Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2... See more...

Aliases for GPRC6A Gene

Aliases for GPRC6A Gene

  • G Protein-Coupled Receptor Class C Group 6 Member A 2 3 5
  • G Protein-Coupled Receptor, Family C, Group 6, Member A 2 3
  • G-Protein Coupled Receptor Family C Group 6 Member A 3 4
  • G-Protein Coupled Receptor GPCR33 3 4
  • G Protein-Coupled Receptor, Class C, Group 6, Member A 2
  • Seven Transmembrane Helix Receptor 3
  • Predicted With SOSUI Analysis 3
  • BA86F4.3 3
  • HGPCR33 4
  • HGPRC6A 4
  • GPCR 3

External Ids for GPRC6A Gene

Previous GeneCards Identifiers for GPRC6A Gene

  • GC06M116948
  • GC06M117136
  • GC06M117158
  • GC06M117219
  • GC06M114692

Summaries for GPRC6A Gene

Entrez Gene Summary for GPRC6A Gene

  • Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

GeneCards Summary for GPRC6A Gene

GPRC6A (G Protein-Coupled Receptor Class C Group 6 Member A) is a Protein Coding gene. Diseases associated with GPRC6A include Hyperparathyroidism and Ocular Albinism. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is CASR.

UniProtKB/Swiss-Prot Summary for GPRC6A Gene

  • Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.

Gene Wiki entry for GPRC6A Gene

Additional gene information for GPRC6A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPRC6A Gene

Genomics for GPRC6A Gene

GeneHancer (GH) Regulatory Elements for GPRC6A Gene

Promoters and enhancers for GPRC6A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J116828 Enhancer 0.3 Ensembl 500.7 +1.0 956 0.2 POU5F1 NANOG GPRC6A CALHM6 lnc-GPRC6A-1
GH06J116829 Enhancer 0.3 Ensembl 500.7 +0.2 156 0.6 MITF GPRC6A DSE CALHM6 lnc-GPRC6A-1
GH06J116827 Enhancer 0.2 Ensembl 500.7 +1.4 1356 0.2 GPRC6A lnc-GPRC6A-1
GH06J116804 Enhancer 0.2 Ensembl 0.4 +24.6 24556 0.2 lnc-GPRC6A-1 GPRC6A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRC6A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPRC6A

Top Transcription factor binding sites by QIAGEN in the GPRC6A gene promoter:
  • AML1a
  • C/EBPbeta
  • CUTL1
  • FOXL1
  • HOXA3
  • IRF-2
  • Nkx2-2
  • Pax-4a
  • SRY

Genomic Locations for GPRC6A Gene

Genomic Locations for GPRC6A Gene
chr6:116,792,085-116,829,057
(GRCh38/hg38)
Size:
36,973 bases
Orientation:
Minus strand
chr6:117,113,248-117,150,200
(GRCh37/hg19)
Size:
36,953 bases
Orientation:
Minus strand

Genomic View for GPRC6A Gene

Genes around GPRC6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC6A Gene

Proteins for GPRC6A Gene

  • Protein details for GPRC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6X5-GPC6A_HUMAN
    Recommended name:
    G-protein coupled receptor family C group 6 member A
    Protein Accession:
    Q5T6X5
    Secondary Accessions:
    • Q6JK43
    • Q6JK44
    • Q8NGU8
    • Q8NHZ9
    • Q8TDT6

    Protein attributes for GPRC6A Gene

    Size:
    926 amino acids
    Molecular mass:
    104753 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.
    Miscellaneous:
    • [Isoform 1]: Major isoform.
    SequenceCaution:
    • Sequence=BAC05904.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GPRC6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPRC6A Gene

Post-translational modifications for GPRC6A Gene

  • N-glycosylated.
  • Glycosylation at Asn121, Asn259, Asn452, Asn332, Asn378, Asn555, Asn567, Asn590, and Asn733
  • Modification sites at PhosphoSitePlus

Other Protein References for GPRC6A Gene

No data available for DME Specific Peptides for GPRC6A Gene

Domains & Families for GPRC6A Gene

Gene Families for GPRC6A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for GPRC6A Gene

Blocks:
  • G-protein coupled receptors family 3 (Metabotropic glutamate receptor-like)
  • Extracellular ligand-binding receptor
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPRC6A Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor GPCR33 (GPC6A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T6X5

UniProtKB/Swiss-Prot:

GPC6A_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC6A: view

Function for GPRC6A Gene

Molecular function for GPRC6A Gene

UniProtKB/Swiss-Prot Function:
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.

Phenotypes From GWAS Catalog for GPRC6A Gene

Gene Ontology (GO) - Molecular Function for GPRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0038023 signaling receptor activity IBA 21873635
genes like me logo Genes that share ontologies with GPRC6A: view
genes like me logo Genes that share phenotypes with GPRC6A: view

Animal Models for GPRC6A Gene

MGI Knock Outs for GPRC6A:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRC6A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPRC6A Gene

Localization for GPRC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC6A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRC6A gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GPRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPRC6A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPRC6A Gene

Pathways & Interactions for GPRC6A Gene

genes like me logo Genes that share pathways with GPRC6A: view

Gene Ontology (GO) - Biological Process for GPRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0019722 calcium-mediated signaling IEA --
GO:0043200 response to amino acid IDA 17478059
genes like me logo Genes that share ontologies with GPRC6A: view

No data available for SIGNOR curated interactions for GPRC6A Gene

Drugs & Compounds for GPRC6A Gene

(26) Drugs for GPRC6A Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-Lysine Approved, Experimental Nutra Full agonist, Agonist 0
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, antagonist 369
L-Glutamine Approved, Investigational Nutra Full agonist, Agonist 0
Calcium Approved Nutra 7884
Urea Approved, Investigational Pharma 0

(14) Additional Compounds for GPRC6A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPRC6A: view

Transcripts for GPRC6A Gene

mRNA/cDNA for GPRC6A Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC6A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2:
SP3: -

Relevant External Links for GPRC6A Gene

GeneLoc Exon Structure for
GPRC6A

Expression for GPRC6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPRC6A Gene

mRNA differential expression in normal tissues according to GTEx for GPRC6A Gene

This gene is overexpressed in Minor Salivary Gland (x25.2), Adrenal Gland (x12.4), and Kidney - Cortex (x7.3).

Protein differential expression in normal tissues from HIPED for GPRC6A Gene

This gene is overexpressed in Monocytes (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPRC6A Gene



Protein tissue co-expression partners for GPRC6A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPRC6A

SOURCE GeneReport for Unigene cluster for GPRC6A Gene:

Hs.266745

mRNA Expression by UniProt/SwissProt for GPRC6A Gene:

Q5T6X5-GPC6A_HUMAN
Tissue specificity: Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.

Evidence on tissue expression from TISSUES for GPRC6A Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with GPRC6A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRC6A Gene

Orthologs for GPRC6A Gene

This gene was present in the common ancestor of animals.

Orthologs for GPRC6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPRC6A 31 30
  • 99.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPRC6A 31 30
  • 89.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPRC6A 30
  • 83.93 (n)
mouse
(Mus musculus)
Mammalia Gprc6a 17 31 30
  • 82.79 (n)
rat
(Rattus norvegicus)
Mammalia Gprc6a 30
  • 81.86 (n)
oppossum
(Monodelphis domestica)
Mammalia GPRC6A 31
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves GPRC6A 31 30
  • 67.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPRC6A 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487890 30
  • 62.28 (n)
zebrafish
(Danio rerio)
Actinopterygii gprc6a 31 30
  • 54.95 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mtt 31
  • 16 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
OneToOne
Species where no ortholog for GPRC6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC6A Gene

ENSEMBL:
Gene Tree for GPRC6A (if available)
TreeFam:
Gene Tree for GPRC6A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPRC6A: view image

Paralogs for GPRC6A Gene

Paralogs for GPRC6A Gene

(5) SIMAP similar genes for GPRC6A Gene using alignment to 1 proteins:

  • GPC6A_HUMAN
genes like me logo Genes that share paralogs with GPRC6A: view

Variants for GPRC6A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPRC6A Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
769689 Benign: not provided 116,792,598(-) A/AGG FRAMESHIFT_VARIANT
769690 Benign: not provided 116,792,599(-) T/TA FRAMESHIFT_VARIANT
769691 Benign: not provided 116,792,602(-) T/TTCC INFRAME_INSERTION
777626 Benign: not provided 116,792,269(-) G/T MISSENSE_VARIANT
rs2274911 - p.Pro91Ser

Additional dbSNP identifiers (rs#s) for GPRC6A Gene

Structural Variations from Database of Genomic Variants (DGV) for GPRC6A Gene

Variant ID Type Subtype PubMed ID
nsv1119207 CNV duplication 24896259
nsv523972 CNV gain 19592680

Variation tolerance for GPRC6A Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.80; 97.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRC6A Gene

Human Gene Mutation Database (HGMD)
GPRC6A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPRC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRC6A Gene

Disorders for GPRC6A Gene

MalaCards: The human disease database

(3) MalaCards diseases for GPRC6A Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPRC6A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPRC6A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPRC6A Gene

Publications for GPRC6A Gene

  1. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. (PMID: 15576628) Wellendorph P … Bräuner-Osborne H (Molecular pharmacology 2005) 3 4 23 54
  2. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. (PMID: 15194188) Wellendorph P … Bräuner-Osborne H (Gene 2004) 3 4 23 54
  3. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. (PMID: 21300955) Dehghan A … Chasman DI (Circulation 2011) 3 41 54
  4. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. (PMID: 20676098) Takata R … Nakagawa H (Nature genetics 2010) 3 41 54
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54

Products for GPRC6A Gene

Sources for GPRC6A Gene