This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016] See more...

Aliases for GPS1 Gene

Aliases for GPS1 Gene

  • G Protein Pathway Suppressor 1 2 3 4 5
  • JAB1-Containing Signalosome Subunit 1 3 4
  • COP9 Signalosome Complex Subunit 1 3 4
  • COPS1 3 4
  • CSN1 3 4
  • SGN1 3 4
  • COP9 Signalosome Subunit 1 2
  • Signalosome Subunit 1 4
  • Protein MFH 4
  • GPS-1 4

External Ids for GPS1 Gene

Previous GeneCards Identifiers for GPS1 Gene

  • GC17P079433
  • GC17P9J0051
  • GC17P080545
  • GC17P077603
  • GC17P080009
  • GC17P075409

Summaries for GPS1 Gene

Entrez Gene Summary for GPS1 Gene

  • This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

GeneCards Summary for GPS1 Gene

GPS1 (G Protein Pathway Suppressor 1) is a Protein Coding gene. Diseases associated with GPS1 include Xeroderma Pigmentosum, Complementation Group E and Corneal Dystrophy, Avellino Type. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTPase inhibitor activity. An important paralog of this gene is PSMD6.

UniProtKB/Swiss-Prot Summary for GPS1 Gene

  • Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Gene Wiki entry for GPS1 Gene

Additional gene information for GPS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPS1 Gene

Genomics for GPS1 Gene

GeneHancer (GH) Regulatory Elements for GPS1 Gene

Promoters and enhancers for GPS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPS1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPS1

Top Transcription factor binding sites by QIAGEN in the GPS1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • NF-kappaB1
  • PPAR-gamma2
  • STAT3

Genomic Locations for GPS1 Gene

Genomic Locations for GPS1 Gene
chr17:82,050,691-82,057,470
(GRCh38/hg38)
Size:
6,780 bases
Orientation:
Plus strand
chr17:80,008,567-80,015,346
(GRCh37/hg19)
Size:
6,780 bases
Orientation:
Plus strand

Genomic View for GPS1 Gene

Genes around GPS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPS1 Gene

Proteins for GPS1 Gene

  • Protein details for GPS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13098-CSN1_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 1
    Protein Accession:
    Q13098
    Secondary Accessions:
    • Q8NA10
    • Q9BWL1

    Protein attributes for GPS1 Gene

    Size:
    491 amino acids
    Molecular mass:
    55537 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and COPS5 (PubMed:11114242). Interacts directly with inositol kinase ITPK1 (PubMed:12324474). Interacts with CAPN8 (By similarity).
    SequenceCaution:
    • Sequence=AAC50906.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GPS1 Gene

    Alternative splice isoforms for GPS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPS1 Gene

Post-translational modifications for GPS1 Gene

  • Ubiquitination at Lys183, Lys224, Lys248, Lys268, Lys422, Lys438, Lys444, and Lys467
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPS1 Gene

Domains & Families for GPS1 Gene

Gene Families for GPS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GPS1 Gene

Blocks:
  • Domain in components of the proteasome, COP9-complex and eIF3 (PCI)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPS1 Gene

GenScript: Design optimal peptide antigens:
  • Protein MFH (CSN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13098

UniProtKB/Swiss-Prot:

CSN1_HUMAN :
  • The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).
  • Belongs to the CSN1 family.
Domain:
  • The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).
  • The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.
Family:
  • Belongs to the CSN1 family.
genes like me logo Genes that share domains with GPS1: view

Function for GPS1 Gene

Molecular function for GPS1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.

Phenotypes From GWAS Catalog for GPS1 Gene

Gene Ontology (GO) - Molecular Function for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity TAS 8943324
GO:0005515 protein binding IPI 17337451
genes like me logo Genes that share ontologies with GPS1: view
genes like me logo Genes that share phenotypes with GPS1: view

Animal Models for GPS1 Gene

MGI Knock Outs for GPS1:
  • Gps1 Gps1<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPS1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPS1 Gene

Localization for GPS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPS1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPS1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0008180 COP9 signalosome IDA,IEA 18850735
genes like me logo Genes that share ontologies with GPS1: view

Pathways & Interactions for GPS1 Gene

genes like me logo Genes that share pathways with GPS1: view

Gene Ontology (GO) - Biological Process for GPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity TAS 8943324
GO:0000338 protein deneddylation IDA,IEA 19141280
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0007254 JNK cascade TAS 8943324
genes like me logo Genes that share ontologies with GPS1: view

No data available for SIGNOR curated interactions for GPS1 Gene

Drugs & Compounds for GPS1 Gene

No Compound Related Data Available

Transcripts for GPS1 Gene

mRNA/cDNA for GPS1 Gene

9 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
28 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPS1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPS1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ·
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7:
SP8:
SP9: - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - -
SP15: - - - - - - -
SP16: - - - - - -
SP17: - - - - - - -
SP18: - - - - -
SP19: - - - - - -
SP20: - -
SP21: - - - - - - - -
SP22: - - - - -
SP23:
SP24:
SP25: - -
SP26:
SP27: - - - - - - -
SP28:

ExUns: 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c
SP1: -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: -
SP24: -
SP25:
SP26:
SP27:
SP28: - -

Relevant External Links for GPS1 Gene

GeneLoc Exon Structure for
GPS1

Expression for GPS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPS1 Gene

Protein differential expression in normal tissues from HIPED for GPS1 Gene

This gene is overexpressed in Lymph node (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPS1 Gene



Protein tissue co-expression partners for GPS1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPS1

SOURCE GeneReport for Unigene cluster for GPS1 Gene:

Hs.268530

mRNA Expression by UniProt/SwissProt for GPS1 Gene:

Q13098-CSN1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for GPS1 Gene

  • Nervous system(4.8)
  • Intestine(3.5)
  • Lung(3.2)
  • Kidney(2.6)
  • Eye(2.5)
  • Skin(2.5)
  • Blood(2.4)
  • Muscle(2.4)
  • Liver(2.3)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with GPS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPS1 Gene

Orthologs for GPS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPS1 31
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPS1 31
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPS1 31 30
  • 90.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPS1 31 30
  • 89.73 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gps1 30
  • 87.07 (n)
mouse
(Mus musculus)
Mammalia Gps1 17 31 30
  • 86.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPS1 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPS1 31 30
  • 80.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPS1 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gps1 30
  • 77.01 (n)
Str.10225 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15278 30
zebrafish
(Danio rerio)
Actinopterygii gps1 31 30
  • 78.87 (n)
OneToOne
Dr.764 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12745 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004953 30
  • 68.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CSN1b 31 32 30
  • 66.52 (n)
OneToOne
BG:DS06874.2 32
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea csn-1 31
  • 20 (a)
OneToOne