Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPRC5D Gene

Aliases for GPRC5D Gene

  • G Protein-Coupled Receptor Class C Group 5 Member D 2 3 5
  • G Protein-Coupled Receptor, Family C, Group 5, Member D 2
  • G Protein-Coupled Receptor, Class C, Group 5, Member D 2
  • G-Protein Coupled Receptor Family C Group 5 Member D 3
  • Orphan G-Protein Coupled Receptor 3

External Ids for GPRC5D Gene

Previous GeneCards Identifiers for GPRC5D Gene

  • GC12M012824
  • GC12M013238
  • GC12M012993
  • GC12M012985
  • GC12M012986
  • GC12M012987
  • GC12M013093

Summaries for GPRC5D Gene

Entrez Gene Summary for GPRC5D Gene

  • The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPRC5D Gene

GPRC5D (G Protein-Coupled Receptor Class C Group 5 Member D) is a Protein Coding gene. Among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPRC5A.

Gene Wiki entry for GPRC5D Gene

Additional gene information for GPRC5D Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRC5D Gene

Genomics for GPRC5D Gene

GeneHancer (GH) Regulatory Elements for GPRC5D Gene

Promoters and enhancers for GPRC5D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J012978 Enhancer 1 Ensembl ENCODE dbSUPER 650.7 -0.4 -429 2.9 RFX1 JUN SIN3A BMI1 RFX5 FOS FOSL2 MAFK NFE2L2 GC12P012980 GPRC5D HEBP1 MIR614 ENSG00000255621 HTR7P1 GPRC5D-AS1 DDX47 EMP1
GH12J012977 Enhancer 0.6 ENCODE dbSUPER 650.7 +1.5 1528 0.1 HLF ZNF24 RUNX3 GPRC5D MIR614 HEBP1 ENSG00000255621 HTR7P1 DDX47 EMP1 ENSG00000221611 GPRC5D-AS1
GH12J012952 Promoter 0.5 EPDnew 650.3 +27.3 27284 0.1 GPRC5D GC12M012943 GPRC5D-AS1
GH12J013193 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -223.6 -223575 19.5 PKNOX1 SIN3A FEZF1 YY1 ZNF143 FOS RXRA REST MAFF STAT3 EMP1 HTR7P1 MIR614 GSG1 DDX47 GPRC5D-AS1 ENSG00000255621 HEBP1 ENSG00000221611 LOH12CR2
GH12J012924 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.4 +52.9 52922 3.3 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 TCF12 POLR2B ATF7 RXRA GPRC5D-AS1 FAM234B GPRC5D ENSG00000256011 GPRC5A MIR614
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRC5D on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPRC5D gene promoter:
  • CUTL1
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • PPAR-gamma2
  • PPAR-gamma1
  • Gfi-1
  • RP58
  • FAC1

Genomic Locations for GPRC5D Gene

Genomic Locations for GPRC5D Gene
38,964 bases
Minus strand
11,373 bases
Minus strand

Genomic View for GPRC5D Gene

Genes around GPRC5D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC5D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC5D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC5D Gene

Proteins for GPRC5D Gene

  • Protein details for GPRC5D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor family C group 5 member D
    Protein Accession:
    Secondary Accessions:
    • Q3KNV3
    • Q7Z5J9
    • Q8TDS6

    Protein attributes for GPRC5D Gene

    345 amino acids
    Molecular mass:
    38791 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPRC5D Gene


neXtProt entry for GPRC5D Gene

Post-translational modifications for GPRC5D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRC5D Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for GPRC5D

No data available for DME Specific Peptides for GPRC5D Gene

Domains & Families for GPRC5D Gene

Gene Families for GPRC5D Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPRC5D Gene


Suggested Antigen Peptide Sequences for GPRC5D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC5D: view

Function for GPRC5D Gene

Phenotypes From GWAS Catalog for GPRC5D Gene

Gene Ontology (GO) - Molecular Function for GPRC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPRC5D: view
genes like me logo Genes that share phenotypes with GPRC5D: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRC5D

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPRC5D Gene

Localization for GPRC5D Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC5D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRC5D gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPRC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 11311935
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPRC5D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPRC5D Gene

Pathways & Interactions for GPRC5D Gene

genes like me logo Genes that share pathways with GPRC5D: view

Pathways by source for GPRC5D Gene

1 BioSystems pathway for GPRC5D Gene

Interacting Proteins for GPRC5D Gene

Gene Ontology (GO) - Biological Process for GPRC5D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPRC5D: view

No data available for SIGNOR curated interactions for GPRC5D Gene

Drugs & Compounds for GPRC5D Gene

No Compound Related Data Available

Transcripts for GPRC5D Gene

mRNA/cDNA for GPRC5D Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPRC5D Gene

G protein-coupled receptor, family C, group 5, member D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5D Gene

No ASD Table

Relevant External Links for GPRC5D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRC5D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPRC5D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRC5D Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x33.9) and Skin - Sun Exposed (Lower leg) (x6.0).

Protein differential expression in normal tissues from HIPED for GPRC5D Gene

This gene is overexpressed in Hair follicle (45.2) and Serum (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPRC5D Gene

Protein tissue co-expression partners for GPRC5D Gene

NURSA nuclear receptor signaling pathways regulating expression of GPRC5D Gene:


SOURCE GeneReport for Unigene cluster for GPRC5D Gene:


mRNA Expression by UniProt/SwissProt for GPRC5D Gene:

Tissue specificity: Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.

Evidence on tissue expression from TISSUES for GPRC5D Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with GPRC5D: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRC5D Gene

Orthologs for GPRC5D Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5D Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPRC5D 34 33
  • 99.13 (n)
(Canis familiaris)
Mammalia GPRC5D 34 33
  • 88.21 (n)
(Bos Taurus)
Mammalia GPRC5D 34 33
  • 85.46 (n)
(Mus musculus)
Mammalia Gprc5d 16 34 33
  • 84.45 (n)
(Rattus norvegicus)
Mammalia Gprc5d 33
  • 83.53 (n)
(Monodelphis domestica)
Mammalia GPRC5D 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
-- 34
  • 44 (a)
(Gallus gallus)
Aves -- 34
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
-- 34
  • 38 (a)
(Danio rerio)
Actinopterygii GPRC5A 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
Species where no ortholog for GPRC5D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC5D Gene

Gene Tree for GPRC5D (if available)
Gene Tree for GPRC5D (if available)
Evolutionary constrained regions (ECRs) for GPRC5D: view image

Paralogs for GPRC5D Gene

Paralogs for GPRC5D Gene

(3) SIMAP similar genes for GPRC5D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPRC5D: view

Variants for GPRC5D Gene

Sequence variations from dbSNP and Humsavar for GPRC5D Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000064075 -- 12,943,032(-) C/T intron_variant
rs1000168465 -- 12,948,551(-) T/A intron_variant
rs1000399523 -- 12,947,958(-) G/T intron_variant
rs1000505118 -- 12,947,299(-) A/G intron_variant
rs1000682054 -- 12,941,679(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPRC5D Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV deletion 23290073
nsv520173 CNV loss 19592680
nsv832333 CNV gain 17160897

Variation tolerance for GPRC5D Gene

Residual Variation Intolerance Score: 39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRC5D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRC5D Gene

Disorders for GPRC5D Gene

Additional Disease Information for GPRC5D

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPRC5D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRC5D Gene

Publications for GPRC5D Gene

  1. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PMID: 11311935) Bräuner-Osborne H … O'Hara P (Biochimica et biophysica acta 2001) 3 4 22 58
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for GPRC5D Gene

Sources for GPRC5D Gene

Loading form....