Aliases for GPRC5A Gene
External Ids for GPRC5A Gene
Previous HGNC Symbols for GPRC5A Gene
Previous GeneCards Identifiers for GPRC5A Gene
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPRC5A Gene
GPRC5A (G Protein-Coupled Receptor Class C Group 5 Member A) is a Protein Coding gene. Diseases associated with GPRC5A include Lung Mucoepidermoid Carcinoma and Lung Cancer. Among its related pathways are Neuroscience and GPCRs, Class C Metabotropic glutamate, pheromone. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPRC5D.
UniProtKB/Swiss-Prot Summary for GPRC5A Gene
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).