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Aliases for GPR87 Gene

Aliases for GPR87 Gene

  • G Protein-Coupled Receptor 87 2 3 5
  • G-Protein Coupled Receptor 95 3 4
  • GPR95 3 4
  • G-Protein Coupled Receptor 87 3
  • Orphan GPCR 87 3
  • KPG_002 3
  • FKSG78 3

External Ids for GPR87 Gene

Previous HGNC Symbols for GPR87 Gene

  • GPR95

Previous GeneCards Identifiers for GPR87 Gene

  • GC03M147953
  • GC03M151844
  • GC03M152293
  • GC03M152332
  • GC03M152494
  • GC03M151012
  • GC03M148385

Summaries for GPR87 Gene

Entrez Gene Summary for GPR87 Gene

  • This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]

GeneCards Summary for GPR87 Gene

GPR87 (G Protein-Coupled Receptor 87) is a Protein Coding gene. Diseases associated with GPR87 include Squamous Cell Carcinoma. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot for GPR87 Gene

  • Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.

Gene Wiki entry for GPR87 Gene

Additional gene information for GPR87 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR87 Gene

Genomics for GPR87 Gene

GeneHancer (GH) Regulatory Elements for GPR87 Gene

Promoters and enhancers for GPR87 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J151314 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 657 +1.0 997 3 SMARCE1 ESRRA JUN CEBPB DPF2 ELF1 CEBPG EP300 RFX5 JUND GPR87 P2RY14 PIR58282 MED12L
GH03J151274 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.8 +39.1 39112 6.1 MEIS2 JUNB BATF RELA SCRT2 ETV6 RUNX3 SPI1 P2RY14 GC03P151277 GPR87 P2RY13 EIF2A MED12L
GH03J151264 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +51.1 51053 2.2 RFX1 BCL11A EBF1 BMI1 IRF4 SPI1 P2RY14 GPR87 SETP11 GC03P151250 MED12L
GH03J151345 Enhancer 0.9 FANTOM5 Ensembl ENCODE 19.2 -29.9 -29894 2.5 POLR2A MAX MYC P2RY13 GPR87 P2RY14 P2RY12 CLRN1 MED12L
GH03J151382 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 10.5 -66.8 -66787 2.9 PKNOX1 EBF1 BATF RELA NFATC1 EED ATF7 ETV6 IKZF2 RUNX3 P2RY12 GPR87 P2RY13 MED12L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR87 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR87 gene promoter:
  • PPAR-alpha
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for GPR87 Gene

Genomic Locations for GPR87 Gene
22,867 bases
Minus strand
22,867 bases
Minus strand

Genomic View for GPR87 Gene

Genes around GPR87 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR87 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR87 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR87 Gene

Proteins for GPR87 Gene

  • Protein details for GPR87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 87
    Protein Accession:
    Secondary Accessions:
    • Q5KU35
    • Q96JZ8
    • Q9BXC2

    Protein attributes for GPR87 Gene

    358 amino acids
    Molecular mass:
    41436 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK29069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR87 Gene

Post-translational modifications for GPR87 Gene

  • Glycosylation at Asn33, isoforms=25, and Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR87 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR87 Gene

Domains & Families for GPR87 Gene

Gene Families for GPR87 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR87 Gene

Suggested Antigen Peptide Sequences for GPR87 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR87: view

Function for GPR87 Gene

Molecular function for GPR87 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.
UniProtKB/Swiss-Prot Induction:
By expression of p53/TP53 and by DNA damage in a TP53-dependent manner.

Gene Ontology (GO) - Molecular Function for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR87: view
genes like me logo Genes that share phenotypes with GPR87: view

Animal Models for GPR87 Gene

MGI Knock Outs for GPR87:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR87

miRNA for GPR87 Gene

miRTarBase miRNAs that target GPR87

Clone Products

  • Addgene plasmids for GPR87

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR87 Gene

Localization for GPR87 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR87 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR87 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR87: view

Pathways & Interactions for GPR87 Gene

genes like me logo Genes that share pathways with GPR87: view

Pathways by source for GPR87 Gene

1 BioSystems pathway for GPR87 Gene

Interacting Proteins for GPR87 Gene

Gene Ontology (GO) - Biological Process for GPR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
GO:0008150 biological_process ND --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR87: view

No data available for SIGNOR curated interactions for GPR87 Gene

Drugs & Compounds for GPR87 Gene

(3) Drugs for GPR87 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ki16425 Pharma Antagonist LPA receptor antagonist 0
LPA Pharma Agonist 0

(1) Additional Compounds for GPR87 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dioctanoy?aelglycerol?ae pyrophos?aephate
genes like me logo Genes that share compounds with GPR87: view

Transcripts for GPR87 Gene

mRNA/cDNA for GPR87 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR87 Gene

G protein-coupled receptor 87:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR87

Alternative Splicing Database (ASD) splice patterns (SP) for GPR87 Gene

No ASD Table

Relevant External Links for GPR87 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR87 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR87 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR87 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.7), Skin - Sun Exposed (Lower leg) (x10.1), Skin - Not Sun Exposed (Suprapubic) (x9.6), Vagina (x7.0), and Minor Salivary Gland (x4.3).

Protein differential expression in normal tissues from HIPED for GPR87 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR87 Gene

Protein tissue co-expression partners for GPR87 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR87 Gene:


SOURCE GeneReport for Unigene cluster for GPR87 Gene:


mRNA Expression by UniProt/SwissProt for GPR87 Gene:

Tissue specificity: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.

Evidence on tissue expression from TISSUES for GPR87 Gene

  • Lung(4.3)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with GPR87: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR87 Gene

Orthologs for GPR87 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR87 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR87 34 33
  • 99.35 (n)
(Canis familiaris)
Mammalia GPR87 34 33
  • 90.5 (n)
(Ornithorhynchus anatinus)
Mammalia GPR87 34
  • 88 (a)
(Bos Taurus)
Mammalia GPR87 34 33
  • 87.8 (n)
(Mus musculus)
Mammalia Gpr87 16 34 33
  • 85.35 (n)
(Rattus norvegicus)
Mammalia Gpr87 33
  • 84.09 (n)
(Monodelphis domestica)
Mammalia GPR87 34
  • 84 (a)
(Gallus gallus)
Aves GPR87 34 33
  • 72.85 (n)
(Anolis carolinensis)
Reptilia GPR87 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr87 33
  • 65.53 (n)
(Danio rerio)
Actinopterygii si:dkey-83h2.2 34
  • 29 (a)
CR626884.1 34
  • 26 (a)
si:ch73-309g22.1 34
  • 21 (a)
Species where no ortholog for GPR87 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR87 Gene

Gene Tree for GPR87 (if available)
Gene Tree for GPR87 (if available)
Evolutionary constrained regions (ECRs) for GPR87: view image

Paralogs for GPR87 Gene

Paralogs for GPR87 Gene

(10) SIMAP similar genes for GPR87 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR87: view

Variants for GPR87 Gene

Sequence variations from dbSNP and Humsavar for GPR87 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_035760 A colorectal cancer sample p.Asp191Tyr
rs1000156578 -- 151,310,394(-) T/C intron_variant
rs1000223751 -- 151,311,996(-) C/A intron_variant
rs1000237872 -- 151,299,151(-) A/G intron_variant
rs1000474755 -- 151,317,237(-) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR87 Gene

Variant ID Type Subtype PubMed ID
esv2726054 CNV deletion 23290073
esv2726055 CNV deletion 23290073
esv3598173 CNV loss 21293372
nsv592045 CNV gain 21841781
nsv954492 CNV duplication 24416366

Variation tolerance for GPR87 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR87 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR87 Gene

Disorders for GPR87 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR87 Gene - From: GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma
  • epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search GPR87 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR87

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR87: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR87 Gene

Publications for GPR87 Gene

  1. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. (PMID: 19602589) Zhang Y … Chen X (Cancer research 2009) 3 4 22 58
  2. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T … Hellebrand S (Journal of molecular biology 2001) 2 3 4 58
  3. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. (PMID: 17905198) Tabata K … Fujita N (Biochemical and biophysical research communications 2007) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPR87 Gene

Sources for GPR87 Gene

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