Aliases for GPSM1 Gene
External Ids for GPSM1 Gene
Previous GeneCards Identifiers for GPSM1 Gene
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for GPSM1 Gene
GPSM1 (G Protein Signaling Modulator 1) is a Protein Coding gene. Diseases associated with GPSM1 include Spherocytosis, Type 5. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase regulator activity and GDP-dissociation inhibitor activity. An important paralog of this gene is GPSM2.
UniProtKB/Swiss-Prot for GPSM1 Gene
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.