Aliases for GPRIN1 Gene

Aliases for GPRIN1 Gene

  • G Protein Regulated Inducer Of Neurite Outgrowth 1 2 3 5
  • G Protein-Regulated Inducer Of Neurite Outgrowth 1 3 4
  • GRIN1 3 4
  • KIAA1893 4

External Ids for GPRIN1 Gene

Previous GeneCards Identifiers for GPRIN1 Gene

  • GC05M175956
  • GC05M175957
  • GC05M176022
  • GC05M170947

Summaries for GPRIN1 Gene

GeneCards Summary for GPRIN1 Gene

GPRIN1 (G Protein Regulated Inducer Of Neurite Outgrowth 1) is a Protein Coding gene. Diseases associated with GPRIN1 include Cerebral Creatine Deficiency Syndrome 2 and Gastric Small Cell Carcinoma. Among its related pathways are MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include phosphoprotein binding.

UniProtKB/Swiss-Prot Summary for GPRIN1 Gene

Additional gene information for GPRIN1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPRIN1 Gene

Genomics for GPRIN1 Gene

GeneHancer (GH) Regulatory Elements for GPRIN1 Gene

Promoters and enhancers for GPRIN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176609 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 +6.7 6737 2.8 EP300 CTCF SIN3A NRF1 PHF8 ZIC2 REST POLR2A ZBTB10 ZNF623 GPRIN1 NSD1 FAF2 ZNF346 piR-33070
GH05J176646 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 -30.7 -30663 3.2 EP300 CTCF NRF1 TCF12 POLR2G PHF8 PHB2 ZFX ZIC2 REST TSPAN17 NONHSAG042332.2 RF00017-5140 lnc-SNCB-4 GPRIN1 HK3 EIF4E1B
GH05J176529 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5 +76.9 76909 22.5 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 TCF12 MYC POLR2G RNF44 CDHR2 FAF2 ENSG00000250909 NSD1 ENSG00000251414 UIMC1 THOC3 CLTB GPRIN1
GH05J176630 Promoter 1.3 EPDnew Ensembl 8.1 -13.1 -13063 0.8 HNRNPK MYC ZIC2 ZNF423 ZBTB26 SAP30 HDAC2 ZNF341 EZH2 CTCF EIF4E1B MIR4281 SNCB lnc-EIF4E1B-2 lnc-SNCB-3 GPRIN1 TSPAN17
GH05J176559 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.5 +56.6 56637 2.2 CTCF RBM25 TCF12 CHD2 ZFHX2 RAD21 SMC3 BCL3 EGR2 TRIM22 GPRIN1 MIR1271 ARL10 KIAA1191 UNC5A CDHR2 RF00017-5137 RF00017-5138
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRIN1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPRIN1

Top Transcription factor binding sites by QIAGEN in the GPRIN1 gene promoter:
  • FOXO1
  • FOXO1a
  • Meis-1
  • Meis-1a
  • Meis-1b
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • SRF

Genomic Locations for GPRIN1 Gene

Genomic Locations for GPRIN1 Gene
chr5:176,595,802-176,617,338
(GRCh38/hg38)
Size:
21,537 bases
Orientation:
Minus strand
chr5:176,022,803-176,037,134
(GRCh37/hg19)
Size:
14,332 bases
Orientation:
Minus strand

Genomic View for GPRIN1 Gene

Genes around GPRIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRIN1 Gene

Proteins for GPRIN1 Gene

  • Protein details for GPRIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2K8-GRIN1_HUMAN
    Recommended name:
    G protein-regulated inducer of neurite outgrowth 1
    Protein Accession:
    Q7Z2K8
    Secondary Accessions:
    • C9JM70
    • Q8ND74
    • Q96PZ4

    Protein attributes for GPRIN1 Gene

    Size:
    1008 amino acids
    Molecular mass:
    102399 Da
    Quaternary structure:
    • Interacts with activated forms of GNAI1, GNAO1 and GNAZ.
    SequenceCaution:
    • Sequence=BAB67786.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPRIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPRIN1 Gene

Post-translational modifications for GPRIN1 Gene

  • Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRIN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPRIN1 Gene

Domains & Families for GPRIN1 Gene

Gene Families for GPRIN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPRIN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPRIN1 Gene

GenScript: Design optimal peptide antigens:
  • G protein-regulated inducer of neurite outgrowth 1 (GRIN1_HUMAN)
genes like me logo Genes that share domains with GPRIN1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GPRIN1 Gene

Function for GPRIN1 Gene

Molecular function for GPRIN1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neurite outgrowth.

Phenotypes From GWAS Catalog for GPRIN1 Gene

Gene Ontology (GO) - Molecular Function for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051219 phosphoprotein binding IEA --
genes like me logo Genes that share ontologies with GPRIN1: view
genes like me logo Genes that share phenotypes with GPRIN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRIN1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPRIN1 Gene

Localization for GPRIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRIN1 Gene

Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Highly enriched in growth cone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRIN1 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
extracellular 1
cytoskeleton 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0030426 growth cone IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with GPRIN1: view

Pathways & Interactions for GPRIN1 Gene

PathCards logo

SuperPathways for GPRIN1 Gene

genes like me logo Genes that share pathways with GPRIN1: view

Pathways by source for GPRIN1 Gene

1 BioSystems pathway for GPRIN1 Gene

Gene Ontology (GO) - Biological Process for GPRIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IEA,IBA 21873635
genes like me logo Genes that share ontologies with GPRIN1: view

No data available for SIGNOR curated interactions for GPRIN1 Gene

Drugs & Compounds for GPRIN1 Gene

No Compound Related Data Available

Transcripts for GPRIN1 Gene

mRNA/cDNA for GPRIN1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRIN1 Gene

No ASD Table

Relevant External Links for GPRIN1 Gene

GeneLoc Exon Structure for
GPRIN1

Expression for GPRIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPRIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRIN1 Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Cerebellar Hemisphere (x5.7), Brain - Frontal Cortex (BA9) (x5.7), Brain - Amygdala (x5.1), Brain - Cerebellum (x4.4), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for GPRIN1 Gene

This gene is overexpressed in Brain (27.6), Pancreas (15.3), Fetal Brain (12.6), and Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRIN1 Gene



Protein tissue co-expression partners for GPRIN1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPRIN1

SOURCE GeneReport for Unigene cluster for GPRIN1 Gene:

Hs.150549

mRNA Expression by UniProt/SwissProt for GPRIN1 Gene:

Q7Z2K8-GRIN1_HUMAN
Tissue specificity: Widely expressed in the central nervous system, with highest levels in spinal cord.

Evidence on tissue expression from TISSUES for GPRIN1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with GPRIN1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRIN1 Gene

Orthologs for GPRIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRIN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPRIN1 31 30
  • 79.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPRIN1 31 30
  • 78.03 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gprin1 30
  • 73.03 (n)
mouse
(Mus musculus)
Mammalia Gprin1 17 31 30
  • 72.6 (n)
chimpanzee
(Pan troglodytes)
Mammalia GPRIN1 31
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPRIN1 31
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPRIN1 31
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPRIN1 31
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPRIN1 31
  • 19 (a)
OneToOne
Species where no ortholog for GPRIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRIN1 Gene

ENSEMBL:
Gene Tree for GPRIN1 (if available)
TreeFam:
Gene Tree for GPRIN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPRIN1: view image

Paralogs for GPRIN1 Gene

No data available for Paralogs for GPRIN1 Gene

Variants for GPRIN1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPRIN1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
768051 Benign: not provided 176,599,134(-) TCCTCCTTCCTC/T FRAMESHIFT_VARIANT
rs10037225 - p.Gly337Ala
rs17854765 - p.Pro121Thr
rs34285890 - p.Ser357Pro
rs6556276 - p.Met300Val

Additional dbSNP identifiers (rs#s) for GPRIN1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPRIN1 Gene

Variant ID Type Subtype PubMed ID
nsv1073939 CNV deletion 25765185
nsv1126732 CNV deletion 24896259
nsv471056 CNV loss 18288195
nsv600345 CNV loss 21841781
nsv600346 CNV loss 21841781

Variation tolerance for GPRIN1 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.91; 87.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRIN1 Gene

Human Gene Mutation Database (HGMD)
GPRIN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPRIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRIN1 Gene

Disorders for GPRIN1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPRIN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cerebral creatine deficiency syndrome 2
  • ccds2
gastric small cell carcinoma
  • small cell carcinoma of stomach
cerebral creatine deficiency syndrome
rett syndrome
  • rtt
pustulosis of palm and sole
  • generalized pustular psoriasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPRIN1

genes like me logo Genes that share disorders with GPRIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPRIN1 Gene

Publications for GPRIN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. A candidate target for G protein action in brain. (PMID: 10480904) Chen LT … Kozasa T (The Journal of biological chemistry 1999) 3 4 54
  4. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. (PMID: 31452512) Pech MF … Settleman J (eLife 2019) 3 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

Products for GPRIN1 Gene

Sources for GPRIN1 Gene