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Aliases for GPR6 Gene

Aliases for GPR6 Gene

  • G Protein-Coupled Receptor 6 2 3 5
  • Sphingosine 1-Phosphate Receptor GPR6 3 4
  • G-Protein Coupled Receptor 6 3

External Ids for GPR6 Gene

Previous GeneCards Identifiers for GPR6 Gene

  • GC06P110135
  • GC06P110323
  • GC06P110345
  • GC06P110406
  • GC06P107866

Summaries for GPR6 Gene

GeneCards Summary for GPR6 Gene

GPR6 (G Protein-Coupled Receptor 6) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is GPR3.

UniProtKB/Swiss-Prot for GPR6 Gene

  • Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).

Gene Wiki entry for GPR6 Gene

Additional gene information for GPR6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR6 Gene

Genomics for GPR6 Gene

GeneHancer (GH) Regulatory Elements for GPR6 Gene

Promoters and enhancers for GPR6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J109978 Enhancer 0.9 ENCODE 650.7 +0.4 427 0.1 MLX ARID4B SIN3A ZNF2 ZNF48 SLC30A9 GLIS2 ZNF143 NFKBIZ MXD4 GPR6 GC06P110094
GH06J109979 Enhancer 0.6 ENCODE 650.7 +0.0 27 0 CTCF PKNOX1 SP2 ZBTB8A ATF2 HIC1 ZNF335 POLR2A ZNF366 ZNF629 GPR6 GC06P110094
GH06J110039 Enhancer 1.2 FANTOM5 Ensembl ENCODE 1.3 +61.7 61658 1.5 ELF3 ZSCAN4 SIN3A ZNF2 RAD21 YY1 ZNF335 ZNF143 BCLAF1 RUNX3 WASF1 GPR6 GC06P110094
GH06J109891 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.2 -84.9 -84855 4.3 SMARCE1 CTCF NEUROD1 DPF2 ELF1 SP1 ZNF217 CTBP1 JUND GATA3 PPIL6 LOC105377938 FIG4 MICAL1 AK9 SMPD2 PIR51283 GPR6
GH06J109943 Enhancer 0.6 ENCODE 0.3 -33.4 -33352 2.2 MAZ RFX1 DPF2 BMI1 FOXA1 SP1 JUND POLR2A FOS FOSL2 GPR6 PIR51283
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR6 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • MEF-2A
  • MEF-2
  • aMEF-2
  • Pax-5
  • FOXD3
  • IRF-7A
  • CUTL1
  • E2F-5

Genomic Locations for GPR6 Gene

Genomic Locations for GPR6 Gene
2,465 bases
Plus strand
2,410 bases
Plus strand

Genomic View for GPR6 Gene

Genes around GPR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR6 Gene

Proteins for GPR6 Gene

  • Protein details for GPR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 6
    Protein Accession:
    Secondary Accessions:
    • B4DHS9
    • J3KQR3
    • Q17RJ7
    • Q5SYL0

    Protein attributes for GPR6 Gene

    362 amino acids
    Molecular mass:
    37881 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR6 Gene


neXtProt entry for GPR6 Gene

Post-translational modifications for GPR6 Gene

  • Glycosylation at Asn51, Asn9, and Asn2
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR6 Gene

Domains & Families for GPR6 Gene

Gene Families for GPR6 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for GPR6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR6: view

Function for GPR6 Gene

Molecular function for GPR6 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).
GENATLAS Biochemistry:
G protein coupled receptor 6,with close homology to GPR3,predominantly expressed in the putamen

Phenotypes From GWAS Catalog for GPR6 Gene

Gene Ontology (GO) - Molecular Function for GPR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 7832990
GO:0038036 sphingosine-1-phosphate receptor activity IEA --
genes like me logo Genes that share ontologies with GPR6: view
genes like me logo Genes that share phenotypes with GPR6: view

Animal Models for GPR6 Gene

MGI Knock Outs for GPR6:
  • Gpr6 Gpr6<tm1Dgen>

Animal Model Products

Clone Products

  • Addgene plasmids for GPR6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR6 Gene

Localization for GPR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR6 Gene

Cell membrane; Multi-pass membrane protein. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 7832990
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR6 Gene

Pathways & Interactions for GPR6 Gene

genes like me logo Genes that share pathways with GPR6: view

Pathways by source for GPR6 Gene

1 BioSystems pathway for GPR6 Gene

Interacting Proteins for GPR6 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: ENSP00000275169 P46095-GPR6_HUMAN for GPR6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GPR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate signaling pathway IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 7832990
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with GPR6: view

No data available for SIGNOR curated interactions for GPR6 Gene

Drugs & Compounds for GPR6 Gene

(2) Drugs for GPR6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Sphingosine Experimental Pharma 0
genes like me logo Genes that share compounds with GPR6: view

Transcripts for GPR6 Gene

mRNA/cDNA for GPR6 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR6 Gene

G protein-coupled receptor 6:
Representative Sequences:

Clone Products

  • Addgene plasmids for GPR6

Alternative Splicing Database (ASD) splice patterns (SP) for GPR6 Gene

No ASD Table

Relevant External Links for GPR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR6 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x17.0), Brain - Putamen (basal ganglia) (x15.9), and Brain - Caudate (basal ganglia) (x10.9).

NURSA nuclear receptor signaling pathways regulating expression of GPR6 Gene:


SOURCE GeneReport for Unigene cluster for GPR6 Gene:


Evidence on tissue expression from TISSUES for GPR6 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPR6: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR6 Gene

Orthologs for GPR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR6 34 33
  • 99.36 (n)
(Canis familiaris)
Mammalia GPR6 34 33
  • 91.16 (n)
(Bos Taurus)
Mammalia GPR6 34 33
  • 86.92 (n)
(Rattus norvegicus)
Mammalia Gpr6 33
  • 86.74 (n)
(Mus musculus)
Mammalia Gpr6 16 34 33
  • 86.65 (n)
(Monodelphis domestica)
Mammalia GPR6 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
(Gallus gallus)
Aves GPR6 34 33
  • 71.93 (n)
(Anolis carolinensis)
Reptilia GPR6 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr6 33
  • 67.66 (n)
(Danio rerio)
Actinopterygii LOC100538060 33
  • 69.44 (n)
si:ch73-362m14.3 34
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7224 33
Species where no ortholog for GPR6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR6 Gene

Gene Tree for GPR6 (if available)
Gene Tree for GPR6 (if available)
Evolutionary constrained regions (ECRs) for GPR6: view image

Paralogs for GPR6 Gene

Paralogs for GPR6 Gene

(2) SIMAP similar genes for GPR6 Gene using alignment to 4 proteins:

  • E7EP76_HUMAN
genes like me logo Genes that share paralogs with GPR6: view

Variants for GPR6 Gene

Sequence variations from dbSNP and Humsavar for GPR6 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000054218 -- 109,978,632(+) C/T intron_variant
rs1000127486 -- 109,977,480(+) A/T upstream_transcript_variant
rs1001801086 -- 109,980,482(+) A/G 3_prime_UTR_variant
rs1002133726 -- 109,980,071(+) A/G coding_sequence_variant, missense_variant
rs1003519718 -- 109,976,845(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR6 Gene

Variant ID Type Subtype PubMed ID
nsv1019690 CNV gain 25217958
nsv823821 CNV gain 20364138

Variation tolerance for GPR6 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR6 Gene

Disorders for GPR6 Gene

Additional Disease Information for GPR6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR6 Gene

Publications for GPR6 Gene

  1. Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. (PMID: 8530049) Song ZH … Bonner TI (Genomics 1995) 2 3 4 58
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  3. Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. (PMID: 19286662) Yin H … Chen YA (The Journal of biological chemistry 2009) 4 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for GPR6 Gene

Sources for GPR6 Gene

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