Aliases for GPRC6A Gene
- G Protein-Coupled Receptor Class C Group 6 Member A 2 3 5
- G Protein-Coupled Receptor, Family C, Group 6, Member A 2 3
- G-Protein Coupled Receptor GPCR33 3 4
- G Protein-Coupled Receptor, Class C, Group 6, Member A 2
- G-Protein Coupled Receptor Family C Group 6 Member A 3
- Seven Transmembrane Helix Receptor 3
External Ids for GPRC6A Gene
Previous GeneCards Identifiers for GPRC6A Gene
Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]
GeneCards Summary for GPRC6A Gene
GPRC6A (G Protein-Coupled Receptor Class C Group 6 Member A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is TAS1R3.
UniProtKB/Swiss-Prot for GPRC6A Gene
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.