This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] See more...

Aliases for GPR63 Gene

Aliases for GPR63 Gene

  • G Protein-Coupled Receptor 63 2 3 5
  • Probable G-Protein Coupled Receptor 63 3 4
  • PSP24-Beta 3 4
  • PSP24-2 3 4
  • PSP24B 3 4
  • Brain Expressed G-Protein-Coupled Receptor PSP24 Beta 3
  • PSP24(Beta) 3

External Ids for GPR63 Gene

Previous GeneCards Identifiers for GPR63 Gene

  • GC06M097114
  • GC06M097262
  • GC06M097291
  • GC06M097352
  • GC06M094680
  • GC06M097242

Summaries for GPR63 Gene

Entrez Gene Summary for GPR63 Gene

  • This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for GPR63 Gene

GPR63 (G Protein-Coupled Receptor 63) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR45.

UniProtKB/Swiss-Prot Summary for GPR63 Gene

Gene Wiki entry for GPR63 Gene

Additional gene information for GPR63 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR63 Gene

Genomics for GPR63 Gene

GeneHancer (GH) Regulatory Elements for GPR63 Gene

Promoters and enhancers for GPR63 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J096836 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 544.8 +0.6 591 2.6 ZSCAN5C ZIC2 POLR2A ZBTB10 ZBTB26 KLF7 TOE1 CTBP1 EZH2 MXI1 GPR63 lnc-NDUFAF4-2 NDUFAF4 piR-37508
GH06J096896 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 42.2 -60.3 -60309 3.2 ZNF217 CTCF TCF12 NRF1 MYC USF1 POLR2G SP1 PHF8 ZFX NDUFAF4 KLHL32 lnc-GPR63-6 GPR63 lnc-KLHL32-6
GH06J096816 Enhancer 0.6 ENCODE CraniofacialAtlas dbSUPER 52.9 +21.0 20967 0.8 BCL6B GPR63 NDUFAF4 piR-37508 lnc-NDUFAF4-2
GH06J096811 Enhancer 0.6 Ensembl dbSUPER 46.2 +26.2 26191 0.6 CTCF ZNF366 SP3 GPR63 NDUFAF4 KLHL32 piR-37508 lnc-NDUFAF4-2
GH06J096814 Enhancer 0.4 Ensembl dbSUPER 52.9 +22.9 22891 0.4 JUNB GPR63 piR-37508 lnc-NDUFAF4-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR63 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR63

Top Transcription factor binding sites by QIAGEN in the GPR63 gene promoter:
  • CUTL1
  • FosB
  • FOXO1
  • FOXO1a
  • Fra-1
  • HSF2
  • JunB
  • JunD
  • LCR-F1
  • NCX

Genomic Locations for GPR63 Gene

Genomic Locations for GPR63 Gene
43,371 bases
Minus strand
43,352 bases
Minus strand

Genomic View for GPR63 Gene

Genes around GPR63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR63 Gene

Proteins for GPR63 Gene

  • Protein details for GPR63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 63
    Protein Accession:
    Secondary Accessions:
    • Q9UJH3

    Protein attributes for GPR63 Gene

    419 amino acids
    Molecular mass:
    47578 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR63 Gene

Post-translational modifications for GPR63 Gene

  • Glycosylation at Asn16, Asn28, and Asn62
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR63 Gene

Domains & Families for GPR63 Gene

Gene Families for GPR63 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR63 Gene


Suggested Antigen Peptide Sequences for GPR63 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94093, Homo sapiens G protein-coupled receptor 63 (GPR63), mRNA (A8K1C4_HUMAN)
  • PSP24-beta (GPR63_HUMAN)
  • G protein-coupled receptor 63 (Q6NWR7_HUMAN)
  • G protein-coupled receptor 63 (Q6NWR8_HUMAN)
  • G protein-coupled receptor 63 (Q6NWR9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR63: view

Function for GPR63 Gene

Molecular function for GPR63 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. May play a role in brain function.

Phenotypes From GWAS Catalog for GPR63 Gene

Gene Ontology (GO) - Molecular Function for GPR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G protein-coupled receptor activity IBA 21873635
genes like me logo Genes that share ontologies with GPR63: view
genes like me logo Genes that share phenotypes with GPR63: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR63

CRISPR Products

Clone Products

  • Addgene plasmids for GPR63

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR63 Gene

Localization for GPR63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR63 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR63 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 4
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA,IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GPR63: view

Pathways & Interactions for GPR63 Gene

PathCards logo

SuperPathways for GPR63 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR63: view

Pathways by source for GPR63 Gene

1 BioSystems pathway for GPR63 Gene

Interacting Proteins for GPR63 Gene


Gene Ontology (GO) - Biological Process for GPR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPR63: view

No data available for SIGNOR curated interactions for GPR63 Gene

Drugs & Compounds for GPR63 Gene

(3) Drugs for GPR63 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(2) Additional Compounds for GPR63 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
dioleoyl phosphatidic acid
Full agonist, Agonist
genes like me logo Genes that share compounds with GPR63: view

Transcripts for GPR63 Gene

mRNA/cDNA for GPR63 Gene

14 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPR63

Alternative Splicing Database (ASD) splice patterns (SP) for GPR63 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -

Relevant External Links for GPR63 Gene

GeneLoc Exon Structure for

Expression for GPR63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR63 Gene

Protein differential expression in normal tissues from HIPED for GPR63 Gene

This gene is overexpressed in Islet of Langerhans (44.9) and Heart (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR63 Gene

Protein tissue co-expression partners for GPR63 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR63

SOURCE GeneReport for Unigene cluster for GPR63 Gene:


mRNA Expression by UniProt/SwissProt for GPR63 Gene:

Tissue specificity: Expressed in brain; detected in the frontal cortex, with lower levels in the thalamus, caudate, hypothalamus and midbrain.

Evidence on tissue expression from TISSUES for GPR63 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPR63: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR63 Gene

Orthologs for GPR63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR63 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR63 31 30
  • 99.68 (n)
(Canis familiaris)
Mammalia GPR63 31 30
  • 91.89 (n)
(Bos Taurus)
Mammalia GPR63 31 30
  • 91.41 (n)
(Rattus norvegicus)
Mammalia Gpr63 30
  • 87.63 (n)
(Mus musculus)
Mammalia Gpr63 17 31 30
  • 87.39 (n)
(Monodelphis domestica)
Mammalia GPR63 31
  • 84 (a)
(Gallus gallus)
Aves GPR63 31 30
  • 77.09 (n)
(Anolis carolinensis)
Reptilia GPR63 31
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr63 30
  • 71.76 (n)
(Danio rerio)
Actinopterygii gpr63 31 30
  • 68.13 (n)
Dr.6459 30
Species where no ortholog for GPR63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR63 Gene

Gene Tree for GPR63 (if available)
Gene Tree for GPR63 (if available)
Evolutionary constrained regions (ECRs) for GPR63: view image

Paralogs for GPR63 Gene

Paralogs for GPR63 Gene

(3) SIMAP similar genes for GPR63 Gene using alignment to 5 proteins:

  • A8K1C4_HUMAN
genes like me logo Genes that share paralogs with GPR63: view

Variants for GPR63 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR63 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs35358396 - p.Val21Met

Additional dbSNP identifiers (rs#s) for GPR63 Gene

Variation tolerance for GPR63 Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR63 Gene

Disorders for GPR63 Gene

Additional Disease Information for GPR63

No disorders were found for GPR63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR63 Gene

Publications for GPR63 Gene

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee DK … O'Dowd BF (Brain research. Molecular brain research 2001) 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  4. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. (PMID: 11027574) Kawasawa Y … Shimizu T (Biochemical and biophysical research communications 2000) 3 4 54
  5. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R … Collins BM (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 54

Products for GPR63 Gene

Sources for GPR63 Gene