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Aliases for GPR65 Gene

Aliases for GPR65 Gene

  • G Protein-Coupled Receptor 65 2 3 5
  • T-Cell Death-Associated Gene 8 Protein 3 4
  • TDAG8 3 4
  • G-Protein Coupled Receptor 65 4
  • Psychosine Receptor 3
  • HTDAG8 3

External Ids for GPR65 Gene

Previous GeneCards Identifiers for GPR65 Gene

  • GC14P085976
  • GC14P082288
  • GC14P086461
  • GC14P087541
  • GC14P088471
  • GC14P068641

Summaries for GPR65 Gene

GeneCards Summary for GPR65 Gene

GPR65 (G Protein-Coupled Receptor 65) is a Protein Coding gene. Diseases associated with GPR65 include Rectal Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR4.

UniProtKB/Swiss-Prot for GPR65 Gene

  • Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity).

Gene Wiki entry for GPR65 Gene

Additional gene information for GPR65 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR65 Gene

Genomics for GPR65 Gene

GeneHancer (GH) Regulatory Elements for GPR65 Gene

Promoters and enhancers for GPR65 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I088004 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 589 +2.5 2474 6.2 PKNOX1 SMAD1 BMI1 BATF IRF4 ATF7 ETV6 IKZF2 RUNX3 SMAD5 GPR65 GALC ENSG00000258407
GH14I087989 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34 -11.8 -11774 8.1 HDGF FOXA2 SMAD1 SIN3A IRF4 YY1 CBX5 ZNF207 ZNF143 SP3 GALC GPR65 FAM35CP ZC3H14 RNU6-835P
GH14I088001 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 30.2 -2.3 -2334 2 REST SP1 ZNF148 IKZF1 ETV6 RUNX3 IKZF2 SPI1 GALC GPR65 RNU6-835P
GH14I088043 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.8 +40.0 40018 3.3 FOXA2 MLX ARID4B ETS1 YY1 SLC30A9 ATF7 FOS RXRA SP5 GALC GPR65 LOC101928791 LINC01146 GC14P088067
GH14I088022 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.9 +20.1 20123 5 FOXA2 ARNT DMAP1 YY1 NCOA2 TCF12 CAVIN1 NCOA1 MXD4 ZNF592 LINC01146 GALC GPR65 LOC101928791
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR65 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR65 gene promoter:

Genomic Locations for GPR65 Gene

Genomic Locations for GPR65 Gene
chr14:88,005,124-88,014,811
(GRCh38/hg38)
Size:
9,688 bases
Orientation:
Plus strand
chr14:88,471,468-88,481,155
(GRCh37/hg19)

Genomic View for GPR65 Gene

Genes around GPR65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR65 Gene

Proteins for GPR65 Gene

  • Protein details for GPR65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYL9-PSYR_HUMAN
    Recommended name:
    Psychosine receptor
    Protein Accession:
    Q8IYL9
    Secondary Accessions:
    • O75819

    Protein attributes for GPR65 Gene

    Size:
    337 amino acids
    Molecular mass:
    39333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR65 Gene

Post-translational modifications for GPR65 Gene

  • Glycosylation at isoforms=2, posLast=7979, and isoforms=166

Other Protein References for GPR65 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR65 Gene

Domains & Families for GPR65 Gene

Gene Families for GPR65 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR65 Gene

Suggested Antigen Peptide Sequences for GPR65 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYL9

UniProtKB/Swiss-Prot:

PSYR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR65: view

Function for GPR65 Gene

Molecular function for GPR65 Gene

GENATLAS Biochemistry:
G protein coupled receptor 65,predominantly expressed in lymphoid tissues,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity).

Phenotypes From GWAS Catalog for GPR65 Gene

Gene Ontology (GO) - Molecular Function for GPR65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IDA 15618224
genes like me logo Genes that share ontologies with GPR65: view
genes like me logo Genes that share phenotypes with GPR65: view

Animal Models for GPR65 Gene

MGI Knock Outs for GPR65:

miRNA for GPR65 Gene

miRTarBase miRNAs that target GPR65

Clone Products

  • Addgene plasmids for GPR65

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR65 Gene

Localization for GPR65 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR65 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR65 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPR65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 9655242
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR65: view

Pathways & Interactions for GPR65 Gene

genes like me logo Genes that share pathways with GPR65: view

Gene Ontology (GO) - Biological Process for GPR65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA,TAS --
GO:0006955 immune response TAS 9655242
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA 15618224
genes like me logo Genes that share ontologies with GPR65: view

No data available for SIGNOR curated interactions for GPR65 Gene

Drugs & Compounds for GPR65 Gene

(1) Drugs for GPR65 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for GPR65 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPR65: view

Transcripts for GPR65 Gene

mRNA/cDNA for GPR65 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR65 Gene

G protein-coupled receptor 65:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR65

Alternative Splicing Database (ASD) splice patterns (SP) for GPR65 Gene

No ASD Table

Relevant External Links for GPR65 Gene

GeneLoc Exon Structure for
GPR65
ECgene alternative splicing isoforms for
GPR65

Expression for GPR65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR65 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR65 Gene

This gene is overexpressed in Whole Blood (x15.1) and Spleen (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of GPR65 Gene:

GPR65

SOURCE GeneReport for Unigene cluster for GPR65 Gene:

Hs.443243

mRNA Expression by UniProt/SwissProt for GPR65 Gene:

Q8IYL9-PSYR_HUMAN
Tissue specificity: Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for GPR65 Gene

  • Blood(4.4)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GPR65: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR65 Gene

Orthologs for GPR65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR65 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia GPR65 33 34
  • 86.84 (n)
cow
(Bos Taurus)
Mammalia GPR65 33 34
  • 84.27 (n)
rat
(Rattus norvegicus)
Mammalia Gpr65 33
  • 79.4 (n)
mouse
(Mus musculus)
Mammalia Gpr65 33 16 34
  • 78.21 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR65 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR65 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR65 33 34
  • 63.26 (n)
lizard
(Anolis carolinensis)
Reptilia GPR65 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr65 33
  • 56.51 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr65 34
  • 33 (a)
OneToOne
Species where no ortholog for GPR65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR65 Gene

ENSEMBL:
Gene Tree for GPR65 (if available)
TreeFam:
Gene Tree for GPR65 (if available)

Paralogs for GPR65 Gene

(10) SIMAP similar genes for GPR65 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPR65: view

Variants for GPR65 Gene

Sequence variations from dbSNP and Humsavar for GPR65 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000069220 -- 88,013,798(+) T/A 3_prime_UTR_variant
rs1000427539 -- 88,004,935(+) T/C upstream_transcript_variant
rs1000460088 -- 88,005,235(+) T/A intron_variant
rs1000530192 -- 88,010,509(+) G/A 5_prime_UTR_variant
rs1000596884 -- 88,012,310(+) C/A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR65 Gene

Variant ID Type Subtype PubMed ID
nsv952879 CNV duplication 24416366
nsv1389 CNV deletion 18451855
dgv673e212 CNV loss 25503493

Variation tolerance for GPR65 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.54; 77.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR65 Gene

Human Gene Mutation Database (HGMD)
GPR65
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR65 Gene

Disorders for GPR65 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR65 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
rectal disease
  • rectal disorders
- elite association - COSMIC cancer census association via MalaCards
Search GPR65 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR65

genes like me logo Genes that share disorders with GPR65: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR65 Gene

Publications for GPR65 Gene

  1. Cloning, characterization, and mapping of human homolog of mouse T-cell death-associated gene. (PMID: 9655242) Kyaw H … Li Y (DNA and cell biology 1998) 2 3 4 22 58
  2. Identification of a molecular target of psychosine and its role in globoid cell formation. (PMID: 11309421) Im DS … Lynch KR (The Journal of cell biology 2001) 3 4 22 58
  3. Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. (PMID: 27287411) Lassen KG … Xavier RJ (Immunity 2016) 3 4 58
  4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
  5. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 44 58

Products for GPR65 Gene

Sources for GPR65 Gene

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