This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic devel... See more...

Aliases for GPRC5A Gene

Aliases for GPRC5A Gene

  • G Protein-Coupled Receptor Class C Group 5 Member A 2 3 5
  • PEIG-1 2 3 4
  • RAIG1 2 3 4
  • G-Protein Coupled Receptor Family C Group 5 Member A 3 4
  • Retinoic Acid-Induced Gene 1 Protein 3 4
  • Retinoic Acid-Induced Protein 3 3 4
  • Phorbol Ester Induced Gene 1 3 4
  • Retinoic Acid Induced 3 2 3
  • GPCR5A 3 4
  • RAI3 3 4
  • TIG1 2 3
  • G Protein-Coupled Receptor, Class C, Group 5, Member A 2
  • Orphan G-Protein-Coupling Receptor PEIG-1 3
  • Phorbol Ester Induced Protein-1 3
  • Retinoic Acid Responsive 3
  • TPA Induced Gene 1 3
  • GPRC5A 5
  • RAIG-1 4

External Ids for GPRC5A Gene

Previous HGNC Symbols for GPRC5A Gene

  • RAI3

Previous GeneCards Identifiers for GPRC5A Gene

  • GC12P012937
  • GC12P013047
  • GC12P012813

Summaries for GPRC5A Gene

Entrez Gene Summary for GPRC5A Gene

  • This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPRC5A Gene

GPRC5A (G Protein-Coupled Receptor Class C Group 5 Member A) is a Protein Coding gene. Diseases associated with GPRC5A include Lung Mucoepidermoid Carcinoma and Lung Cancer. Among its related pathways are Neuroscience and GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPRC5D.

UniProtKB/Swiss-Prot Summary for GPRC5A Gene

  • Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).

Gene Wiki entry for GPRC5A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPRC5A Gene

Genomics for GPRC5A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPRC5A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J012887 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 610.2 -0.3 -258 8.2 RNF2 CREB1 PRDM10 ZNF629 CTCF ZNF692 TARDBP FOXA1 PRDM1 ZIC2 GPRC5A DDX47 LRP6 HSALNG0089416
GH12J012869 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 600.4 -19.0 -19020 5.9 CREB1 ARID3A TEAD4 ZNF629 TARDBP ZIC2 REST ATF7 SP1 RFX1 lnc-GPRC5A-4 GPRC5A MIR614 RPL13AP20 LOC112267864 DDX47
GH12J012924 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.1 +35.4 35419 4 GATAD2A TFE3 LEF1 IKZF1 RBFOX2 RXRB MTA1 NR2C1 IRF2 REST GPRC5D-AS1 FAM234B GPRC5A GPRC5D ENSG00000256011 MIR614 lnc-GPRC5A-2
GH12J012879 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -8.4 -8358 6.8 CREB1 GATAD2A TEAD4 ZNF629 TARDBP ZHX2 JUND FOXA1 PRDM1 ZIC2 HSALNG0089416 HSALNG0089417 DDX47 LRP6 GPRC5A RPL13AP20
GH12J012834 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 -53.2 -53239 9.4 CTCF ZBTB33 PRDM10 ZNF629 ZNF692 JUND ZNF300 ZIC2 PATZ1 REST LOC107984492 DDX47 GPRC5A PTMAP9 MIR614 ENSG00000256011 GPRC5D-AS1 GPRC5D LRP6 RPL13AP20
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRC5A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPRC5A

Top Transcription factor binding sites by QIAGEN in the GPRC5A gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • En-1
  • HFH-3
  • IRF-7A
  • LyF-1
  • p53
  • STAT3

Genomic Locations for GPRC5A Gene

Genomic Locations for GPRC5A Gene
chr12:12,891,559-12,917,937
(GRCh38/hg38)
Size:
26,379 bases
Orientation:
Plus strand
chr12:13,043,716-13,070,871
(GRCh37/hg19)
Size:
27,156 bases
Orientation:
Plus strand

Genomic View for GPRC5A Gene

Genes around GPRC5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRC5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRC5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRC5A Gene

Proteins for GPRC5A Gene

  • Protein details for GPRC5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFJ5-RAI3_HUMAN
    Recommended name:
    Retinoic acid-induced protein 3
    Protein Accession:
    Q8NFJ5
    Secondary Accessions:
    • B3KV45
    • O95357

    Protein attributes for GPRC5A Gene

    Size:
    357 amino acids
    Molecular mass:
    40251 Da
    Quaternary structure:
    • Interacts (via its transmembrane domain) with EGFR.

neXtProt entry for GPRC5A Gene

Post-translational modifications for GPRC5A Gene

  • Phosphorylated in two conserved double-tyrosine motifs, TYR-317/TYR-320 and TYR-347/TYR-350, by EGFR; leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. TYR-317 and TYR-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation.
  • Glycosylation at Asn158
  • Ubiquitination at Lys348 and Lys353
  • Modification sites at PhosphoSitePlus

Other Protein References for GPRC5A Gene

No data available for DME Specific Peptides for GPRC5A Gene

Domains & Families for GPRC5A Gene

Gene Families for GPRC5A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPRC5A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPRC5A Gene

GenScript: Design optimal peptide antigens:
  • Retinoic acid-induced gene 1 protein (RAI3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NFJ5

UniProtKB/Swiss-Prot:

RAI3_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with GPRC5A: view

Function for GPRC5A Gene

Molecular function for GPRC5A Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA).

Phenotypes From GWAS Catalog for GPRC5A Gene

Gene Ontology (GO) - Molecular Function for GPRC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005515 protein binding IPI 25311788
GO:0030295 protein kinase activator activity IBA 21873635
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with GPRC5A: view
genes like me logo Genes that share phenotypes with GPRC5A: view

Animal Models for GPRC5A Gene

MGI Knock Outs for GPRC5A:

Animal Model Products

CRISPR Products

miRNA for GPRC5A Gene

miRTarBase miRNAs that target GPRC5A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPRC5A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPRC5A Gene

Localization for GPRC5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPRC5A Gene

Cell membrane. Multi-pass membrane protein. Cytoplasmic vesicle membrane. Multi-pass membrane protein. Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles. {ECO:0000269 PubMed:18000218}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRC5A gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 4
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPRC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005886 plasma membrane IDA 18000218
GO:0005887 integral component of plasma membrane TAS 9857033
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPRC5A: view

Pathways & Interactions for GPRC5A Gene

genes like me logo Genes that share pathways with GPRC5A: view

Pathways by source for GPRC5A Gene

1 BioSystems pathway for GPRC5A Gene
1 Cell Signaling Technology pathway for GPRC5A Gene

Gene Ontology (GO) - Biological Process for GPRC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9857033
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity ISS --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0032147 activation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with GPRC5A: view

No data available for SIGNOR curated interactions for GPRC5A Gene

Drugs & Compounds for GPRC5A Gene

(1) Drugs for GPRC5A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Agonist, Full agonist, Antagonist, Target 273

(1) Additional Compounds for GPRC5A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPRC5A: view

Transcripts for GPRC5A Gene

mRNA/cDNA for GPRC5A Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPRC5A

Alternative Splicing Database (ASD) splice patterns (SP) for GPRC5A Gene

No ASD Table

Relevant External Links for GPRC5A Gene

GeneLoc Exon Structure for
GPRC5A

Expression for GPRC5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPRC5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPRC5A Gene

This gene is overexpressed in Lung (x12.9).

Protein differential expression in normal tissues from HIPED for GPRC5A Gene

This gene is overexpressed in Urine (29.5), Lung (20.8), Amniocyte (7.7), and Cervix (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRC5A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPRC5A

SOURCE GeneReport for Unigene cluster for GPRC5A Gene:

Hs.631733

mRNA Expression by UniProt/SwissProt for GPRC5A Gene:

Q8NFJ5-RAI3_HUMAN
Tissue specificity: Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.

Evidence on tissue expression from TISSUES for GPRC5A Gene

  • Lung(4.8)
  • Intestine(4.8)
  • Kidney(3.4)
  • Liver(2.4)
  • Pancreas(2.3)
  • Thyroid gland(2.2)
  • Stomach(2.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with GPRC5A: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRC5A Gene

Orthologs for GPRC5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRC5A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPRC5A 30 31
  • 99.16 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPRC5A 30 31
  • 82.63 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPRC5A 30 31
  • 80.3 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gprc5a 30
  • 79.43 (n)
Mouse
(Mus musculus)
Mammalia Gprc5a 30 17 31
  • 79.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GPRC5A 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GPRC5A 30
  • 61.33 (n)
-- 31
  • 53 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 52 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gprc5a 30
  • 55.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68729 30
Zebrafish
(Danio rerio)
Actinopterygii GPRC5A 31
  • 30 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 20 (a)
OneToMany
Species where no ortholog for GPRC5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPRC5A Gene

ENSEMBL:
Gene Tree for GPRC5A (if available)
TreeFam:
Gene Tree for GPRC5A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPRC5A: view image

Paralogs for GPRC5A Gene

Paralogs for GPRC5A Gene

(3) SIMAP similar genes for GPRC5A Gene using alignment to 3 proteins:

  • RAI3_HUMAN
  • F5GWG3_HUMAN
  • H0YFN2_HUMAN
genes like me logo Genes that share paralogs with GPRC5A: view

Variants for GPRC5A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPRC5A Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
722733 Likely Benign: not provided 12,908,942(+) C/T SYNONYMOUS_VARIANT
722961 Likely Benign: not provided 12,908,348(+) G/A SYNONYMOUS_VARIANT
781065 Benign: not provided 12,908,320(+) C/G MISSENSE_VARIANT
rs11550683 - p.Cys9Phe
rs12368599 - p.Thr182Ala

Additional dbSNP identifiers (rs#s) for GPRC5A Gene

Structural Variations from Database of Genomic Variants (DGV) for GPRC5A Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV deletion 23290073
nsv1159986 CNV deletion 26073780
nsv832333 CNV gain 17160897

Variation tolerance for GPRC5A Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.34; 63.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRC5A Gene

Human Gene Mutation Database (HGMD)
GPRC5A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPRC5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRC5A Gene

Disorders for GPRC5A Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPRC5A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of lung
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPRC5A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GPRC5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPRC5A Gene

Publications for GPRC5A Gene

  1. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. (PMID: 9857033) Cheng Y … Lotan R (The Journal of biological chemistry 1998) 2 3 4 23
  2. Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene. (PMID: 18000218) Tao Q … Lotan R (Journal of the National Cancer Institute 2007) 3 4 23
  3. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). (PMID: 10945465) Robbins MJ … Pangalos MN (Genomics 2000) 3 4 23
  4. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. (PMID: 10783259) Bräuner-Osborne H … Krogsgaard-Larsen P (Genomics 2000) 3 4 23
  5. Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells. (PMID: 8832110) Cafferata EG … Santa-Coloma TA (Cellular and molecular biology (Noisy-le-Grand, France) 1996) 2 3 4

Products for GPRC5A Gene

  • Signalway ELISA kits for GPRC5A

Sources for GPRC5A Gene