Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPRC5B Gene

Aliases for GPRC5B Gene

  • G Protein-Coupled Receptor Class C Group 5 Member B 2 3 5
  • G Protein-Coupled Receptor, Family C, Group 1, Member B 2 3
  • Retinoic Acid-Induced Gene 2 Protein 3 4
  • RAIG-2 3 4
  • RAIG2 3 4
  • G Protein-Coupled Receptor, Family C, Group 5, Member B 2
  • G Protein-Coupled Receptor, Class C, Group 5, Member B 2
  • G-Protein Coupled Receptor Family C Group 5 Member B 3
  • Retinoic Acid Responsive Gene Protein 3
  • A-69G12.1 4

External Ids for GPRC5B Gene

Previous GeneCards Identifiers for GPRC5B Gene

  • GC16M019362
  • GC16M019797
  • GC16M019836
  • GC16M019777
  • GC16M018406

Summaries for GPRC5B Gene

Entrez Gene Summary for GPRC5B Gene

  • This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for GPRC5B Gene

GPRC5B (G Protein-Coupled Receptor Class C Group 5 Member B) is a Protein Coding gene. Among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled receptor binding. An important paralog of this gene is GPRC5C.

UniProtKB/Swiss-Prot for GPRC5B Gene

  • Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Gene Wiki entry for GPRC5B Gene

Additional gene information for GPRC5B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRC5B Gene

Genomics for GPRC5B Gene

GeneHancer (GH) Regulatory Elements for GPRC5B Gene

Promoters and enhancers for GPRC5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J019881 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 666.4 +2.5 2495 4 CTCF MXI1 ZNF777 ZNF792 RB1 BACH1 SIN3A ZIC2 KDM3A ZNF205 GPRC5B THUMPD1 VPS35L KNOP1 CCP110 LARP7P2 GC16M019876
GH16J019886 Enhancer 1.2 ENCODE dbSUPER 650.7 -0.3 -287 0.2 HDGF CLOCK ATF1 FOXA2 ARNT ZNF133 ARID4B SIN3A IRF4 ZNF48 GPRC5B LOC105371116 GC16M019876
GH16J019859 Enhancer 1 Ensembl ENCODE dbSUPER 12.4 +25.1 25128 3.7 FOXA2 SIN3A EBF1 ATF2 SP1 POLR2A POU5F1 ZBTB33 ATF7 KNOP1 GPRC5B VPS35L ACSM5 LARP7P2
GH16J019757 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.1 +127.9 127915 0.8 ELF3 SOX13 FOXA2 SAP130 CEBPG DMAP1 RARA TEAD3 PRPF4 CREM KNOP1 GPRC5B CCP110 IQCK LOC105371115
GH16J019857 Enhancer 0.6 dbSUPER 12.4 +27.8 27764 1.4 FOXA2 ATF4 ZFHX2 EGR1 GLIS1 ZBTB17 EGR2 SP7 KNOP1 GPRC5B VPS35L LARP7P2 IQCK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRC5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPRC5B gene promoter:
  • RFX1
  • N-Myc
  • AhR
  • SEF-1 (1)
  • Pbx1a
  • POU2F1b
  • POU2F1
  • POU2F1a
  • POU2F1c
  • Arnt

Genomic Locations for GPRC5B Gene

Genomic Locations for GPRC5B Gene
29,477 bases
Minus strand
28,874 bases
Minus strand

Genomic View for GPRC5B Gene

Genes around GPRC5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC5B Gene

Proteins for GPRC5B Gene

  • Protein details for GPRC5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor family C group 5 member B
    Protein Accession:
    Secondary Accessions:
    • D2DFB0
    • O75205
    • Q8NBZ8

    Protein attributes for GPRC5B Gene

    403 amino acids
    Molecular mass:
    44795 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPRC5B Gene


neXtProt entry for GPRC5B Gene

Post-translational modifications for GPRC5B Gene

No data available for DME Specific Peptides for GPRC5B Gene

Domains & Families for GPRC5B Gene

Gene Families for GPRC5B Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPRC5B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 3 family.
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC5B: view

Function for GPRC5B Gene

Molecular function for GPRC5B Gene

UniProtKB/Swiss-Prot Function:
Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA).

Phenotypes From GWAS Catalog for GPRC5B Gene

Gene Ontology (GO) - Molecular Function for GPRC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding ISS --
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0019901 protein kinase binding ISS --
GO:0030295 protein kinase activator activity IDA 23169819
genes like me logo Genes that share ontologies with GPRC5B: view
genes like me logo Genes that share phenotypes with GPRC5B: view

Animal Models for GPRC5B Gene

MGI Knock Outs for GPRC5B:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPRC5B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPRC5B Gene

Localization for GPRC5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC5B Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in the plasma membrane and perinuclear vesicles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRC5B gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 4
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPRC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 16502470
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with GPRC5B: view

Pathways & Interactions for GPRC5B Gene

genes like me logo Genes that share pathways with GPRC5B: view

Pathways by source for GPRC5B Gene

1 BioSystems pathway for GPRC5B Gene

Interacting Proteins for GPRC5B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NZH0-GPC5B_HUMAN ENSP00000300571 for GPRC5B Gene via IID STRING

Gene Ontology (GO) - Biological Process for GPRC5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0032147 activation of protein kinase activity IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS --
GO:0045666 positive regulation of neuron differentiation ISS --
genes like me logo Genes that share ontologies with GPRC5B: view

No data available for SIGNOR curated interactions for GPRC5B Gene

Drugs & Compounds for GPRC5B Gene

No Compound Related Data Available

Transcripts for GPRC5B Gene

mRNA/cDNA for GPRC5B Gene

Unigene Clusters for GPRC5B Gene

G protein-coupled receptor, family C, group 5, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: -

Relevant External Links for GPRC5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRC5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPRC5B Gene

mRNA differential expression in normal tissues according to GTEx for GPRC5B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.3), Brain - Substantia nigra (x4.3), and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for GPRC5B Gene

This gene is overexpressed in Urine (59.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRC5B Gene

NURSA nuclear receptor signaling pathways regulating expression of GPRC5B Gene:


SOURCE GeneReport for Unigene cluster for GPRC5B Gene:


mRNA Expression by UniProt/SwissProt for GPRC5B Gene:

Tissue specificity: Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach.

Evidence on tissue expression from TISSUES for GPRC5B Gene

  • Nervous system(5)
  • Kidney(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with GPRC5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRC5B Gene

Orthologs for GPRC5B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPRC5B 34 33
  • 99.34 (n)
(Bos Taurus)
Mammalia GPRC5B 34 33
  • 89.92 (n)
(Canis familiaris)
Mammalia GPRC5B 34 33
  • 89.75 (n)
(Mus musculus)
Mammalia Gprc5b 16 34 33
  • 86.32 (n)
(Rattus norvegicus)
Mammalia Gprc5b 33
  • 85.54 (n)
(Monodelphis domestica)
Mammalia GPRC5B 34
  • 84 (a)
(Gallus gallus)
Aves GPRC5B 34 33
  • 72.57 (n)
(Anolis carolinensis)
Reptilia GPRC5B 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gprc5b 33
  • 70.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3029 33
(Danio rerio)
Actinopterygii LOC570207 33
  • 58.48 (n)
gprc5ba 34
  • 47 (a)
gprc5bb 34
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for GPRC5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRC5B Gene

Gene Tree for GPRC5B (if available)
Gene Tree for GPRC5B (if available)
Evolutionary constrained regions (ECRs) for GPRC5B: view image

Paralogs for GPRC5B Gene

Paralogs for GPRC5B Gene

(3) SIMAP similar genes for GPRC5B Gene using alignment to 7 proteins:

  • B7Z831_HUMAN
  • H3BN33_HUMAN
  • H3BT47_HUMAN
  • H3BT93_HUMAN
genes like me logo Genes that share paralogs with GPRC5B: view

Variants for GPRC5B Gene

Sequence variations from dbSNP and Humsavar for GPRC5B Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000166718 -- 19,865,322(-) G/A intron_variant
rs1000276436 -- 19,869,203(-) C/A intron_variant
rs1000344869 -- 19,859,536(-) G/A 3_prime_UTR_variant
rs1000361769 -- 19,877,256(-) TTTTTTT/TTTTTT intron_variant
rs1000417351 -- 19,877,656(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPRC5B Gene

Variant ID Type Subtype PubMed ID
nsv103121 CNV deletion 16902084
nsv1069928 CNV deletion 25765185
nsv1134507 CNV deletion 24896259
nsv428321 CNV loss 18775914
nsv436835 CNV insertion 17901297

Variation tolerance for GPRC5B Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRC5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRC5B Gene

Disorders for GPRC5B Gene

Additional Disease Information for GPRC5B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPRC5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPRC5B Gene

Publications for GPRC5B Gene

  1. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. (PMID: 10783259) Bräuner-Osborne H … Krogsgaard-Larsen P (Genomics 2000) 2 3 4 22 58
  2. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). (PMID: 10945465) Robbins MJ … Pangalos MN (Genomics 2000) 3 4 22 58
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 58
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  5. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 44 58

Products for GPRC5B Gene

Sources for GPRC5B Gene

Loading form....