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This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]
GPR61 (G Protein-Coupled Receptor 61) is a Protein Coding gene. Among its related pathways are GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR62.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 28827538 |
GO:1990763 | arrestin family protein binding | IDA | 28827538 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005768 | endosome | IBA,IDA | 28827538 |
GO:0005886 | plasma membrane | IBA,IDA | 28827538 |
GO:0010008 | endosome membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | GPCRs, Other |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA,IMP | 28827538 |
GO:0043950 | positive regulation of cAMP-mediated signaling | IMP | 28827538 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | - | - | |||||||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPR61 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPR61 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gpr61 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gpr61 30 |
|
||
Dog (Canis familiaris) |
Mammalia | GPR61 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GPR61 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GPR61 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GPR61 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gpr61 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC571338 30 |
|
||
gpr61 31 |
|
OneToOne | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
No disorders were found for GPR61 Gene.