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Aliases for GPRIN1 Gene

Aliases for GPRIN1 Gene

  • G Protein Regulated Inducer Of Neurite Outgrowth 1 2 3 5
  • GRIN1 3 4
  • G Protein-Regulated Inducer Of Neurite Outgrowth 1 3
  • KIAA1893 4

External Ids for GPRIN1 Gene

Previous GeneCards Identifiers for GPRIN1 Gene

  • GC05M175956
  • GC05M175957
  • GC05M176022
  • GC05M170947

Summaries for GPRIN1 Gene

GeneCards Summary for GPRIN1 Gene

GPRIN1 (G Protein Regulated Inducer Of Neurite Outgrowth 1) is a Protein Coding gene. Diseases associated with GPRIN1 include Pustulosis Of Palm And Sole. Among its related pathways are MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include phosphoprotein binding. An important paralog of this gene is GPRIN2.

UniProtKB/Swiss-Prot for GPRIN1 Gene

  • May be involved in neurite outgrowth.

Additional gene information for GPRIN1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRIN1 Gene

Genomics for GPRIN1 Gene

GeneHancer (GH) Regulatory Elements for GPRIN1 Gene

Promoters and enhancers for GPRIN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I176609 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.4 +7.2 7187 1.3 ARNT SIN3A ZNF2 GLIS2 ZNF416 ZNF143 RUNX3 KLF13 SP3 MIER2 GPRIN1 NSD1 FAF2 ZNF346 GC05M176610 PIR54069
GH05I176646 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.9 -30.6 -30589 3 HDGF PKNOX1 SMAD1 ATF1 ARNT SIN3A ZNF48 YY1 TCF12 POLR2B TSPAN17 GPRIN1 HK3 EIF4E1B ENSG00000248484
GH05I176539 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5 +71.6 71553 11.8 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 CDHR2 RN7SL684P FAF2 ENSG00000250909 ENSG00000251414 NSD1 ZNF346-IT1 RNF44 UIMC1 CLTB
GH05I176628 Promoter/Enhancer 1.3 EPDnew Ensembl 8.1 -12.3 -12322 2.3 PKNOX1 SIN3A ZNF335 GLIS2 SCRT2 ZNF143 SP3 SP5 TSHZ1 ZNF623 MIR4281 SNCB EIF4E1B TSPAN17 GPRIN1 GC05M176632
GH05I177308 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 4.5 -693.7 -693656 4.9 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B E2F8 MXD3 FAM193B RGS14 UIMC1 NSD1 PHYKPL HNRNPAB ENSG00000251414 ZNF346 ENSG00000250909
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPRIN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPRIN1 gene promoter:

Genomic Locations for GPRIN1 Gene

Genomic Locations for GPRIN1 Gene
21,537 bases
Minus strand

Genomic View for GPRIN1 Gene

Genes around GPRIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRIN1 Gene

Proteins for GPRIN1 Gene

  • Protein details for GPRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G protein-regulated inducer of neurite outgrowth 1
    Protein Accession:
    Secondary Accessions:
    • C9JM70
    • Q8ND74
    • Q96PZ4

    Protein attributes for GPRIN1 Gene

    1008 amino acids
    Molecular mass:
    102399 Da
    Quaternary structure:
    • Interacts with activated forms of GNAI1, GNAO1 and GNAZ.
    • Sequence=BAB67786.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPRIN1 Gene


neXtProt entry for GPRIN1 Gene

Post-translational modifications for GPRIN1 Gene

  • Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPRIN1 Gene

Domains & Families for GPRIN1 Gene

Gene Families for GPRIN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPRIN1 Gene


Suggested Antigen Peptide Sequences for GPRIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPRIN1: view

No data available for UniProtKB/Swiss-Prot for GPRIN1 Gene

Function for GPRIN1 Gene

Molecular function for GPRIN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neurite outgrowth.

Phenotypes From GWAS Catalog for GPRIN1 Gene

genes like me logo Genes that share phenotypes with GPRIN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRIN1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPRIN1 Gene

Localization for GPRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRIN1 Gene

Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Highly enriched in growth cone. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRIN1 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with GPRIN1: view

Pathways & Interactions for GPRIN1 Gene

genes like me logo Genes that share pathways with GPRIN1: view

Pathways by source for GPRIN1 Gene

1 BioSystems pathway for GPRIN1 Gene

Interacting Proteins for GPRIN1 Gene

Gene Ontology (GO) - Biological Process for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IBA --
genes like me logo Genes that share ontologies with GPRIN1: view

No data available for SIGNOR curated interactions for GPRIN1 Gene

Drugs & Compounds for GPRIN1 Gene

No Compound Related Data Available

Transcripts for GPRIN1 Gene

mRNA/cDNA for GPRIN1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(93) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPRIN1 Gene

G protein regulated inducer of neurite outgrowth 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRIN1 Gene

No ASD Table

Relevant External Links for GPRIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPRIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRIN1 Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Cerebellar Hemisphere (x5.7), Brain - Frontal Cortex (BA9) (x5.7), Brain - Amygdala (x5.1), Brain - Cerebellum (x4.4), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for GPRIN1 Gene

This gene is overexpressed in Brain (27.6), Pancreas (15.3), Fetal Brain (12.6), and Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRIN1 Gene

Protein tissue co-expression partners for GPRIN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPRIN1 Gene:


SOURCE GeneReport for Unigene cluster for GPRIN1 Gene:


mRNA Expression by UniProt/SwissProt for GPRIN1 Gene:

Tissue specificity: Widely expressed in the central nervous system, with highest levels in spinal cord.

Evidence on tissue expression from TISSUES for GPRIN1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with GPRIN1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRIN1 Gene

Orthologs for GPRIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPRIN1 33 34
  • 79.39 (n)
(Canis familiaris)
Mammalia GPRIN1 33 34
  • 78.03 (n)
(Rattus norvegicus)
Mammalia Gprin1 33
  • 73.03 (n)
(Mus musculus)
Mammalia Gprin1 33 16 34
  • 72.6 (n)
(Pan troglodytes)
Mammalia GPRIN1 34
  • 50 (a)
(Monodelphis domestica)
Mammalia GPRIN1 34
  • 41 (a)
(Gallus gallus)
Aves GPRIN1 34
  • 27 (a)
(Anolis carolinensis)
Reptilia GPRIN1 34
  • 46 (a)
(Danio rerio)
Actinopterygii GPRIN1 34
  • 19 (a)
Species where no ortholog for GPRIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRIN1 Gene

Gene Tree for GPRIN1 (if available)
Gene Tree for GPRIN1 (if available)

Paralogs for GPRIN1 Gene

Paralogs for GPRIN1 Gene

genes like me logo Genes that share paralogs with GPRIN1: view

Variants for GPRIN1 Gene

Sequence variations from dbSNP and Humsavar for GPRIN1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000175303 -- 176,606,299(-) C/T intron_variant
rs1000191224 -- 176,603,564(-) G/T intron_variant
rs1000586514 -- 176,596,461(-) A/G 3_prime_UTR_variant
rs1000729707 -- 176,608,654(-) C/G intron_variant
rs1000737234 -- 176,600,433(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPRIN1 Gene

Variant ID Type Subtype PubMed ID
nsv1073939 CNV deletion 25765185
nsv1126732 CNV deletion 24896259
nsv471056 CNV loss 18288195
nsv600345 CNV loss 21841781
nsv600346 CNV loss 21841781

Variation tolerance for GPRIN1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.91; 87.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRIN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRIN1 Gene

Disorders for GPRIN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPRIN1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
pustulosis of palm and sole
  • acropustulosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPRIN1

genes like me logo Genes that share disorders with GPRIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPRIN1 Gene

Publications for GPRIN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A candidate target for G protein action in brain. (PMID: 10480904) Chen LT … Kozasa T (The Journal of biological chemistry 1999) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for GPRIN1 Gene

Sources for GPRIN1 Gene

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