The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017] See more...

Aliases for GPR88 Gene

Aliases for GPR88 Gene

  • G Protein-Coupled Receptor 88 2 3 5
  • Striatum-Specific G-Protein Coupled Receptor 3 4
  • Probable G-Protein Coupled Receptor 88 3 4
  • STRG 3 4
  • G-Protein Coupled Receptor 88 2
  • G Protein Coupled Receptor 88 2
  • COCPMR 3

External Ids for GPR88 Gene

Previous GeneCards Identifiers for GPR88 Gene

  • GC01P101794
  • GC01P100184
  • GC01P100294
  • GC01P100715
  • GC01P100776
  • GC01P101003
  • GC01P099128

Summaries for GPR88 Gene

Entrez Gene Summary for GPR88 Gene

  • The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]

GeneCards Summary for GPR88 Gene

GPR88 (G Protein-Coupled Receptor 88) is a Protein Coding gene. Diseases associated with GPR88 include Chorea, Childhood-Onset, With Psychomotor Retardation. Among its related pathways are GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR75.

UniProtKB/Swiss-Prot Summary for GPR88 Gene

  • Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.

Gene Wiki entry for GPR88 Gene

Additional gene information for GPR88 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR88 Gene

Genomics for GPR88 Gene

GeneHancer (GH) Regulatory Elements for GPR88 Gene

Promoters and enhancers for GPR88 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J100539 Promoter 0.9 Ensembl 500.7 +1.2 1161 2.2 ZIC2 ZBTB26 EZH2 ZNF341 CTCF MYC SMC3 SP2 ZNF263 MXI1 GPR88 CDC14A VCAM1 piR-31937-007
GH01J100538 Promoter 0.6 EPDnew 500.7 0.0 0 0.1 SMC3 EZH2 ZBTB20 GPR88 ENSG00000228086
GH01J100719 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 +183.1 183082 3.6 REST RELA POLR2A CTCF CEBPG NBN USF1 WRNIP1 IKZF1 TBP VCAM1 ENSG00000228086 GPR88 HSALNG0005548
GH01J100583 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.8 +47.1 47055 2.4 EP300 NCOR1 JUND TCF7 SKI TEAD1 FOXA2 ZNF316 MAFF FOS piR-39972-001 GPR88 VCAM1 piR-50852-004
GH01J100438 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10.3 -97.7 -97664 3.6 ZBTB11 TRIM28 TOE1 MYC CTBP1 TAF9B MXI1 OSR2 HDAC3 MBD2 CDC14A ENSG00000228086 GPR88 MFSD14A SLC35A3 lnc-GPR88-1 lnc-DBT-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR88 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR88

Top Transcription factor binding sites by QIAGEN in the GPR88 gene promoter:
  • En-1
  • HNF-1
  • HNF-1A
  • LCR-F1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • p53
  • POU2F1
  • S8

Genomic Locations for GPR88 Gene

Genomic Locations for GPR88 Gene
chr1:100,538,139-100,542,027
(GRCh38/hg38)
Size:
3,889 bases
Orientation:
Plus strand
chr1:101,003,693-101,007,583
(GRCh37/hg19)
Size:
3,891 bases
Orientation:
Plus strand

Genomic View for GPR88 Gene

Genes around GPR88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR88 Gene

Proteins for GPR88 Gene

  • Protein details for GPR88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN0-GPR88_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 88
    Protein Accession:
    Q9GZN0
    Secondary Accessions:
    • Q29S24
    • Q6VN48

    Protein attributes for GPR88 Gene

    Size:
    384 amino acids
    Molecular mass:
    40246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR88 Gene

Post-translational modifications for GPR88 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR88 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR88 Gene

Domains & Families for GPR88 Gene

Gene Families for GPR88 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • G-protein coupled receptors
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for GPR88 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR88 Gene

GenScript: Design optimal peptide antigens:
  • Striatum-specific G-protein coupled receptor (GPR88_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZN0

UniProtKB/Swiss-Prot:

GPR88_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR88: view

Function for GPR88 Gene

Molecular function for GPR88 Gene

UniProtKB/Swiss-Prot Function:
Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.

Phenotypes From GWAS Catalog for GPR88 Gene

Gene Ontology (GO) - Molecular Function for GPR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity ISS --
GO:0004930 G protein-coupled receptor activity IEA --
GO:0008020 G protein-coupled photoreceptor activity IBA 21873635
genes like me logo Genes that share ontologies with GPR88: view
genes like me logo Genes that share phenotypes with GPR88: view

Human Phenotype Ontology for GPR88 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPR88 Gene

MGI Knock Outs for GPR88:
  • Gpr88 Gpr88<tm1.1(cre/GFP)Rpa>

Animal Model Products

CRISPR Products

miRNA for GPR88 Gene

miRTarBase miRNAs that target GPR88

Clone Products

  • Addgene plasmids for GPR88

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPR88 Gene

Localization for GPR88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR88 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood. {ECO:0000250 UniProtKB:Q9ESP4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR88 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GPR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with GPR88: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR88 Gene

Pathways & Interactions for GPR88 Gene

PathCards logo

SuperPathways for GPR88 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR88: view

Pathways by source for GPR88 Gene

1 BioSystems pathway for GPR88 Gene

Interacting Proteins for GPR88 Gene

;

Gene Ontology (GO) - Biological Process for GPR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway NAS 11056049
GO:0007602 phototransduction IBA 21873635
GO:0007626 locomotory behavior IEA --
GO:0009584 detection of visible light IEA --
genes like me logo Genes that share ontologies with GPR88: view

No data available for SIGNOR curated interactions for GPR88 Gene

Drugs & Compounds for GPR88 Gene

(1) Drugs for GPR88 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
COMPOUND 2 [PMID: 24793972] Pharma 0
genes like me logo Genes that share compounds with GPR88: view

Transcripts for GPR88 Gene

mRNA/cDNA for GPR88 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPR88

Alternative Splicing Database (ASD) splice patterns (SP) for GPR88 Gene

No ASD Table

Relevant External Links for GPR88 Gene

GeneLoc Exon Structure for
GPR88

Expression for GPR88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR88 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x18.9), Brain - Caudate (basal ganglia) (x15.2), and Brain - Nucleus accumbens (basal ganglia) (x11.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR88

SOURCE GeneReport for Unigene cluster for GPR88 Gene:

Hs.170053

mRNA Expression by UniProt/SwissProt for GPR88 Gene:

Q9GZN0-GPR88_HUMAN
Tissue specificity: Expressed predominantly in the striatum.

Evidence on tissue expression from TISSUES for GPR88 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPR88: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR88 Gene

Orthologs for GPR88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR88 31 30
  • 99.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR88 31 30
  • 93.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR88 31 30
  • 92.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr88 17 31 30
  • 90.28 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR88 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr88 30
  • 88.45 (n)
chicken
(Gallus gallus)
Aves GPR88 31 30
  • 74.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR88 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr88 30
  • 57.04 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr88 31 30
  • 54.87 (n)
OneToOne
Species where no ortholog for GPR88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR88 Gene

ENSEMBL:
Gene Tree for GPR88 (if available)
TreeFam:
Gene Tree for GPR88 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR88: view image

Paralogs for GPR88 Gene

Variants for GPR88 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR88 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs875989788 Pathogenic: Chorea, childhood-onset, with psychomotor retardation 100,539,839(+) C/A NONSENSE
rs2809819 - p.Val190Ile
rs3001995 - p.Gln318His

Additional dbSNP identifiers (rs#s) for GPR88 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR88 Gene

Variant ID Type Subtype PubMed ID
esv22185 CNV loss 19812545
nsv546889 CNV gain 21841781
nsv823653 CNV loss 20364138
nsv830826 CNV gain 17160897

Variation tolerance for GPR88 Gene

Gene Damage Index Score: 8.18; 84.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR88 Gene

Human Gene Mutation Database (HGMD)
GPR88
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR88

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR88 Gene

Disorders for GPR88 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR88 Gene - From: OMIM, ClinVar, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GPR88 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GPR88_HUMAN
  • Chorea, childhood-onset, with psychomotor retardation (COCPMR) [MIM:616939]: An autosomal recessive neurodevelopmental disorder characterized by abnormal involuntary movements, marked speech delay, intellectual disability and learning difficulties. {ECO:0000269 PubMed:27123486}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for GPR88

genes like me logo Genes that share disorders with GPR88: view

No data available for Genatlas for GPR88 Gene

Publications for GPR88 Gene

  1. Deleterious mutation in GPR88 is associated with chorea, speech delay, and learning disabilities. (PMID: 27123486) Alkufri F … Elpeleg O (Neurology. Genetics 2016) 3 4 54
  2. A novel G-protein-coupled receptor gene expressed in striatum. (PMID: 11056049) Mizushima K … Ito T (Genomics 2000) 3 4 54
  3. Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. (PMID: 28154160) Badgandi HB … Mukhopadhyay S (The Journal of cell biology 2017) 3 54
  4. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. (PMID: 27499251) Jin C … Blough BE (ACS chemical neuroscience 2016) 3 54
  5. Association study in three different populations between the GPR88 gene and major psychoses. (PMID: 24689078) Del Zompo M … Meloni R (Molecular genetics & genomic medicine 2014) 3 54

Products for GPR88 Gene

Sources for GPR88 Gene