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Aliases for GPR89B Gene

Aliases for GPR89B Gene

  • G Protein-Coupled Receptor 89B 2 3 5
  • G Protein-Coupled Receptor 89C 2 3
  • GPR89C 3 4
  • Putative NF-Kappa-B-Activating Protein 90 3
  • Putative MAPK-Activating Protein PM01 3
  • Putative Golgi PH Regulator C 3
  • G Protein-Coupled Receptor 89 2
  • Putative Protein GPR89C 3
  • Golgi PH Regulator A 3
  • Golgi PH Regulator B 3
  • Protein GPR89B 4
  • Protein GPR89 3
  • UNQ192 3
  • SH120 3
  • GPR89 3
  • GPHRB 4
  • GPHR 3

External Ids for GPR89B Gene

Previous HGNC Symbols for GPR89B Gene

  • GPR89
  • GPR89C

Previous GeneCards Identifiers for GPR89B Gene

  • GC01U901427
  • GC01P145868
  • GC01P147400
  • GC01M119728

Summaries for GPR89B Gene

GeneCards Summary for GPR89B Gene

GPR89B (G Protein-Coupled Receptor 89B) is a Protein Coding gene. Diseases associated with GPR89B include Leprosy 3. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89A.

UniProtKB/Swiss-Prot for GPR89B Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Wiki entry for GPR89B Gene

Additional gene information for GPR89B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89B Gene

Genomics for GPR89B Gene

GeneHancer (GH) Regulatory Elements for GPR89B Gene

Promoters and enhancers for GPR89B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J147927 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +1.3 1349 3.9 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B POLR2B FOS SP3 NFYC REST LOC105371229 GPR89B GJA8 NBPF14 PIR60446
GH01J147538 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 85.6 -387.4 -387383 5.8 PKNOX1 FOXA2 ARNT NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF416 BCL9 LOC647481 GPR89B LOC101927468 ACP6 OR13Z3P OR13Z2P OR13Z1P LOC100130018 ENSG00000235988
GH01J148262 Promoter/Enhancer 1.6 Ensembl ENCODE 81.3 +335.7 335699 2.7 HNRNPUL1 PKNOX1 SMAD1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 RNU1-120P TRQ-CTG4-1 LOC647481 GPR89B BCL9 ACP6 ENSG00000227700 LOC101927468 LINC01731
GH01J148887 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.7 +964.5 964453 10.5 HDGF PKNOX1 FOXA2 SIN3A DMAP1 YY1 ZNF213 FOS DEK REST PDE4DIP GPR89B LOC647481 HIST2H2BD HIST2H2AB HIST2H2AC HIST2H2BC ENSG00000261716 GC01M148879 RNU2-38P
GH01J148521 Promoter 1.4 Ensembl 66.2 +594.3 594308 1.8 CLOCK FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ENSG00000274210 LOC647481 GPR89B ACP6 BCL9 PIR60228
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR89B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR89B gene promoter:
  • ER-alpha
  • Pax-6
  • ZID

Genomic Locations for GPR89B Gene

Genomic Locations for GPR89B Gene
65,129 bases
Plus strand
65,248 bases
Plus strand

Genomic View for GPR89B Gene

Genes around GPR89B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89B Gene

Proteins for GPR89B Gene

  • Protein details for GPR89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi pH regulator B
    Protein Accession:
    Secondary Accessions:
    • A6NKF9
    • A6NN37
    • B2RUV3
    • B3KMN3
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89B Gene

    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    • Does not seem to be able to bind GTP.
    • Sequence=AAF36121.1; Type=Erroneous termination; Positions=297; Note=Translated as Cys.; Evidence={ECO:0000305};

neXtProt entry for GPR89B Gene

Post-translational modifications for GPR89B Gene

  • Glycosylation at isoforms=243 and isoforms=180
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR89B Gene

Domains & Families for GPR89B Gene

Gene Families for GPR89B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR89B Gene

Suggested Antigen Peptide Sequences for GPR89B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89B: view

Function for GPR89B Gene

Molecular function for GPR89B Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Phenotypes From GWAS Catalog for GPR89B Gene

Gene Ontology (GO) - Molecular Function for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0008308 voltage-gated anion channel activity IBA --
genes like me logo Genes that share ontologies with GPR89B: view
genes like me logo Genes that share phenotypes with GPR89B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR89B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR89B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89B Gene

Localization for GPR89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89B Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR89B gene
Compartment Confidence
golgi apparatus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IBA --
genes like me logo Genes that share ontologies with GPR89B: view

Pathways & Interactions for GPR89B Gene

SuperPathways for GPR89B Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015031 protein transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GPR89B: view

No data available for Pathways by source and SIGNOR curated interactions for GPR89B Gene

Drugs & Compounds for GPR89B Gene

No Compound Related Data Available

Transcripts for GPR89B Gene

mRNA/cDNA for GPR89B Gene

Unigene Clusters for GPR89B Gene

G protein-coupled receptor 89B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR89B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89B Gene

No ASD Table

Relevant External Links for GPR89B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR89B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR89B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPR89B Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR89B Gene:


SOURCE GeneReport for Unigene cluster for GPR89B Gene:


mRNA Expression by UniProt/SwissProt for GPR89B Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GPR89B Gene

  • Nervous system(4.7)
  • Lung(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with GPR89B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR89B Gene

Orthologs for GPR89B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR89B 34 33
  • 99.78 (n)
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
LOC483157 33
  • 93.77 (n)
(Bos Taurus)
Mammalia GPR89 34 33
  • 94.17 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Gpr89b 33
  • 89.23 (n)
(Mus musculus)
Mammalia Gpr89 16 34 33
  • 88.5 (n)
(Gallus gallus)
Aves GPR89 34
  • 95 (a)
GPR89B 33
  • 83.11 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 33
  • 79 (n)
(Danio rerio)
Actinopterygii GPR89A 34
  • 90 (a)
si:ch73-390b10.2 33
  • 77.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 33
  • 60.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 34 33
  • 59.22 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 33
  • 58.11 (n)
Y75B8A.16 34
  • 55 (a)
C11H1.2 34
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 33
  • 54.38 (n)
(Oryza sativa)
Liliopsida Os04g0600800 33
  • 56.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1303 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1303 33
Species where no ortholog for GPR89B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89B Gene

Gene Tree for GPR89B (if available)
Gene Tree for GPR89B (if available)
Evolutionary constrained regions (ECRs) for GPR89B: view image

Paralogs for GPR89B Gene

Paralogs for GPR89B Gene

(2) SIMAP similar genes for GPR89B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR89B: view

Variants for GPR89B Gene

Sequence variations from dbSNP and Humsavar for GPR89B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs111351195 -- 147,931,479(+) T/A intron_variant
rs111406915 -- 147,953,519(+) T/C intron_variant
rs111483535 -- 147,945,521(+) A/G intron_variant
rs111630648 -- 147,985,979(+) A/G genic_downstream_transcript_variant, intron_variant
rs112166383 -- 147,938,388(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89B Gene

Variant ID Type Subtype PubMed ID
dgv184n106 CNV deletion 24896259
dgv327n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
nsv1000564 CNV gain 25217958
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1078214 CNV deletion 25765185
nsv1132304 CNV duplication 24896259
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv511130 CNV loss 21212237
nsv946274 CNV duplication 23825009
nsv946311 CNV duplication 23825009
nsv946312 CNV duplication 23825009
nsv951832 CNV deletion 24416366

Variation tolerance for GPR89B Gene

Gene Damage Index Score: 1.25; 25.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR89B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89B Gene

Disorders for GPR89B Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR89B Gene - From: DISEASES

Disorder Aliases PubMed IDs
leprosy 3
  • leprosy, susceptibility to, 3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR89B

genes like me logo Genes that share disorders with GPR89B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR89B Gene

Publications for GPR89B Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y … Kinoshita T (Nature cell biology 2008) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for GPR89B Gene

Sources for GPR89B Gene

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