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Aliases for GPR78 Gene

Aliases for GPR78 Gene

  • G Protein-Coupled Receptor 78 2 3 5
  • G-Protein Coupled Receptor 78 3

External Ids for GPR78 Gene

Previous GeneCards Identifiers for GPR78 Gene

  • GC04P008571
  • GC04P008762
  • GC04P008775
  • GC04P008776
  • GC04P008700
  • GC04P008501

Summaries for GPR78 Gene

Entrez Gene Summary for GPR78 Gene

  • The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for GPR78 Gene

GPR78 (G Protein-Coupled Receptor 78) is a Protein Coding gene. Diseases associated with GPR78 include Schizophrenia. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR26.

UniProtKB/Swiss-Prot for GPR78 Gene

  • Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Gene Wiki entry for GPR78 Gene

Additional gene information for GPR78 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR78 Gene

Genomics for GPR78 Gene

GeneHancer (GH) Regulatory Elements for GPR78 Gene

Promoters and enhancers for GPR78 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J008580 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.3 +22.2 22240 1.7 ARID4B SIN3A ZNF2 ZNF48 ZNF766 GLIS2 ZNF143 SP3 NCOA1 MXD4 GPR78 CPZ
GH04J008557 Enhancer 0.4 ENCODE dbSUPER 656.5 -0.2 -153 1.2 GPR78 GC04M008538
GH04J007936 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 14 -619.4 -619395 5.5 NFIB SIN3A ZNF48 ZEB1 ZNF335 GLIS2 RCOR1 EGR2 NFYC CEBPB AFAP1 GC04P007938 LOC389199 TRMT44 CPZ GPR78
GH04J007870 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 12 -686.8 -686775 3.9 MXI1 JUN SIN3A BRCA1 POLR2A ZNF26 SCRT2 ATF7 MAFK ZNF639 AFAP1 GC04M007832 CPZ TRMT44 LOC389199 GPR78 PIR60658
GH04J007977 Enhancer 1.1 Ensembl ENCODE dbSUPER 11 -579.9 -579876 2.9 KLF1 USF1 ZFP64 ZNF140 ZNF266 KLF17 ZNF697 ZNF213 ZNF433 TCF7L2 TRMT44 GMPSP1 GPR78 CPZ PIR60893 PIR56008 ABLIM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR78 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR78 gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for GPR78 Gene

Genomic Locations for GPR78 Gene
chr4:8,558,725-8,619,761
(GRCh38/hg38)
Size:
61,037 bases
Orientation:
Plus strand
chr4:8,560,452-8,621,486
(GRCh37/hg19)
Size:
61,035 bases
Orientation:
Plus strand

Genomic View for GPR78 Gene

Genes around GPR78 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR78 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR78 Gene

Proteins for GPR78 Gene

  • Protein details for GPR78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P69-GPR78_HUMAN
    Recommended name:
    G-protein coupled receptor 78
    Protein Accession:
    Q96P69
    Secondary Accessions:
    • Q8NGV3

    Protein attributes for GPR78 Gene

    Size:
    363 amino acids
    Molecular mass:
    39332 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR78 Gene

Post-translational modifications for GPR78 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR78 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR78 Gene

Domains & Families for GPR78 Gene

Gene Families for GPR78 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR78 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96P69

UniProtKB/Swiss-Prot:

GPR78_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR78: view

Function for GPR78 Gene

Molecular function for GPR78 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.

Gene Ontology (GO) - Molecular Function for GPR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 17363172
GO:0005515 protein binding IPI 26940976
genes like me logo Genes that share ontologies with GPR78: view
genes like me logo Genes that share phenotypes with GPR78: view

Animal Model Products

Clone Products

  • Addgene plasmids for GPR78

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR78 Gene

Localization for GPR78 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR78 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR78 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GPR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR78: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR78 Gene

Pathways & Interactions for GPR78 Gene

SuperPathways for GPR78 Gene

No Data Available

Interacting Proteins for GPR78 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371927%0d%0a9606.ENSP00000267884%0d%0a9606.ENSP00000216774%0d%0a9606.ENSP00000305230%0d%0a9606.ENSP00000312066%0d%0a9606.ENSP00000352163%0d%0a
Selected Interacting proteins: ENSP00000371927 Q96P69-GPR78_HUMAN for GPR78 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA,IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA 17363172
genes like me logo Genes that share ontologies with GPR78: view

No data available for Pathways by source and SIGNOR curated interactions for GPR78 Gene

Drugs & Compounds for GPR78 Gene

No Compound Related Data Available

Transcripts for GPR78 Gene

mRNA/cDNA for GPR78 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR78 Gene

G protein-coupled receptor 78:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR78

Alternative Splicing Database (ASD) splice patterns (SP) for GPR78 Gene

No ASD Table

Relevant External Links for GPR78 Gene

GeneLoc Exon Structure for
GPR78
ECgene alternative splicing isoforms for
GPR78

Expression for GPR78 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR78 Gene

mRNA differential expression in normal tissues according to GTEx for GPR78 Gene

This gene is overexpressed in Esophagus - Mucosa (x31.8) and Vagina (x7.5).

NURSA nuclear receptor signaling pathways regulating expression of GPR78 Gene:

GPR78

SOURCE GeneReport for Unigene cluster for GPR78 Gene:

Hs.740355

mRNA Expression by UniProt/SwissProt for GPR78 Gene:

Q96P69-GPR78_HUMAN
Tissue specificity: High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.
genes like me logo Genes that share expression patterns with GPR78: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR78 Gene

Orthologs for GPR78 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR78 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR78 34 33
  • 99.08 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR78 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR78 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR78 34 33
  • 62.64 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPR78 (2 of 2) 34
  • 49 (a)
OneToMany
gpr78 34
  • 45 (a)
OneToMany
Species where no ortholog for GPR78 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR78 Gene

ENSEMBL:
Gene Tree for GPR78 (if available)
TreeFam:
Gene Tree for GPR78 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR78: view image

Paralogs for GPR78 Gene

Paralogs for GPR78 Gene

(1) SIMAP similar genes for GPR78 Gene using alignment to 4 proteins:

  • GPR78_HUMAN
  • B2R7M4_HUMAN
  • D6RB95_HUMAN
  • L8E9J7_HUMAN
genes like me logo Genes that share paralogs with GPR78: view

Variants for GPR78 Gene

Sequence variations from dbSNP and Humsavar for GPR78 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000720 -- 8,582,368(+) C/T intron_variant
rs1000297181 -- 8,585,203(+) C/T intron_variant
rs10006769 -- 8,584,035(+) C/T intron_variant
rs1000731675 -- 8,580,576(+) A/G 5_prime_UTR_variant, non_coding_transcript_variant
rs1000761743 -- 8,580,700(+) G/C 5_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR78 Gene

Variant ID Type Subtype PubMed ID
esv2759222 CNV gain+loss 17122850
esv34196 OTHER inversion 12058347
nsv1005698 CNV gain 25217958
nsv1014219 CNV gain 25217958
nsv4225 CNV insertion 18451855
nsv428437 CNV gain 18775914
nsv470015 CNV loss 18288195

Variation tolerance for GPR78 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR78 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR78

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR78 Gene

Disorders for GPR78 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR78 Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search GPR78 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR78

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR78: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR78 Gene

Publications for GPR78 Gene

  1. Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia. (PMID: 16389273) Underwood SL … Evans KL (Molecular psychiatry 2006) 3 22 44 58
  2. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4 58
  3. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PMID: 19328558) Yosifova A … Nakamura Y (Journal of affective disorders 2009) 3 44 58
  4. Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. (PMID: 17363172) Jones PG … Pausch MH (Biochimica et biophysica acta 2007) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GPR78 Gene

Sources for GPR78 Gene

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