Aliases for GPRIN3 Gene

Aliases for GPRIN3 Gene

  • GPRIN Family Member 3 2 3 5
  • GRIN3 2 3 4
  • G Protein-Regulated Inducer Of Neurite Outgrowth 3 3 4
  • FLJ42625 2
  • KIAA2027 4
  • GPRIN3 5

External Ids for GPRIN3 Gene

Previous GeneCards Identifiers for GPRIN3 Gene

  • GC04M090387
  • GC04M090165
  • GC04M085916

Summaries for GPRIN3 Gene

GeneCards Summary for GPRIN3 Gene

GPRIN3 (GPRIN Family Member 3) is a Protein Coding gene. Diseases associated with GPRIN3 include Ovary Serous Adenocarcinoma. An important paralog of this gene is GPRIN2.

UniProtKB/Swiss-Prot Summary for GPRIN3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPRIN3 Gene

Genomics for GPRIN3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPRIN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J089310 Promoter/Enhancer 0.7 Ensembl dbSUPER 257.6 -1.6 -1601 0.8 ZNF146 ZNF580 GPRIN3 HSALNG0035787-001 ENSG00000251095 SNCA
GH04J089292 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 27.5 +7.2 7185 16.4 ZSCAN16 FEZF1 ZIC2 CTCF FOXA2 ZNF341 TAL1 RXRA ZNF843 KLF9 GPRIN3 FAM13A lnc-TIGD2-7 ENSG00000251095
GH04J089280 Enhancer 1 FANTOM5 ENCODE dbSUPER 32.8 +21.5 21516 11.7 CEBPA CEBPB VEZF1 MAFF CTCF EP300 JUND NFE2 ZNF589 ZNF148 GPRIN3 HSALNG0035788 lnc-TIGD2-7 ENSG00000251095 FAM13A
GH04J089242 Enhancer 0.8 Ensembl ENCODE dbSUPER 18 +63.6 63600 3.2 FOXA2 FOXA1 RAD21 HLF RXRA lnc-FAM13A-2 GPRIN3 HSALNG0035784 HSALNG0035786 FAM13A
GH04J089251 Enhancer 1 Ensembl ENCODE dbSUPER 12.1 +51.2 51164 9.9 FEZF1 CTCF CEBPB REST TRIM22 SMC3 RAD21 ZNF146 PRDM6 MAX GPRIN3 HSALNG0035786 ENSG00000251095 FAM13A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRIN3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPRIN3

Top Transcription factor binding sites by QIAGEN in the GPRIN3 gene promoter:
  • AML1a
  • AREB6
  • Chx10
  • CUTL1
  • FOXF2
  • FOXO1
  • FOXO1a
  • HSF2
  • RSRFC4
  • STAT5A

Genomic Locations for GPRIN3 Gene

Latest Assembly
71,418 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
71,418 bases
Minus strand

(GRCh37/hg19 by Ensembl)
71,625 bases
Minus strand

Genomic View for GPRIN3 Gene

Genes around GPRIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRIN3 Gene

Proteins for GPRIN3 Gene

  • Protein details for GPRIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G protein-regulated inducer of neurite outgrowth 3
    Protein Accession:
    Secondary Accessions:
    • Q8IVE4

    Protein attributes for GPRIN3 Gene

    776 amino acids
    Molecular mass:
    82439 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC23123.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPRIN3 Gene

Post-translational modifications for GPRIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRIN3 Gene

No data available for DME Specific Peptides for GPRIN3 Gene

Domains & Families for GPRIN3 Gene

Gene Families for GPRIN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPRIN3 Gene


Suggested Antigen Peptide Sequences for GPRIN3 Gene

GenScript: Design optimal peptide antigens:
  • GPRIN family member 3 (A0AVI5_HUMAN)
  • G protein-regulated inducer of neurite outgrowth 3 (GRIN3_HUMAN)
genes like me logo Genes that share domains with GPRIN3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GPRIN3 Gene

Function for GPRIN3 Gene

Molecular function for GPRIN3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neurite outgrowth.

Phenotypes From GWAS Catalog for GPRIN3 Gene

genes like me logo Genes that share phenotypes with GPRIN3: view

miRNA for GPRIN3 Gene

miRTarBase miRNAs that target GPRIN3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPRIN3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPRIN3 Gene

Localization for GPRIN3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRIN3 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPRIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with GPRIN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GPRIN3 Gene

Pathways & Interactions for GPRIN3 Gene

PathCards logo

SuperPathways for GPRIN3 Gene

No Data Available

Interacting Proteins for GPRIN3 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000476603 Q6ZVF9-GRIN3_HUMAN for GPRIN3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPRIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IBA 21873635
genes like me logo Genes that share ontologies with GPRIN3: view

No data available for Pathways by source and SIGNOR curated interactions for GPRIN3 Gene

Drugs & Compounds for GPRIN3 Gene

No Compound Related Data Available

Transcripts for GPRIN3 Gene

mRNA/cDNA for GPRIN3 Gene

5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPRIN3

Alternative Splicing Database (ASD) splice patterns (SP) for GPRIN3 Gene

No ASD Table

Relevant External Links for GPRIN3 Gene

GeneLoc Exon Structure for

Expression for GPRIN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPRIN3 Gene

mRNA differential expression in normal tissues according to GTEx for GPRIN3 Gene

This gene is overexpressed in Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for GPRIN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.4), Plasma (20.6), and CD8 Tcells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRIN3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPRIN3

SOURCE GeneReport for Unigene cluster for GPRIN3 Gene:


Evidence on tissue expression from TISSUES for GPRIN3 Gene

  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with GPRIN3: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRIN3 Gene

Orthologs for GPRIN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRIN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPRIN3 30 31
  • 99.05 (n)
(Bos Taurus)
Mammalia GPRIN3 30 31
  • 80.49 (n)
(Canis familiaris)
Mammalia GPRIN3 30 31
  • 75.47 (n)
(Rattus norvegicus)
Mammalia Gprin3 30
  • 73.78 (n)
(Mus musculus)
Mammalia Gprin3 30 17 31
  • 72.55 (n)
(Gallus gallus)
Aves GPRIN3 31
  • 27 (a)
(Anolis carolinensis)
Reptilia GPRIN3 31
  • 29 (a)
(Danio rerio)
Actinopterygii GPRIN3 31
  • 19 (a)
Species where no ortholog for GPRIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPRIN3 Gene

Gene Tree for GPRIN3 (if available)
Gene Tree for GPRIN3 (if available)
Evolutionary constrained regions (ECRs) for GPRIN3: view image

Paralogs for GPRIN3 Gene

Paralogs for GPRIN3 Gene

genes like me logo Genes that share paralogs with GPRIN3: view

Variants for GPRIN3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPRIN3 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs28647517 Benign: not provided 89,249,086(-) G/T
NM_198281.3(GPRIN3):c.1025C>A (p.Ala342Glu)
rs11733183 - p.Pro390Ser
rs11734353 - p.Leu39Val
rs17015286 - p.Arg746Lys
rs28622301 - p.Ser382Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GPRIN3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GPRIN3 Gene

Variant ID Type Subtype PubMed ID
esv3569577 CNV loss 25503493
nsv1012406 CNV loss 25217958
nsv461576 CNV gain 19166990
nsv470051 CNV gain 18288195
nsv594806 CNV gain 21841781
nsv819116 CNV gain 19587683
nsv830002 CNV gain 17160897

Variation tolerance for GPRIN3 Gene

Residual Variation Intolerance Score: 95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.23; 76.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRIN3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRIN3 Gene

Disorders for GPRIN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPRIN3 Gene - From: COP

Disorder Aliases PubMed IDs
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPRIN3

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GPRIN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPRIN3 Gene

Publications for GPRIN3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Identification and biochemical analysis of GRIN1 and GRIN2. (PMID: 15488195) Iida N … Kozasa T (Methods in enzymology 2004) 2 3
  3. PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential. (PMID: 32062451) Yadav L … Varjosalo M (iScience 2020) 3
  4. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3
  5. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. (PMID: 31741433) Zeng H … Cong F (eLife 2019) 3

Products for GPRIN3 Gene

Sources for GPRIN3 Gene