX6 Gene

Genomic Locations for GPX6 Gene
chr6:28,503,296-28,528,215
(GRCh38/hg38)
Size:
24,920 bases
Orientation:
Minus strand
chr6:28,471,073-28,495,992
(GRCh37/hg19)
Size:
24,920 bases
Orientation:
Minus strand

Genomic View for GPX6 Gene

Genes around GPX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX6 Gene

Proteins for GPX6 Gene

  • Protein details for GPX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59796-GPX6_HUMAN
    Recommended name:
    Glutathione peroxidase 6
    Protein Accession:
    P59796
    Secondary Accessions:
    • Q4PJ17

    Protein attributes for GPX6 Gene

    Size:
    221 amino acids
    Molecular mass:
    24971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPX6 Gene

Selected DME Specific Peptides for GPX6 Gene

P59796:
  • WNFEKFL
  • ELNALQE
  • WNFEKFLVG
  • NQFGKQEPG
  • FEKFLVGPDGVP
  • NSEILLGLKYV
  • LAFPCNQF
  • QYPELNALQ
  • KGDVNGE
  • FPCNQFG

Post-translational modifications for GPX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX6 Gene

Gene Families for GPX6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for GPX6 Gene

InterPro:
Blocks:
  • Glutathione peroxidase
ProtoNet:

Suggested Antigen Peptide Sequences for GPX6 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione peroxidase 6 (Olfactory) (A3KN74_HUMAN)
  • Glutathione peroxidase (E7ERK5_HUMAN)
  • Glutathione peroxidase 6 (GPX6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P59796

UniProtKB/Swiss-Prot:

GPX6_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX6: view

Function for GPX6 Gene

Molecular function for GPX6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;.

Enzyme Numbers (IUBMB) for GPX6 Gene

Phenotypes From GWAS Catalog for GPX6 Gene

Gene Ontology (GO) - Molecular Function for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA,IBA 21873635
GO:0004602 glutathione peroxidase activity IEA,IBA 21873635
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX6: view
genes like me logo Genes that share phenotypes with GPX6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPX6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPX6 Gene

Localization for GPX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX6 gene
Compartment Confidence
extracellular 4
plasma membrane 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with GPX6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPX6 Gene

Pathways & Interactions for GPX6 Gene

genes like me logo Genes that share pathways with GPX6: view

Pathways by source for GPX6 Gene

1 GeneGo (Thomson Reuters) pathway for GPX6 Gene
  • Glutathione metabolism

Gene Ontology (GO) - Biological Process for GPX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX6: view

No data available for SIGNOR curated interactions for GPX6 Gene

Drugs & Compounds for GPX6 Gene

(5) Drugs for GPX6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxidized glutathione Approved, Experimental, Investigational Pharma Target 0
Glutathione Approved, Investigational Nutra Target, Target, cofactor 0
Hydrogen peroxide Approved, Vet_approved Pharma 115
Selenium Approved, Investigational, Vet_approved Pharma 227
Water Approved Pharma 0

(5) Additional Compounds for GPX6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
  • (15S)-Hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • (5Z,8Z,11Z,13E,15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
71774-08-8
5-HETE
  • (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid
  • (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (6E,8Z,11Z,14Z)-5-Hydroperoxyicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-icosatetraenoic acid
  • 6,8,11,14-Eicosatetraenoic acid 5-hydroperoxide
  • Arachidonic acid 5-hydroperoxide
74581-83-2
genes like me logo Genes that share compounds with GPX6: view

Transcripts for GPX6 Gene

mRNA/cDNA for GPX6 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPX6

Alternative Splicing Database (ASD) splice patterns (SP) for GPX6 Gene

No ASD Table

Relevant External Links for GPX6 Gene

GeneLoc Exon Structure for
GPX6

Expression for GPX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX6 Gene

This gene is overexpressed in Testis (x43.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPX6

SOURCE GeneReport for Unigene cluster for GPX6 Gene:

Hs.448570

mRNA Expression by UniProt/SwissProt for GPX6 Gene:

P59796-GPX6_HUMAN
Tissue specificity: Expressed in olfactory epithelium and embryos.
genes like me logo Genes that share expression patterns with GPX6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX6 Gene

Orthologs for GPX6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPX6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPX6 30 31
  • 98.94 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPX6 30 31
  • 88.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPX6 30 31
  • 87.33 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gpx6 30 17 31
  • 81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpx6 30
  • 79.64 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 67 (a)
OneToMany
Chicken
(Gallus gallus)
Aves GPX3 31
  • 58 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii gpx3 31
  • 54 (a)
OneToMany
Species where no ortholog for GPX6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPX6 Gene

ENSEMBL:
Gene Tree for GPX6 (if available)
TreeFam:
Gene Tree for GPX6 (if available)

Paralogs for GPX6 Gene

Paralogs for GPX6 Gene

(4) SIMAP similar genes for GPX6 Gene using alignment to 3 proteins:

  • GPX6_HUMAN
  • A3KN74_HUMAN
  • E7ERK5_HUMAN
genes like me logo Genes that share paralogs with GPX6: view

Variants for GPX6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPX6 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
781864 Benign: not provided 28,504,476(-) T/C MISSENSE_VARIANT
785161 Benign: not provided 28,510,835(-) A/G MISSENSE_VARIANT
rs34825130 - p.Tyr53His
rs34955392 - p.Asp161Gly
rs35062161 - p.Tyr72Asn

Additional dbSNP identifiers (rs#s) for GPX6 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPX6 Gene

Variant ID Type Subtype PubMed ID
dgv3296n106 CNV deletion 24896259
esv3576110 CNV gain 25503493
nsv1074388 CNV deletion 25765185
nsv601210 CNV gain 21841781
nsv601211 CNV loss 21841781
nsv830621 CNV gain 17160897

Variation tolerance for GPX6 Gene

Residual Variation Intolerance Score: 92.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX6 Gene

Disorders for GPX6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPX6 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search GPX6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPX6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GPX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX6 Gene

Publications for GPX6 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  2. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  3. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov GV … Gladyshev VN (Science (New York, N.Y.) 2003) 3 4
  4. Composition and evolution of the vertebrate and mammalian selenoproteomes. (PMID: 22479358) Mariotti M … Gladyshev VN (PloS one 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for GPX6 Gene

Sources for GPX6 Gene