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Aliases for GPR84 Gene

Aliases for GPR84 Gene

  • G Protein-Coupled Receptor 84 2 3 5
  • EX33 3 4
  • Inflammation-Related G Protein-Coupled Receptor EX33 3
  • Inflammation-Related G-Protein Coupled Receptor EX33 4
  • G-Protein Coupled Receptor 84 3
  • GPCR4 3

External Ids for GPR84 Gene

Previous GeneCards Identifiers for GPR84 Gene

  • GC12M054882
  • GC12M054472
  • GC12M053042
  • GC12M054756
  • GC12M051796

Summaries for GPR84 Gene

GeneCards Summary for GPR84 Gene

GPR84 (G Protein-Coupled Receptor 84) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for GPR84 Gene

  • Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.

Gene Wiki entry for GPR84 Gene

Additional gene information for GPR84 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR84 Gene

Genomics for GPR84 Gene

GeneHancer (GH) Regulatory Elements for GPR84 Gene

Promoters and enhancers for GPR84 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J054362 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 656.9 +1.3 1252 2.4 MAX REST POLR2A IKZF1 EED ETV6 PRDM1 RUNX3 IKZF2 GPR84 ENSG00000258086 ENSG00000258137 LOC102724050
GH12J054407 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.5 -50.5 -50535 16.8 HDGF PKNOX1 SMAD1 SIN3A YBX1 YY1 POLR2B FOS SP3 REST ITGA5 NCKAP1L GPR84 ZNF385A GTSF1 PHC1P1 MAP3K12 ENSG00000260470 CALCOCO1 GC12P054401
GH12J054354 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25.7 +7.3 7251 6.6 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 MCM3 SP3 NFYC SP1 PCBP2 ENSG00000258344 CBX5 GPR84 ZNF385A MAP3K12 ATF7 LOC100652999 HNRNPA1
GH12J054381 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 15.9 -21.5 -21488 10.5 HDGF PKNOX1 CLOCK IRF4 FOS SP3 ZNF592 SMARCA4 GLIS1 ZNF624 ZNF385A LOC105378250 GPR84 OR6C74 OR10A7 MAP3K12 MIR148B ITGA5 RNU6-950P COPZ1
GH12J054291 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.5 +68.1 68141 11.8 HDGF PKNOX1 SMAD1 ARNT ARID4B YBX1 DMAP1 ZNF2 POLR2B ZNF766 NFE2 HNRNPA1 RNU6-950P AAAS MIR148B GPR84 ZNF385A LOC100652999 FLJ12825 GTSF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR84 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR84 gene promoter:
  • STAT1
  • Zic3
  • c-Ets-1
  • p53
  • GATA-2
  • FOXD3
  • C/EBPalpha
  • NF-1
  • STAT1alpha
  • STAT1beta

Genomic Locations for GPR84 Gene

Genomic Locations for GPR84 Gene
chr12:54,350,784-54,365,253
(GRCh38/hg38)
Size:
14,470 bases
Orientation:
Minus strand
chr12:54,756,229-54,758,271
(GRCh37/hg19)
Size:
2,043 bases
Orientation:
Minus strand

Genomic View for GPR84 Gene

Genes around GPR84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR84 Gene

Proteins for GPR84 Gene

  • Protein details for GPR84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQS5-GPR84_HUMAN
    Recommended name:
    G-protein coupled receptor 84
    Protein Accession:
    Q9NQS5
    Secondary Accessions:
    • B6V9G7

    Protein attributes for GPR84 Gene

    Size:
    396 amino acids
    Molecular mass:
    43705 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR84 Gene

Post-translational modifications for GPR84 Gene

  • Glycosylation at Asn8 and Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR84 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR84 Gene

Domains & Families for GPR84 Gene

Gene Families for GPR84 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR84 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR84 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQS5

UniProtKB/Swiss-Prot:

GPR84_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR84: view

Function for GPR84 Gene

Molecular function for GPR84 Gene

UniProtKB/Swiss-Prot Function:
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
UniProtKB/Swiss-Prot Induction:
By bacterial lipopolysaccharides (LPS) in the monocytic leukemia cell line THP-1.

Phenotypes From GWAS Catalog for GPR84 Gene

Gene Ontology (GO) - Molecular Function for GPR84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001604 urotensin II receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004966 galanin receptor activity IBA --
GO:0008528 G-protein coupled peptide receptor activity IBA --
genes like me logo Genes that share ontologies with GPR84: view
genes like me logo Genes that share phenotypes with GPR84: view

Animal Models for GPR84 Gene

MGI Knock Outs for GPR84:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR84

Clone Products

  • Addgene plasmids for GPR84

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR84 Gene

Localization for GPR84 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR84 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR84 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with GPR84: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR84 Gene

Pathways & Interactions for GPR84 Gene

genes like me logo Genes that share pathways with GPR84: view

Pathways by source for GPR84 Gene

Gene Ontology (GO) - Biological Process for GPR84 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR84: view

No data available for SIGNOR curated interactions for GPR84 Gene

Drugs & Compounds for GPR84 Gene

(8) Drugs for GPR84 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lauric acid Approved, Experimental Pharma Agonist 0
2-hydroxy capric acid Pharma Full agonist, Agonist 0
3-hydroxy capric acid Pharma Full agonist, Agonist 0
6-n-octylaminouracil Pharma Full agonist, Agonist 0
decanoic acid Pharma Full agonist, Agonist 154

(2) Additional Compounds for GPR84 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-hydroxy lauric acid
Full agonist, Agonist
3-hydroxy lauric acid
Full agonist, Agonist
genes like me logo Genes that share compounds with GPR84: view

Transcripts for GPR84 Gene

mRNA/cDNA for GPR84 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR84 Gene

G protein-coupled receptor 84:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR84

Alternative Splicing Database (ASD) splice patterns (SP) for GPR84 Gene

No ASD Table

Relevant External Links for GPR84 Gene

GeneLoc Exon Structure for
GPR84
ECgene alternative splicing isoforms for
GPR84

Expression for GPR84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR84 Gene

mRNA differential expression in normal tissues according to GTEx for GPR84 Gene

This gene is overexpressed in Whole Blood (x32.4).

Protein differential expression in normal tissues from HIPED for GPR84 Gene

This gene is overexpressed in Cervix (56.5) and Peripheral blood mononuclear cells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR84 Gene



Protein tissue co-expression partners for GPR84 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR84 Gene:

GPR84

SOURCE GeneReport for Unigene cluster for GPR84 Gene:

Hs.306199

mRNA Expression by UniProt/SwissProt for GPR84 Gene:

Q9NQS5-GPR84_HUMAN
Tissue specificity: Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peripheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes.

Evidence on tissue expression from TISSUES for GPR84 Gene

  • Heart(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GPR84: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR84 Gene

Orthologs for GPR84 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR84 34 33
  • 99.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR84 34 33
  • 88.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR84 34 33
  • 84.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr84 16 34 33
  • 84.01 (n)
rat
(Rattus norvegicus)
Mammalia Gpr84 33
  • 83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR84 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR84 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr84 33
  • 61.69 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr84 34 33
  • 54.7 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tre1 34 33
  • 46.61 (n)
OneToMany
EG:22E5.11 35
  • 26 (a)
CG4313 34
  • 16 (a)
OneToMany
moody 34
  • 14 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004930 33
  • 42.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
-- 34
  • 20 (a)
OneToMany
Species where no ortholog for GPR84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR84 Gene

ENSEMBL:
Gene Tree for GPR84 (if available)
TreeFam:
Gene Tree for GPR84 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR84: view image

Paralogs for GPR84 Gene

No data available for Paralogs for GPR84 Gene

Variants for GPR84 Gene

Sequence variations from dbSNP and Humsavar for GPR84 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001211370 -- 54,363,426(-) C/T coding_sequence_variant, synonymous_variant
rs1002951924 -- 54,365,196(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1004708660 -- 54,366,627(-) C/T upstream_transcript_variant
rs1004762387 -- 54,366,212(-) T/C/G upstream_transcript_variant
rs1005334499 -- 54,366,296(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR84 Gene

Variant ID Type Subtype PubMed ID
nsv1049160 CNV gain 25217958
nsv559000 CNV loss 21841781

Variation tolerance for GPR84 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR84

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR84 Gene

Disorders for GPR84 Gene

Additional Disease Information for GPR84

No disorders were found for GPR84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR84 Gene

Publications for GPR84 Gene

  1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T … Hellebrand S (Journal of molecular biology 2001) 2 3 4 58
  2. Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes. (PMID: 11404393) Yousefi S … Jarai G (Journal of leukocyte biology 2001) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GPR84 Gene

Sources for GPR84 Gene

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