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Aliases for GPRC5C Gene

Aliases for GPRC5C Gene

  • G Protein-Coupled Receptor Class C Group 5 Member C 2 3 5
  • Retinoic Acid-Induced Gene 3 Protein 3 4
  • RAIG-3 3 4
  • RAIG3 3 4
  • G Protein-Coupled Receptor, Family C, Group 5, Member C 2
  • G Protein-Coupled Receptor, Class C, Group 5, Member C 2
  • G-Protein Coupled Receptor Family C Group 5 Member C 3
  • Retinoic Acid Responsive Gene Protein 3
  • Orphan G-Protein Coupled Receptor 3

External Ids for GPRC5C Gene

Previous GeneCards Identifiers for GPRC5C Gene

  • GC17M072433
  • GC17P075486
  • GC17P072891
  • GC17P073025
  • GC17P073024
  • GC17P069938
  • GC17P072427
  • GC17P067838

Summaries for GPRC5C Gene

Entrez Gene Summary for GPRC5C Gene

  • The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPRC5C Gene

GPRC5C (G Protein-Coupled Receptor Class C Group 5 Member C) is a Protein Coding gene. Among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPRC5B.

UniProtKB/Swiss-Prot for GPRC5C Gene

  • This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Gene Wiki entry for GPRC5C Gene

Additional gene information for GPRC5C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRC5C Gene

Genomics for GPRC5C Gene

GeneHancer (GH) Regulatory Elements for GPRC5C Gene

Promoters and enhancers for GPRC5C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074426 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 668.6 +6.1 6122 8.5 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 GPRC5C NAT9 ENSG00000266765 LINC02092 ENSG00000265927 ENSG00000265935 RN7SL573P NUP85 MRPL58 DNAI2
GH17J074424 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 650.7 +0.3 310 1.5 ZNF316 MAFF POLR2A MAFG EMSY MAFK FOXA1 GPRC5C CD300A CD300LD GC17M074409
GH17J074477 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 25.5 +54.4 54410 3.7 BACH1 MAX ZMYM3 EBF1 ZNF664 CTBP1 ATF7 IKZF2 RUNX3 SMARCE1 GPRC5C CD300LB CD300E CD300C BTBD17 CD300LD CD300LF TMEM104 CD300A TTYH2
GH17J074442 Enhancer 1.4 Ensembl ENCODE dbSUPER 21.7 +20.6 20563 5.7 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 SP3 SP5 ZHX2 GC17P074445 GPRC5C CD300A GPR142 CD300E CD300LD NT5C GC17M074409
GH17J074526 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +105.8 105798 7.4 HDGF HDAC1 PKNOX1 RB1 BATF IRF4 RAD21 YY1 ZNF143 ZNF207 CD300LB CD300E CD300LD CD300A CD300C CD300LF GPR142 GPRC5C TMEM104 TTYH2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRC5C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPRC5C gene promoter:
  • IRF-2
  • YY1
  • HEN1
  • NF-AT
  • NF-AT1

Genomic Locations for GPRC5C Gene

Genomic Locations for GPRC5C Gene
27,156 bases
Plus strand
26,803 bases
Plus strand

Genomic View for GPRC5C Gene

Genes around GPRC5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC5C Gene

Proteins for GPRC5C Gene

  • Protein details for GPRC5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor family C group 5 member C
    Protein Accession:
    Secondary Accessions:
    • B5BUN4
    • Q2NL85
    • Q9NZG5

    Protein attributes for GPRC5C Gene

    441 amino acids
    Molecular mass:
    48193 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH16860.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI10849.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25081.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI25082.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG54752.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC00633.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GPRC5C Gene


neXtProt entry for GPRC5C Gene

Post-translational modifications for GPRC5C Gene

  • Glycosylation at Asn191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPRC5C Gene

Domains & Families for GPRC5C Gene

Gene Families for GPRC5C Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for GPRC5C Gene


Suggested Antigen Peptide Sequences for GPRC5C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC5C: view

Function for GPRC5C Gene

Molecular function for GPRC5C Gene

UniProtKB/Swiss-Prot Function:
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA).

Phenotypes From GWAS Catalog for GPRC5C Gene

Gene Ontology (GO) - Molecular Function for GPRC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPRC5C: view
genes like me logo Genes that share phenotypes with GPRC5C: view

Animal Models for GPRC5C Gene

MGI Knock Outs for GPRC5C:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRC5C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPRC5C Gene

Localization for GPRC5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC5C Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRC5C gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Microtubule organizing center (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPRC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 10783259
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with GPRC5C: view

Pathways & Interactions for GPRC5C Gene

genes like me logo Genes that share pathways with GPRC5C: view

Pathways by source for GPRC5C Gene

1 BioSystems pathway for GPRC5C Gene

Gene Ontology (GO) - Biological Process for GPRC5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPRC5C: view

No data available for SIGNOR curated interactions for GPRC5C Gene

Drugs & Compounds for GPRC5C Gene

No Compound Related Data Available

Transcripts for GPRC5C Gene

Unigene Clusters for GPRC5C Gene

G protein-coupled receptor, family C, group 5, member C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP7: -

Relevant External Links for GPRC5C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRC5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPRC5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRC5C Gene

This gene is overexpressed in Stomach (x5.2) and Liver (x4.6).

Protein differential expression in normal tissues from HIPED for GPRC5C Gene

This gene is overexpressed in Urine (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRC5C Gene

Protein tissue co-expression partners for GPRC5C Gene

NURSA nuclear receptor signaling pathways regulating expression of GPRC5C Gene:


SOURCE GeneReport for Unigene cluster for GPRC5C Gene:


mRNA Expression by UniProt/SwissProt for GPRC5C Gene:

Tissue specificity: Expression is highest in the periphery, particularly in the stomach, but also in the kidney, liver, pancreas, and prostate. In brain, levels of expression are generally lower than in the periphery, with the exception of cerebellum, spinal cord, and dorsal root ganglia (DRG).

Evidence on tissue expression from TISSUES for GPRC5C Gene

  • Pancreas(4.4)
  • Liver(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with GPRC5C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRC5C Gene

Orthologs for GPRC5C Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPRC5C 34 33
  • 99.04 (n)
(Canis familiaris)
Mammalia GPRC5C 34 33
  • 89.44 (n)
(Bos Taurus)
Mammalia GPRC5C 34 33
  • 87.6 (n)
(Mus musculus)
Mammalia Gprc5c 16 34 33
  • 86.74 (n)
(Rattus norvegicus)
Mammalia Gprc5c 33
  • 86.36 (n)
(Monodelphis domestica)
Mammalia GPRC5C 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia GPRC5C 34
  • 74 (a)
(Gallus gallus)
Aves GPRC5C 34 33
  • 69.48 (n)
(Anolis carolinensis)
Reptilia GPRC5C 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC496814 33
  • 63.03 (n)
Str.16451 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2244 33
(Danio rerio)
Actinopterygii gprc5c 34 33
  • 58.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for GPRC5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC5C Gene

Gene Tree for GPRC5C (if available)
Gene Tree for GPRC5C (if available)
Evolutionary constrained regions (ECRs) for GPRC5C: view image

Paralogs for GPRC5C Gene

Paralogs for GPRC5C Gene

(3) SIMAP similar genes for GPRC5C Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with GPRC5C: view

Variants for GPRC5C Gene

Sequence variations from dbSNP and Humsavar for GPRC5C Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000013361 -- 74,442,072(+) G/A intron_variant
rs1000063068 -- 74,449,170(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000071447 -- 74,436,417(+) G/T intron_variant
rs1000081342 -- 74,443,315(+) G/A intron_variant
rs1000093808 -- 74,448,995(+) C/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPRC5C Gene

Variant ID Type Subtype PubMed ID
dgv12e196 CNV duplication 17116639
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641237 CNV gain 21293372
nsv517569 CNV gain+loss 19592680
nsv833539 CNV loss 17160897
nsv952366 CNV deletion 24416366

Variation tolerance for GPRC5C Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRC5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRC5C Gene

Disorders for GPRC5C Gene

Additional Disease Information for GPRC5C

No disorders were found for GPRC5C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRC5C Gene

Publications for GPRC5C Gene

  1. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). (PMID: 10945465) Robbins MJ … Pangalos MN (Genomics 2000) 2 3 4 22 58
  2. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. (PMID: 11311935) Bräuner-Osborne H … O'Hara P (Biochimica et biophysica acta 2001) 3 4 22 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPRC5C Gene

Sources for GPRC5C Gene

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