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Aliases for GPR82 Gene

Aliases for GPR82 Gene

  • G Protein-Coupled Receptor 82 2 3 5
  • Probable G-Protein Coupled Receptor 82 3

External Ids for GPR82 Gene

Previous GeneCards Identifiers for GPR82 Gene

  • GC0XP039612
  • GC0XP039832
  • GC0XP040428
  • GC0XP040614
  • GC0XP041339
  • GC0XP041468
  • GC0XP041583
  • GC0XP039314

Summaries for GPR82 Gene

Entrez Gene Summary for GPR82 Gene

  • The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR82 Gene

GPR82 (G Protein-Coupled Receptor 82) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR171.

UniProtKB/Swiss-Prot for GPR82 Gene

  • Orphan receptor.

Gene Wiki entry for GPR82 Gene

Additional gene information for GPR82 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR82 Gene

Genomics for GPR82 Gene

GeneHancer (GH) Regulatory Elements for GPR82 Gene

Promoters and enhancers for GPR82 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ041723 Promoter/Enhancer 0.9 EPDnew Ensembl 650.7 -0.1 -51 1.8 ATF2 RUNX3 SPI1 GPR82 GPR34 CASK
GH0XJ041558 Enhancer 1 Ensembl ENCODE 13.5 -163.7 -163683 3 PKNOX1 BATF ZNF766 EGR1 FOS ATF7 RUNX3 CREM JUNB REST GPR82 CASK-AS1 RNU6-1321P GC0XM041571 CASK
GH0XJ041689 Enhancer 0.5 Ensembl 14.1 -34.3 -34254 0.2 SP1 JUND RXRA EGR1 MAX HNF4A GPR34 GPR82 CASK
GH0XJ041237 Enhancer 1 FANTOM5 Ensembl ENCODE 3.8 -485.5 -485474 1.7 JUND POLR2A JUN MAX MYC USP9X GPR82 DDX3X GC0XP041235 GC0XM041252
GH0XJ041718 Enhancer 0.8 Ensembl ENCODE 0.7 -4.6 -4602 2.9 CTCF MEIS2 RFX1 EBF1 DPF2 ATF2 POLR2A BCL11A IKZF1 EED CASK GPR82 GPR34
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR82 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR82 gene promoter:
  • AP-1
  • Hand1
  • E47
  • AML1a
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • POU3F2 (N-Oct-5b)
  • Evi-1
  • Meis-1
  • GR

Genomic Locations for GPR82 Gene

Genomic Locations for GPR82 Gene
5,981 bases
Plus strand
5,981 bases
Plus strand

Genomic View for GPR82 Gene

Genes around GPR82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR82 Gene

Proteins for GPR82 Gene

  • Protein details for GPR82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 82
    Protein Accession:
    Secondary Accessions:
    • Q5VT13

    Protein attributes for GPR82 Gene

    336 amino acids
    Molecular mass:
    38409 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR82 Gene

Post-translational modifications for GPR82 Gene

  • Glycosylation at Asn4 and isoforms=3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR82 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR82 Gene

Domains & Families for GPR82 Gene

Gene Families for GPR82 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR82 Gene


Suggested Antigen Peptide Sequences for GPR82 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR82: view

Function for GPR82 Gene

Molecular function for GPR82 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for GPR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with GPR82: view
genes like me logo Genes that share phenotypes with GPR82: view

Animal Models for GPR82 Gene

MGI Knock Outs for GPR82:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR82

Clone Products

  • Addgene plasmids for GPR82

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR82 Gene

Localization for GPR82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR82 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR82 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GPR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR82: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR82 Gene

Pathways & Interactions for GPR82 Gene

SuperPathways for GPR82 Gene

No Data Available

Interacting Proteins for GPR82 Gene

Gene Ontology (GO) - Biological Process for GPR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR82: view

No data available for Pathways by source and SIGNOR curated interactions for GPR82 Gene

Drugs & Compounds for GPR82 Gene

No Compound Related Data Available

Transcripts for GPR82 Gene

mRNA/cDNA for GPR82 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR82 Gene

G protein-coupled receptor 82:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR82

Alternative Splicing Database (ASD) splice patterns (SP) for GPR82 Gene

No ASD Table

Relevant External Links for GPR82 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR82 Gene

mRNA differential expression in normal tissues according to GTEx for GPR82 Gene

This gene is overexpressed in Whole Blood (x4.5) and Small Intestine - Terminal Ileum (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of GPR82 Gene:


SOURCE GeneReport for Unigene cluster for GPR82 Gene:


Evidence on tissue expression from TISSUES for GPR82 Gene

  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with GPR82: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR82 Gene

Orthologs for GPR82 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR82 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR82 34 33
  • 99.5 (n)
(Canis familiaris)
Mammalia GPR82 34 33
  • 89.48 (n)
(Bos Taurus)
Mammalia GPR82 34 33
  • 87.79 (n)
(Mus musculus)
Mammalia Gpr82 16 34 33
  • 86.34 (n)
(Rattus norvegicus)
Mammalia Gpr82 33
  • 85.22 (n)
(Monodelphis domestica)
Mammalia GPR82 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia GPR82 34
  • 66 (a)
(Gallus gallus)
Aves GPR82 34 33
  • 60.06 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 18 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr82 33
  • 53.84 (n)
(Danio rerio)
Actinopterygii LOC101883502 33
  • 47.54 (n)
GPR82 34
  • 18 (a)
Species where no ortholog for GPR82 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR82 Gene

Gene Tree for GPR82 (if available)
Gene Tree for GPR82 (if available)
Evolutionary constrained regions (ECRs) for GPR82: view image

Paralogs for GPR82 Gene

Paralogs for GPR82 Gene

(1) SIMAP similar genes for GPR82 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR82: view

Variants for GPR82 Gene

Sequence variations from dbSNP and Humsavar for GPR82 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs193921104 uncertain-significance, Malignant tumor of prostate 41,727,508(+) G/A/T coding_sequence_variant, missense_variant
rs137964251 likely-benign, not provided 41,727,704(+) C/A coding_sequence_variant, missense_variant
rs146786893 likely-benign, not provided 41,727,580(+) G/A coding_sequence_variant, missense_variant
rs1023065 likely-benign, not specified 41,727,965(+) T/C coding_sequence_variant, synonymous_variant
rs1000014335 -- 41,726,803(+) T/C 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR82 Gene

Variant ID Type Subtype PubMed ID
esv33720 CNV loss 17666407
nsv523134 CNV gain 19592680

Variation tolerance for GPR82 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR82 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR82 Gene

Disorders for GPR82 Gene

Additional Disease Information for GPR82

No disorders were found for GPR82 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR82 Gene

Publications for GPR82 Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  4. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey PS … Stratton MR (Nature genetics 2009) 3 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58

Products for GPR82 Gene

Sources for GPR82 Gene

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