Aliases for GPX2 Gene
External Ids for GPX2 Gene
Previous GeneCards Identifiers for GPX2 Gene
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
GeneCards Summary for GPX2 Gene
GPX2 (Glutathione Peroxidase 2) is a Protein Coding gene. Diseases associated with GPX2 include Ileocolitis and Colorectal Cancer. Among its related pathways are Glutathione metabolism and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include electron transfer activity and glutathione peroxidase activity. An important paralog of this gene is GPX1.
UniProtKB/Swiss-Prot Summary for GPX2 Gene
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.