Aliases for GPR83 Gene

Aliases for GPR83 Gene

  • G Protein-Coupled Receptor 83 2 3 5
  • Probable G-Protein Coupled Receptor 83 3 4
  • G-Protein Coupled Receptor 72 3 4
  • GPR72 3 4
  • Glucocorticoid Induced Receptor 3
  • G Protein-Coupled Receptor 72 2
  • KIAA1540 4
  • GPR83 5
  • GIR 3

External Ids for GPR83 Gene

Previous HGNC Symbols for GPR83 Gene

  • GPR72

Previous GeneCards Identifiers for GPR83 Gene

  • GC11U990275
  • GC11M094295
  • GC11M093798
  • GC11M093750
  • GC11M094110
  • GC11M090176

Summaries for GPR83 Gene

GeneCards Summary for GPR83 Gene

GPR83 (G Protein-Coupled Receptor 83) is a Protein Coding gene. Diseases associated with GPR83 include Tick Infestation and Branchiootic Syndrome. Among its related pathways are Signaling by GPCR and GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PRLHR.

UniProtKB/Swiss-Prot Summary for GPR83 Gene

Gene Wiki entry for GPR83 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR83 Gene

Genomics for GPR83 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR83 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J094400 Promoter 1.1 EPDnew Ensembl 600.7 +0.0 18 1.2 ZNF512 ZIC2 EZH2 ZNF341 ZBTB20 GABPA ZBTB26 POLR2A ZBTB17 ZFHX2 GPR83 ANKRD49 MRE11 piR-57195-062 IZUMO1R
GH11J094402 Enhancer 0.7 Ensembl 600.7 -1.0 -982 0.4 GATAD2A RXRB CEBPA SOX13 FOXA2 TEAD1 SAP130 FOSL2 SMAD4 RARA GPR83 MRE11 HSALNG0086516 ANKRD49
GH11J094199 Enhancer 1 Ensembl ENCODE 22.3 +201.1 201119 3 GATAD2A TFE3 RFX1 RXRB REST SP1 CEBPA SOX13 RFX3 ETS1 lnc-GPR83-2 GPR83 PANX1 ENSG00000250519 LOC105369435 piR-55194-077 IZUMO1R
GH11J094192 Enhancer 0.5 Ensembl 20.2 +208.2 208218 1.6 JUND FOS FOSL2 RXRA ATF3 GPR83 ENSG00000250519 ARPC3P3 LOC105369435 PANX1 IZUMO1R
GH11J094183 Enhancer 0.9 Ensembl ENCODE 9.2 +216.0 216018 4 CTCF TEAD4 JUND FOXA1 ZNF143 REST RAD21 POLR2A TRIM22 CBX3 ENSG00000250519 MF281456 GPR83 PANX1 IZUMO1R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR83 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR83

Top Transcription factor binding sites by QIAGEN in the GPR83 gene promoter:
  • CUTL1
  • FOXO4
  • Meis-1
  • Meis-1a
  • Meis-1b
  • MZF-1
  • Pax-3
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1a

Genomic Locations for GPR83 Gene

Genomic Locations for GPR83 Gene
24,104 bases
Minus strand
24,109 bases
Minus strand

Genomic View for GPR83 Gene

Genes around GPR83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR83 Gene

Proteins for GPR83 Gene

  • Protein details for GPR83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 83
    Protein Accession:
    Secondary Accessions:
    • B0M0K5
    • Q6NWR4
    • Q9P1Y8

    Protein attributes for GPR83 Gene

    423 amino acids
    Molecular mass:
    48339 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA96064.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GPR83 Gene

Post-translational modifications for GPR83 Gene

  • Glycosylation at Asn37, Asn46, and Asn134
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR83 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR83 Gene

Domains & Families for GPR83 Gene

Gene Families for GPR83 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for GPR83 Gene

  • Neuropeptide Y receptor signature

Suggested Antigen Peptide Sequences for GPR83 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 72 (GPR83_HUMAN)
  • G protein-coupled receptor 83 (Q6NWR3_HUMAN)
  • Glucocorticoid induced receptor (Q9H011_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR83: view

Function for GPR83 Gene

Molecular function for GPR83 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be a neuropeptide Y receptor.

Phenotypes From GWAS Catalog for GPR83 Gene

Gene Ontology (GO) - Molecular Function for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,TAS 10760605
GO:0004983 neuropeptide Y receptor activity IEA --
genes like me logo Genes that share ontologies with GPR83: view
genes like me logo Genes that share phenotypes with GPR83: view

Animal Models for GPR83 Gene

MGI Knock Outs for GPR83:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR83

CRISPR Products

miRNA for GPR83 Gene

miRTarBase miRNAs that target GPR83

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR83

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR83 Gene

Localization for GPR83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR83 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR83 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IDA 28154160
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0097730 non-motile cilium IEA --
genes like me logo Genes that share ontologies with GPR83: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR83 Gene

Pathways & Interactions for GPR83 Gene

genes like me logo Genes that share pathways with GPR83: view

Pathways by source for GPR83 Gene

Interacting Proteins for GPR83 Gene

Gene Ontology (GO) - Biological Process for GPR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0051384 response to glucocorticoid IEA --
genes like me logo Genes that share ontologies with GPR83: view

No data available for SIGNOR curated interactions for GPR83 Gene

Drugs & Compounds for GPR83 Gene

(2) Drugs for GPR83 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibitor, Inhibition 453
Candesartan Experimental Pharma Antagonist Angiotensin II receptor 1 (AT1) antagonist 176
genes like me logo Genes that share compounds with GPR83: view

Transcripts for GPR83 Gene

mRNA/cDNA for GPR83 Gene

9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR83

Alternative Splicing Database (ASD) splice patterns (SP) for GPR83 Gene

No ASD Table

Relevant External Links for GPR83 Gene

GeneLoc Exon Structure for

Expression for GPR83 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR83 Gene

mRNA differential expression in normal tissues according to GTEx for GPR83 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.3), Brain - Cerebellum (x10.7), and Brain - Hypothalamus (x4.4).

Protein differential expression in normal tissues from HIPED for GPR83 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR83 Gene

Protein tissue co-expression partners for GPR83 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR83

SOURCE GeneReport for Unigene cluster for GPR83 Gene:


mRNA Expression by UniProt/SwissProt for GPR83 Gene:

Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for GPR83 Gene

  • Nervous system(4.6)
  • Blood(2.2)
  • Intestine(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with GPR83: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR83 Gene

Orthologs for GPR83 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR83 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR83 30 31
  • 99.21 (n)
(Bos Taurus)
Mammalia GPR83 31
  • 91 (a)
(Canis familiaris)
Mammalia GPR83 30 31
  • 89.95 (n)
(Mus musculus)
Mammalia Gpr83 30 17 31
  • 86.06 (n)
(Rattus norvegicus)
Mammalia Gpr83 30
  • 86.03 (n)
(Monodelphis domestica)
Mammalia GPR83 31
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia GPR83 31
  • 74 (a)
(Gallus gallus)
Aves GPR83 30 31
  • 74.94 (n)
(Anolis carolinensis)
Reptilia GPR83 31
  • 53 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100486806 30
  • 71.87 (n)
(Danio rerio)
Actinopterygii GPR83 31
  • 61 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta NepYr 31
  • 24 (a)
(Caenorhabditis elegans)
Secernentea npr-22 31
  • 22 (a)
Species where no ortholog for GPR83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GPR83 Gene

Gene Tree for GPR83 (if available)
Gene Tree for GPR83 (if available)
Evolutionary constrained regions (ECRs) for GPR83: view image

Paralogs for GPR83 Gene

(18) SIMAP similar genes for GPR83 Gene using alignment to 3 proteins:

  • F5GZ43_HUMAN
  • Q6NWR3_HUMAN Pseudogenes for GPR83 Gene

genes like me logo Genes that share paralogs with GPR83: view

Variants for GPR83 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR83 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
734557 Likely Benign: not provided 94,401,031(-) G/A SYNONYMOUS_VARIANT
782544 Benign: not provided 94,380,767(-) G/T MISSENSE_VARIANT
rs3740868 - p.Pro374Gln

Additional dbSNP identifiers (rs#s) for GPR83 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR83 Gene

Variant ID Type Subtype PubMed ID
esv2671948 CNV deletion 23128226
esv3627321 CNV loss 21293372
nsv523083 CNV gain 19592680
nsv832233 CNV gain 17160897

Variation tolerance for GPR83 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR83 Gene

Disorders for GPR83 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GPR83 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tick infestation
  • tick infestations
branchiootic syndrome
  • branchiootic syndrome 1
epidermolysis bullosa, junctional, herlitz type
  • epidermolysis bullosa junctionalis, herlitz type
- elite association - COSMIC cancer census association via MalaCards
Search GPR83 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with GPR83: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR83 Gene

Publications for GPR83 Gene

  1. Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. (PMID: 10760605) Parker R … Herzog H (Biochimica et biophysica acta 2000) 2 3 4
  2. Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83). (PMID: 11060465) De Moerlooze L … Parmentier M (Cytogenetics and cell genetics 2000) 2 3 23
  3. Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells. (PMID: 20200545) Hansen W … Buer J (Genes and immunity 2010) 3 23
  4. G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. (PMID: 16785516) Hansen W … Buer J (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4

Products for GPR83 Gene

Sources for GPR83 Gene