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Aliases for GPR89A Gene

Aliases for GPR89A Gene

  • G Protein-Coupled Receptor 89A 2 3 5
  • Putative NF-Kappa-B-Activating Protein 90 3 4
  • Putative MAPK-Activating Protein PM01 3 4
  • GPR89 3 4
  • SH120 3 4
  • Golgi PH Regulator A 3
  • Protein GPR89A 4
  • Protein GPR89 3
  • GPR89B 3
  • UNQ192 3
  • GPHRA 4
  • GPHR 3

External Ids for GPR89A Gene

Previous GeneCards Identifiers for GPR89A Gene

  • GC01P145867
  • GC01M144476
  • GC01M145764

Summaries for GPR89A Gene

Entrez Gene Summary for GPR89A Gene

  • GPR89A is a nearly identical copy of the GPR89B gene (MIM 612806).[supplied by OMIM, Jun 2009]

GeneCards Summary for GPR89A Gene

GPR89A (G Protein-Coupled Receptor 89A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include signal transducer activity and voltage-gated anion channel activity. An important paralog of this gene is GPR89B.

UniProtKB/Swiss-Prot for GPR89A Gene

  • Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Additional gene information for GPR89A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR89A Gene

Genomics for GPR89A Gene

GeneHancer (GH) Regulatory Elements for GPR89A Gene

Promoters and enhancers for GPR89A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I145605 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.3 -276 3.4 HDGF PKNOX1 ARNT NEUROD1 SIN3A ZNF2 ZBTB7B POLR2B FOS SP3 GPR89A NBPF25P PIR60534
GH01I146034 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 29 +429.6 429591 5.6 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 HFE2 GC01P146046 PIR58458 TRG-TCC2-1 TRH-GTG1-1 TRK-CTT2-1 TRE-CTC1-1 PIAS3 POLR3C NBPF20
GH01I146226 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21 +620.1 620076 3.3 HDGF CLOCK ARNT SIN3A FEZF1 ZNF2 ZBTB7B POLR2B ZNF213 ZNF302 ENSG00000213240 LOC105371254 NOTCH2NL PIAS3 POLR3C NBPF20 ENSG00000234225 GPR89A NUDT17 PEX11B
GH01I145976 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 26 +374.3 374323 10.6 CLOCK YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC NBPF20 POLR3C GPR89A PIAS3 ANKRD35 HFE2 RBM8A LIX1L-AS1 PEX11B ENSG00000213240
GH01I144997 Enhancer 1.5 Ensembl ENCODE dbSUPER 22.4 -608.4 -608438 4.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF766 PIAS3 NBPF20 POLR3C PFN1P6 GPR89A NUDT17 LOC645166 LIX1L-AS1 GNRHR2 ENSG00000271644
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR89A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR89A gene promoter:

Genomic Locations for GPR89A Gene

Genomic Locations for GPR89A Gene
63,018 bases
Plus strand

Genomic View for GPR89A Gene

Genes around GPR89A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR89A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR89A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR89A Gene

Proteins for GPR89A Gene

  • Protein details for GPR89A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi pH regulator A
    Protein Accession:
    Secondary Accessions:
    • A6NN37
    • B2RUV3
    • B3KMN3
    • B4DLT3
    • B4DXE7
    • Q53FQ9
    • Q5T2V8
    • Q5T5P5
    • Q659E2
    • Q6NVY5
    • Q9P0S4
    • Q9Y302

    Protein attributes for GPR89A Gene

    455 amino acids
    Molecular mass:
    52917 Da
    Quaternary structure:
    • Homotrimer.
    • Does not seem to be able to bind GTP.

    Alternative splice isoforms for GPR89A Gene


neXtProt entry for GPR89A Gene

Post-translational modifications for GPR89A Gene

  • Glycosylation at posLast=180180 and posLast=243243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR89A Gene

Domains & Families for GPR89A Gene

Gene Families for GPR89A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GPR89A Gene

Suggested Antigen Peptide Sequences for GPR89A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
  • Belongs to the Golgi pH regulator (TC 1.A.38) family.
genes like me logo Genes that share domains with GPR89A: view

Function for GPR89A Gene

Molecular function for GPR89A Gene

UniProtKB/Swiss-Prot Function:
Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.

Phenotypes From GWAS Catalog for GPR89A Gene

Gene Ontology (GO) - Molecular Function for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IMP,HMP 12761501
GO:0005244 voltage-gated ion channel activity IEA --
GO:0008308 voltage-gated anion channel activity IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

Phenotypes for GPR89A Gene

GenomeRNAi human phenotypes for GPR89A:
genes like me logo Genes that share phenotypes with GPR89A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR89A Gene

Localization for GPR89A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR89A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030660 Golgi-associated vesicle membrane IDA 18794847
GO:0032580 Golgi cisterna membrane IDA 18794847
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Subcellular locations from COMPARTMENTS for GPR89A Gene

Pathways & Interactions for GPR89A Gene

SuperPathways for GPR89A Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR89A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with GPR89A: view

No data available for Pathways by source and SIGNOR curated interactions for GPR89A Gene

Drugs & Compounds for GPR89A Gene

No Compound Related Data Available

Transcripts for GPR89A Gene

mRNA/cDNA for GPR89A Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR89A Gene

G protein-coupled receptor 89A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR89A Gene

No ASD Table

Relevant External Links for GPR89A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR89A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR89A Gene

Protein differential expression in normal tissues from HIPED for GPR89A Gene

This gene is overexpressed in Nasal epithelium (60.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR89A Gene

Protein tissue co-expression partners for GPR89A Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR89A Gene:


SOURCE GeneReport for Unigene cluster for GPR89A Gene:


mRNA Expression by UniProt/SwissProt for GPR89A Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for GPR89A Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with GPR89A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR89A Gene

Orthologs for GPR89A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR89A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR89B 33 34
  • 99.71 (n)
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
LOC483157 33
  • 93.7 (n)
(Bos Taurus)
Mammalia GPR89 33 34
  • 94.09 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Gpr89b 33
  • 89.16 (n)
(Mus musculus)
Mammalia Gpr89 34 33
  • 88.42 (n)
(Gallus gallus)
Aves GPR89 34
  • 95 (a)
GPR89B 33
  • 83.19 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490107 33
  • 79.07 (n)
(Danio rerio)
Actinopterygii GPR89A 34
  • 90 (a)
si:ch73-390b10.2 33
  • 77.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011252 33
  • 60.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8090 33 34
  • 59.14 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y75B8A.16 33
  • 58.11 (n)
Y75B8A.16 34
  • 55 (a)
C11H1.2 34
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GTG2 33
  • 54.38 (n)
(Oryza sativa)
Liliopsida Os04g0600800 33
  • 56.76 (n)
Species where no ortholog for GPR89A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR89A Gene

Gene Tree for GPR89A (if available)
Gene Tree for GPR89A (if available)

Paralogs for GPR89A Gene

Paralogs for GPR89A Gene

(2) SIMAP similar genes for GPR89A Gene using alignment to 4 proteins: Pseudogenes for GPR89A Gene

genes like me logo Genes that share paralogs with GPR89A: view

Variants for GPR89A Gene

Sequence variations from dbSNP and Humsavar for GPR89A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs10910846 -- 145,659,481(+) G/A genic_downstream_transcript_variant, intron_variant
rs111338698 -- 145,659,066(+) C/A genic_downstream_transcript_variant, intron_variant
rs111383109 -- 145,619,259(+) A/C intron_variant
rs111488177 -- 145,641,195(+) A/C intron_variant
rs111533600 -- 145,630,557(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR89A Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv332n100 CNV gain+loss 25217958
dgv532n54 CNV gain 21841781
dgv95e212 CNV gain 25503493
esv3572342 CNV gain 25503493
esv3587421 CNV loss 21293372
esv3587422 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv469752 CNV loss 16826518
nsv831392 CNV gain 17160897
nsv946271 CNV duplication 23825009
nsv946272 CNV duplication 23825009
nsv998178 CNV loss 25217958

Variation tolerance for GPR89A Gene

Gene Damage Index Score: 0.79; 16.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR89A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR89A Gene

Disorders for GPR89A Gene

Additional Disease Information for GPR89A

No disorders were found for GPR89A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR89A Gene

Publications for GPR89A Gene

  1. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 4 58
  2. Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. (PMID: 19135895) Pandey S … Assmann SM (Cell 2009) 3 4 58
  3. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. (PMID: 18794847) Maeda Y … Kinoshita T (Nature cell biology 2008) 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for GPR89A Gene

Sources for GPR89A Gene

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