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The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
GPR78 (G Protein-Coupled Receptor 78) is a Protein Coding gene. Diseases associated with GPR78 include Schizophrenia. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR26.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA,IDA | 17363172 |
GO:0005515 | protein binding | IPI | 26940976 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IDA | 17363172 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPR78 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GPR78 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GPR78 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GPR78 30 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | GPR78 (2 of 2) 31 |
|
OneToMany | |
gpr78 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
717205 | Benign: not provided | 8,580,988(+) | C/T | SYNONYMOUS_VARIANT | |
729411 | Likely Benign: not provided | 8,581,130(+) | C/T | SYNONYMOUS_VARIANT | |
730508 | Benign: not provided | 8,581,510(+) | C/T | SYNONYMOUS_VARIANT | |
767949 | Benign: not provided | 8,581,306(+) | G/A | SYNONYMOUS_VARIANT | |
rs11941659 | - | p.Ala330Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759222 | CNV | gain+loss | 17122850 |
esv34196 | OTHER | inversion | 12058347 |
nsv1005698 | CNV | gain | 25217958 |
nsv1014219 | CNV | gain | 25217958 |
nsv4225 | CNV | insertion | 18451855 |
nsv428437 | CNV | gain | 18775914 |
nsv470015 | CNV | loss | 18288195 |
Disorder | Aliases | PubMed IDs |
---|---|---|
schizophrenia |
|
|