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Aliases for GPR62 Gene

Aliases for GPR62 Gene

  • G Protein-Coupled Receptor 62 2 3 5
  • G-Protein Coupled Receptor KPG_005 3 4
  • G-Protein Coupled Receptor GPCR8 3 4
  • HGPCR8 3 4
  • Probable G-Protein Coupled Receptor 62 3
  • G-Protein Coupled Receptor 62 3
  • KPG_005 3
  • GPCR8 3

External Ids for GPR62 Gene

Previous GeneCards Identifiers for GPR62 Gene

  • GC03P051082
  • GC03P051243
  • GC03P051845
  • GC03P051948
  • GC03P051964

Summaries for GPR62 Gene

GeneCards Summary for GPR62 Gene

GPR62 (G Protein-Coupled Receptor 62) is a Protein Coding gene. Among its related pathways are GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR61.

UniProtKB/Swiss-Prot for GPR62 Gene

  • Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).

Gene Wiki entry for GPR62 Gene

Additional gene information for GPR62 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR62 Gene

Genomics for GPR62 Gene

GeneHancer (GH) Regulatory Elements for GPR62 Gene

Promoters and enhancers for GPR62 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J051955 Enhancer 0.9 Ensembl ENCODE dbSUPER 654.8 +0.8 822 2 ZNF664 CTCF POLR2A MAX CTBP2 EZH2 GPR62 RPL29 NT5DC2 PARP3 GC03P051963
GH03J051953 Enhancer 0.9 ENCODE dbSUPER 650.7 -1.9 -1857 0.6 JUN CEBPG ZIC2 ZNF316 ELK1 MAFK ZBTB20 ELK4 CEBPB ZEB2 GPR62 ENSG00000280422 PARP3
GH03J051954 Enhancer 0.6 ENCODE dbSUPER 650.7 -1.1 -1054 0.1 ZBTB20 SPI1 GPR62 ENSG00000280422
GH03J052044 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.4 +96.3 96308 14 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF416 DUSP7 DCAF1 GPR62 RAD54L2 PHF7 NT5DC2 RPL29 PCBP4 WDR82 SFMBT1
GH03J051980 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15.2 +28.9 28890 6.8 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ACY1 ABHD14B GPR62 PARP3 RPL29 ABHD14A-ACY1 ABHD14A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR62 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR62 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • GATA-2
  • Max1
  • GR
  • PPAR-alpha
  • C/EBPalpha
  • GR-alpha
  • HOXA3
  • Lmo2

Genomic Locations for GPR62 Gene

Genomic Locations for GPR62 Gene
chr3:51,955,314-51,957,504
(GRCh38/hg38)
Size:
2,191 bases
Orientation:
Plus strand
chr3:51,989,330-51,991,520
(GRCh37/hg19)
Size:
2,191 bases
Orientation:
Plus strand

Genomic View for GPR62 Gene

Genes around GPR62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR62 Gene

Proteins for GPR62 Gene

  • Protein details for GPR62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZJ7-GPR62_HUMAN
    Recommended name:
    G-protein coupled receptor 62
    Protein Accession:
    Q9BZJ7
    Secondary Accessions:
    • F1DAM4
    • Q5KU27

    Protein attributes for GPR62 Gene

    Size:
    368 amino acids
    Molecular mass:
    37614 Da
    Quaternary structure:
    • Homodimers (By similarity). Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR62 in the endosomal compartment (PubMed:28827538).

neXtProt entry for GPR62 Gene

Post-translational modifications for GPR62 Gene

  • Glycosylation at Asn8 and Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR62 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR62 Gene

Domains & Families for GPR62 Gene

Gene Families for GPR62 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR62 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR62 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZJ7

UniProtKB/Swiss-Prot:

GPR62_HUMAN :
  • Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR62: view

Function for GPR62 Gene

Molecular function for GPR62 Gene

UniProtKB/Swiss-Prot Function:
Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).

Gene Ontology (GO) - Molecular Function for GPR62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 28827538
GO:0042802 identical protein binding ISS --
GO:1990763 arrestin family protein binding IDA 28827538
genes like me logo Genes that share ontologies with GPR62: view
genes like me logo Genes that share phenotypes with GPR62: view

Animal Model Products

Clone Products

  • Addgene plasmids for GPR62

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GPR62 Gene

Localization for GPR62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR62 Gene

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Colocalizes with ARRB2 in the endosome (PubMed:28827538). {ECO:0000269 PubMed:28827538}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR62 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005768 endosome IDA 28827538
GO:0005886 plasma membrane IEA,IDA 28827538
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR62: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR62 Gene

Pathways & Interactions for GPR62 Gene

SuperPathways for GPR62 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR62: view

Pathways by source for GPR62 Gene

1 BioSystems pathway for GPR62 Gene

Gene Ontology (GO) - Biological Process for GPR62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 28827538
GO:0043950 positive regulation of cAMP-mediated signaling IDA,IEA 28827538
GO:0048016 inositol phosphate-mediated signaling IDA 28827538
genes like me logo Genes that share ontologies with GPR62: view

No data available for SIGNOR curated interactions for GPR62 Gene

Drugs & Compounds for GPR62 Gene

No Compound Related Data Available

Transcripts for GPR62 Gene

mRNA/cDNA for GPR62 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR62 Gene

G protein-coupled receptor 62:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR62

Alternative Splicing Database (ASD) splice patterns (SP) for GPR62 Gene

No ASD Table

Relevant External Links for GPR62 Gene

GeneLoc Exon Structure for
GPR62
ECgene alternative splicing isoforms for
GPR62

Expression for GPR62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of GPR62 Gene:

GPR62

SOURCE GeneReport for Unigene cluster for GPR62 Gene:

Hs.232213

mRNA Expression by UniProt/SwissProt for GPR62 Gene:

Q9BZJ7-GPR62_HUMAN
Tissue specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.

Evidence on tissue expression from TISSUES for GPR62 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GPR62: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR62 Gene

Orthologs for GPR62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR62 33
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia GPR62 34 33
  • 86.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR62 34 33
  • 86.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr62 16 34 33
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Gpr62 33
  • 82.52 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR62 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-111e5.4 34
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToMany
Species where no ortholog for GPR62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR62 Gene

ENSEMBL:
Gene Tree for GPR62 (if available)
TreeFam:
Gene Tree for GPR62 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR62: view image

Paralogs for GPR62 Gene

Paralogs for GPR62 Gene

genes like me logo Genes that share paralogs with GPR62: view

Variants for GPR62 Gene

Sequence variations from dbSNP and Humsavar for GPR62 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000238463 -- 51,954,372(+) T/A/G upstream_transcript_variant
rs1000651797 -- 51,957,116(+) G/T 3_prime_UTR_variant
rs1001217335 -- 51,957,657(+) G/T downstream_transcript_variant
rs1001722755 -- 51,956,435(+) C/A coding_sequence_variant, stop_gained
rs1001776841 -- 51,956,219(+) C/A/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR62 Gene

Variant ID Type Subtype PubMed ID
nsv1003453 CNV gain 25217958
nsv1126647 CNV deletion 24896259
nsv508922 CNV insertion 20534489
nsv520211 CNV gain 19592680
nsv954857 CNV deletion 24416366

Variation tolerance for GPR62 Gene

Gene Damage Index Score: 4.49; 64.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR62

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR62 Gene

Disorders for GPR62 Gene

Additional Disease Information for GPR62

No disorders were found for GPR62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR62 Gene

Publications for GPR62 Gene

  1. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee DK … O'Dowd BF (Brain research. Molecular brain research 2001) 2 3 4 58
  2. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. (PMID: 28827538) Oishi A … Jockers R (Scientific reports 2017) 3 4 58
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R … Collins BM (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58

Products for GPR62 Gene

Sources for GPR62 Gene

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