Aliases for GPR89A Gene
Aliases for GPR89A Gene
External Ids for GPR89A Gene
- HGNC: 31984
- Entrez Gene: 653519
- Ensembl: ENSG00000117262
- OMIM: 612821
- UniProtKB: B7ZAQ6
Previous GeneCards Identifiers for GPR89A Gene
- GC01P145867
- GC01M144476
- GC01M145764
Summaries for GPR89A Gene
-
GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]
GeneCards Summary for GPR89A Gene
GPR89A (G Protein-Coupled Receptor 89A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89B.
UniProtKB/Swiss-Prot for GPR89A Gene
-
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.
Additional gene information for GPR89A Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89A Gene
Genomics for GPR89A Gene
GeneHancer (GH) Regulatory Elements for GPR89A Gene
Promoters and enhancers for GPR89A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GPR89A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GPR89A gene promoter:
Regulatory Element Products
Genomic Locations for GPR89A Gene
Genomic Locations for GPR89A Gene
- chr1:145,607,960-145,670,977
- (GRCh38/hg38)
- Size:
- 63,018 bases
- Orientation:
- Plus strand
- chr1:145,764,411-145,827,103
- (GRCh37/hg19)
Genomic View for GPR89A Gene
Genes around GPR89A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.1 by Ensembl
- 1q21.1 by Entrez Gene
- 1q21.1 by HGNC
GPR89A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPR89A Gene
Proteins for GPR89A Gene
-
Protein details for GPR89A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- B7ZAQ6-GPHRA_HUMAN
- Recommended name:
- Golgi pH regulator A
- Protein Accession:
- B7ZAQ6
- A6NN37
- B2RUV3
- B3KMN3
- B4DLT3
- B4DXE7
- Q53FQ9
- Q5T2V8
- Q5T5P5
- Q659E2
- Q6NVY5
- Q9P0S4
- Q9Y302
Protein attributes for GPR89A Gene
- Size:
- 455 amino acids
- Molecular mass:
- 52917 Da
- Quaternary structure:
-
- Homotrimer.
- Miscellaneous:
-
- Does not seem to be able to bind GTP.
Protein Expression for GPR89A Gene
Post-translational modifications for GPR89A Gene
Other Protein References for GPR89A Gene
Antibody Products
- Novus Biologicals Antibodies for GPR89A
-
Abcam antibodies for GPR89A
- Invitrogen Antibodies for GPR89A
- Search GeneTex for Antibodies for GPR89A
Protein Products
-
OriGene Purified Proteins for GPR89A
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- Search GeneTex for Proteins for GPR89A
Assay Products
No data available for DME Specific Peptides for GPR89A Gene
Domains & Families for GPR89A Gene
Gene Families for GPR89A Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for GPR89A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPR89A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
B7ZAQ6- Family:
-
- Belongs to the Golgi pH regulator (TC 1.A.38) family.
Function for GPR89A Gene
Molecular function for GPR89A Gene
- UniProtKB/Swiss-Prot Function:
- Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.
Phenotypes From GWAS Catalog for GPR89A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | signal transducer activity | IMP,HMP | 12761501 |
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0008308 | voltage-gated anion channel activity | IDA | 18794847 |
Phenotypes for GPR89A Gene
- GenomeRNAi human phenotypes for GPR89A:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR89A gene
-
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- Search ViGene Biosciences for GPR89A
CRISPR Products
-
OriGene CRISPR knockouts for GPR89A
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- Applied Biological Materials CRISPR for GPR89A
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR89A
- GenScript: Design CRISPR guide RNA sequences for GPR89A
miRNA for GPR89A Gene
- miRTarBase miRNAs that target GPR89A
-
- hsa-mir-92a-3p (MIRT049018)
- hsa-mir-511-5p (MIRT446909)
- hsa-mir-526b-5p (MIRT446910)
- hsa-mir-6071 (MIRT446911)
- hsa-mir-5701 (MIRT446912)
- hsa-mir-431-5p (MIRT446913)
- hsa-mir-8077 (MIRT446914)
- hsa-mir-7160-5p (MIRT446915)
- hsa-mir-4663 (MIRT446916)
- hsa-mir-4424 (MIRT446917)
- hsa-mir-496 (MIRT446918)
- hsa-mir-3692-5p (MIRT446919)
- hsa-mir-93-3p (MIRT446920)
- hsa-mir-6728-3p (MIRT446921)
miRNA Products
- Search ViGene Biosciences for GPR89A
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GPR89A
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- genomics-online: shRNA clones - Search results for available GPR89A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR89A gene
Clone Products
- Sino Biological Human cDNA Clone for GPR89A
- VectorBuilder custom plasmid, inducible vectors for GPR89A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR89A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GPR89A gene related products
- orf clones - Search results for available GPR89A gene related products
- Applied Biological Materials Clones for GPR89A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GPR89A
-
ViGene Biosciences adenoviral particle packaged cDNA for GPR89A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GPR89A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR89A gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89A Gene
Localization for GPR89A Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPR89A Gene
- Golgi apparatus membrane; Multi-pass membrane protein.
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030660 | Golgi-associated vesicle membrane | IDA | 18794847 |
| GO:0032580 | Golgi cisterna membrane | IDA | 18794847 |
No data available for Subcellular locations from COMPARTMENTS for GPR89A Gene
Pathways & Interactions for GPR89A Gene
No Data Available
Interacting Proteins for GPR89A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0034765 | regulation of ion transmembrane transport | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GPR89A Gene
Transcripts for GPR89A Gene
mRNA/cDNA for GPR89A Gene
- (8) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GPR89A Gene
- G protein-coupled receptor 89A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for GPR89A
- genomics-online: gRNA clones - Search results for available GPR89A gene related products
- Applied Biological Materials CRISPR for GPR89A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPR89A
- GenScript: Design CRISPR guide RNA sequences for GPR89A
miRNA Products
- Search ViGene Biosciences for GPR89A
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for GPR89A
- Browse OriGene Inhibitory RNA Products For GPR89A
- genomics-online: shRNA clones - Search results for available GPR89A gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GPR89A gene
Clone Products
- Sino Biological Human cDNA Clone for GPR89A
- VectorBuilder custom plasmid, inducible vectors for GPR89A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR89A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GPR89A gene related products
- orf clones - Search results for available GPR89A gene related products
- Applied Biological Materials Clones for GPR89A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GPR89A Gene
This gene is overexpressed in Nasal epithelium (60.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR89A Gene
NURSA nuclear receptor signaling pathways regulating expression of GPR89A Gene:
GPR89ASOURCE GeneReport for Unigene cluster for GPR89A Gene:
Hs.504320mRNA Expression by UniProt/SwissProt for GPR89A Gene:
B7ZAQ6-GPHRA_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for GPR89A Gene
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for GPR89A
- genomics-online: primer clones - Search results for available GPR89A gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR89A Gene
Orthologs for GPR89A Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GPR89B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| LOC483157 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | GPR89 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Gpr89b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Gpr89 34 33 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | GPR89 34 |
|
OneToMany | |
| GPR89B 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100490107 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | GPR89A 34 |
|
OneToMany | |
| si:ch73-390b10.2 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011252 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8090 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_Y75B8A.16 33 |
|
||
| Y75B8A.16 34 |
|
ManyToMany | |||
| C11H1.2 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | GTG2 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0600800 33 |
|
- Species where no ortholog for GPR89A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GPR89A Gene
(2) SIMAP similar genes for GPR89A Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for GPR89A Gene
Variants for GPR89A Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs10910846 | -- | 145,659,481(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs111338698 | -- | 145,659,066(+) | C/A | genic_downstream_transcript_variant, intron_variant | |
| rs111383109 | -- | 145,619,259(+) | A/C | intron_variant | |
| rs111488177 | -- | 145,641,195(+) | A/C | intron_variant | |
| rs111533600 | -- | 145,630,557(+) | A/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv331n100 | CNV | gain | 25217958 |
| dgv332n100 | CNV | gain+loss | 25217958 |
| dgv532n54 | CNV | gain | 21841781 |
| dgv95e212 | CNV | gain | 25503493 |
| esv3572342 | CNV | gain | 25503493 |
| esv3587421 | CNV | loss | 21293372 |
| esv3587422 | CNV | gain | 21293372 |
| nsv1005055 | CNV | loss | 25217958 |
| nsv1015025 | CNV | gain | 25217958 |
| nsv469752 | CNV | loss | 16826518 |
| nsv831392 | CNV | gain | 17160897 |
| nsv946271 | CNV | duplication | 23825009 |
| nsv946272 | CNV | duplication | 23825009 |
| nsv998178 | CNV | loss | 25217958 |
Gene Damage Index Score:
0.79;
16.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPR89A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPR89A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89A Gene
Disorders for GPR89A Gene
Additional Disease Information for GPR89A
No disorders were found for GPR89A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR89A Gene
Publications for GPR89A Gene
- Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 4 58
- Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PMID: 19135895) Pandey S … Assmann SM (Cell 2009) 3 4 58
- GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y … Kinoshita T (Nature cell biology 2008) 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for GPR89A Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for GPR89A
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GPR89A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 46 available GPR89A Antibodies ranked by validation data
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- antibodies-online: Search results for available GPR89A related products ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for GPR89A gene
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Sources for GPR89A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
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