Aliases for GPS1 Gene
External Ids for GPS1 Gene
Previous GeneCards Identifiers for GPS1 Gene
This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]
GeneCards Summary for GPS1 Gene
GPS1 (G Protein Pathway Suppressor 1) is a Protein Coding gene. Diseases associated with GPS1 include Xeroderma Pigmentosum, Complementation Group E and Corneal Dystrophy, Avellino Type. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTPase inhibitor activity. An important paralog of this gene is PSMD6.
UniProtKB/Swiss-Prot Summary for GPS1 Gene
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.