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The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants enc... See more...
Aliases for GPRC5C Gene
Aliases for GPRC5C Gene
External Ids for GPRC5C Gene
- HGNC: 13309
- NCBI Entrez Gene: 55890
- Ensembl: ENSG00000170412
- OMIM®: 605949
- UniProtKB/Swiss-Prot: Q9NQ84
Previous GeneCards Identifiers for GPRC5C Gene
- GC17M072433
- GC17P075486
- GC17P072891
- GC17P073025
- GC17P073024
- GC17P069938
- GC17P072427
- GC17P067838
Summaries for GPRC5C Gene
-
The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPRC5C Gene
GPRC5C (G Protein-Coupled Receptor Class C Group 5 Member C) is a Protein Coding gene. Among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPRC5B.
UniProtKB/Swiss-Prot Summary for GPRC5C Gene
-
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
Additional gene information for GPRC5C Gene
- HGNC (13309)
- NCBI Entrez Gene (55890)
- Ensembl (ENSG00000170412)
- OMIM® (605949)
- UniProtKB/Swiss-Prot (Q9NQ84)
- Open Targets Platform(ENSG00000170412)
- Search for GPRC5C at DataMed
- Search for GPRC5C at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPRC5C Gene
Genomics for GPRC5C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GPRC5C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPRC5C on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPRC5C
- Top Transcription factor binding sites by QIAGEN in the GPRC5C gene promoter:
-
- HEN1
- IRF-2
- NF-AT
- NF-AT1
- YY1
Genomic Locations for GPRC5C Gene
Latest Assembly
- chr17:74,424,851-74,451,658
- (GRCh38/hg38)
- Size:
- 26,808 bases
- Orientation:
- Plus strand
Previous Assembly
- chr17:72,428,227-72,447,797
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 19,571 bases
- Orientation:
- Plus strand
- chr17:72,420,990-72,447,792
- (GRCh37/hg19 by Ensembl)
- Size:
- 26,803 bases
- Orientation:
- Plus strand
Genomic View for GPRC5C Gene
Genes around GPRC5C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
GPRC5C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPRC5C Gene
Proteins for GPRC5C Gene
-
Protein details for GPRC5C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQ84-GPC5C_HUMAN
- Recommended name:
- G-protein coupled receptor family C group 5 member C
- Protein Accession:
- Q9NQ84
- B5BUN4
- Q2NL85
- Q9NZG5
Protein attributes for GPRC5C Gene
- Size:
- 441 amino acids
- Molecular mass:
- 48193 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH16860.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI10849.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25081.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25082.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG54752.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC00633.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for GPRC5C Gene
Post-translational modifications for GPRC5C Gene
Other Protein References for GPRC5C Gene
Antibodies for research
- LifeSpan BioSciences GPRC5C Antibody (LS-A4082) and GPRC5C Antibody (LS-A4077)
- G Biosciences Immunotag™ GPRC5C Antibody
-
Custom Antibody ServicesOriGene Antibodies for GPRC5C
- Novus Biologicals Antibodies for GPRC5C
-
Abcam antibodies for GPRC5C
- Invitrogen Antibodies for GPRC5C (AFLGC-GPRC5C)
-
Boster Bio Antibodies for GPRC5C
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for GPRC5C
- Origene Custom Protein Services for GPRC5C
- antibodies-online: Show 6 available GPRC5C Proteins ranked by validation data
- Compare Top GPRC5C Proteins
-
Quality Products:
-
Abcam proteins for GPRC5C
Assay products for research
No data available for DME Specific Peptides for GPRC5C Gene
Domains & Families for GPRC5C Gene
Gene Families for GPRC5C Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for GPRC5C Gene
- GenScript: Design optimal peptide antigens:
-
- Retinoic acid-induced gene 3 protein (GPC5C_HUMAN)
- GPRC5C protein (Q9BSP0_HUMAN)
- cDNA FLJ20242 fis, clone COLF6369 (Q9NXI0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NQ84- Family:
-
- Belongs to the G-protein coupled receptor 3 family.
Function for GPRC5C Gene
Molecular function for GPRC5C Gene
- UniProtKB/Swiss-Prot Function:
- This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
- UniProtKB/Swiss-Prot Induction:
- By all-trans retinoic acid (ATRA).
Phenotypes From GWAS Catalog for GPRC5C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | TAS,IEA | -- |
| GO:0005515 | protein binding | IPI | -- |
| GO:0030295 | protein kinase activator activity | IBA | 21873635 |
Phenotypes for GPRC5C Gene
- MGI mutant phenotypes for GPRC5C:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for GPRC5C:
-
- no effect
- shRNA abundance <= 50%
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased homologous recombination repair frequency
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Negative genetic interaction between BLM-/- and BLM+/+
- Increased Nanog expression
Animal Models for GPRC5C Gene
- MGI Knock Outs for GPRC5C:
-
- Gprc5c Gprc5c<tm1Yhir>
Animal Models for research
-
Taconic Biosciences Mouse Models for GPRC5C
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GPRC5C - Starting at $85 >
- * GPRC5C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GPRC5C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPRC5C
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPRC5C
miRNA for GPRC5C Gene
- miRTarBase miRNAs that target GPRC5C
-
- mmu-miR-149-5p (MIRT014557)
- hsa-miR-335-5p (MIRT018924)
- hsa-miR-6780a-5p (MIRT570839)
- hsa-miR-6779-5p (MIRT570840)
- hsa-miR-3689c (MIRT570841)
- hsa-miR-3689b-3p (MIRT570842)
- hsa-miR-3689a-3p (MIRT570843)
- hsa-miR-1273h-5p (MIRT570844)
- hsa-miR-30b-3p (MIRT570845)
- hsa-miR-6770-3p (MIRT570846)
- hsa-miR-4730 (MIRT570847)
- hsa-miR-6778-5p (MIRT570848)
- hsa-miR-1233-5p (MIRT570849)
- hsa-miR-663b (MIRT570850)
- hsa-miR-6799-5p (MIRT570851)
- hsa-miR-6883-5p (MIRT570852)
- hsa-miR-6785-5p (MIRT570853)
- hsa-miR-4728-5p (MIRT570854)
- hsa-miR-149-3p (MIRT570855)
- hsa-miR-7106-5p (MIRT570856)
- hsa-miR-4745-3p (MIRT570857)
- hsa-miR-1538 (MIRT570858)
- hsa-miR-6894-5p (MIRT570859)
- hsa-miR-219b-5p (MIRT570860)
- hsa-miR-3605-5p (MIRT570861)
- mmu-miR-669b-5p (MIRT586965)
- mmu-miR-5101 (MIRT586966)
- mmu-miR-129-5p (MIRT586967)
- mmu-miR-1896 (MIRT586968)
- mmu-miR-129-2-3p (MIRT586969)
- mmu-miR-129-1-3p (MIRT586970)
- mmu-miR-3085-3p (MIRT586971)
- mmu-miR-3064-5p (MIRT586972)
- mmu-miR-1933-5p (MIRT586973)
- mmu-miR-490-5p (MIRT586974)
- mmu-miR-3470a (MIRT586975)
- mmu-miR-3110-5p (MIRT586976)
- mmu-miR-5125 (MIRT586977)
- hsa-miR-1298-3p (MIRT762391)
- hsa-miR-3180-5p (MIRT765262)
- hsa-miR-4667-5p (MIRT770839)
- hsa-miR-4700-5p (MIRT771298)
- hsa-miR-486-3p (MIRT772672)
- hsa-miR-488-5p (MIRT772684)
- hsa-miR-520a-5p (MIRT773763)
- hsa-miR-525-5p (MIRT773903)
- hsa-miR-5589-3p (MIRT774804)
- hsa-miR-637 (MIRT776143)
- hsa-miR-7155-5p (MIRT781549)
- hsa-miR-8089 (MIRT782441)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPRC5C
- Browse OriGene Inhibitory RNA Products For GPRC5C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPRC5C
Clone products for research
- Applied Biological Materials (abm): Clones for GPRC5C - Starting at $45 >
- * GPRC5C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG200111
- MG207027
- MG215978
- MG218736
- MR200111
- MR200111L3
- MR200111L4
- MR207027
- MR207027L3
- MR207027L4
- MR215978
- MR215978L3
- MR215978L4
- MR218736
- MR218736L3
- MR218736L4
- RC211081
- RC211081L1
- RC211081L2
- RC211081L3
- RC211081L4
- RC221173
- RC221173L1
- RC221173L2
- RC221173L3
- RC221173L4
- RG211081
- RG221173
- RR216676
- MR200111L3V
- MR200111L4V
- MR207027L3V
- MR207027L4V
- MR215978L3V
- MR215978L4V
- MR218736L3V
- MR218736L4V
- RC211081L1V
- RC211081L2V
- RC211081L3V
- RC211081L4V
- RC221173L1V
- RC221173L2V
- RC221173L3V
- RC221173L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPRC5C
- Addgene plasmids for GPRC5C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPRC5C
Cell Lines for research
-
Horizon Cell Lines for GPRC5C
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPRC5C Gene
Localization for GPRC5C Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPRC5C Gene
- Cell membrane. Multi-pass membrane protein. Cytoplasmic vesicle membrane. Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Centriolar satellite (1)
- Cytosol (1)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0005887 | integral component of plasma membrane | TAS | 10783259 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | -- |
Pathways & Interactions for GPRC5C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | GPCRs, Class C Metabotropic glutamate, pheromone | ||
Pathways by source for GPRC5C Gene
1 BioSystems pathway for GPRC5C Gene
Interacting Proteins for GPRC5C Gene
GPS-Prot Interaction Network for GPRC5C
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS,IEA | -- |
| GO:0032147 | activation of protein kinase activity | IEA | -- |
No data available for SIGNOR curated interactions for GPRC5C Gene
Transcripts for GPRC5C Gene
mRNA/cDNA for GPRC5C Gene
- 4 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000342648 1273 nts (view in UCSC)
- ENST00000392627 1813 nts (view in UCSC)
- ENST00000392628 1529 nts (view in UCSC)
- ENST00000392629 1419 nts (view in UCSC)
- ENST00000481232 1592 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GPRC5C - Starting at $85 >
- * GPRC5C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GPRC5C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPRC5C
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPRC5C
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPRC5C
- Browse OriGene Inhibitory RNA Products For GPRC5C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPRC5C
Clone products for research
- Applied Biological Materials (abm): Clones for GPRC5C - Starting at $45 >
- * GPRC5C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG200111
- MG207027
- MG215978
- MG218736
- MR200111
- MR200111L3
- MR200111L4
- MR207027
- MR207027L3
- MR207027L4
- MR215978
- MR215978L3
- MR215978L4
- MR218736
- MR218736L3
- MR218736L4
- RC211081
- RC211081L1
- RC211081L2
- RC211081L3
- RC211081L4
- RC221173
- RC221173L1
- RC221173L2
- RC221173L3
- RC221173L4
- RG211081
- RG221173
- RR216676
- MR200111L3V
- MR200111L4V
- MR207027L3V
- MR207027L4V
- MR215978L3V
- MR215978L4V
- MR218736L3V
- MR218736L4V
- RC211081L1V
- RC211081L2V
- RC211081L3V
- RC211081L4V
- RC221173L1V
- RC221173L2V
- RC221173L3V
- RC221173L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPRC5C
- Addgene plasmids for GPRC5C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPRC5C
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: | - |
Relevant External Links for GPRC5C Gene
- GeneLoc Exon Structure for
- GPRC5C
Expression for GPRC5C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Kidney (Urinary System)
- S-shaped Body Cells S-shaped Body
- S-shaped Body
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
-
Thyroid (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for GPRC5C Gene
This gene is overexpressed in Stomach (x5.2) and Liver (x4.6).
This gene is overexpressed in Urine (61.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRC5C Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPRC5C
SOURCE GeneReport for Unigene cluster for GPRC5C Gene:
Hs.446438mRNA Expression by UniProt/SwissProt for GPRC5C Gene:
Q9NQ84-GPC5C_HUMAN
Tissue specificity:
Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).
Evidence on tissue expression from TISSUES for GPRC5C Gene
- Pancreas(4.5)
- Liver(4.4)
- Nervous system(4.2)
- Kidney(2.2)
- Thyroid gland(2.1)
- Lung(2)
Primer products for research
-
OriGene qPCR primer pairs for GPRC5C
-
OriGene qPCR primer pairs and template standards for GPRC5C
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRC5C Gene
Orthologs for GPRC5C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GPRC5C 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GPRC5C 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GPRC5C 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gprc5c 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gprc5c 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | GPRC5C 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GPRC5C 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GPRC5C 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GPRC5C 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC496814 30 |
|
||
| Str.16451 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2244 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gprc5c 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for GPRC5C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GPRC5C Gene
- ENSEMBL:
- Gene Tree for GPRC5C (if available)
- TreeFam:
- Gene Tree for GPRC5C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPRC5C: view image
Paralogs for GPRC5C Gene
Variants for GPRC5C Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPRC5C Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs80079984 | Benign: not provided | 74,439,981(+) |
A/G NM_022036.4(GPRC5C):c.205A>G (p.Ile69Val) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12e196 | CNV | duplication | 17116639 |
| dgv3282n100 | CNV | gain | 25217958 |
| dgv372n27 | CNV | gain | 19166990 |
| dgv5768n54 | CNV | gain | 21841781 |
| dgv5774n54 | CNV | gain | 21841781 |
| esv2751770 | CNV | gain | 17911159 |
| esv2761978 | CNV | gain | 21179565 |
| esv33995 | CNV | loss | 17666407 |
| esv3573820 | CNV | gain | 25503493 |
| esv3641230 | CNV | gain | 21293372 |
| esv3641237 | CNV | gain | 21293372 |
| nsv517569 | CNV | gain+loss | 19592680 |
| nsv833539 | CNV | loss | 17160897 |
| nsv952366 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.20;
52.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPRC5C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPRC5C
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRC5C Gene
Disorders for GPRC5C Gene
Additional Disease Information for GPRC5C
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for GPRC5C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRC5C Gene
Publications for GPRC5C Gene
- Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). (PMID: 10945465) Robbins MJ … Pangalos MN (Genomics 2000) 2 3 4 23
- Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PMID: 11311935) Bräuner-Osborne H … O'Hara P (Biochimica et biophysica acta 2001) 3 4 23
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for GPRC5C Gene
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Sources for GPRC5C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB