External Ids for GPR78 Gene
Previous GeneCards Identifiers for GPR78 Gene
The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for GPR78 Gene
GPR78 (G Protein-Coupled Receptor 78) is a Protein Coding gene. Diseases associated with GPR78 include Schizophrenia. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR26.
UniProtKB/Swiss-Prot Summary for GPR78 Gene
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.