Aliases for GPR89B Gene

Aliases for GPR89B Gene

  • G Protein-Coupled Receptor 89B 2 3 5
  • G Protein-Coupled Receptor 89C 2 3
  • Golgi PH Regulator B 3 4
  • GPR89C 3 4
  • SH120 2 3
  • Putative NF-Kappa-B-Activating Protein 90 3
  • Putative MAPK-Activating Protein PM01 3
  • G Protein-Coupled Receptor 89 2
  • Putative Golgi PH Regulator C 3
  • Putative Protein GPR89C 3
  • Golgi PH Regulator A 3
  • Protein GPR89B 4
  • Protein GPR89 3
  • UNQ192 3
  • GPR89B 5
  • GPR89 3
  • GPHRB 4
  • GPHR 3

External Ids for GPR89B Gene

Previous HGNC Symbols for GPR89B Gene

  • GPR89
  • GPR89C

Previous GeneCards Identifiers for GPR89B Gene

  • GC01U901427
  • GC01P145868
  • GC01P147400
  • GC01M119728

Summaries for GPR89B Gene

GeneCards Summary for GPR89B Gene

GPR89B (G Protein-Coupled Receptor 89B) is a Protein Coding gene. Diseases associated with GPR89B include Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb and Hemochromatosis, Type 2A. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89A.

UniProtKB/Swiss-Prot Summary for GPR89B Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Gene Wiki entry for GPR89B Gene

Additional gene information for GPR89B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR89B Gene

Genomics for GPR89B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR89B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR89B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR89B

Top Transcription factor binding sites by QIAGEN in the GPR89B gene promoter:
  • ER-alpha
  • Pax-6
  • ZID

Genomic Locations for GPR89B Gene

Genomic Locations for GPR89B Gene
65,219 bases
Plus strand
65,248 bases
Plus strand

Genomic View for GPR89B Gene

Genes around GPR89B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89B Gene

Proteins for GPR89B Gene

  • Protein details for GPR89B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi pH regulator B
    Protein Accession:
    Secondary Accessions:
    • A6NKF9
    • A6NN37
    • B2RUV3
    • B3KMN3
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89B Gene

    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    • Sequence=AAF36121.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
    • Does not seem to be able to bind GTP.

neXtProt entry for GPR89B Gene

Post-translational modifications for GPR89B Gene

  • Glycosylation at Asn180 and Asn243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR89B Gene

Domains & Families for GPR89B Gene

Gene Families for GPR89B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR89B Gene

Suggested Antigen Peptide Sequences for GPR89B Gene

GenScript: Design optimal peptide antigens:
  • Protein GPR89B (GPHRB_HUMAN)
  • Protein GPR89C (GPHRC_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89B: view

Function for GPR89B Gene

Molecular function for GPR89B Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Phenotypes From GWAS Catalog for GPR89B Gene

Gene Ontology (GO) - Molecular Function for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0008308 voltage-gated anion channel activity IBA 21873635
genes like me logo Genes that share ontologies with GPR89B: view
genes like me logo Genes that share phenotypes with GPR89B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR89B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR89B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89B Gene

Localization for GPR89B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89B Gene

Golgi apparatus membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR89B gene
Compartment Confidence
golgi apparatus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005623 cell IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR89B: view

Pathways & Interactions for GPR89B Gene

PathCards logo

SuperPathways for GPR89B Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR89B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015031 protein transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GPR89B: view

No data available for Pathways by source and SIGNOR curated interactions for GPR89B Gene

Drugs & Compounds for GPR89B Gene

No Compound Related Data Available

Transcripts for GPR89B Gene

mRNA/cDNA for GPR89B Gene

19 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR89B

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89B Gene

No ASD Table

Relevant External Links for GPR89B Gene

GeneLoc Exon Structure for

Expression for GPR89B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR89B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPR89B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR89B

SOURCE GeneReport for Unigene cluster for GPR89B Gene:


mRNA Expression by UniProt/SwissProt for GPR89B Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GPR89B Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Stomach(4.3)
  • Lung(4.2)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with GPR89B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR89B Gene

Orthologs for GPR89B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR89B 30 31
  • 99.78 (n)
(Canis familiaris)
Mammalia -- 31
  • 98 (a)
LOC483157 30
  • 93.77 (n)
(Bos Taurus)
Mammalia GPR89 30 31
  • 94.17 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 93 (a)
(Rattus norvegicus)
Mammalia Gpr89b 30
  • 89.23 (n)
(Mus musculus)
Mammalia Gpr89 30 17 31
  • 88.5 (n)
(Gallus gallus)
Aves GPR89 31
  • 95 (a)
GPR89B 30
  • 83.11 (n)
(Anolis carolinensis)
Reptilia -- 31
  • 94 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100490107 30
  • 79 (n)
(Danio rerio)
Actinopterygii GPR89A 31
  • 90 (a)
si:ch73-390b10.2 30
  • 77.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 30
  • 60.94 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8090 30 31
  • 59.22 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 30
  • 58.11 (n)
Y75B8A.16 31
  • 55 (a)
C11H1.2 31
  • 53 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons GTG2 30
  • 54.38 (n)
(Oryza sativa)
Liliopsida Os04g0600800 30
  • 56.76 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1303 30
Species where no ortholog for GPR89B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GPR89B Gene

Gene Tree for GPR89B (if available)
Gene Tree for GPR89B (if available)
Evolutionary constrained regions (ECRs) for GPR89B: view image

Paralogs for GPR89B Gene

Paralogs for GPR89B Gene

(2) SIMAP similar genes for GPR89B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR89B: view

Variants for GPR89B Gene

Additional dbSNP identifiers (rs#s) for GPR89B Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR89B Gene

Variant ID Type Subtype PubMed ID
dgv184n106 CNV deletion 24896259
dgv327n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
nsv1000564 CNV gain 25217958
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1078214 CNV deletion 25765185
nsv1132304 CNV duplication 24896259
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv511130 CNV loss 21212237
nsv946274 CNV duplication 23825009
nsv946311 CNV duplication 23825009
nsv946312 CNV duplication 23825009
nsv951832 CNV deletion 24416366

Variation tolerance for GPR89B Gene

Gene Damage Index Score: 1.25; 25.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR89B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR89B Gene

Disorders for GPR89B Gene

MalaCards: The human disease database

(6) MalaCards diseases for GPR89B Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1q21.1 deletion syndrome, 1.35-mb
  • chromosome 1q21.1 deletion syndrome
hemochromatosis, type 2a
  • hfe2a
thrombocytopenia-absent radius syndrome
  • tar
duodenal atresia
  • duodenal stenosis
brooke-spiegler syndrome
  • cylindromatosis, familial
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with GPR89B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR89B Gene

Publications for GPR89B Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
  2. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y … Kinoshita T (Nature cell biology 2008) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development. (PMID: 30352685) Van Alstyne M … Pellizzoni L (Biochemical and biophysical research communications 2018) 3

Products for GPR89B Gene

Sources for GPR89B Gene