This locus represents naturally occurring read-through transcription between the neighboring GPR75 (G protein-coupled receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on chromosome 2. The transcript includes exons from both GPR75 and ASB3 and translation initiates in the 5' non-coding exon of GPR75. The resulting protein has a novel N-terminus but is otherwise i... See more...

Aliases for GPR75-ASB3 Gene

Aliases for GPR75-ASB3 Gene

  • GPR75-ASB3 Readthrough 2 3
  • Ankyrin Repeat And SOCS Box Protein 3 3 4
  • ASB-3 3 4
  • ASB3 3 5
  • Ankyrin Repeat And SOCS Box Containing 3 5
  • GPR75-ASB3 Protein 3

External Ids for GPR75-ASB3 Gene

Previous GeneCards Identifiers for GPR75-ASB3 Gene

  • GC02M053897
  • GC02M053759

Summaries for GPR75-ASB3 Gene

Entrez Gene Summary for GPR75-ASB3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring GPR75 (G protein-coupled receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on chromosome 2. The transcript includes exons from both GPR75 and ASB3 and translation initiates in the 5' non-coding exon of GPR75. The resulting protein has a novel N-terminus but is otherwise identical to that encoded by ASB3.[provided by RefSeq, Feb 2011]

GeneCards Summary for GPR75-ASB3 Gene

GPR75-ASB3 (GPR75-ASB3 Readthrough) is a Protein Coding gene. An important paralog of this gene is ASB14.

UniProtKB/Swiss-Prot Summary for GPR75-ASB3 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Additional gene information for GPR75-ASB3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR75-ASB3 Gene

Genomics for GPR75-ASB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR75-ASB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J053859 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.3 259 1.4 RBM22 POLR2A GABPB1 SSRP1 SIN3A MAFK TAF1 EGR1 EZH2 ASB3 GPR75 GPR75-ASB3 lnc-ASB3-2 ACYP2 MIR3682 ERLEC1
GH02J053861 Enhancer 0.2 Ensembl 600.7 -1.4 -1351 0.2 ASB3 GPR75 GPR75-ASB3 lnc-ASB3-2 lnc-GPR75-ASB3-1 ACYP2
GH02J053766 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 4.1 +92.1 92087 2.7 HNRNPL GATAD2A REST SIX5 IKZF1 CTCF POLR2A ZNF7 ZNF143 PHF21A CHAC2 ACYP2 GPR75-ASB3 ERLEC1 ASB3 lnc-ASB3-2
GH02J053785 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 4.2 +73.4 73359 4 CREB1 GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 SIX5 IKZF1 NFKBIZ ERLEC1 ASB3 ACYP2 GPR75 GPR75-ASB3 CHAC2 lnc-ASB3-2
GH02J053811 Enhancer 0.6 ENCODE 11.8 +47.2 47203 2.5 ATF7 CEBPB ZNF316 MAFF ATF3 MAFK EP300 CEBPG ATF4 ATF2 ERLEC1 ASB3 GPR75-ASB3 ACYP2 piR-48749-020 lnc-ASB3-2 GPR75
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR75-ASB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR75-ASB3

Genomic Locations for GPR75-ASB3 Gene

Genomic Locations for GPR75-ASB3 Gene
chr2:53,532,672-53,860,160
(GRCh38/hg38)
Size:
327,489 bases
Orientation:
Minus strand
chr2:53,897,430-54,087,297
(GRCh37/hg19)
Size:
189,868 bases
Orientation:
Minus strand

Genomic View for GPR75-ASB3 Gene

Genes around GPR75-ASB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR75-ASB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR75-ASB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR75-ASB3 Gene

Proteins for GPR75-ASB3 Gene

  • Protein details for GPR75-ASB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y575-ASB3_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 3
    Protein Accession:
    Q9Y575
    Secondary Accessions:
    • B3KPA3
    • D6W5B4
    • D6W5B5
    • G8JLA9
    • Q2TAI4
    • Q53TN0
    • Q53TN8
    • Q9NVZ2

    Protein attributes for GPR75-ASB3 Gene

    Size:
    518 amino acids
    Molecular mass:
    57745 Da
    Quaternary structure:
    • Interacts with ELOB and TNFRSF1B.
    SequenceCaution:
    • Sequence=AAI10916.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPR75-ASB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR75-ASB3 Gene

Post-translational modifications for GPR75-ASB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR75-ASB3 Gene

No data available for DME Specific Peptides for GPR75-ASB3 Gene

Domains & Families for GPR75-ASB3 Gene

Gene Families for GPR75-ASB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPR75-ASB3 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
  • SOCS protein, C-terminal
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y575

UniProtKB/Swiss-Prot:

ASB3_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with GPR75-ASB3: view

No data available for Suggested Antigen Peptide Sequences for GPR75-ASB3 Gene

Function for GPR75-ASB3 Gene

Molecular function for GPR75-ASB3 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Phenotypes From GWAS Catalog for GPR75-ASB3 Gene

Gene Ontology (GO) - Molecular Function for GPR75-ASB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with GPR75-ASB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR75-ASB3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR75-ASB3 Gene

Localization for GPR75-ASB3 Gene

Gene Ontology (GO) - Cellular Components for GPR75-ASB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with GPR75-ASB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GPR75-ASB3 Gene

Pathways & Interactions for GPR75-ASB3 Gene

PathCards logo

SuperPathways for GPR75-ASB3 Gene

No Data Available

UniProtKB/Swiss-Prot Q9Y575-ASB3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for GPR75-ASB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with GPR75-ASB3: view

No data available for Pathways by source and SIGNOR curated interactions for GPR75-ASB3 Gene

Drugs & Compounds for GPR75-ASB3 Gene

No Compound Related Data Available

Transcripts for GPR75-ASB3 Gene

mRNA/cDNA for GPR75-ASB3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR75-ASB3

Alternative Splicing Database (ASD) splice patterns (SP) for GPR75-ASB3 Gene

No ASD Table

Relevant External Links for GPR75-ASB3 Gene

GeneLoc Exon Structure for
GPR75-ASB3

Expression for GPR75-ASB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR75-ASB3 Gene

Protein differential expression in normal tissues from HIPED for GPR75-ASB3 Gene

This gene is overexpressed in Lung (62.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPR75-ASB3 Gene



Protein tissue co-expression partners for GPR75-ASB3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR75-ASB3

genes like me logo Genes that share expression patterns with GPR75-ASB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR75-ASB3 Gene

Orthologs for GPR75-ASB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR75-ASB3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ASB3 30 31
  • 99.55 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia ASB3 30
  • 90.41 (n)
-- 31
  • 87 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia ASB3 30 31
  • 89.51 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Asb3 30 17 31
  • 86.23 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Asb3 30
  • 86.23 (n)
Oppossum
(Monodelphis domestica)
Mammalia ASB3 31
  • 71 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 68 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ASB3 30 31
  • 65.62 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 69 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia asb3 30
  • 62.39 (n)
Zebrafish
(Danio rerio)
Actinopterygii asb3 30 31
  • 52.96 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea M60.7 31
  • 20 (a)
OneToMany
Species where no ortholog for GPR75-ASB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GPR75-ASB3 Gene

ENSEMBL:
Gene Tree for GPR75-ASB3 (if available)
TreeFam:
Gene Tree for GPR75-ASB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR75-ASB3: view image

Paralogs for GPR75-ASB3 Gene

Paralogs for GPR75-ASB3 Gene

(16) SIMAP similar genes for GPR75-ASB3 Gene using alignment to 1 proteins:

  • H7BYZ6_HUMAN
genes like me logo Genes that share paralogs with GPR75-ASB3: view

Variants for GPR75-ASB3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR75-ASB3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
775714 Benign: not provided 53,809,234(-) T/C SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GPR75-ASB3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR75-ASB3 Gene

Variant ID Type Subtype PubMed ID
dgv1913n106 CNV deletion 24896259
dgv3844n100 CNV loss 25217958
esv2661223 CNV deletion 23128226
esv2720076 CNV deletion 23290073
esv3556877 CNV deletion 23714750
esv3583829 CNV loss 25503493
nsv1009829 CNV loss 25217958
nsv1072942 CNV deletion 25765185
nsv2730 CNV insertion 18451855
nsv834058 CNV gain+loss 17160897
nsv979005 CNV duplication 23825009

Variation tolerance for GPR75-ASB3 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR75-ASB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR75-ASB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR75-ASB3 Gene

Disorders for GPR75-ASB3 Gene

Additional Disease Information for GPR75-ASB3

No disorders were found for GPR75-ASB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR75-ASB3 Gene

Publications for GPR75-ASB3 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4
  4. Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II. (PMID: 15899873) Chung AS … Chin YE (Molecular and cellular biology 2005) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

Products for GPR75-ASB3 Gene

  • Signalway Proteins for GPR75-ASB3

Sources for GPR75-ASB3 Gene