This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (n... See more...

Aliases for GPS2 Gene

Aliases for GPS2 Gene

  • G Protein Pathway Suppressor 2 2 3 4 5
  • GPS-2 3 4
  • AMF-1 3

External Ids for GPS2 Gene

Previous GeneCards Identifiers for GPS2 Gene

  • GC17M007614
  • GC17M007945
  • GC17M007158
  • GC17M007416
  • GC17M007156
  • GC17M007215
  • GC17M007112

Summaries for GPS2 Gene

Entrez Gene Summary for GPS2 Gene

  • This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPS2 Gene

GPS2 (G Protein Pathway Suppressor 2) is a Protein Coding gene. Diseases associated with GPS2 include Liposarcoma and Hepatitis C Virus. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Human T-cell leukemia virus 1 infection. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and GTPase inhibitor activity.

UniProtKB/Swiss-Prot Summary for GPS2 Gene

  • Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:19858209, PubMed:24943844). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the proinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081).
  • (Microbial infection) Required for efficient replication of hepatitis C virus (HCV) by promoting the interaction between VAPA and HCV virus protein NS5A.

Gene Wiki entry for GPS2 Gene

Additional gene information for GPS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPS2 Gene

Genomics for GPS2 Gene

GeneHancer (GH) Regulatory Elements for GPS2 Gene

Promoters and enhancers for GPS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007312 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505.3 +1.0 1019 4 ZBTB40 ZNF217 EP300 CTCF SIN3A POLR2G USF1 PHF8 ZFX ZNF10 GPS2 NEURL4 DVL2 EIF5A SNORD10 ACAP1 SNORA48 PER1 PLSCR3 CTC1
GH17J007319 Promoter 0.3 EPDnew 500.7 -1.7 -1733 0.1 ENSG00000261915 GPS2 lnc-NEURL4-1 NEURL4 L13712-011
GH17J008172 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.2 -859.4 -859403 5.2 RXRA ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A MYC TCF12 POLR2G USF1 VAMP2 ENSG00000266824 LOC105371520 TMEM107 SNORD118 lnc-VAMP2-5 DVL2 CNTROB CTC1 WRAP53
GH17J007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -165.3 -165303 13.1 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 ZSCAN5C NRF1 TCF12 MYC POLR2A ZBTB4 SLC35G6 KIAA0753 DVL2 PFAS ENSG00000265749 SNORD10 SNORA48 KCTD11
GH17J007571 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -262.6 -262595 14.2 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 TCF12 MYC SNORD10 EIF4A1 CD68 SNORA67 piR-52509-001 MPDU1 DVL2 PFAS CTC1 CNTROB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPS2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPS2

Top Transcription factor binding sites by QIAGEN in the GPS2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for GPS2 Gene

Genomic Locations for GPS2 Gene
chr17:7,311,324-7,315,564
(GRCh38/hg38)
Size:
4,241 bases
Orientation:
Minus strand
chr17:7,214,643-7,218,883
(GRCh37/hg19)
Size:
4,241 bases
Orientation:
Minus strand

Genomic View for GPS2 Gene

Genes around GPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPS2 Gene

Proteins for GPS2 Gene

  • Protein details for GPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13227-GPS2_HUMAN
    Recommended name:
    G protein pathway suppressor 2
    Protein Accession:
    Q13227
    Secondary Accessions:
    • B4DXA1
    • Q6FHM8

    Protein attributes for GPS2 Gene

    Size:
    327 amino acids
    Molecular mass:
    36689 Da
    Quaternary structure:
    • Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2 (PubMed:11931768, PubMed:19858209, PubMed:21240272). Interacts (when sumoylated at Lys-71) with TBL1X; leading to protect GPS2 from degradation by the proteasome (PubMed:24943844, PubMed:21240272). Interacts with UBE2N; leading to inhibit UBE2N/Ubc13 activity (By similarity). Interacts with TRAF1 (By similarity). Interacts with TRAF2 (By similarity). Interacts with TRAF6 (By similarity). Interacts with PPARG (when in the liganded conformation) (By similarity). Interacts with (sumoylated) NR1H2; interaction with sumoylated NR1H2 and NR5A2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (PubMed:20159957). Interacts with (sumoylated) NR5A2; interaction with sumoylated NR1H2 and NR5A2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (PubMed:20159957). Interacts with NR1H3 (PubMed:19481530). Interacts with RFX4 (By similarity). Interacts with ANKRD26 (PubMed:22666460).
    • (Microbial infection) Interacts (via coiled coil domain) with hepatitis C virus (HCV) NS5A.
    SequenceCaution:
    • Sequence=CAB75677.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPS2 Gene

    Alternative splice isoforms for GPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPS2 Gene

Post-translational modifications for GPS2 Gene

  • Sumoylation regulates its subcellular location (PubMed:24943844). Sumoylation at Lys-45 and Lys-71 regulates the shuttling between the cytoplasm and the nucleus (PubMed:24943844). Sumoylation at Lys-71 is required for interaction with TBL1X (By similarity). Sumoylated at Lys-45 and Lys-71 in mitochondrion (By similarity). Desumoylation by SENP1 leads to relocation from the mitochondria to the nucleus (By similarity).
  • Ubiquitinated at the C-terminus by SIAH2; leading to its degradation by the proteasome. Interaction with TBL1X and methylation at Arg-323 protect GPS2 against ubiquitination and degradation.
  • Methylated at Arg-312 and Arg-323 by PRMT6. Methylation at Arg-323 protects from degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPS2 Gene

No data available for DME Specific Peptides for GPS2 Gene

Domains & Families for GPS2 Gene

Gene Families for GPS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for GPS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPS2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61446, highly similar to G protein pathway suppressor 2 (B4DXA1_HUMAN)
  • G protein pathway suppressor 2 (GPS2_HUMAN)
  • GPS2 protein (Q3SY98_HUMAN)
  • GPS2 protein (Q6FHM8_HUMAN)
genes like me logo Genes that share domains with GPS2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GPS2 Gene

Function for GPS2 Gene

Molecular function for GPS2 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:19858209, PubMed:24943844). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (PubMed:20159957). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the proinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (PubMed:8943324). Acts as a tumor-suppressor in liposarcoma (PubMed:27460081).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Required for efficient replication of hepatitis C virus (HCV) by promoting the interaction between VAPA and HCV virus protein NS5A.
UniProtKB/Swiss-Prot Induction:
Down-regulated in liposarcoma (PubMed:27460081). Down-regulated in macrophages of patients with adipose tissue inflammation and type-2 diabetes (PubMed:27270589).

Phenotypes From GWAS Catalog for GPS2 Gene

Gene Ontology (GO) - Molecular Function for GPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 19481530
GO:0003714 transcription corepressor activity IDA 11931768
GO:0005095 GTPase inhibitor activity TAS 8943324
GO:0005515 protein binding IPI 11931768
GO:0030332 cyclin binding IPI 15159402
genes like me logo Genes that share ontologies with GPS2: view
genes like me logo Genes that share phenotypes with GPS2: view

Animal Models for GPS2 Gene

MGI Knock Outs for GPS2:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for GPS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPS2 Gene

Localization for GPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPS2 Gene

Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Sumoylation regulates the subcellular location (PubMed:24943844). Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response (By similarity). {ECO:0000250 UniProtKB:Q921N8, ECO:0000269 PubMed:24943844}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPS2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA,IEA 29499132
GO:0005829 cytosol IEA,IDA 29499132
genes like me logo Genes that share ontologies with GPS2: view

Pathways & Interactions for GPS2 Gene

genes like me logo Genes that share pathways with GPS2: view

Pathways by source for GPS2 Gene

Gene Ontology (GO) - Biological Process for GPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11931768
GO:0000188 inactivation of MAPK activity TAS 8943324
GO:0007254 JNK cascade TAS 8943324
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway ISS --
GO:0010875 positive regulation of cholesterol efflux IDA 19481530
genes like me logo Genes that share ontologies with GPS2: view

No data available for SIGNOR curated interactions for GPS2 Gene

Drugs & Compounds for GPS2 Gene

No Compound Related Data Available

Transcripts for GPS2 Gene

mRNA/cDNA for GPS2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPS2

Alternative Splicing Database (ASD) splice patterns (SP) for GPS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - -
SP2:
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b · 24c · 24d ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29a · 29b · 29c ^ 30a · 30b
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: -
SP6: - - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GPS2 Gene

GeneLoc Exon Structure for
GPS2

Expression for GPS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPS2 Gene

Protein differential expression in normal tissues from HIPED for GPS2 Gene

This gene is overexpressed in Ovary (39.6), CD4 Tcells (8.7), and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPS2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPS2

SOURCE GeneReport for Unigene cluster for GPS2 Gene:

Hs.438219

mRNA Expression by UniProt/SwissProt for GPS2 Gene:

Q13227-GPS2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for GPS2 Gene

  • Nervous system(3.3)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with GPS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPS2 Gene

Orthologs for GPS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPS2 31 30
  • 99.49 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPS2 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPS2 31 30
  • 91.54 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gps2 17 31 30
  • 91.13 (n)
rat
(Rattus norvegicus)
Mammalia Gps2 30
  • 91.13 (n)
dog
(Canis familiaris)
Mammalia GPS2 31 30
  • 90.01 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPS2 31
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gps2 30
  • 69.33 (n)
Str.4949 30
African clawed frog
(Xenopus laevis)
Amphibia gps2-prov 30
zebrafish
(Danio rerio)
Actinopterygii gps2 31 30
  • 66.25 (n)
OneToOne
-- 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2137 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9458 31
  • 33 (a)
OneToOne
Species where no ortholog for GPS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPS2 Gene

ENSEMBL:
Gene Tree for GPS2 (if available)
TreeFam:
Gene Tree for GPS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPS2: view image

Paralogs for GPS2 Gene

(1) SIMAP similar genes for GPS2 Gene using alignment to 9 proteins:

  • GPS2_HUMAN
  • B4DXA1_HUMAN
  • I3L1H4_HUMAN
  • I3L242_HUMAN
  • I3L3Y9_HUMAN
  • I3L4X7_HUMAN
  • K7ESJ6_HUMAN
  • K7ESM1_HUMAN
  • Q3SY98_HUMAN

Pseudogenes.org Pseudogenes for GPS2 Gene

genes like me logo Genes that share paralogs with GPS2: view

No data available for Paralogs for GPS2 Gene

Variants for GPS2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPS2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
768828 Benign: not provided 7,314,165(-) G/A INTRON_VARIANT
786645 Benign: not provided 7,314,601(-) G/A INTRON_VARIANT
rs2292065 - p.Thr306Ala

Additional dbSNP identifiers (rs#s) for GPS2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPS2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639865 CNV loss 21293372
esv3639866 CNV gain 21293372
nsv1963 CNV deletion 18451855
nsv457659 CNV loss 19166990
nsv509650 CNV insertion 20534489
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Variation tolerance for GPS2 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPS2 Gene

Disorders for GPS2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for GPS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
liposarcoma
hepatitis c virus
  • hepatitis c virus, susceptibility to
spindle cell sarcoma
  • sarcoma
compensatory emphysema
timothy grass allergy
- elite association - COSMIC cancer census association via MalaCards
Search GPS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPS2

genes like me logo Genes that share disorders with GPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPS2 Gene

Publications for GPS2 Gene

  1. G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation. (PMID: 19858209) Cheng X … Kao HY (The Journal of biological chemistry 2009) 3 4 23 54
  2. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. (PMID: 8943324) Spain BH … Colicelli J (Molecular and cellular biology 1996) 2 3 4 54
  3. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. (PMID: 29499132) Cardamone MD … Perissi V (Molecular cell 2018) 3 4 54
  4. G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma. (PMID: 27460081) Huang XD … Li PY (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 4 54
  5. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. (PMID: 27270589) Fan R … Treuter E (Nature medicine 2016) 3 4 54

Products for GPS2 Gene