Aliases for GPX5 Gene
External Ids for GPX5 Gene
Previous GeneCards Identifiers for GPX5 Gene
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
GeneCards Summary for GPX5 Gene
GPX5 (Glutathione Peroxidase 5) is a Protein Coding gene. Diseases associated with GPX5 include Photokeratitis and Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency. Among its related pathways are Detoxification of Reactive Oxygen Species and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include glutathione peroxidase activity. An important paralog of this gene is GPX3.
UniProtKB/Swiss-Prot Summary for GPX5 Gene
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.