GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002] See more...

Aliases for GPR75 Gene

Aliases for GPR75 Gene

  • G Protein-Coupled Receptor 75 2 3 5
  • Probable G-Protein Coupled Receptor 75 3 4
  • GPRchr2 3
  • WI31133 3

External Ids for GPR75 Gene

Previous GeneCards Identifiers for GPR75 Gene

  • GC02M054118
  • GC02M054266
  • GC02M054037
  • GC02M054054
  • GC02M053991
  • GC02M054080
  • GC02M053814

Summaries for GPR75 Gene

Entrez Gene Summary for GPR75 Gene

  • GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]

GeneCards Summary for GPR75 Gene

GPR75 (G Protein-Coupled Receptor 75) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is GPR83.

UniProtKB/Swiss-Prot Summary for GPR75 Gene

  • G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.

Gene Wiki entry for GPR75 Gene

Additional gene information for GPR75 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR75 Gene

Genomics for GPR75 Gene

GeneHancer (GH) Regulatory Elements for GPR75 Gene

Promoters and enhancers for GPR75 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J053859 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.1 132 1.4 POLR2A POLR2G RBM22 GABPB1 SSRP1 SIN3A MAFK TAF1 AGO2 EGR1 ASB3 GPR75 GPR75-ASB3 lnc-ASB3-2 ACYP2 MIR3682
GH02J053866 Promoter 0.3 EPDnew 500.4 -6.8 -6843 0.1 GPR75 ASB3 GPR75-ASB3 lnc-GPR75-ASB3-1 PSME4
GH02J053861 Enhancer 0.2 Ensembl 500.7 -1.5 -1478 0.2 ASB3 GPR75 GPR75-ASB3 lnc-ASB3-2 lnc-GPR75-ASB3-1
GH02J053785 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 4.5 +73.2 73232 4 EP300 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 TCF12 POLR2G GTF2E2 PHF8 ERLEC1 ASB3 ACYP2 GPR75 GPR75-ASB3 CHAC2 lnc-ASB3-2
GH02J054041 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -183.6 -183610 3.6 EP300 FOXK2 ZNF217 TCF12 POLR2G NCOR1 KDM6A TCF7 FOXA1 ZBTB25 ACYP2 RNU7-172P EML6 TSPYL6 HMGB1P31 GPR75 lnc-ERLEC1-4-002 piR-38813 lnc-PSME4-2 NONHSAG027765.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR75 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR75

Top Transcription factor binding sites by QIAGEN in the GPR75 gene promoter:
  • GATA-1
  • HTF
  • IRF-7A
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-6
  • POU2F1a
  • SRF
  • SRF (504 AA)

Genomic Locations for GPR75 Gene

Genomic Locations for GPR75 Gene
chr2:53,852,912-53,860,033
(GRCh38/hg38)
Size:
7,122 bases
Orientation:
Minus strand
chr2:54,080,050-54,087,170
(GRCh37/hg19)
Size:
7,121 bases
Orientation:
Minus strand

Genomic View for GPR75 Gene

Genes around GPR75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR75 Gene

Proteins for GPR75 Gene

  • Protein details for GPR75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95800-GPR75_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 75
    Protein Accession:
    O95800
    Secondary Accessions:
    • B2RC02
    • Q6NWR2

    Protein attributes for GPR75 Gene

    Size:
    540 amino acids
    Molecular mass:
    59359 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR75 Gene

Post-translational modifications for GPR75 Gene

  • Glycosylation at Asn2, Asn12, and Asn25
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR75 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR75 Gene

Domains & Families for GPR75 Gene

Gene Families for GPR75 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR75 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR75 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 75 (GPR75_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95800

UniProtKB/Swiss-Prot:

GPR75_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR75: view

Function for GPR75 Gene

Molecular function for GPR75 Gene

UniProtKB/Swiss-Prot Function:
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
GENATLAS Biochemistry:
G protein-coupled receptor 75,expressed in the retinal pigment epithelium and in the brain,G protein-coupled receptor superfamily

Phenotypes From GWAS Catalog for GPR75 Gene

Gene Ontology (GO) - Molecular Function for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity ISS --
GO:0016493 C-C chemokine receptor activity ISS,IEA --
genes like me logo Genes that share ontologies with GPR75: view
genes like me logo Genes that share phenotypes with GPR75: view

Animal Model Products

miRNA for GPR75 Gene

miRTarBase miRNAs that target GPR75

Clone Products

  • Addgene plasmids for GPR75

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR75 Gene

Localization for GPR75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR75 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR75 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0005887 integral component of plasma membrane TAS 10381362
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR75: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR75 Gene

Pathways & Interactions for GPR75 Gene

PathCards logo

SuperPathways for GPR75 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR75: view

Pathways by source for GPR75 Gene

1 BioSystems pathway for GPR75 Gene

Interacting Proteins for GPR75 Gene

;

Gene Ontology (GO) - Biological Process for GPR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway ISS --
GO:0070098 chemokine-mediated signaling pathway IEA,ISS --
GO:1901214 regulation of neuron death ISS,IEA --
genes like me logo Genes that share ontologies with GPR75: view

No data available for SIGNOR curated interactions for GPR75 Gene

Drugs & Compounds for GPR75 Gene

(1) Drugs for GPR75 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCL5 Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with GPR75: view

Transcripts for GPR75 Gene

mRNA/cDNA for GPR75 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GPR75

Alternative Splicing Database (ASD) splice patterns (SP) for GPR75 Gene

No ASD Table

Relevant External Links for GPR75 Gene

GeneLoc Exon Structure for
GPR75

Expression for GPR75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR75 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR75

mRNA Expression by UniProt/SwissProt for GPR75 Gene:

O95800-GPR75_HUMAN
Tissue specificity: Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).

Evidence on tissue expression from TISSUES for GPR75 Gene

  • Nervous system(4.4)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with GPR75: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR75 Gene

Orthologs for GPR75 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR75 31 30
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR75 31 30
  • 90.06 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr75 17 31 30
  • 85.43 (n)
rat
(Rattus norvegicus)
Mammalia Gpr75 30
  • 85.12 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR75 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR75 31 30
  • 76.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR75 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr75 30
  • 74.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100538001 30
  • 66.02 (n)
gpr75 31
  • 65 (a)
OneToOne
Species where no ortholog for GPR75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR75 Gene

ENSEMBL:
Gene Tree for GPR75 (if available)
TreeFam:
Gene Tree for GPR75 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR75: view image

Paralogs for GPR75 Gene

Variants for GPR75 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR75 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs34000641 - p.Ala116Thr
rs35349235 - p.Cys160Gly
rs3731969 - p.Leu433Val
rs72799238 - p.Asn78Lys
rs763005023 - p.Ser108Thr

Additional dbSNP identifiers (rs#s) for GPR75 Gene

Variation tolerance for GPR75 Gene

Residual Variation Intolerance Score: 30.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR75 Gene

Human Gene Mutation Database (HGMD)
GPR75
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR75

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR75 Gene

Disorders for GPR75 Gene

Additional Disease Information for GPR75

No disorders were found for GPR75 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR75 Gene

Publications for GPR75 Gene

  1. Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16. (PMID: 10381362) Tarttelin EE … Gregory-Evans CY (Biochemical and biophysical research communications 1999) 2 3 4 54
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration. (PMID: 11466257) Sauer CG … Weber BH (The British journal of ophthalmology 2001) 4 23 54
  5. The orphan G-protein-coupled receptor 75 signaling is activated by the chemokine CCL5. (PMID: 29772059) Dedoni S … Mocchetti I (Journal of neurochemistry 2018) 3 54

Products for GPR75 Gene

Sources for GPR75 Gene