Aliases for GPR68 Gene
External Ids for GPR68 Gene
Previous GeneCards Identifiers for GPR68 Gene
The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]
GeneCards Summary for GPR68 Gene
GPR68 (G Protein-Coupled Receptor 68) is a Protein Coding gene. Diseases associated with GPR68 include Amelogenesis Imperfecta, Hypomaturation Type, Iia6 and Amelogenesis Imperfecta. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is LPAR5.
UniProtKB/Swiss-Prot Summary for GPR68 Gene
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).