Aliases for GPR68 Gene
External Ids for GPR68 Gene
Previous GeneCards Identifiers for GPR68 Gene
The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]
GeneCards Summary for GPR68 Gene
GPR68 (G Protein-Coupled Receptor 68) is a Protein Coding gene. Diseases associated with GPR68 include Amelogenesis Imperfecta, Hypomaturation Type, Iia6 and Amelogenesis Imperfecta Hypomaturation Type. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is LPAR5.
UniProtKB/Swiss-Prot Summary for GPR68 Gene
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).