This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in pr... See more...

Aliases for GPX5 Gene

Aliases for GPX5 Gene

  • Glutathione Peroxidase 5 2 3 4 5
  • Epididymis-Specific Glutathione Peroxidase-Like Protein 3 4
  • Epididymal Secretory Glutathione Peroxidase 3 4
  • Epididymal Androgen-Related Protein 2 3
  • EC 1.11.1.9 4 51
  • GSHPx-5 3 4
  • GPx-5 3 4
  • EGLP 3 4
  • Epididymis Secretory Sperm Binding Protein Li 75p 3
  • HEL-S-75p 3
  • EC 1.11.1 51
  • GPX5 5

External Ids for GPX5 Gene

Previous GeneCards Identifiers for GPX5 Gene

  • GC06P028551
  • GC06P028602
  • GC06P028603
  • GC06P028604
  • GC06P028493
  • GC06P028300

Summaries for GPX5 Gene

Entrez Gene Summary for GPX5 Gene

  • This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]

GeneCards Summary for GPX5 Gene

GPX5 (Glutathione Peroxidase 5) is a Protein Coding gene. Diseases associated with GPX5 include Photokeratitis and Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency. Among its related pathways are Detoxification of Reactive Oxygen Species and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX3.

UniProtKB/Swiss-Prot Summary for GPX5 Gene

  • Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Gene Wiki entry for GPX5 Gene

Additional gene information for GPX5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPX5 Gene

Genomics for GPX5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPX5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPX5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPX5

Top Transcription factor binding sites by QIAGEN in the GPX5 gene promoter:
  • AML1a
  • C/EBPalpha
  • Elk-1
  • FOXO1
  • FOXO1a
  • MIF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF (504 AA)
  • SRY

Genomic Locations for GPX5 Gene

Genomic Locations for GPX5 Gene
chr6:28,525,881-28,534,955
(GRCh38/hg38)
Size:
9,075 bases
Orientation:
Plus strand
chr6:28,493,702-28,502,729
(GRCh37/hg19)
Size:
9,028 bases
Orientation:
Plus strand

Genomic View for GPX5 Gene

Genes around GPX5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX5 Gene

Proteins for GPX5 Gene

  • Protein details for GPX5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75715-GPX5_HUMAN
    Recommended name:
    Epididymal secretory glutathione peroxidase
    Protein Accession:
    O75715
    Secondary Accessions:
    • A1A4Y0

    Protein attributes for GPX5 Gene

    Size:
    221 amino acids
    Molecular mass:
    25202 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GPX5 Gene

    Alternative splice isoforms for GPX5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPX5 Gene

Selected DME Specific Peptides for GPX5 Gene

O75715:
  • QYPELNALQ
  • LKYVRPGGGF
  • KGDVNGE
  • WNFEKFL
  • ELNALQE
  • WNFEKFLVG
  • NQFGKQEPG
  • LVVLGFPC
  • EILPGLKYVRPG
  • FPCNQFG
  • VNVATYC

Post-translational modifications for GPX5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GPX5 Gene

Gene Families for GPX5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for GPX5 Gene

InterPro:
Blocks:
  • Glutathione peroxidase
ProtoNet:

Suggested Antigen Peptide Sequences for GPX5 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione peroxidase (A1A4Y0_HUMAN)
  • Glutathione peroxidase 5 (GPX5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75715

UniProtKB/Swiss-Prot:

GPX5_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX5: view

Function for GPX5 Gene

Molecular function for GPX5 Gene

UniProtKB/Swiss-Prot Function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;.

Enzyme Numbers (IUBMB) for GPX5 Gene

Phenotypes From GWAS Catalog for GPX5 Gene

Gene Ontology (GO) - Molecular Function for GPX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IBA 21873635
GO:0004602 glutathione peroxidase activity IBA 21873635
GO:0008430 selenium binding IBA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX5: view
genes like me logo Genes that share phenotypes with GPX5: view

Animal Models for GPX5 Gene

MGI Knock Outs for GPX5:
  • Gpx5 Gpx5<tm1.1(KOMP)Vlcg>
  • Gpx5 Gpx5<tm1115.2Arte>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPX5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX5 Gene

Localization for GPX5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX5 gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with GPX5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPX5 Gene

Pathways & Interactions for GPX5 Gene

genes like me logo Genes that share pathways with GPX5: view

Pathways by source for GPX5 Gene

1 GeneGo (Thomson Reuters) pathway for GPX5 Gene
  • Glutathione metabolism

Interacting Proteins for GPX5 Gene

Gene Ontology (GO) - Biological Process for GPX5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 9639555
GO:0006979 response to oxidative stress IEA --
GO:0034599 cellular response to oxidative stress TAS --
GO:0042744 hydrogen peroxide catabolic process IBA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with GPX5: view

No data available for SIGNOR curated interactions for GPX5 Gene

Drugs & Compounds for GPX5 Gene

(9) Drugs for GPX5 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxidized glutathione Approved, Experimental, Investigational Pharma Target 0
Glutathione Approved, Investigational Nutra Target, Target, cofactor 0
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 2588
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3412
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2451

(6) Additional Compounds for GPX5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
  • (15S)-Hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • (5Z,8Z,11Z,13E,15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
71774-08-8
5-HETE
  • (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid
  • (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (6E,8Z,11Z,14Z)-5-Hydroperoxyicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-icosatetraenoic acid
  • 6,8,11,14-Eicosatetraenoic acid 5-hydroperoxide
  • Arachidonic acid 5-hydroperoxide
74581-83-2
genes like me logo Genes that share compounds with GPX5: view

Transcripts for GPX5 Gene

mRNA/cDNA for GPX5 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPX5

Alternative Splicing Database (ASD) splice patterns (SP) for GPX5 Gene

No ASD Table

Relevant External Links for GPX5 Gene

GeneLoc Exon Structure for
GPX5

Expression for GPX5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPX5 Gene

mRNA differential expression in normal tissues according to GTEx for GPX5 Gene

This gene is overexpressed in Testis (x50.3).

Protein differential expression in normal tissues from HIPED for GPX5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPX5 Gene



Protein tissue co-expression partners for GPX5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPX5

SOURCE GeneReport for Unigene cluster for GPX5 Gene:

Hs.248129

mRNA Expression by UniProt/SwissProt for GPX5 Gene:

O75715-GPX5_HUMAN
Tissue specificity: Epididymis.
genes like me logo Genes that share expression patterns with GPX5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX5 Gene

Orthologs for GPX5 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPX5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPX5 31
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia GPX5 30 31
  • 84.32 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpx5 30
  • 82.42 (n)
Mouse
(Mus musculus)
Mammalia Gpx5 30 17 31
  • 81.97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPX5 30 31
  • 81 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 65 (a)
OneToMany
Chicken
(Gallus gallus)
Aves GPX3 31
  • 60 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii gpx3 31
  • 52 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y94H6A.4 30
  • 49.62 (n)
C11E4.2 32
  • 39 (a)
C11E4.1 32
  • 37 (a)
Species where no ortholog for GPX5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for GPX5 Gene

ENSEMBL:
Gene Tree for GPX5 (if available)
TreeFam:
Gene Tree for GPX5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPX5: view image

Paralogs for GPX5 Gene

Paralogs for GPX5 Gene

(5) SIMAP similar genes for GPX5 Gene using alignment to 1 proteins:

  • GPX5_HUMAN
genes like me logo Genes that share paralogs with GPX5: view

Variants for GPX5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPX5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs386352313 Uncertain Significance: not provided 28,526,041(+) C/T SYNONYMOUS_VARIANT
rs58554303 - p.Leu85Pro
rs769188 - p.Leu85Val

Additional dbSNP identifiers (rs#s) for GPX5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPX5 Gene

Variant ID Type Subtype PubMed ID
dgv3296n106 CNV deletion 24896259
esv3576110 CNV gain 25503493
nsv1074388 CNV deletion 25765185
nsv601210 CNV gain 21841781
nsv601211 CNV loss 21841781
nsv830621 CNV gain 17160897

Variation tolerance for GPX5 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX5 Gene

Disorders for GPX5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPX5 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search GPX5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPX5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GPX5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX5 Gene

Publications for GPX5 Gene

  1. The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract. (PMID: 9639555) Hall L … Jury JA (The Biochemical journal 1998) 2 3 4 23
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  3. Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy. (PMID: 20200426) Moyer AM … Weinshilboum RM (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  4. Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes. (PMID: 17531267) Koh CS … Corbier C (Journal of molecular biology 2007) 23 26
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4

Products for GPX5 Gene

  • Signalway Proteins for GPX5

Sources for GPX5 Gene