Aliases for GPSM1 Gene
External Ids for GPSM1 Gene
Previous GeneCards Identifiers for GPSM1 Gene
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for GPSM1 Gene
GPSM1 (G Protein Signaling Modulator 1) is a Protein Coding gene. Diseases associated with GPSM1 include Spherocytosis, Type 5. Among its related pathways are Signaling by GPCR and Amphetamine addiction. Gene Ontology (GO) annotations related to this gene include GTPase regulator activity and GDP-dissociation inhibitor activity. An important paralog of this gene is GPSM2.
UniProtKB/Swiss-Prot for GPSM1 Gene
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.