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Aliases for GPR61 Gene

Aliases for GPR61 Gene

  • G Protein-Coupled Receptor 61 2 3 5
  • Biogenic Amine Receptor-Like G-Protein Coupled Receptor 3 4
  • BALGR 3 4
  • GPCR3 3 4
  • Probable G-Protein Coupled Receptor 61 3
  • Biogenic Amine Receptor-Like GPCR 3
  • G-Protein Coupled Receptor 61 3

External Ids for GPR61 Gene

Previous GeneCards Identifiers for GPR61 Gene

  • GC01P110561
  • GC01P109011
  • GC01P109185
  • GC01P109381
  • GC01P109794
  • GC01P110082
  • GC01P107975

Summaries for GPR61 Gene

Entrez Gene Summary for GPR61 Gene

  • This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPR61 Gene

GPR61 (G Protein-Coupled Receptor 61) is a Protein Coding gene. Among its related pathways are GPCRs, Other. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR62.

UniProtKB/Swiss-Prot for GPR61 Gene

  • Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity).

Gene Wiki entry for GPR61 Gene

Additional gene information for GPR61 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR61 Gene

Genomics for GPR61 Gene

GeneHancer (GH) Regulatory Elements for GPR61 Gene

Promoters and enhancers for GPR61 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J109538 Enhancer 0.6 dbSUPER 658.1 +0.0 26 3.5 ZFP69B MXI1 USF1 POLR2A EGR1 ZNF692 ZNF143 KLF14 GPR61 SYPL2 GSTM2 ENSG00000254942
GH01J109761 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.7 +225.0 224957 5.9 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 ZNF766 FOS ATF7 EPS8L3 GSTM3 AHCYL1 ENSG00000228703 AMPD2 ENSG00000254942 GPR61 GNAT2 GNAI3 CSF1
GH01J109546 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 6.9 +8.2 8174 3.5 CLOCK DMAP1 YBX1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 GNAI3 GC01M109545 ENSG00000258634 ENSG00000235005 ENSG00000232971 RPL17P7 UBL4B RPS27P6 GSTM2 SYPL2
GH01J109563 Enhancer 0.9 Ensembl ENCODE 17.5 +24.3 24250 2.2 MEIS2 PKNOX1 CEBPG ZNF384 CTBP1 ZBTB48 ZNF600 ATF7 PRDM10 ZNF362 GPR61 RNU6V AMPD2 ENSG00000228703 GNAT2 ENSG00000254942 ENSG00000225113 MIR197 GSTM2 GNAI3
GH01J109958 Enhancer 1.4 Ensembl ENCODE dbSUPER 10 +420.3 420270 3.7 FOXA2 MLX ZFP64 SIN3A DMAP1 ETS1 ZNF121 DEK NFKBIZ RXRA CSF1 ENSG00000235005 GSTM3 GPR61 GC01P109974 GC01P109923
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR61 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR61 gene promoter:
  • ER-alpha
  • Ik-2
  • HEN1
  • Pax-4a
  • Chx10
  • AP-2alphaA
  • SRY
  • AP-2alpha
  • AP-2beta
  • AP-2gamma

Genomic Locations for GPR61 Gene

Genomic Locations for GPR61 Gene
chr1:109,539,872-109,548,406
(GRCh38/hg38)
Size:
8,535 bases
Orientation:
Plus strand
chr1:110,082,494-110,091,028
(GRCh37/hg19)
Size:
8,535 bases
Orientation:
Plus strand

Genomic View for GPR61 Gene

Genes around GPR61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR61 Gene

Proteins for GPR61 Gene

  • Protein details for GPR61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZJ8-GPR61_HUMAN
    Recommended name:
    G-protein coupled receptor 61
    Protein Accession:
    Q9BZJ8
    Secondary Accessions:
    • A8K1W2
    • Q6NWS0
    • Q8TDV4
    • Q96PR4

    Protein attributes for GPR61 Gene

    Size:
    451 amino acids
    Molecular mass:
    49292 Da
    Quaternary structure:
    • Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment (PubMed:28827538).
    SequenceCaution:
    • Sequence=AAK12637.1; Type=Frameshift; Positions=415; Evidence={ECO:0000305};

neXtProt entry for GPR61 Gene

Post-translational modifications for GPR61 Gene

  • Glycosylation at isoforms=12
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR61 Gene

No data available for DME Specific Peptides for GPR61 Gene

Domains & Families for GPR61 Gene

Gene Families for GPR61 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GPR61 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZJ8

UniProtKB/Swiss-Prot:

GPR61_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR61: view

Function for GPR61 Gene

Molecular function for GPR61 Gene

UniProtKB/Swiss-Prot Function:
Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity).

Phenotypes From GWAS Catalog for GPR61 Gene

Gene Ontology (GO) - Molecular Function for GPR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 28827538
GO:1990763 arrestin family protein binding IDA 28827538
genes like me logo Genes that share ontologies with GPR61: view
genes like me logo Genes that share phenotypes with GPR61: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR61

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR61

Clone Products

  • Addgene plasmids for GPR61

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR61 Gene

Localization for GPR61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR61 Gene

Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Colocalizes with ARRB2/beta-arrestin-2 in the endosome (PubMed:28827538). {ECO:0000269 PubMed:28827538}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR61 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for GPR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 28827538
GO:0005886 plasma membrane IDA,IEA 28827538
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR61: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR61 Gene

Pathways & Interactions for GPR61 Gene

SuperPathways for GPR61 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with GPR61: view

Pathways by source for GPR61 Gene

1 BioSystems pathway for GPR61 Gene

Interacting Proteins for GPR61 Gene

Gene Ontology (GO) - Biological Process for GPR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IMP 28827538
GO:0043950 positive regulation of cAMP-mediated signaling IMP 28827538
genes like me logo Genes that share ontologies with GPR61: view

No data available for SIGNOR curated interactions for GPR61 Gene

Drugs & Compounds for GPR61 Gene

No Compound Related Data Available

Transcripts for GPR61 Gene

mRNA/cDNA for GPR61 Gene

Unigene Clusters for GPR61 Gene

G protein-coupled receptor 61:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR61

Clone Products

  • Addgene plasmids for GPR61

Alternative Splicing Database (ASD) splice patterns (SP) for GPR61 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5
SP1: - -
SP2: - -
SP3:

Relevant External Links for GPR61 Gene

GeneLoc Exon Structure for
GPR61
ECgene alternative splicing isoforms for
GPR61

Expression for GPR61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR61 Gene

This gene is overexpressed in Pituitary (x6.2), Brain - Cortex (x5.9), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR61 Gene



Protein tissue co-expression partners for GPR61 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR61 Gene:

GPR61

SOURCE GeneReport for Unigene cluster for GPR61 Gene:

Hs.709782

mRNA Expression by UniProt/SwissProt for GPR61 Gene:

Q9BZJ8-GPR61_HUMAN
Tissue specificity: Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level).

Evidence on tissue expression from TISSUES for GPR61 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPR61: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR61 Gene

Orthologs for GPR61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR61 34 33
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR61 34 33
  • 92.31 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr61 16 34 33
  • 91 (n)
rat
(Rattus norvegicus)
Mammalia Gpr61 33
  • 91 (n)
dog
(Canis familiaris)
Mammalia GPR61 34 33
  • 89.95 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR61 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR61 34 33
  • 72.4 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR61 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr61 33
  • 65.82 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC571338 33
  • 64.26 (n)
gpr61 34
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
OneToMany
Species where no ortholog for GPR61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR61 Gene

ENSEMBL:
Gene Tree for GPR61 (if available)
TreeFam:
Gene Tree for GPR61 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR61: view image

Paralogs for GPR61 Gene

Paralogs for GPR61 Gene

genes like me logo Genes that share paralogs with GPR61: view

Variants for GPR61 Gene

Sequence variations from dbSNP and Humsavar for GPR61 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000024569 -- 109,535,553(+) A/G upstream_transcript_variant
rs1000481273 -- 109,535,845(+) T/C upstream_transcript_variant
rs1000780038 -- 109,536,431(+) G/A upstream_transcript_variant
rs1001013342 -- 109,541,155(+) T/C intron_variant
rs1001211076 -- 109,544,679(+) C/T 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant

Variation tolerance for GPR61 Gene

Residual Variation Intolerance Score: 7.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR61

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR61 Gene

Disorders for GPR61 Gene

Additional Disease Information for GPR61

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR61 Gene

Publications for GPR61 Gene

  1. Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain. (PMID: 11690637) Cikos S … Koppel J (Biochimica et biophysica acta 2001) 2 3 4 22 58
  2. Identification of four novel human G protein-coupled receptors expressed in the brain. (PMID: 11165367) Lee DK … O'Dowd BF (Brain research. Molecular brain research 2001) 2 3 4 58
  3. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. (PMID: 28827538) Oishi A … Jockers R (Scientific reports 2017) 3 4 58
  4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for GPR61 Gene

  • Addgene plasmids for GPR61

Sources for GPR61 Gene

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