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Aliases for GPR83 Gene

Aliases for GPR83 Gene

  • G Protein-Coupled Receptor 83 2 3 5
  • G-Protein Coupled Receptor 72 3 4
  • GPR72 3 4
  • Probable G-Protein Coupled Receptor 83 3
  • Glucocorticoid Induced Receptor 3
  • G Protein-Coupled Receptor 72 2
  • KIAA1540 4
  • GIR 3

External Ids for GPR83 Gene

Previous HGNC Symbols for GPR83 Gene

  • GPR72

Previous GeneCards Identifiers for GPR83 Gene

  • GC11U990275
  • GC11M093798
  • GC11M093750
  • GC11M094110
  • GC11M090176

Summaries for GPR83 Gene

GeneCards Summary for GPR83 Gene

GPR83 (G Protein-Coupled Receptor 83) is a Protein Coding gene. Among its related pathways are GPCRs, Other and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is TACR3.

UniProtKB/Swiss-Prot for GPR83 Gene

  • Orphan receptor. Could be a neuropeptide Y receptor.

Gene Wiki entry for GPR83 Gene

Additional gene information for GPR83 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR83 Gene

Genomics for GPR83 Gene

GeneHancer (GH) Regulatory Elements for GPR83 Gene

Promoters and enhancers for GPR83 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J094400 Promoter/Enhancer 1.1 EPDnew Ensembl 650.7 +0.0 27 1.1 ZIC2 GABPA ZFP69B ZNF335 ZFHX2 GLIS2 POLR2A ZNF512 ZNF341 ZBTB26 GPR83 ANKRD49 MRE11 GC11M094380 GC11M094381
GH11J094199 Enhancer 0.9 ENCODE 22.3 +200.8 200774 2.2 FOXA2 MLX BMI1 RAD21 RARA ETS1 YY1 FOS CREM THAP11 LOC105369435 GC11P094202 GPR83 PANX1 GC11P094183
GH11J094183 Enhancer 0.9 Ensembl ENCODE 8.3 +217.3 217305 0.6 CTCF TEAD4 MAX IRF4 RAD21 TEAD3 ZNF335 POLR2A ZNF143 SMC3 GC11P094183 GPR83 PANX1 GC11M094189
GH11J093523 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.3 +876.2 876210 4.4 HDGF PKNOX1 FOXA2 RAD21 RARA YY1 BCLAF1 IKZF2 RUNX3 EGR2 SMCO4 SLC36A4 GPR83 DEUP1 MED17 SRP14P2 GC11M093919
GH11J094303 Enhancer 0.5 Ensembl ENCODE 8.3 +97.1 97130 2.2 MNT IZUMO1R GPR83 MRE11 ENSG00000255893 LOC105369435 GC11P094202 GC11P094183
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR83 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR83 gene promoter:
  • Pax-3
  • PPAR-gamma2
  • PPAR-gamma1
  • Meis-1
  • Meis-1b
  • Meis-1a
  • MZF-1
  • CUTL1
  • FOXO4
  • SREBP-1a

Genomic Locations for GPR83 Gene

Genomic Locations for GPR83 Gene
24,109 bases
Minus strand
24,109 bases
Minus strand

Genomic View for GPR83 Gene

Genes around GPR83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR83 Gene

Proteins for GPR83 Gene

  • Protein details for GPR83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 83
    Protein Accession:
    Secondary Accessions:
    • B0M0K5
    • Q6NWR4
    • Q9P1Y8

    Protein attributes for GPR83 Gene

    423 amino acids
    Molecular mass:
    48339 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA96064.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR83 Gene

Post-translational modifications for GPR83 Gene

  • Glycosylation at isoforms=134, Asn46, and isoforms=37
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR83 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR83 Gene

Domains & Families for GPR83 Gene

Gene Families for GPR83 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for GPR83 Gene

Suggested Antigen Peptide Sequences for GPR83 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR83: view

Function for GPR83 Gene

Molecular function for GPR83 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be a neuropeptide Y receptor.

Phenotypes From GWAS Catalog for GPR83 Gene

Gene Ontology (GO) - Molecular Function for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS 10760605
GO:0004983 neuropeptide Y receptor activity IEA --
genes like me logo Genes that share ontologies with GPR83: view
genes like me logo Genes that share phenotypes with GPR83: view

Animal Models for GPR83 Gene

MGI Knock Outs for GPR83:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR83

CRISPR Products

miRNA for GPR83 Gene

miRTarBase miRNAs that target GPR83

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR83

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR83 Gene

Localization for GPR83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR83 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR83 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0097730 non-motile cilium IEA --
genes like me logo Genes that share ontologies with GPR83: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR83 Gene

Pathways & Interactions for GPR83 Gene

genes like me logo Genes that share pathways with GPR83: view

Pathways by source for GPR83 Gene

Gene Ontology (GO) - Biological Process for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0051384 response to glucocorticoid IEA --
genes like me logo Genes that share ontologies with GPR83: view

No data available for SIGNOR curated interactions for GPR83 Gene

Drugs & Compounds for GPR83 Gene

(2) Drugs for GPR83 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibition, Inhibitor 425
Candesartan Experimental Pharma Antagonist Angiotensin II receptor 1 (AT1) antagonist 158
genes like me logo Genes that share compounds with GPR83: view

Transcripts for GPR83 Gene

mRNA/cDNA for GPR83 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR83 Gene

G protein-coupled receptor 83:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR83

Alternative Splicing Database (ASD) splice patterns (SP) for GPR83 Gene

No ASD Table

Relevant External Links for GPR83 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR83 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR83 Gene

mRNA differential expression in normal tissues according to GTEx for GPR83 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.3), Brain - Cerebellum (x10.7), and Brain - Hypothalamus (x4.4).

Protein differential expression in normal tissues from HIPED for GPR83 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR83 Gene

Protein tissue co-expression partners for GPR83 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR83 Gene:


SOURCE GeneReport for Unigene cluster for GPR83 Gene:


mRNA Expression by UniProt/SwissProt for GPR83 Gene:

Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for GPR83 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPR83: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR83 Gene

Orthologs for GPR83 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR83 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR83 34 33
  • 99.21 (n)
(Bos Taurus)
Mammalia GPR83 34
  • 91 (a)
(Canis familiaris)
Mammalia GPR83 34 33
  • 89.95 (n)
(Mus musculus)
Mammalia Gpr83 16 34 33
  • 86.06 (n)
(Rattus norvegicus)
Mammalia Gpr83 33
  • 86.03 (n)
(Monodelphis domestica)
Mammalia GPR83 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia GPR83 34
  • 74 (a)
(Gallus gallus)
Aves GPR83 34 33
  • 74.94 (n)
(Anolis carolinensis)
Reptilia GPR83 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486806 33
  • 71.87 (n)
(Danio rerio)
Actinopterygii GPR83 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta NepYr 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea npr-22 34
  • 22 (a)
Species where no ortholog for GPR83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR83 Gene

Gene Tree for GPR83 (if available)
Gene Tree for GPR83 (if available)
Evolutionary constrained regions (ECRs) for GPR83: view image

Paralogs for GPR83 Gene

Paralogs for GPR83 Gene

(18) SIMAP similar genes for GPR83 Gene using alignment to 3 proteins:

  • F5GZ43_HUMAN
  • Q6NWR3_HUMAN Pseudogenes for GPR83 Gene

genes like me logo Genes that share paralogs with GPR83: view

Variants for GPR83 Gene

Sequence variations from dbSNP and Humsavar for GPR83 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000255824 -- 94,397,030(-) T/C intron_variant
rs1000340762 -- 94,387,082(-) G/A/T intron_variant
rs1000369209 -- 94,385,433(-) G/T intron_variant
rs1000371783 -- 94,387,234(-) T/C intron_variant
rs1000384596 -- 94,392,612(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR83 Gene

Variant ID Type Subtype PubMed ID
esv2671948 CNV deletion 23128226
esv3627321 CNV loss 21293372
nsv523083 CNV gain 19592680
nsv832233 CNV gain 17160897

Variation tolerance for GPR83 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR83 Gene

Disorders for GPR83 Gene

Additional Disease Information for GPR83

No disorders were found for GPR83 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR83 Gene

Publications for GPR83 Gene

  1. Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. (PMID: 10760605) Parker R … Herzog H (Biochimica et biophysica acta 2000) 2 3 4 58
  2. Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83). (PMID: 11060465) De Moerlooze L … Parmentier M (Cytogenetics and cell genetics 2000) 2 3 22 58
  3. Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. (PMID: 20200545) Hansen W … Buer J (Genes and immunity 2010) 3 22 58
  4. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. (PMID: 16785516) Hansen W … Buer J (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 22 58
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58

Products for GPR83 Gene

Sources for GPR83 Gene

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