Aliases for GPR75 Gene
External Ids for GPR75 Gene
Previous GeneCards Identifiers for GPR75 Gene
GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.[supplied by OMIM, Jul 2002]
GeneCards Summary for GPR75 Gene
GPR75 (G Protein-Coupled Receptor 75) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is GPR83.
UniProtKB/Swiss-Prot Summary for GPR75 Gene
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.