GPR89A Gene (Protein Coding)

G Protein-Coupled Receptor 89A

GC01P145607
GIFtS:
32
GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009] See more...

Aliases for GPR89A Gene

Aliases for GPR89A Gene

  • G Protein-Coupled Receptor 89A 2 3 5
  • Putative NF-Kappa-B-Activating Protein 90 3 4
  • Putative MAPK-Activating Protein PM01 3 4
  • Golgi PH Regulator A 3 4
  • GPR89 3 4
  • SH120 3 4
  • Protein GPR89A 4
  • Protein GPR89 3
  • GPR89B 3
  • UNQ192 3
  • GPHRA 4
  • GPHR 3

External Ids for GPR89A Gene

Previous GeneCards Identifiers for GPR89A Gene

  • GC01P145867
  • GC01M144476
  • GC01M145764

Summaries for GPR89A Gene

Entrez Gene Summary for GPR89A Gene

  • GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]

GeneCards Summary for GPR89A Gene

GPR89A (G Protein-Coupled Receptor 89A) is a Protein Coding gene. Diseases associated with GPR89A include Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb and Thrombocytopenia-Absent Radius Syndrome. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89B.

UniProtKB/Swiss-Prot Summary for GPR89A Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Additional gene information for GPR89A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR89A Gene

Genomics for GPR89A Gene

GeneHancer (GH) Regulatory Elements for GPR89A Gene

Promoters and enhancers for GPR89A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR89A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR89A

Top Transcription factor binding sites by QIAGEN in the GPR89A gene promoter:
  • Pax-6
  • ZID

Genomic Locations for GPR89A Gene

Genomic Locations for GPR89A Gene
chr1:145,607,960-145,670,977
(GRCh38/hg38)
Size:
63,018 bases
Orientation:
Plus strand
chr1:145,764,411-145,827,103
(GRCh37/hg19)
Size:
62,693 bases
Orientation:
Minus strand

Genomic View for GPR89A Gene

Genes around GPR89A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPR89A Gene

Proteins for GPR89A Gene

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  • Protein details for GPR89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B7ZAQ6-GPHRA_HUMAN
    Recommended name:
    Golgi pH regulator A
    Protein Accession:
    B7ZAQ6
    Secondary Accessions:
    • A6NN37
    • B2RUV3
    • B3KMN3
    • B4DLT3
    • B4DXE7
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89A Gene

    Size:
    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    Miscellaneous:
    • Does not seem to be able to bind GTP.

    Alternative splice isoforms for GPR89A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR89A Gene

Protein Expression for GPR89A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GPR89A Gene

  • Glycosylation at Asn180 and Asn243
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR89A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR89A Gene

Domains & Families for GPR89A Gene

Gene Families for GPR89A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR89A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR89A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53806, highly similar to Protein GPR89A (B4DLT3_HUMAN)
  • Putative NF-kappa-B-activating protein 90 (GPHRA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B7ZAQ6

UniProtKB/Swiss-Prot:

GPHRA_HUMAN :
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
Family:
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89A: view

Function for GPR89A Gene

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Molecular function for GPR89A Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Phenotypes From GWAS Catalog for GPR89A Gene

Gene Ontology (GO) - Molecular Function for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005244 voltage-gated ion channel activity IEA --
GO:0008308 voltage-gated anion channel activity IDA,IBA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

Phenotypes for GPR89A Gene

GenomeRNAi human phenotypes for GPR89A:
genes like me logo Genes that share phenotypes with GPR89A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR89A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89A Gene

Localization for GPR89A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR89A gene
Compartment Confidence
golgi apparatus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

Pathways & Interactions for GPR89A Gene

PathCards logo

SuperPathways for GPR89A Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015031 protein transport IEA --
GO:0015698 inorganic anion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Pathways by source and SIGNOR curated interactions for GPR89A Gene

Drugs & Compounds for GPR89A Gene

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  1. Drug
No Compound Related Data Available

Transcripts for GPR89A Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GPR89A Gene

2 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR89A

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89A Gene

No ASD Table

Relevant External Links for GPR89A Gene

GeneLoc Exon Structure for
GPR89A

Expression for GPR89A Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR89A Gene

mRNA expression in normal human tissues for GPR89A Gene
mRNA expression by BioGPS for GPR89A GenemRNA expression by GTEx for GPR89A Gene

Protein differential expression in normal tissues from HIPED for GPR89A Gene

This gene is overexpressed in Nasal epithelium (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR89A Gene



Protein tissue co-expression partners for GPR89A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR89A

SOURCE GeneReport for Unigene cluster for GPR89A Gene:

Hs.504320

mRNA Expression by UniProt/SwissProt for GPR89A Gene:

B7ZAQ6-GPHRA_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GPR89A Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with GPR89A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR89A Gene

Orthologs for GPR89A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GPR89B 31 30
  • 99.71 (n)
 OneToMany
dog
(Canis familiaris)
 Mammalia -- 31
  • 98 (a)
 OneToMany
LOC483157 30
  • 93.7 (n)
cow
(Bos Taurus)
 Mammalia GPR89 31 30
  • 94.09 (n)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 93 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 93 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Gpr89b 30
  • 89.16 (n)
mouse
(Mus musculus)
 Mammalia Gpr89 31 30
  • 88.42 (n)
 OneToMany
chicken
(Gallus gallus)
 Aves GPR89 31
  • 95 (a)
 OneToMany
GPR89B 30
  • 83.19 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 94 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100490107 30
  • 79.07 (n)
zebrafish
(Danio rerio)
 Actinopterygii GPR89A 31
  • 90 (a)
 OneToMany
si:ch73-390b10.2 30
  • 77.68 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP011252 30
  • 60.94 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG8090 31 30
  • 59.14 (n)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea CELE_Y75B8A.16 30
  • 58.11 (n)
Y75B8A.16 31
  • 55 (a)
 ManyToMany
C11H1.2 31
  • 53 (a)
 ManyToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons GTG2 30
  • 54.38 (n)
rice
(Oryza sativa)
 Liliopsida Os04g0600800 30
  • 56.76 (n)
Species where no ortholog for GPR89A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89A Gene

ENSEMBL:
Gene Tree for GPR89A (if available)
TreeFam:
Gene Tree for GPR89A (if available)

Paralogs for GPR89A Gene

Paralogs for GPR89A Gene

(2) SIMAP similar genes for GPR89A Gene using alignment to 4 proteins:

  • GPHRA_HUMAN
  • B4DLT3_HUMAN
  • E9PKY3_HUMAN
  • E9PRZ5_HUMAN

Pseudogenes.org Pseudogenes for GPR89A Gene

genes like me logo Genes that share paralogs with GPR89A: view

Variants for GPR89A Gene

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Additional dbSNP identifiers (rs#s) for GPR89A Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR89A Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv332n100 CNV gain+loss 25217958
dgv532n54 CNV gain 21841781
dgv95e212 CNV gain 25503493
esv3572342 CNV gain 25503493
esv3587421 CNV loss 21293372
esv3587422 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv469752 CNV loss 16826518
nsv831392 CNV gain 17160897
nsv946271 CNV duplication 23825009
nsv946272 CNV duplication 23825009
nsv998178 CNV loss 25217958

Variation tolerance for GPR89A Gene

Gene Damage Index Score: 0.79; 16.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR89A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR89A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR89A Gene

Disorders for GPR89A Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPR89A Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1q21.1 deletion syndrome, 1.35-mb
  • chromosome 1q21.1 deletion syndrome
thrombocytopenia-absent radius syndrome
  • tar
neonatal thyrotoxicosis
duodenal atresia
  • duodenal stenosis
chromosome 1p36 deletion syndrome
  • monosomy 1p36 syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR89A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR89A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR89A Gene

Publications for GPR89A Gene

  1. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 4 54
  2. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PMID: 19135895) Pandey S … Assmann SM (Cell 2009) 3 4 54
  3. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y … Kinoshita T (Nature cell biology 2008) 3 4 54
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

ExternalLinks

View latest publications for GPR89A gene in Mastermind

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