The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is pred... See more...

Aliases for GPX2 Gene

Aliases for GPX2 Gene

  • Glutathione Peroxidase 2 2 3 4 5
  • Glutathione Peroxidase 2 (Gastrointestinal) 2 3
  • Glutathione Peroxidase-Related Protein 2 3 4
  • Gastrointestinal Glutathione Peroxidase 3 4
  • EC 1.11.1.9 4 52
  • GSHPx-2 3 4
  • GPRP-2 3 4
  • GPx-GI 3 4
  • GPx-2 3 4
  • Glutathione Peroxidase-Gastrointestinal 4
  • EC 1.11.1 52
  • GSHPX-GI 3
  • GSHPx-GI 4
  • GI-GPx 3
  • GPRP 3

External Ids for GPX2 Gene

Previous GeneCards Identifiers for GPX2 Gene

  • GC14M062733
  • GC14M059199
  • GC14M063395
  • GC14M064475
  • GC14M065405
  • GC14M045575

Summaries for GPX2 Gene

Entrez Gene Summary for GPX2 Gene

  • The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

GeneCards Summary for GPX2 Gene

GPX2 (Glutathione Peroxidase 2) is a Protein Coding gene. Diseases associated with GPX2 include Ileocolitis and Barrett Esophagus. Among its related pathways are Detoxification of Reactive Oxygen Species and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include electron transfer activity and glutathione peroxidase activity. An important paralog of this gene is GPX1.

UniProtKB/Swiss-Prot Summary for GPX2 Gene

  • Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Gene Wiki entry for GPX2 Gene

Additional gene information for GPX2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPX2 Gene

Genomics for GPX2 Gene

GeneHancer (GH) Regulatory Elements for GPX2 Gene

Promoters and enhancers for GPX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPX2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPX2

Top Transcription factor binding sites by QIAGEN in the GPX2 gene promoter:
  • CUTL1
  • HNF-4alpha1
  • HNF-4alpha2
  • p53
  • Pax-4a

Genomic Locations for GPX2 Gene

Genomic Locations for GPX2 Gene
chr14:64,939,152-64,942,905
(GRCh38/hg38)
Size:
3,754 bases
Orientation:
Minus strand
chr14:65,405,870-65,409,531
(GRCh37/hg19)
Size:
3,662 bases
Orientation:
Minus strand

Genomic View for GPX2 Gene

Genes around GPX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPX2 Gene

Proteins for GPX2 Gene

  • Protein details for GPX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18283-GPX2_HUMAN
    Recommended name:
    Glutathione peroxidase 2
    Protein Accession:
    P18283
    Secondary Accessions:
    • Q6PJ52
    • Q8WWI7
    • Q9NRP9

    Protein attributes for GPX2 Gene

    Size:
    190 amino acids
    Molecular mass:
    21954 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for GPX2 Gene

neXtProt entry for GPX2 Gene

Selected DME Specific Peptides for GPX2 Gene

P18283:
  • WNFEKFL
  • LIENVASLUG
  • LMTDPKLI
  • IAKSFYDLSAI
  • NEEILNSLKYVR
  • LVVLGFPC
  • FPCNQFG
  • AWNFEKFL

Post-translational modifications for GPX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPX2 Gene

Domains & Families for GPX2 Gene

Gene Families for GPX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GPX2 Gene

Blocks:
  • Glutathione peroxidase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPX2 Gene

GenScript: Design optimal peptide antigens:
  • Glutathione peroxidase-related protein 2 (GPX2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18283

UniProtKB/Swiss-Prot:

GPX2_HUMAN :
  • Belongs to the glutathione peroxidase family.
Family:
  • Belongs to the glutathione peroxidase family.
genes like me logo Genes that share domains with GPX2: view

Function for GPX2 Gene

Molecular function for GPX2 Gene

UniProtKB/Swiss-Prot Function:
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2 glutathione + H2O2 = glutathione disulfide + 2 H2O; Xref=Rhea:RHEA:16833, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.11.1.9;.
GENATLAS Biochemistry:
glutathione peroxidase 2,expressed in liver and gastrointestinal tissues,catabolic pathway of activated oxygen species,free radical detoxification

Enzyme Numbers (IUBMB) for GPX2 Gene

Phenotypes From GWAS Catalog for GPX2 Gene

Gene Ontology (GO) - Molecular Function for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IBA 21873635
GO:0004602 glutathione peroxidase activity IEA,IBA 21873635
GO:0009055 electron transfer activity TAS 8428933
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with GPX2: view
genes like me logo Genes that share phenotypes with GPX2: view

Animal Models for GPX2 Gene

MGI Knock Outs for GPX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPX2

CRISPR Products

miRNA for GPX2 Gene

miRTarBase miRNAs that target GPX2

Clone Products

  • Addgene plasmids for GPX2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPX2 Gene

Localization for GPX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPX2 Gene

Cytoplasm. Note=Mainly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPX2 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8428933
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GPX2: view

Pathways & Interactions for GPX2 Gene

genes like me logo Genes that share pathways with GPX2: view

Gene Ontology (GO) - Biological Process for GPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IEA --
GO:0022900 electron transport chain IEA --
GO:0034599 cellular response to oxidative stress TAS --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with GPX2: view

No data available for SIGNOR curated interactions for GPX2 Gene

Drugs & Compounds for GPX2 Gene

(7) Drugs for GPX2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target, cofactor 0
Selenium Approved, Investigational, Vet_approved Pharma 226
Hydrogen peroxide Approved, Vet_approved Pharma 103
Oxidized glutathione Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0

(11) Additional Compounds for GPX2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
15(S)-HETE
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
  • (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate
  • (15S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
  • (15S)-Hydroxyeicosa-(5Z,8Z,11Z,13E)-tetraenoic acid
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroxyicosa-5,8,11,13-tetraenoic acid
54845-95-3
15(S)-HPETE
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
  • (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • (5Z,8Z,11Z,13E,15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid
  • 15-Hydroperoxyeicosatetraenoate
  • 15-Hydroperoxyeicosatetraenoic acid
70981-96-3
5(S)-Hydroperoxyeicosatetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate
  • (5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid
71774-08-8
5-HETE
  • (5S,6E,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • (6E,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid
  • (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid
  • 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid
  • 5(S)-Hydroxyeicosatetraenoic acid
70608-72-9
5-Hpete
  • (6E,8Z,11Z,14Z)-5-Hydroperoxyicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid
  • 5-Hydroperoxy-(6E,8Z,11Z,14Z)-icosatetraenoic acid
  • 6,8,11,14-Eicosatetraenoic acid 5-hydroperoxide
  • Arachidonic acid 5-hydroperoxide
74581-83-2
genes like me logo Genes that share compounds with GPX2: view

Transcripts for GPX2 Gene

mRNA/cDNA for GPX2 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPX2

Alternative Splicing Database (ASD) splice patterns (SP) for GPX2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for GPX2 Gene

GeneLoc Exon Structure for
GPX2

Expression for GPX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPX2 Gene

This gene is overexpressed in Liver (x17.2), Colon - Transverse (x8.7), Bladder (x7.0), and Stomach (x5.0).

Protein differential expression in normal tissues from HIPED for GPX2 Gene

This gene is overexpressed in Salivary gland (14.0), Stomach (11.7), Cardia (7.6), and Rectum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPX2 Gene



Protein tissue co-expression partners for GPX2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPX2

SOURCE GeneReport for Unigene cluster for GPX2 Gene:

Hs.2704

mRNA Expression by UniProt/SwissProt for GPX2 Gene:

P18283-GPX2_HUMAN
Tissue specificity: Mostly in liver and gastrointestinal tract, not found in heart or kidney.

Evidence on tissue expression from TISSUES for GPX2 Gene

  • Liver(4.6)
  • Intestine(4.5)
  • Nervous system(4.2)
  • Lung(3.3)
  • Stomach(2.9)
  • Gall bladder(2.5)
genes like me logo Genes that share expression patterns with GPX2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPX2 Gene

Orthologs for GPX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPX2 31 30
  • 99.82 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPX2 31 30
  • 95.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPX2 31 30
  • 92.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPX2 31
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpx2 30
  • 90 (n)
mouse
(Mus musculus)
Mammalia Gpx2 17 31 30
  • 89.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPX2 31
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPX2 31 30
  • 74.37 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpx2 30
  • 68.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7237 30
zebrafish
(Danio rerio)
Actinopterygii gpx1b 31
  • 64 (a)
ManyToMany
gpx1 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8637 30
Species where no ortholog for GPX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPX2 Gene

ENSEMBL:
Gene Tree for GPX2 (if available)
TreeFam:
Gene Tree for GPX2 (if available)

Paralogs for GPX2 Gene

Paralogs for GPX2 Gene

(6) SIMAP similar genes for GPX2 Gene using alignment to 4 proteins:

  • GPX2_HUMAN
  • G3V323_HUMAN
  • G3V4J6_HUMAN
  • H0YJK8_HUMAN

Pseudogenes.org Pseudogenes for GPX2 Gene

genes like me logo Genes that share paralogs with GPX2: view

Variants for GPX2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPX2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs17880492 - p.Arg146Cys
rs17881652 - p.Pro126Leu
VAR_003615 - p.Ala37Leu
VAR_003616 - p.Ile176Met

Additional dbSNP identifiers (rs#s) for GPX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPX2 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073

Variation tolerance for GPX2 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPX2 Gene

Disorders for GPX2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GPX2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GPX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPX2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPX2 Gene

Publications for GPX2 Gene

  1. Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. (PMID: 8428933) Chu FF … Esworthy RS (The Journal of biological chemistry 1993) 2 3 4 23 54
  2. Simultaneous genotyping of 11 non-synonymous SNPs in the 4 glutathione peroxidase genes using the multiplex single base extension method. (PMID: 19161995) Iida R … Yasuda T (Clinica chimica acta; international journal of clinical chemistry 2009) 3 23 41 54
  3. Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma. (PMID: 18483336) Peters U … Foster CB (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 23 41 54
  4. A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma. (PMID: 17277236) Murphy SJ … Murray LJ (Carcinogenesis 2007) 3 23 41 54
  5. Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents. (PMID: 10806356) Kelner MJ … Lanham KA (Gene 2000) 3 4 23 54

Products for GPX2 Gene

  • Addgene plasmids for GPX2

Sources for GPX2 Gene