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Aliases for GPRASP2 Gene

Aliases for GPRASP2 Gene

  • G Protein-Coupled Receptor Associated Sorting Protein 2 2 3 5
  • G-Protein Coupled Receptor-Associated Sorting Protein 2 3
  • GASP-2 4
  • GASP2 3

External Ids for GPRASP2 Gene

Previous GeneCards Identifiers for GPRASP2 Gene

  • GC0XP101773
  • GC0XP101853
  • GC0XP101974
  • GC0XP091571
  • GC0XP101977
  • GC0XP101979
  • GC0XP101985

Summaries for GPRASP2 Gene

Entrez Gene Summary for GPRASP2 Gene

  • The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for GPRASP2 Gene

GPRASP2 (G Protein-Coupled Receptor Associated Sorting Protein 2) is a Protein Coding gene. Diseases associated with GPRASP2 include X-Linked External Auditory Canal Atresia-Dilated Internal Auditory Canal-Facial Dysmorphism Syndrome. Gene Ontology (GO) annotations related to this gene include binding and amyloid-beta binding. An important paralog of this gene is GPRASP1.

UniProtKB/Swiss-Prot for GPRASP2 Gene

  • May play a role in regulation of a variety of G-protein coupled receptors.

Gene Wiki entry for GPRASP2 Gene

Additional gene information for GPRASP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPRASP2 Gene

Genomics for GPRASP2 Gene

GeneHancer (GH) Regulatory Elements for GPRASP2 Gene

Promoters and enhancers for GPRASP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ102598 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 654.4 -112.4 -112375 2.4 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF207 ZNF143 GPRASP2 ARMCX5 ARMCX5-GPRASP2 GPRASP1 ENSG00000227211 ENSG00000270050
GH0XJ102711 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +0.8 828 2.4 PKNOX1 ATF1 ZBTB7B RAD21 ZEB1 YY1 ZNF335 GLIS2 SCRT2 ATF7 GPRASP2 BHLHB9 GC0XM102718 ARMCX5-GPRASP2
GH0XJ102650 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.2 -60.2 -60200 2.4 CTCF KLF1 SP3 ZNF843 RAD21 ATF2 ZNF335 ZFHX2 ZBTB48 PATZ1 GPRASP1 GPRASP2 ENSG00000270050 ARMCX5-GPRASP2
GH0XJ103310 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 4.8 +598.7 598735 1.4 HDAC1 ATF1 SIN3A POLR2B GLIS2 EGR1 ZNF366 ATF7 CREM EGR2 BEX2 TCEAL7 BEX4 BEX1 GPRASP2 TCEAL5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPRASP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPRASP2 gene promoter:
  • Nkx2-5
  • Egr-1
  • NF-kappaB1
  • NF-kappaB
  • NF-kappaB2
  • AML1a
  • POU3F1
  • HNF-3beta

Genomic Locations for GPRASP2 Gene

Genomic Locations for GPRASP2 Gene
5,558 bases
Plus strand
6,504 bases
Plus strand

Genomic View for GPRASP2 Gene

Genes around GPRASP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPRASP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPRASP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPRASP2 Gene

Proteins for GPRASP2 Gene

  • Protein details for GPRASP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor-associated sorting protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DXA0
    • Q8NAB4

    Protein attributes for GPRASP2 Gene

    838 amino acids
    Molecular mass:
    93773 Da
    Quaternary structure:
    • Interacts with cytoplasmic tails of a variety of G-protein coupled receptors such as muscarinic acetylcholine receptor M1/CHRM1 and calcitonin receptor/CALCR.

neXtProt entry for GPRASP2 Gene

Post-translational modifications for GPRASP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPRASP2 Gene

Antibody Products

  • Abcam antibodies for GPRASP2
  • Boster Bio Antibodies for GPRASP2
  • Santa Cruz Biotechnology (SCBT) Antibodies for GPRASP2

No data available for DME Specific Peptides for GPRASP2 Gene

Domains & Families for GPRASP2 Gene

Gene Families for GPRASP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPRASP2 Gene


Suggested Antigen Peptide Sequences for GPRASP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPRASP family.
  • Belongs to the GPRASP family.
genes like me logo Genes that share domains with GPRASP2: view

Function for GPRASP2 Gene

Molecular function for GPRASP2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulation of a variety of G-protein coupled receptors.

Gene Ontology (GO) - Molecular Function for GPRASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding IEA --
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with GPRASP2: view
genes like me logo Genes that share phenotypes with GPRASP2: view

Animal Model Products

miRNA for GPRASP2 Gene

miRTarBase miRNAs that target GPRASP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPRASP2 Gene

Localization for GPRASP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPRASP2 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPRASP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with GPRASP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GPRASP2 Gene

Pathways & Interactions for GPRASP2 Gene

SuperPathways for GPRASP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPRASP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPRASP2 Gene

Drugs & Compounds for GPRASP2 Gene

No Compound Related Data Available

Transcripts for GPRASP2 Gene

Unigene Clusters for GPRASP2 Gene

G protein-coupled receptor associated sorting protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPRASP2 Gene

No ASD Table

Relevant External Links for GPRASP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPRASP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPRASP2 Gene

Protein differential expression in normal tissues from HIPED for GPRASP2 Gene

This gene is overexpressed in Adrenal (21.6), Fetal Brain (19.7), and Heart (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPRASP2 Gene

Protein tissue co-expression partners for GPRASP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPRASP2 Gene:


SOURCE GeneReport for Unigene cluster for GPRASP2 Gene:


mRNA Expression by UniProt/SwissProt for GPRASP2 Gene:

Tissue specificity: Expressed in the brain.

Evidence on tissue expression from TISSUES for GPRASP2 Gene

  • Nervous system(4.6)
  • Kidney(4.2)
  • Lung(4.2)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with GPRASP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPRASP2 Gene

Orthologs for GPRASP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPRASP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPRASP2 34
  • 99 (a)
(Canis familiaris)
Mammalia GPRASP2 34
  • 83 (a)
(Bos Taurus)
Mammalia GPRASP2 34
  • 80 (a)
(Mus musculus)
Mammalia Gprasp2 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
(Gallus gallus)
Aves -- 34
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 22 (a)
(Danio rerio)
Actinopterygii ARMCX3 34
  • 18 (a)
Species where no ortholog for GPRASP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPRASP2 Gene

Gene Tree for GPRASP2 (if available)
Gene Tree for GPRASP2 (if available)
Evolutionary constrained regions (ECRs) for GPRASP2: view image

Paralogs for GPRASP2 Gene

(1) SIMAP similar genes for GPRASP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPRASP2: view

Variants for GPRASP2 Gene

Sequence variations from dbSNP and Humsavar for GPRASP2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000512925 -- 102,711,874(+) C/A upstream_transcript_variant
rs1002404477 -- 102,712,379(+) C/A 5_prime_UTR_variant
rs1002453286 -- 102,712,663(+) T/C intron_variant
rs1003053804 -- 102,716,354(+) T/C coding_sequence_variant, synonymous_variant
rs1003294759 -- 102,717,443(+) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for GPRASP2 Gene

Variant ID Type Subtype PubMed ID
nsv526716 CNV gain 19592680

Variation tolerance for GPRASP2 Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPRASP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPRASP2 Gene

Disorders for GPRASP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPRASP2 Gene - From: Orphanet

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPRASP2

genes like me logo Genes that share disorders with GPRASP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPRASP2 Gene

Publications for GPRASP2 Gene

  1. Identification of a novel family of G protein-coupled receptor associated sorting proteins. (PMID: 15086532) Simonin F … Kieffer BL (Journal of neurochemistry 2004) 2 3 4 58
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPRASP2 Gene

Sources for GPRASP2 Gene

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