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Aliases for GPR85 Gene

Aliases for GPR85 Gene

  • G Protein-Coupled Receptor 85 2 3 5
  • Super Conserved Receptor Expressed In Brain 2 3 4
  • SREB2 3 4
  • Probable G-Protein Coupled Receptor 85 3
  • Seven Transmembrane Helix Receptor 3
  • SREB 3

External Ids for GPR85 Gene

Previous GeneCards Identifiers for GPR85 Gene

  • GC07M111205
  • GC07M112267
  • GC07M112280
  • GC07M112314
  • GC07M112507
  • GC07M112720
  • GC07M107088

Summaries for GPR85 Gene

Entrez Gene Summary for GPR85 Gene

  • Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]

GeneCards Summary for GPR85 Gene

GPR85 (G Protein-Coupled Receptor 85) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR173.

UniProtKB/Swiss-Prot for GPR85 Gene

  • Orphan receptor.

Gene Wiki entry for GPR85 Gene

Additional gene information for GPR85 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR85 Gene

Genomics for GPR85 Gene

GeneHancer (GH) Regulatory Elements for GPR85 Gene

Promoters and enhancers for GPR85 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J113085 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.5 +0.6 589 2.8 PKNOX1 ATF1 ZNF2 ZNF766 GLIS2 GATA2 FOS ATF7 KLF13 MCM3 GPR85 TMEM168 SMIM30 ENSG00000279288
GH07J112448 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 +636.5 636526 6 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN IFRD1 LSMEM1 MTCYBP24 MTND5P8 MTND6P24 LOC101928012 ENSG00000270997 TMEM168 GPR85 IMMP2L
GH07J113117 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7 -30.4 -30424 2.1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 SMIM30 TMEM168 GPR85 ENSG00000225457
GH07J113460 Enhancer 0.6 FANTOM5 1.9 -372.5 -372480 0.3 RXRA YY1 NR2F2 SP1 JUND ATF3 HNF4G HNF4A ZBTB33 GPR85 GC07M113450 GC07P113463
GH07J113100 Enhancer 0.6 ENCODE 0.4 -12.5 -12526 0.9 MEIS2 PKNOX1 ZSCAN4 NFIC POLR2A CBX5 RCOR1 EMSY MAFK CHD2 ENSG00000225457 SMIM30 GPR85
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR85 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR85 gene promoter:
  • CUTL1
  • SRY
  • POU3F2
  • RSRFC4
  • POU2F1a
  • POU2F1
  • ATF-2
  • Evi-1
  • S8
  • GR

Genomic Locations for GPR85 Gene

Genomic Locations for GPR85 Gene
9,448 bases
Minus strand
9,448 bases
Minus strand

Genomic View for GPR85 Gene

Genes around GPR85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR85 Gene

Proteins for GPR85 Gene

  • Protein details for GPR85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 85
    Protein Accession:
    Secondary Accessions:
    • Q9JHI6
    • Q9NPD1

    Protein attributes for GPR85 Gene

    370 amino acids
    Molecular mass:
    41995 Da
    Quaternary structure:
    • Interacts with DLG4 AND DLG3.

neXtProt entry for GPR85 Gene

Post-translational modifications for GPR85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPR85 Gene

Domains & Families for GPR85 Gene

Gene Families for GPR85 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR85 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR85: view

Function for GPR85 Gene

Molecular function for GPR85 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR85 Gene

Gene Ontology (GO) - Molecular Function for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS,IEA 10833454
GO:0005515 protein binding IPI 25780553
genes like me logo Genes that share ontologies with GPR85: view
genes like me logo Genes that share phenotypes with GPR85: view

Animal Models for GPR85 Gene

MGI Knock Outs for GPR85:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR85

Clone Products

  • Addgene plasmids for GPR85

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR85 Gene

Localization for GPR85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR85 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR85 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 25780553
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR85: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR85 Gene

Pathways & Interactions for GPR85 Gene

genes like me logo Genes that share pathways with GPR85: view

Pathways by source for GPR85 Gene

1 BioSystems pathway for GPR85 Gene

Interacting Proteins for GPR85 Gene

Gene Ontology (GO) - Biological Process for GPR85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10833454
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR85: view

No data available for SIGNOR curated interactions for GPR85 Gene

Drugs & Compounds for GPR85 Gene

No Compound Related Data Available

Transcripts for GPR85 Gene

Unigene Clusters for GPR85 Gene

G protein-coupled receptor 85:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR85

Clone Products

  • Addgene plasmids for GPR85

Alternative Splicing Database (ASD) splice patterns (SP) for GPR85 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - -

Relevant External Links for GPR85 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR85 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR85 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR85 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPR85 Gene:


SOURCE GeneReport for Unigene cluster for GPR85 Gene:


mRNA Expression by UniProt/SwissProt for GPR85 Gene:

Tissue specificity: Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.

Evidence on tissue expression from TISSUES for GPR85 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with GPR85: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR85 Gene

Orthologs for GPR85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR85 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR85 34 33
  • 99.64 (n)
(Monodelphis domestica)
Mammalia GPR85 34
  • 99 (a)
(Bos Taurus)
Mammalia GPR85 34 33
  • 97.48 (n)
(Canis familiaris)
Mammalia GPR85 34 33
  • 97.21 (n)
(Rattus norvegicus)
Mammalia Gpr85 33
  • 95.59 (n)
(Mus musculus)
Mammalia Gpr85 16 34 33
  • 94.95 (n)
(Ornithorhynchus anatinus)
Mammalia GPR85 34
  • 94 (a)
(Gallus gallus)
Aves GPR85 34 33
  • 91.17 (n)
(Anolis carolinensis)
Reptilia GPR85 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr85 33
  • 87.39 (n)
(Danio rerio)
Actinopterygii gpr85 34 33
  • 77.66 (n)
sreb2 33
Species where no ortholog for GPR85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR85 Gene

Gene Tree for GPR85 (if available)
Gene Tree for GPR85 (if available)
Evolutionary constrained regions (ECRs) for GPR85: view image

Paralogs for GPR85 Gene

Paralogs for GPR85 Gene

(7) SIMAP similar genes for GPR85 Gene using alignment to 5 proteins:

  • A4D0T8_HUMAN
genes like me logo Genes that share paralogs with GPR85: view

Variants for GPR85 Gene

Sequence variations from dbSNP and Humsavar for GPR85 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000158609 -- 113,089,657(-) C/A upstream_transcript_variant
rs1000858246 -- 113,081,920(-) C/T 3_prime_UTR_variant
rs1000938943 -- 113,086,843(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001531956 -- 113,089,203(-) A/G upstream_transcript_variant
rs1002157413 -- 113,085,032(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR85 Gene

Variant ID Type Subtype PubMed ID
esv2759556 CNV gain 17122850
nsv435847 CNV deletion 17901297
nsv464689 CNV gain 19166990
nsv5907 CNV insertion 18451855
nsv608226 CNV gain 21841781
nsv7405 OTHER inversion 18451855

Variation tolerance for GPR85 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR85 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR85 Gene

Disorders for GPR85 Gene

Additional Disease Information for GPR85

No disorders were found for GPR85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR85 Gene

Publications for GPR85 Gene

  1. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. (PMID: 10833454) Matsumoto M … Furuichi K (Biochemical and biophysical research communications 2000) 2 3 4 22 58
  2. The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. (PMID: 10978537) Hellebrand S … Wittenberger T (Biochimica et biophysica acta 2000) 2 3 4 58
  3. The association of GPR85 with PSD-95-neuroligin complex and autism spectrum disorder: a molecular analysis. (PMID: 25780553) Fujita-Jimbo E … Momoi T (Molecular autism 2015) 3 4 58
  4. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 44 58
  5. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. (PMID: 15893849) Matsumoto M … Kleinman JE (Brain research. Molecular brain research 2005) 3 22 58

Products for GPR85 Gene

  • Addgene plasmids for GPR85

Sources for GPR85 Gene

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