Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPRIN2 Gene

Aliases for GPRIN2 Gene

  • G Protein Regulated Inducer Of Neurite Outgrowth 2 2 3 5
  • KIAA0514 2 3 4
  • G Protein-Regulated Inducer Of Neurite Outgrowth 2 3 4
  • GRIN2 3 4

External Ids for GPRIN2 Gene

Previous HGNC Symbols for GPRIN2 Gene

  • KIAA0514

Previous GeneCards Identifiers for GPRIN2 Gene

  • GC10P046414
  • GC10P046993
  • GC10M046548

Summaries for GPRIN2 Gene

GeneCards Summary for GPRIN2 Gene

GPRIN2 (G Protein Regulated Inducer Of Neurite Outgrowth 2) is a Protein Coding gene. An important paralog of this gene is GPRIN3.

UniProtKB/Swiss-Prot for GPRIN2 Gene

Gene Wiki entry for GPRIN2 Gene

Additional gene information for GPRIN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRIN2 Gene

Genomics for GPRIN2 Gene

GeneHancer (GH) Regulatory Elements for GPRIN2 Gene

Promoters and enhancers for GPRIN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J046555 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.7 746 2 HDGF ZNF680 ZNF560 ZIC2 KLF7 POLR2A KLF9 AEBP2 ZNF274 ZFHX2 GPRIN2 NPY4R PARGP1 BMS1P1 BMS1P2 AGAP4 AGAP9 WASHC2C ENSG00000229227 AGAP10P
GH10J046516 Enhancer 0.8 Ensembl ENCODE 7.9 +39.9 39947 1.3 MAFK REST SP1 JUND ZNF157 FOS FOSL2 SIN3A ZNF335 ZFX GC10P046518 GPRIN2 PIR56474 ENSG00000285402
GH10J046538 Enhancer 1 FANTOM5 ENCODE 4 +16.7 16674 2.6 ZNF148 MLLT1 ELF1 PRDM1 SP1 REST POLR2A CTCF ATF3 TEAD1 SYT15 WASHC2C PARGP1 FAM21FP GPRIN2 PIR31182 GC10P046518
GH10J046468 Enhancer 1 FANTOM5 ENCODE 3.2 +88.4 88412 1.2 CC2D1A CTCF RAD21 ARID2 PRDM10 REST SMARCC1 ZBTB44 SP1 ZNF580 PIR43306 LINC00842 GPRIN2 NPY4R ENSG00000285402
GH10J046250 Enhancer 0.3 Ensembl 4.9 +306.6 306646 0.2 ZFHX2 PIR53286 ANXA8L1 GPRIN2 ANTXRLP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRIN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPRIN2 gene promoter:
  • AP-4
  • C/EBPalpha
  • E2F
  • E2F-1
  • E47
  • NF-1
  • NF-1/L
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for GPRIN2 Gene

Genomic Locations for GPRIN2 Gene
12,985 bases
Minus strand
12,098 bases
Plus strand

Genomic View for GPRIN2 Gene

Genes around GPRIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRIN2 Gene

Proteins for GPRIN2 Gene

  • Protein details for GPRIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G protein-regulated inducer of neurite outgrowth 2
    Protein Accession:
    Secondary Accessions:
    • Q5SVF0

    Protein attributes for GPRIN2 Gene

    458 amino acids
    Molecular mass:
    47450 Da
    Quaternary structure:
    • Interacts with activated forms of GNAO1 and GNAZ.
    • Sequence=BAA25440.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPRIN2 Gene

Post-translational modifications for GPRIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPRIN2 Gene

Domains & Families for GPRIN2 Gene

Gene Families for GPRIN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPRIN2 Gene


Suggested Antigen Peptide Sequences for GPRIN2 Gene

GenScript: Design optimal peptide antigens:
  • G protein-regulated inducer of neurite outgrowth 2 (GRIN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPRIN2: view

No data available for UniProtKB/Swiss-Prot for GPRIN2 Gene

Function for GPRIN2 Gene

Molecular function for GPRIN2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neurite outgrowth.

Gene Ontology (GO) - Molecular Function for GPRIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15778465
genes like me logo Genes that share ontologies with GPRIN2: view
genes like me logo Genes that share phenotypes with GPRIN2: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for GPRIN2 - Now 50% OFF >
  • * GPRIN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GPRIN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPRIN2 Gene

Localization for GPRIN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRIN2 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPRIN2 Gene

Pathways & Interactions for GPRIN2 Gene

PathCards logo

SuperPathways for GPRIN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPRIN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPRIN2 Gene

Drugs & Compounds for GPRIN2 Gene

No Compound Related Data Available

Transcripts for GPRIN2 Gene

mRNA/cDNA for GPRIN2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for GPRIN2 Gene

G protein regulated inducer of neurite outgrowth 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for GPRIN2 - Now 50% OFF >
  • * GPRIN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * GPRIN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for GPRIN2 Gene

No ASD Table

Relevant External Links for GPRIN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPRIN2 Gene

mRNA differential expression in normal tissues according to GTEx for GPRIN2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.8), Skin - Not Sun Exposed (Suprapubic) (x6.6), Lung (x5.0), Brain - Cerebellar Hemisphere (x4.7), and Brain - Cerebellum (x4.5).

Protein differential expression in normal tissues from HIPED for GPRIN2 Gene

This gene is overexpressed in Heart (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPRIN2 Gene

Protein tissue co-expression partners for GPRIN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPRIN2 Gene:


SOURCE GeneReport for Unigene cluster for GPRIN2 Gene:


mRNA Expression by UniProt/SwissProt for GPRIN2 Gene:

Tissue specificity: Expressed specifically in the cerebellum.
genes like me logo Genes that share expression patterns with GPRIN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRIN2 Gene

Orthologs for GPRIN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRIN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPRIN2 35 34
  • 94.91 (n)
(Bos Taurus)
Mammalia GPRIN2 35 34
  • 83.22 (n)
(Mus musculus)
Mammalia Gprin2 17 35 34
  • 78.9 (n)
(Rattus norvegicus)
Mammalia Gprin2 34
  • 77.95 (n)
(Canis familiaris)
Mammalia GPRIN2 35
  • 67 (a)
(Monodelphis domestica)
Mammalia GPRIN2 35
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia GPRIN2 35
  • 33 (a)
(Gallus gallus)
Aves GPRIN2 35
  • 26 (a)
(Anolis carolinensis)
Reptilia GPRIN2 35
  • 27 (a)
(Danio rerio)
Actinopterygii si:ch211-149b19.2 35
  • 9 (a)
Dr.23013 34
Species where no ortholog for GPRIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRIN2 Gene

Gene Tree for GPRIN2 (if available)
Gene Tree for GPRIN2 (if available)
Evolutionary constrained regions (ECRs) for GPRIN2: view image

Paralogs for GPRIN2 Gene

Paralogs for GPRIN2 Gene

genes like me logo Genes that share paralogs with GPRIN2: view

Variants for GPRIN2 Gene

Sequence variations from dbSNP and Humsavar for GPRIN2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000155995 -- 46,555,124(-) T/G intron_variant
rs1000330131 -- 46,558,899(-) G/A upstream_transcript_variant
rs1000565599 -- 46,544,846(-) A/G 3_prime_UTR_variant
rs1000957539 -- 46,547,764(-) C/T 3_prime_UTR_variant
rs1000976129 -- 46,543,665(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPRIN2 Gene

Variant ID Type Subtype PubMed ID
dgv116e214 CNV gain 21293372
dgv147n67 CNV gain 20364138
dgv148n67 CNV gain 20364138
dgv216e212 CNV loss 25503493
dgv218e212 CNV loss 25503493
dgv219e212 CNV gain 25503493
dgv223e212 CNV loss 25503493
dgv22e55 CNV gain 17911159
dgv409e59 CNV duplication 20981092
dgv412e59 CNV duplication 20981092
dgv440n106 CNV duplication 24896259
dgv734n100 CNV gain 25217958
dgv737n100 CNV loss 25217958
dgv738n100 CNV loss 25217958
dgv739n100 CNV gain 25217958
dgv740n100 CNV gain+loss 25217958
dgv742n100 CNV loss 25217958
dgv743n100 CNV gain 25217958
dgv747n100 CNV gain+loss 25217958
dgv748n100 CNV gain 25217958
dgv749n100 CNV gain+loss 25217958
dgv750n100 CNV loss 25217958
dgv751n100 CNV gain 25217958
dgv752n100 CNV loss 25217958
dgv753n100 CNV gain 25217958
dgv759n100 CNV loss 25217958
dgv760n100 CNV gain 25217958
dgv763n100 CNV gain 25217958
dgv764n100 CNV loss 25217958
dgv765n100 CNV loss 25217958
dgv767n100 CNV gain 25217958
dgv768n100 CNV loss 25217958
dgv771n100 CNV loss 25217958
dgv780n100 CNV gain 25217958
dgv781n100 CNV loss 25217958
dgv782n100 CNV loss 25217958
dgv783n100 CNV gain 25217958
dgv8n68 CNV gain 17160897
esv2632472 CNV gain 19546169
esv2736152 CNV deletion 23290073
esv3330359 CNV duplication 20981092
esv3385822 CNV duplication 20981092
esv3440422 CNV duplication 20981092
esv3576928 CNV gain 25503493
esv3578829 CNV loss 25503493
esv3584617 CNV loss 24956385
esv3891799 CNV gain 25118596
nsv1041409 CNV loss 25217958
nsv1044044 CNV gain+loss 25217958
nsv1047710 CNV gain+loss 25217958
nsv1049394 CNV loss 25217958
nsv1050225 CNV gain+loss 25217958
nsv1050696 CNV gain 25217958
nsv1075819 CNV duplication 25765185
nsv1152446 CNV duplication 26484159
nsv437670 CNV loss 16327808
nsv438172 CNV loss 16468122
nsv482145 CNV gain 20164927
nsv550722 CNV gain 21841781
nsv550723 CNV gain 21841781
nsv820817 CNV duplication 20802225
nsv947929 CNV duplication 23825009
nsv951576 CNV duplication 24416366

Variation tolerance for GPRIN2 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.81; 97.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRIN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRIN2 Gene

Disorders for GPRIN2 Gene

Additional Disease Information for GPRIN2

No disorders were found for GPRIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRIN2 Gene

Publications for GPRIN2 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A candidate target for G protein action in brain. (PMID: 10480904) Chen LT … Kozasa T (The Journal of biological chemistry 1999) 3 4 58
  5. Familial Esophageal Squamous Cell Carcinoma with damaging rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes. (PMID: 29405996) Khalilipour N … Abbaszadegan MR (Cancer genetics 2018) 3 58

Products for GPRIN2 Gene

Sources for GPRIN2 Gene

Loading form....