The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011] See more...

Aliases for GPR82 Gene

Aliases for GPR82 Gene

  • G Protein-Coupled Receptor 82 2 3 5
  • Probable G-Protein Coupled Receptor 82 3 4

External Ids for GPR82 Gene

Previous GeneCards Identifiers for GPR82 Gene

  • GC0XP039612
  • GC0XP039832
  • GC0XP040428
  • GC0XP040614
  • GC0XP041339
  • GC0XP041468
  • GC0XP041583
  • GC0XP039314

Summaries for GPR82 Gene

Entrez Gene Summary for GPR82 Gene

  • The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR82 Gene

GPR82 (G Protein-Coupled Receptor 82) is a Protein Coding gene. Diseases associated with GPR82 include Diaphragmatic Eventration. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot Summary for GPR82 Gene

Gene Wiki entry for GPR82 Gene

Additional gene information for GPR82 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR82 Gene

Genomics for GPR82 Gene

GeneHancer (GH) Regulatory Elements for GPR82 Gene

Promoters and enhancers for GPR82 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ041724 Promoter 0.9 EPDnew Ensembl 500.7 +0.3 346 1.4 SPI1 ATF2 MEF2A MTA2 RUNX3 GPR82 CASK lnc-GPR34-1
GH0XJ041723 Promoter 0.3 Ensembl 500.7 -0.7 -654 0.2 GPR82 piR-30876-114 CASK
GH0XJ041722 Promoter 0.3 Ensembl 500.7 -1.3 -1254 0.2 GPR82 piR-30876-114 CASK
GH0XJ041690 Promoter 1 EPDnew Ensembl 14.1 -34.6 -34554 2.4 JUND FOXM1 RXRA MAX HNF4A EGR1 SP1 FOXA2 GPR34 GPR82 RF00017-8335 CASK
GH0XJ041556 Enhancer 1 Ensembl ENCODE 13.5 -165.1 -165054 6.6 CTCF JUND FOS EP300 TRIM28 REST RAD21 SMC3 MYNN TCF12 GPR82 CASK-AS1 RF00026-1158 RNU6-1321P CASK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR82 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR82

Top Transcription factor binding sites by QIAGEN in the GPR82 gene promoter:
  • AML1a
  • AP-1
  • E47
  • Evi-1
  • GR
  • Hand1
  • Meis-1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for GPR82 Gene

Genomic Locations for GPR82 Gene
chrX:41,724,155-41,730,135
(GRCh38/hg38)
Size:
5,981 bases
Orientation:
Plus strand
chrX:41,583,408-41,589,388
(GRCh37/hg19)
Size:
5,981 bases
Orientation:
Plus strand

Genomic View for GPR82 Gene

Genes around GPR82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR82 Gene

Proteins for GPR82 Gene

  • Protein details for GPR82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P67-GPR82_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 82
    Protein Accession:
    Q96P67
    Secondary Accessions:
    • Q5VT13

    Protein attributes for GPR82 Gene

    Size:
    336 amino acids
    Molecular mass:
    38409 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR82 Gene

Post-translational modifications for GPR82 Gene

  • Glycosylation at Asn3 and Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR82 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR82 Gene

Domains & Families for GPR82 Gene

Gene Families for GPR82 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR82 Gene

Suggested Antigen Peptide Sequences for GPR82 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 82 (GPR82_HUMAN)
  • cDNA, FLJ94295, Homo sapiens G protein-coupled receptor 82 (GPR82), mRNA (Q5VT13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96P67

UniProtKB/Swiss-Prot:

GPR82_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR82: view

Function for GPR82 Gene

Molecular function for GPR82 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR82: view
genes like me logo Genes that share phenotypes with GPR82: view

Animal Models for GPR82 Gene

MGI Knock Outs for GPR82:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR82

Clone Products

  • Addgene plasmids for GPR82

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR82 Gene

Localization for GPR82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR82 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR82 gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for GPR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR82: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR82 Gene

Pathways & Interactions for GPR82 Gene

PathCards logo

SuperPathways for GPR82 Gene

No Data Available

Interacting Proteins for GPR82 Gene

;

Gene Ontology (GO) - Biological Process for GPR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR82: view

No data available for Pathways by source and SIGNOR curated interactions for GPR82 Gene

Drugs & Compounds for GPR82 Gene

No Compound Related Data Available

Transcripts for GPR82 Gene

mRNA/cDNA for GPR82 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GPR82

Alternative Splicing Database (ASD) splice patterns (SP) for GPR82 Gene

No ASD Table

Relevant External Links for GPR82 Gene

GeneLoc Exon Structure for
GPR82

Expression for GPR82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR82 Gene

mRNA differential expression in normal tissues according to GTEx for GPR82 Gene

This gene is overexpressed in Whole Blood (x4.5) and Small Intestine - Terminal Ileum (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR82

SOURCE GeneReport for Unigene cluster for GPR82 Gene:

Hs.567457

Evidence on tissue expression from TISSUES for GPR82 Gene

  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with GPR82: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR82 Gene

Orthologs for GPR82 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR82 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR82 31 30
  • 99.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR82 31 30
  • 89.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR82 31 30
  • 87.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr82 17 31 30
  • 86.34 (n)
rat
(Rattus norvegicus)
Mammalia Gpr82 30
  • 85.22 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR82 31
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR82 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR82 31 30
  • 60.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 18 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr82 30
  • 53.84 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883502 30
  • 47.54 (n)
GPR82 31
  • 18 (a)
OneToOne
Species where no ortholog for GPR82 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR82 Gene

ENSEMBL:
Gene Tree for GPR82 (if available)
TreeFam:
Gene Tree for GPR82 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR82: view image

Paralogs for GPR82 Gene

(1) SIMAP similar genes for GPR82 Gene using alignment to 1 proteins:

  • GPR82_HUMAN
genes like me logo Genes that share paralogs with GPR82: view

Variants for GPR82 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR82 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs1023065 Likely Benign: not specified 41,727,965(+) T/C SYNONYMOUS_VARIANT,INTRON_VARIANT
rs137964251 Likely Benign: not provided 41,727,704(+) C/A MISSENSE_VARIANT,INTRON_VARIANT
rs146786893 Likely Benign: not provided 41,727,580(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
rs193921104 Uncertain Significance: Malignant tumor of prostate 41,727,508(+) G/T MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GPR82 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR82 Gene

Variant ID Type Subtype PubMed ID
esv33720 CNV loss 17666407
nsv523134 CNV gain 19592680

Variation tolerance for GPR82 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR82 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR82

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR82 Gene

Disorders for GPR82 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR82 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diaphragmatic eventration
- elite association - COSMIC cancer census association via MalaCards
Search GPR82 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR82

genes like me logo Genes that share disorders with GPR82: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR82 Gene

Publications for GPR82 Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 54
  4. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey PS … Stratton MR (Nature genetics 2009) 3 54
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 54

Products for GPR82 Gene

Sources for GPR82 Gene